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Search Results: 1 - 10 of 4822 matches for " Hiroshi Hirose "
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Induction of Oral Tolerance in Neonatal Mice by Transfer of Food Allergens as IgA-Immune Complexes in Breast Milk  [PDF]
Kumiko Kizu, Ayu Matsunaga, Junko Hirose, Akihiro Kimura, Hiroshi Narita
Food and Nutrition Sciences (FNS) , 2015, DOI: 10.4236/fns.2015.62023
Abstract: Various opinions have been presented on the merits and demerits that breastfeeding gives for the allergic onset of the babies. In this report, we focused on whether food proteins eaten by mother mice and secreted into breast milk as IgA-immune complexes contribute to the allergy prevention through oral tolerance in infants who ingest the milk. BALB/c mice were divided into two groups; E-group fed only egg white proteins and M-group fed only cow’s milk proteins as a dietary protein source. After immunizing M-group infants fed their own mother’s milk with ovalbumin/alum, diarrhea associated with experimental Th2 intestinal inflammation was induced by oral administration of ovalbumin. The diarrhea was dramatically suppressed in E-group infants. Concomitantly, low level of serum anti-ovalbumin- and ovomucoid-IgG1 and IgE, suppression of IL-4 synthesis by spleen cells, and low incidence of anaphylactic death after intravenous injection of ovalbumin were observed preferentially in E-infants. Immune complexes of respective dietary proteins and IgA were found in the breast milk obtained from each group of mother. Oral administration of pseudo immune complex chemically synthesized with ovalbumin and monoclonal mouse IgA in advance effectively suppressed anti-ovalbumin-IgG1 synthesis in adult mice after immunization with ovalbumin. The tolerance induced by the pseudo immune complex of ovalbumin diminished spontaneously while mice did not take egg white proteins. Thus, immune tolerance and then prevention of allergic disorder against dietary proteins were acquired via breastfeeding by mothers feeding the relevant proteins, probably through the immune complexes of dietary proteins and sIgAs secreted into breast milk.
Roles of IL-22 in Allergic Airway Inflammation
Koichi Hirose,Kentaro Takahashi,Hiroshi Nakajima
Journal of Allergy , 2013, DOI: 10.1155/2013/260518
Roles of IL-22 in Allergic Airway Inflammation
Koichi Hirose,Kentaro Takahashi,Hiroshi Nakajima
Journal of Allergy , 2013, DOI: 10.1155/2013/260518
Abstract: IL-23- and IL-17A-producing CD4+ T cell (Th17 cell) axis plays a crucial role in the development of chronic inflammatory diseases. In addition, it has been demonstrated that Th17 cells and their cytokines such as IL-17A and IL-17F are involved in the pathogenesis of severe asthma. Recently, IL-22, an IL-10 family cytokine that is produced by Th17 cells, has been shown to be expressed at the site of allergic airway inflammation and to inhibit allergic inflammation in mice. In addition to Th17 cells, innate lymphoid cells also produce IL-22 in response to allergen challenge. Functional IL-22 receptor complex is expressed on lung epithelial cells, and IL-22 inhibits cytokine and chemokine production from lung epithelial cells. In this paper, we summarize the recent progress on the roles of IL-22 in the regulation of allergic airway inflammation and discuss its therapeutic potential in asthma. 1. Introduction Asthma is a chronic inflammatory disease that is accompanied by intense eosinophilic infiltration, goblet cell hyperplasia, and airway hyperreactivity (AHR) [1]. In atopic asthma patients, it is well established that these features are mediated by antigen-specific Th2 cells and their cytokines including IL-4, IL-5, and IL-13 [2, 3]. In addition, several lines of evidence have shown that not only Th2 cell-derived cytokines but also Th17 cell-derived cytokines such as IL-17A and IL-17F are expressed in the airways in severe asthma patients, and that the levels of IL-17A and IL-17F in the airways are correlated with the severity of asthma, suggesting the involvement of Th17 cell-derived cytokines in the pathogenesis of severe asthma [4, 5]. Moreover, we and others have shown that Th17 cells are involved in the development of antigen-induced airway inflammation in murine asthma models [6–8]. Interestingly, recent studies have shown that IL-22, one of Th17 cell-derived cytokines, is detected in bronchoalveolar lavage fluid (BALF) in murine asthma models [8, 9]. Furthermore, it has been reported that the levels of IL-22 mRNA are increased in peripheral blood mononuclear cells in asthma patients [10, 11], and that the levels of IL-22 in sera tend to correlate with the severity of asthma [12]. In this paper, we briefly summarize the roles of IL-22 in the regulation of allergic inflammation in asthma. 2. IL-22 and IL-22 Receptor IL-22 is an IL-10 family cytokine that is originally identified from IL-9-stimulated T lymphoma cells and designated as IL-TIF (IL-10-related T cell-derived inducible factor) [13]. Functional IL-22 receptor consists of IL-22R1 and
Matching of the Gray Whales of off Sakhalin and the Pacific Coast of Japan, with a Note on the Stranding at Wadaura, Japan in March, 2016  [PDF]
Gen Nakamura, Hiroshi Katsumata, Yujin Kim, Minoru Akagi, Ayumi Hirose, Kazutoshi Arai, Hidehiro Kato
Open Journal of Animal Sciences (OJAS) , 2017, DOI: 10.4236/ojas.2017.72014
Abstract: The coast of Japan is a migratory corridor for the western stock of the gray whales (Eschrichtius robustus), which was once considered as extinct and remains endangered. According to the historical records, from 1955 to 2014, only 21 gray whales occurrence has been recorded in 59 years. However, from 2015 to 2016, intensive occurrence including the seven sightings and the two strandings were noted. In this paper, we found that those sightings were re-sightings of the same individual, which was initially sighted off Sakhalin during August, 2014. On 4 March, 2016, a young female gray whale (8.9 m in body length) was stranded at Wadaura beach, Chiba prefecture. We also conducted research on this animal including taking pictures and external measurements. In addition, we flensed this animal to observe the internal organs and collect a skeletal specimen. The reason for the death of this animal remains unclear; however, from its external characteristics, we identified that this animal was not an identical one, sighted off Sakhalin and the coast of Japan from 2014 to 2016. On 5 April, 2016, another young female gray whale (7 m in body length) was stranded at Arai beach, Shizuoka prefecture. We concluded that from 2015 to 2016, at least three distinct gray whales have migrated along the coast of Japan.
C-Reactive Protein, High-Molecular-Weight Adiponectin and Development of Metabolic Syndrome in the Japanese General Population: A Longitudinal Cohort Study
Yoshifumi Saisho, Hiroshi Hirose, Rachel Roberts, Takayuki Abe, Hiroshi Kawabe, Hiroshi Itoh
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073430
Abstract: Aims To clarify predictive values of C-reactive protein (CRP) and high-molecular-weight (HMW) adiponectin for development of metabolic syndrome. Research Design and Methods We conducted a prospective cohort study of Japanese workers who had participated in an annual health checkup in 2007 and 2011. A total of 750 subjects (558 men and 192 women, age 46±8 years) who had not met the criteria of metabolic syndrome and whose CRP and HMW-adiponectin levels had been measured in 2007 were enrolled in this study. Associations between CRP, HMW-adiponectin and development of metabolic syndrome after 4 years were assessed by logistic regression analysis and their predictive values were compared by receiver operating characteristic analysis. Results Among 750 subjects, 61 (8.1%) developed metabolic syndrome defined by modified National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria and 53 (7.1%) developed metabolic syndrome defined by Japan Society for the Study of Obesity (JASSO) in 2011. Although CRP and HMW-adiponectin were both significantly correlated with development of metabolic syndrome, multivariate logistic regression analysis revealed that HMW-adiponectin but not CRP was associated with metabolic syndrome independently of BMI or waist circumference. Adding these biomarkers to BMI or waist circumference did not improve the predictive value for metabolic syndrome. Conclusion Our findings indicate that the traditional markers of adiposity such as BMI or waist circumference remain superior markers for predicting metabolic syndrome compared to CRP, HMW-adiponectin, or the combination of both among the Japanese population.
Unrecognized States in the Former USSR and Kosovo: A Focus on Standing Armies  [PDF]
Yoko Hirose
Open Journal of Political Science (OJPS) , 2016, DOI: 10.4236/ojps.2016.61007
Abstract: The end of the Cold War and the collapse of the USSR and Yugoslavia result in a proliferation of unrecognized and weak states, which continue to exist today. This article considers the relationship between unrecognized states and the major powers, Russia and the United States, by focusing on the foreign military bases or standing armies of the latter. In addition, unrecognized states, their parent countries, and similar states have received significant merits and profits from being unrecognized states, and this situation has also helped the survival of unrecognized states. It is possible that unrecognized states can be understood as part of the global strategies of the two great powers and that these states have been maintained through a complex negotiation process that is designed to maintain the superpowers’ global influence.
Rheological Behavior of Nanosilica Suspensions in Poly(Ethylene Oxide) Solutions with Sodium Chloride  [PDF]
Yuji Hirose
Materials Sciences and Applications (MSA) , 2017, DOI: 10.4236/msa.2017.85022
Abstract: Suspensions of silica nanoparticles showed shear-thickening profiles under steady shear conditions up on addition of a small amount of poly(ethylene oxide) (PEO). The suspensions turned into gels upon shaking and their fluidity was recovered several minutes after resting. We studied the rheological properties of these shake gels with small amounts of sodium chloride (NaCl). Gelation occurred at lower shear rates upon addition of small amounts of NaCl. In addition, the time taken by the gelated samples to recover their original viscosity increased with the increasing NaCl content. The weakened repulsive interactions between the silica particles upon NaCl addition lead to particles in closer proximity, and three-dimensional networks of PEO chains are easily formed as the electric double layer of the particles becomes thinner.
Quality Control System for Beer Developed with Monoclonal Antibodies Specific to Barley Lipid Transfer Protein
Yukie Murakami-Yamaguchi,Junko Hirose,Kumiko Kizu,Fumiko Okazaki,Wataru Fujii,Hiroshi Narita
Antibodies , 2012, DOI: 10.3390/antib1030259
Abstract: Non-specific lipid transfer protein (LTP) in barley grain reacted with the IgE in sera drawn from food allergy patients. A sandwich-type of enzyme-linked immunosorbent assay (ELISA) was developed with mouse monoclonal antibodies raised against LTP purified with barley flour. This ELISA showed a practical working range of 0.3–3 ng/mL and no cross-reactivity with wheat, adlay and rye. Using this ELISA, LTP was determined in several types of barley-foods, including fermented foods such as malt vinegar, barley-malt miso and beer. LTP content in beer of the same kind was approximately constant, even if manufacturing factory and production days were different. Not only as a factor of foam formation and stability but also as an allergen, controlling and monitoring of LTP in beer should be considered. Taken together, our LTP-detecting ELISA can be proposed as an appropriate system for the quality control of beer.
Prediction of protein motions from amino acid sequence and its application to protein-protein interaction
Shuichi Hirose, Kiyonobu Yokota, Yutaka Kuroda, Hiroshi Wako, Shigeru Endo, Satoru Kanai, Tamotsu Noguchi
BMC Structural Biology , 2010, DOI: 10.1186/1472-6807-10-20
Abstract: In this work, we present a novel method for predicting two kinds of protein motions in ordered structures. The prediction uses only information from the amino acid sequence. We prepared a dataset of the internal and external motions of segments in many proteins by application of NMA. Subsequently, we analyzed the relation between thermal motion assessed from X-ray crystallographic B-factor and internal/external motions calculated by NMA. Results show that attributes of amino acids related to the internal motion have different features from those related to the B-factors, although those related to the external motion are correlated strongly with the B-factors. Next, we developed a method to predict internal and external motions from amino acid sequences based on the Random Forest algorithm. The proposed method uses information associated with adjacent amino acid residues and secondary structures predicted from the amino acid sequence. The proposed method exhibited moderate correlation between predicted internal and external motions with those calculated by NMA. It has the highest prediction accuracy compared to a na?ve model and three published predictors.Finally, we applied the proposed method predicting the internal motion to a set of 20 proteins that undergo large conformational change upon protein-protein interaction. Results show significant overlaps between the predicted high internal motion regions and the observed conformational change regions.A protein molecule is not a rigid body. The scale of protein motions is very broad: motions range from local fluctuations such as those seen in loop regions to global ones involving changes in the relative position of rigid domains. Flexible regions and linkers connecting rigid regions are often observed in large proteins. Flexible regions are often necessary for proteins to perform their specific biological functions [1-4], e.g. by enabling proteins to adjust their conformations in response to external stimulation. Suc
Pulmonary-Renal Syndrome with Negative ANCAs and Anti-GBM Antibody
Hiroshi Yamaguchi,Atsuhisa Shirakami,Takashi Haku,Takashige Taoka,Yoshikazu Nakanishi,Toru Inai,Takanori Hirose
Case Reports in Nephrology , 2013, DOI: 10.1155/2013/434531
Abstract: We report the case of a 76-year-old woman who was referred to our hospital for a gradually worsening cough and renal dysfunction. Although pneumonia was initially suspected, imaging findings of the lungs revealed diffuse alveolar hemorrhage at a later date. Renal failure developed and hemodiafiltration was performed on the 9th day. Rapidly progressive glomerulonephritis with crescent formation was diagnosed by renal biopsy. This case presentation has important clinical implications because uncategorizable pulmonary-renal syndrome (PRS) without the presence of ANCAs and anti-GBM antibody is extremely rare and has high rates of morbidity and mortality. No treatment has been established. 1. Introduction Pulmonary renal-syndrome (PRS), characterized by a combination of diffuse alveolar hemorrhage (DAH) and rapidly progressive glomerulonephritis (RPGN), is caused by varied etiologies, including Goodpasture’s syndrome, antineutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis (ASVV), cryoglobulinemia, systemic lupus erythematosus, environmental factors, and certain drugs [1, 2]. ASSV, which can be caused by microscopic polyangiitis (MPA), Wegener’s granulomatosis, and Churg-Strauss syndrome, accounts for approximately 70% of the cases of PRS. Antiproteinase-3 (anti-PR3, c-ANCA) and antimyeloperoxidase (anti-MPO, p-ANCA) antibodies, which have been reported to play a major role in the pathogenesis of ASSV, are detectable in 70–90% of cases and facilitate diagnosis. Our present patient could not be classified into known subgroups because all commercially available serologic studies were negative. Therefore, a renal biopsy was performed for diagnostic clues at a later date. As a result, PRS was diagnosed on the basis of clinical manifestations and pathological findings. 2. Case Report A 76-year-old Japanese woman presented to our hospital complaining of a worsening cough of 10-day duration. Her past medical history included hypertension since age 70. Her activities of daily living had been independent before admission. On admission, her vital signs were as follows: body temperature, 35.3°C; heart rate, 86 beats/min; SpO2, 96% (on room air); respiratory rate, 14 breaths/min; and blood pressure, 161/78?mmHg. No skin lesions or peripheral neuropathy were noted. A laboratory examination revealed leukocytosis (white blood cell count [WBC]: 11,900/mm), normocytic normochromic anemia (Hb: 6.1?g/dL), elevation of C-reactive protein (CRP) level (6.1?mg/dL), and renal dysfunction (BUN: 42.6?mg/dL, Cr: 4.04?mg/dL). Urinalysis showed the following
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