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Search Results: 1 - 10 of 4903 matches for " Hiroshi Kuroda "
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Molecular Breeding of Advanced Microorganisms for Biofuel Production
Hiroshi Sakuragi,Kouichi Kuroda,Mitsuyoshi Ueda
Journal of Biomedicine and Biotechnology , 2011, DOI: 10.1155/2011/416931
Abstract: Large amounts of fossil fuels are consumed every day in spite of increasing environmental problems. To preserve the environment and construct a sustainable society, the use of biofuels derived from different kinds of biomass is being practiced worldwide. Although bioethanol has been largely produced, it commonly requires food crops such as corn and sugar cane as substrates. To develop a sustainable energy supply, cellulosic biomass should be used for bioethanol production instead of grain biomass. For this purpose, cell surface engineering technology is a very promising method. In biobutanol and biodiesel production, engineered host fermentation has attracted much attention; however, this method has many limitations such as low productivity and low solvent tolerance of microorganisms. Despite these problems, biofuels such as bioethanol, biobutanol, and biodiesel are potential energy sources that can help establish a sustainable society.
Plasma-Electrolysis of Dinitrophenol in Gas-Liquid Boundary and Interpretation Using Molecular Orbital Theory  [PDF]
Hiroshi Okawa, Hiroki Kuroda, Keiko Hirayama-Katayama, Shin-Ichiro Kojima, Tetsuya Akitsu
World Journal of Engineering and Technology (WJET) , 2019, DOI: 10.4236/wjet.2019.71010
The advanced oxidation of 2,4-dinitrophenol (DNP), 2,5-DNP, and 3,4-DNP in aqueous solution has been investigated using a multi-gas, dielectric barrier discharge. Dielectric barrier discharge was operated in the aqueous solution and gas boundary. The degradation was measured by high performance liquid chromatography (HPLC). The acceleration of the advanced-oxidation has been investigated by the combination of the anion exchange polymer membrane. The result indicated that the degradation pathways involve a rapid detachment of the nitro group and a slow opening of the aromatic-ring. The hydroxyl radical and the excited hydroxyl anion are responsible for the primary attack of the DNP with the production of dihydroxy-nitrobenzenes. The attack of hydroxyl radical occurs at the benzene ring carbon activated by the presence of a phenolic OH group and a nitro group. The result suggested that the reaction is dominated by a pseudo-first order kinetic reaction. The degradation process is interpreted using Molecular Orbital Theory.
LaCo2B2: A Co-based layered superconductor with a ThCr2Si2-type structure
Hiroshi Mizoguchi,Toshiaki Kuroda,Toshio Kamiya,Hideo Hosono
Physics , 2011, DOI: 10.1103/PhysRevLett.106.237001
Abstract: LaCo2B2 with a ThCr2Si2-type structure composed of alternately stacked La and CoB layers exhibits metallic electrical conductivity and Pauli paramagnetic behavior down to 2K. Bulk superconductivity with a Tc of ~4K emerges upon substitution with dopant elements; i.e., isovalent substitution to form (La1-xYx)Co2B2, or aliovalent substitution to form La(Co1-xFex)2B2. Highly covalent bonding between Co 3d and B 2p levels in the CoB layers, which is caused by the B 2p level being shallower than the Fermi level, removes magnetic ordering from Co 3d electrons even in the undoped samples.
Prediction of protein motions from amino acid sequence and its application to protein-protein interaction
Shuichi Hirose, Kiyonobu Yokota, Yutaka Kuroda, Hiroshi Wako, Shigeru Endo, Satoru Kanai, Tamotsu Noguchi
BMC Structural Biology , 2010, DOI: 10.1186/1472-6807-10-20
Abstract: In this work, we present a novel method for predicting two kinds of protein motions in ordered structures. The prediction uses only information from the amino acid sequence. We prepared a dataset of the internal and external motions of segments in many proteins by application of NMA. Subsequently, we analyzed the relation between thermal motion assessed from X-ray crystallographic B-factor and internal/external motions calculated by NMA. Results show that attributes of amino acids related to the internal motion have different features from those related to the B-factors, although those related to the external motion are correlated strongly with the B-factors. Next, we developed a method to predict internal and external motions from amino acid sequences based on the Random Forest algorithm. The proposed method uses information associated with adjacent amino acid residues and secondary structures predicted from the amino acid sequence. The proposed method exhibited moderate correlation between predicted internal and external motions with those calculated by NMA. It has the highest prediction accuracy compared to a na?ve model and three published predictors.Finally, we applied the proposed method predicting the internal motion to a set of 20 proteins that undergo large conformational change upon protein-protein interaction. Results show significant overlaps between the predicted high internal motion regions and the observed conformational change regions.A protein molecule is not a rigid body. The scale of protein motions is very broad: motions range from local fluctuations such as those seen in loop regions to global ones involving changes in the relative position of rigid domains. Flexible regions and linkers connecting rigid regions are often observed in large proteins. Flexible regions are often necessary for proteins to perform their specific biological functions [1-4], e.g. by enabling proteins to adjust their conformations in response to external stimulation. Suc
Dyeing Fabrics by Using Extracts from Mulberry Branch/Trunk 1. Dyeability and Fluorescence Property  [PDF]
Th? Kim Thu Nguy?n, Akihiro Kuroda, Hiroshi Urakawa, Hidekazu Yasunaga
American Journal of Plant Sciences (AJPS) , 2017, DOI: 10.4236/ajps.2017.88128
Abstract: The dyeing of wool, silk, cotton, ramie, nylon, acrylic and polyester fabric by using the extracts from mulberry branches and trunks was tried and the dyeability was studied. While the dyeability of the ethanol-extracts from mulberry is low, that of the water-extracts is high for wool, nylon and silk fabrics. They are dyed brownish and yellowish colours. The obtained colours depend on the extracts concentration in the dye solution, dyeing time, dye solution pH and dyeing temperature. Wool, nylon and silk fabrics are dyed deeper with an increase in the dyeing temperature. The mulberry extracts show fluorescence and reducing property. The results indicate that the mulberry extracts contain flavonols such as morin, kaempferol or quercetin, which form complexes with Al3+ and show fluorescence. The wool treated with the mulberry extracts or AlCl3/mulberry extracts shows fluorescence with ultraviolet light irradiation.
Effect of the Position of Reaction-Site in Amphipathic-Type Thioester in Aqueous Amidation Reaction  [PDF]
Ikumi Otomo, Chiaki Kuroda
Advances in Chemical Engineering and Science (ACES) , 2015, DOI: 10.4236/aces.2015.53032
Abstract: Amphipathic-type thioesters CH3(CH2)mCOS(CH2)nCOONa (m + n = 12) were synthesized and their reaction with various alkylamines was examined. Compounds having thioester moiety close to carboxylate (m = 10, n = 2) afforded the corresponding amides in good yields, while the substrate having thioester moiety distant from carboxylate (m = 2, n = 10) afforded the amides in relatively low yield. In all cases, the difference in yield due to the chain length of amine was not observed. The results indicated that the reaction took place effectively near the surface of micelle. However, the reaction was found to occur not only on micelle surface but also in solution.
No association between the sigma receptor type 1 gene and schizophrenia: results of analysis and meta-analysis of case-control studies
Naohiko Uchida, Hiroshi Ujike, Kenji Nakata, Manabu Takaki, Akira Nomura, Takeshi Katsu, Yuji Tanaka, Takaki Imamura, Ayumu Sakai, Shigetoshi Kuroda
BMC Psychiatry , 2003, DOI: 10.1186/1471-244x-3-13
Abstract: A case-control association study between two polymorphisms of the SIGMAR1 gene, G-241T/C-240T and Gln2Pro, and schizophrenia in Japanese population, and meta-analysis including present and previous studies.There was no significant association of any allele or genotype of the polymorphisms with schizophrenia. Neither significant association was observed with hebephrenic or paranoid subtype of schizophrenia. Furthermore, a meta-analysis including the present and previous studies comprising 779 controls and 636 schizophrenics also revealed no significant association between the SIGMAR1 gene and schizophrenia.In view of this evidence, it is likely that the SIGMAR1 gene does not confer susceptibility to schizophrenia.Sigma receptors were originally designated as a subtype of opioid receptors to mediate psychotomimetic actions of certain opioids such as N-allylnormetazocine [1], but now they has been defined as non-opiate and non-phencyclidine binding sites [2]. Sigma receptors are expressed in various tissues and supposed to be involved in diverse physiological functions. Especially, substantial roles of sigma receptors in pathogenesis of psychoses including schizophrenia have been suggested by many preclinical and clinical studies. In preclinical studies, putative sigma receptor antagonists including BMY-14802 and NE-100 improved two classes of animal models of schizophrenia, behavioral sensitization to psychostimulants [3-5] and phencyclidine-induced cognitive dysfunction [6]. Binding studies revealed that sigma receptors are expressed densely in mesolimbic and mesocortical areas including cortex and hippocampus [7,8], where structural abnormalities were reported in schizophrenic brains. In addition, postmortem studies showed a reduced sigma receptor density in the brain of schizophrenia compared to that of controls [9,10]. In clinical trials, putative selective antagonists of sigma receptors, such as SL 82.0715 and panamesine, showed successful therapeutic effects for
Interview: Prof. F. Miura.
T. Kuroda
Hellenic Orthodontic Review , 2001,
The Impact of Regional Jets in the Airline Market in the US
Ernesto Kuroda
Revista de Literatura dos Transportes , 2010,
Abstract: This article is based on a paper entitled “Technological Innovation in the Airline Industry: The impact of Regional Jets” written by Jan K. Brueckner and Vivek Pai, and aims to analyze the impact caused by Regional Jets (RJs) in the North American market, which started and got stronger from the 90s. The hypothesis that RJs would have opened new point to point (PP) routes that were previously uneconomical is raised, but data gathered from four major airlines in the North American market contradicts this theory. Last, there’s a discussion about possible negative impacts that the use of regional jets can be causing.[Paper in Portuguese]
Health care response to the tsunami in Taro District, Miyako, Iwate Prefecture
Hitoshi Kuroda
Western Pacific Surveillance and Response , 2011,
Abstract: Problem : In the Taro District (population: 4434), the great tsunami of 11 March 2011 destroyed the central region including the clinic, the sole medical facility (one physician, 13 nurses and other staff) in the district, and many citizens were forced to live in evacuation centres.Context: The Taro District experienced massive damage during the tsunamis of 1896 and 1933. Since then countermeasures to tsunamis have been implemented. The great tsunami on 11 March 2011 caused catastrophic damage to the low-lying areas where approximately 2500 people lived; 1609 buildings were completely destroyed, and approximately 200 people died or were missing across the district.Action: The Taro National Health Insurance Clinic, the sole medical facility in the Taro District, was required to play a central role in a variety of activities to care for residents in severely affected areas. First of all, evacuees needed to move to neighbouring hospitals or safer evacuation centres because lifeline services were cut off to the first evacuation centre. Then, the clinic staff worked in a temporary clinic; they visited the evacuation centres to assess the public health and medical situation, cared for wounded residents, managed infection control and encouraged a normal lifestyle where possible. Additional medical, pharmaceutical and logistical support was received from outside the district.Outcome: There was no noticeably severe damage to health, although there was manifestation of and deterioration in lifestyle-related diseases (e.g. diabetes, hypertension, obesity). Health care activities gradually returned to their pre-disaster levels. At the end of July 2011, the evacuation centres closed, and all evacuees moved to temporary accommodations.Discussion: Isolated rural health practitioners were required to be involved in a wide variety of activities related to the disaster in addition to their routine work: e.g. preventive health (public health and safety activities), routine medical care, acute medical care, psychological care, post-mortems and recovery of medical facilities. Although the whole health care system returned to near-normal six months after the disaster, it is important to plan how to develop more resilient medical systems to respond to disasters, especially in rural areas. This article describes my experience and lessons learnt in responding to this disaster.
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