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Search Results: 1 - 10 of 5160 matches for " Hiroshi Miyazaki "
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Atherogenic lipids profile relates to postprandial hyperglycemia and hyperinsulinemia due to whole body insulin resistance in prediabetic subjects  [PDF]
Yoshinori Miyazaki, Makoto Furugen, Hiroshi Akasaka, Shigeyuki Saitoh, Tetsuji Miura
Journal of Diabetes Mellitus (JDM) , 2012, DOI: 10.4236/jdm.2012.23044
Abstract: Backgrounds: Differences in serum lipids profiles in different type of glucose intolerance are unclear. Aims: To characterize lipid profiles in different type of glucose intolerance, and to assess relationships between serum lipids profile and disturbance of glucose metabolism in prediabetic subjects. Methods: Using the measurements in medical check-up with 75 goral glucose tolerance test (OGTT), total of 620 male subjects, who are not on medications for metabolic diseases or hypertension, were divided into normal fasting glucose and glucose tolerance (NFG/ NGT), isolated impaired fasting glucose (iIFG), isolated impaired glucose tolerance (iIGT) and combined IFG and IGT (IFG/IGT) based on results of the OGTT. Results: Age and body mass index (BMI) were similar in the four groups. Matsuda index (an index of whole body insulin sensitivity) was lower in iIFG, iIGT and IFG/IGT as compared with NFG/NGT. Plasma insulin excursion during the OGTT was significantly higher in IFG/IGT versus NFG/NGT. Serum triglyceride level (TG) and TG to HDL ratio (TG/HDL) were higher in IFG/IGT versus NFG/NGT. Matsuda index was positively correlated with HDL and was inversely correlated with TG, LDL, non-HDL, TG/ HDL and LDL to HDL ratio (LDL/HDL). Backward stepwise multiple regression analysis indicated that increases in BMI, plasma insulin level at 60 min (PI60) and plasma glucose level at 120 min in the OGTT were independently associated with increases in TG and TG/HDL. Increases in BMI and PI60 were related to an increase in non-HDL and LDL/HDL and a decrease in HDL. Conclusions: These results indicate that postprandial hyperglycemia and hyperinsulinemia based on advanced insulin resistance are closely related to lipid risk factors of atherosclerotic macrovascular disease in prediabetic subjects.
Development of a Molecular Marker to Identify a Candidate Line of Turmeric (Curcuma longa L.) with a High Curcumin Content  [PDF]
Hiroshi Hayakawa, Tetsuya Kobayashi, Yukio Minaniya, Katsura Ito, Akira Miyazaki, Tatsuya Fukuda, Yoshinori Yamamoto
American Journal of Plant Sciences (AJPS) , 2011, DOI: 10.4236/ajps.2011.21002
Abstract: Dried and fresh rhizomes of the spice turmeric (Curcuma longa L.) are well known in traditional medicine, and curcu- min is widely used in various geographic regions. Although there are differences in the amount of curcumin within this species, identification of the candidate line by rhizome is difficult because of the relative simplicity of its morphological characteristics. To accurately identify lines of C. longa with a high content of curcumin, we analysed several sequences of chloroplast DNA. First, to determine the appropriate outgroup taxa in which to conduct infras-pecific analyses of C. longa, we reconstructed the molecular phylogenetic tree of C. longa and its allied species. The results showed that C. aromatica and C. zedoaria are closely related to C. longa. Next, to develop a molecular marker for identifying lines of C. longa with a high content of curcumin, a network analysis using chloroplast microsatellite regions was performed. Results showed that a unique haplotype within C. longa corresponds to the high curcumin content line. Therefore, the chloroplast microsatellite regions used for the analysis allowed us to determine the lines of this species with high cur- cumin content.
Clarithromycin Attenuates the Bronchial Epithelial Damage Induced by Mycoplasma pneumoniae Infection  [PDF]
Hiroshi Tanaka, Hisato Sadakata, Tae Nagami, Shun Miyazaki, Tsutomu Tomita, Shuhei Shirata, Takehiro Yamagishi
Advances in Microbiology (AiM) , 2014, DOI: 10.4236/aim.2014.411075
Abstract: To analyze the bronchial epithelial cell damage induced by Mycoplasma pneumonia and the therapeutic effects of clarithromycin, we observed bronchial tissue damage by using a mouse model and performing immunostaining and scanning electron microscopy. The immunostaining study showed that M. pneumoniae-labeled fluorescence was found on the mucosal epithelium of mice, 6 days after inoculation. Clarithromycin treatment reduced the fluorescence. In this study, we demonstrated that the morphological alterations of bronchial mucosa, including the shortening and loss of ciliavisualized by scanning electron microscopy, and the inflammatory cell migration in the submucosal tissue visualized by differential interference contrast microscopy, were induced by mycoplasmal infection. We also showed that clarithromycin treatment, when administered from the first day of inoculation, attenuated both the bronchial epithelial damage and inflammatory cell migration in the submucosal tissue. These results suggest that the therapeutic effects of clarithromycin against mycoplasmal infection, may be due to its antibacterial and anti-inflammatory activities.
Phase Diagram of $β'$-(BEDT-TTF)$_2$ICl$_2$ under High Pressure Based on the First-Principles Electronic Structure
Hiori Kino,Hiroshi Kontani,Tsuyoshi Miyazaki
Physics , 2003, DOI: 10.1143/JPSJ.73.25
Abstract: We present a theoretical study on the superconductivity of $\beta'$-(BEDT-TTF)$_2$ICl$_2$ at $T_{\rm c}=$14.2 K under a high hydrostatic pressure recently found, which is the highest among organic superconductors. In the present work, we study an effective model using the fluctuation-exchange (FLEX) approximation based on the results of first-principles calculation. In the obtained phase diagram, the superconductivity with $d_{xy}$-like symmetry is realized next to the antiferromagnetic phase, as a result of the one-dimensional to two-dimensional crossover driven by the pressure.
A Moxa Stimulation on the Leg Affected the Function of Stomach via Autonomic Nerve System and Polymodal Receptors  [PDF]
Junji Miyazaki, Hiroshi Kuge, Hidetoshi Mori, Eriko Izumi, Hideaki Tanaka, Mayumi Watanabe
Health (Health) , 2016, DOI: 10.4236/health.2016.88078
Abstract: The moxa therapy is a popular traditional hyperthermia therapy in East Asia. The moxa is made from dried mugwort (Artemisiaargyi). The moxa is usually put on a meridian point and then is burnt on to obtain a hyperthermic stimulation to the skin. However, very few researches have been studied in the effects and mechanism of the moxa therapy. Therefore, in this study, we gave the moxa stimulation to healthy subjects. In the moxa group, the moxa was lit on the ST36 (Zusanli: an acupuncture point in anterior tibialis of the leg) for 5 minutes. Their responses were traced with electrogastrogram (EGG) and assessed the change of gastric function. At the same time, their heart rate (HR) was recorded and observed to study the mechanism of moxa treatment. And then their results were compared with those of the control group. After the moxa stimulation, EGG showed significant increase and stayed 3.0 - 3.1 cpm while HR prominently decreased. On the other hand, the control group did not indicate such results. Those results are common to the re-sponse of acupuncture-like stimulation by the reflex arc which consists of receptor, sensory neuron, central nervous system, motor neuron and effector. It may be explained as below: the elements of the acupuncture-like stimulation and the moxa are pain and hyperthermia respectively and they both are received by polymodal receptors. Thus the moxa stimulation applied on ST36 may be ef-fective to enhance stomach function.
A Novel Photonic Material for Designing Arbitrarily Shaped Waveguides in Two Dimensions
Hiroshi Miyazaki,Masashi Hase,Hideki T. Miyazaki,Yoichi Kurokawa,Norio Shinya
Physics , 2003, DOI: 10.1103/PhysRevB.67.235109
Abstract: We investigate numerically optical properties of novel two-dimensional photonic materials where parallel dielectric rods are randomly placed with the restriction that the distance between rods is larger than a certain value. A large complete photonic gap (PG) is found when rods have sufficient density and dielectric contrast. Our result shows that neither long-range nor short-range order is an essential prerequisite to the formation of PGs. A universal principle is proposed for designing arbitrarily shaped waveguides, where waveguides are fenced with side walls of periodic rods and surrounded by the novel photonic materials. We observe highly efficient transmission of light for various waveguides. Due to structural uniformity, the novel photonic materials are best suited for filling up the outer region of waveguides of arbitrary shape and dimension comparable with the wavelength.
Mechanisms of Ovarian Cancer Metastasis: Biochemical Pathways
Kentaro Nakayama,Naomi Nakayama,Hiroshi Katagiri,Kohji Miyazaki
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms130911705
Abstract: Ovarian cancer is the most lethal gynecologic malignancy. Despite advances in chemotherapy, the five-year survival rate of advanced ovarian cancer patients with peritoneal metastasis remains around 30%. The most significant prognostic factor is stage, and most patients present at an advanced stage with peritoneal dissemination. There is often no clearly identifiable precursor lesion; therefore, the events leading to metastatic disease are poorly understood. This article reviews metastatic suppressor genes, the epithelial-mesenchymal transition (EMT), and the tumor microenvironment as they relate to ovarian cancer metastasis. Additionally, novel chemotherapeutic agents targeting the metastasis-related biochemical pathways are discussed.
Enzyme-Immobilized Microfluidic Process Reactors
Yuya Asanomi,Hiroshi Yamaguchi,Masaya Miyazaki,Hideaki Maeda
Molecules , 2011, DOI: 10.3390/molecules16076041
Abstract: Microreaction technology, which is an interdisciplinary science and engineering area, has been the focus of different fields of research in the past few years. Several microreactors have been developed. Enzymes are a type of catalyst, which are useful in the production of substance in an environmentally friendly way, and they also have high potential for analytical applications. However, not many enzymatic processes have been commercialized, because of problems in stability of the enzymes, cost, and efficiency of the reactions. Thus, there have been demands for innovation in process engineering, particularly for enzymatic reactions, and microreaction devices represent important tools for the development of enzyme processes. In this review, we summarize the recent advances of microchannel reaction technologies especially for enzyme immobilized microreactors. We discuss the manufacturing process of microreaction devices and the advantages of microreactors compared to conventional reaction devices. Fundamental techniques for enzyme immobilized microreactors and important applications of this multidisciplinary technology are also included in our topics.
Determination of Key Intermediates in Cholesterol and Bile Acid Biosynthesis by Stable Isotope Dilution Mass Spectrometry
Tadashi Yoshida, Akira Honda, Hiroshi Miyazaki and Yasushi Matsuzaki
Analytical Chemistry Insights , 2012,
Abstract: For more than a decade, we have developed stable isotope dilution mass spectrometry methods to quantify key intermediates in cholesterol and bile acid biosynthesis, mevalonate and oxysterols, respectively. The methods are more sensitive and reproducible than conventional radioisotope (RI), gas-chromatography (GC) or high-performance liquid chromatography (HPLC) methods, so that they are applicable not only to samples from experimental animals but also to small amounts of human specimens. In this paper, we review the development of stable isotope dilution mass spectrometry for quantifying mevalonate and oxysterols in biological materials, and demonstrate the usefulness of this technique.
Determination of Key Intermediates in Cholesterol and Bile Acid Biosynthesis by Stable Isotope Dilution Mass Spectrometry
Tadashi Yoshida,Akira Honda,Hiroshi Miyazaki,Yasushi Matsuzaki
Analytical Chemistry Insights , 2008,
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