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Search Results: 1 - 10 of 701 matches for " Hiroko Yamane "
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Clinical Research in Japan: ways to Alleviate Unnecessary Regulatory Burdens - DOI: 10.3395/reciis.v1i1.44en
Koji Kawakami,Hiroko Yamane
RECIIS : Electronic Journal of Communication, Information & Innovation in Health , 2007,
Abstract: For drug discovery and development today, synergy between pure science, clinical research, and the organization of clinical trials is essential. In Japan, there is a delay in the institutional response to this need. This paper identifies one of the bottlenecks in the Japanese regulatory process. Clinical research undertaken by university researchers and medical doctors are not integrated into the Japanese drug approval procedure. Therefore, their efforts and research data are wasted in the inherently unpredictable nature of long and costly biomedical research. Collaborative efforts between companies and researchers/medical doctors should be encouraged through institutional incentives, by integrating university and medical clinical research ab initio into regulatory process. In order to achieve this, it would be necessary to promote commercial exchange of database information and short-term employment of researchers in those projects leading to regulatory approval.
Patent policy and public health in developing countries: lessons from Japan
Aoki Reiko,Kubo Kensuke,Yamane Hiroko
Bulletin of the World Health Organization , 2006,
Biorational control methods for protection of stored grain legumes against bruchid beetles  [PDF]
Takashi Yamane
Agricultural Sciences (AS) , 2013, DOI: 10.4236/as.2013.412104

Bruchid beetles such as Callosobruchus maculatus are known to the storage pests of grain legumes and cause tremendous damage. The main method to protect from them is chemical insecticides or fumigants. But, they would cause some problems such as environmental pollution, hazard to health. So, it is necessary to develop the grain legumes protection methods or systems using less chemical insecticides or fumigants from the perspective of integrated pest management (IPM). In this paper, I review the works of legumes grain protection methods without chemical insecticides or fumigants especially for the natural parasitoids, essential oils and other methods recently developed.

The Treatment Strategy of Patients with Sleep Apnea Syndrome in Our Department and Subsequent Course  [PDF]
Takanori Fujioka, Hideo Yamane
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2014, DOI: 10.4236/ijohns.2014.34033

It is known that acute or chronic heart failure can develop in patients with grave sleep apnea syndrome (SAS), and known to have the social problem including an accident and the decrease of the labor will. Several medical treatments are now available for SAS. We considered problems of the treatment based on the practice situation of our department about the present conditions and subsequent treatment. The subjects consisted of 306 patients. We measured Epworth Sleepiness Scale (ESS) and apnea hypopnea index (AHI) after polysomnography in all patients at the first time and 6 months later. So, it was found that AHI and ESS decreased when we could be treated in the SAS patients appropriately. It was confirmed that the choice of the appropriate regimen was important.

Detecting Bank Conflict of GPU Programs Using Symbolic Execution—Case Study  [PDF]
Koki Hamaya, Satoshi Yamane
Journal of Software Engineering and Applications (JSEA) , 2017, DOI: 10.4236/jsea.2017.102009
Abstract: GPU (Graphics Processing Unit) is used in various areas. Therefore, the demand for the verification of GPU programs is increasing. In this paper, we suggest the method to detect bank conflict by using symbolic execution. Bank conflict is one of the bugs happening in GPU and it leads the performance of programs lower. Bank conflict happens when some processing units in GPU access the same shared memory. Symbolic execution is the method to analysis programs with symbolic values. By using it, we can detect bank conflict on GPU programs which use many threads. We implement a prototype of the detector for bank conflict and evaluate it with some GPU programs. The result states that we can detect bank conflict on the programs with no loop regardless of the number of threads.
Protection of Cardiomyocytes from the Hypoxia-Mediated Injury by a Peptide Targeting the Activator of G-Protein Signaling 8
Motohiko Sato, Masahiro Hiraoka, Hiroko Suzuki, Miho Sakima, Abdullah Al Mamun, Yukiko Yamane, Takayuki Fujita, Utako Yokoyama, Satoshi Okumura, Yoshihiro Ishikawa
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091980
Abstract: Signaling via heterotrimeric G-protein is involved in the development of human diseases including ischemia-reperfusion injury of the heart. We previously identified an ischemia-inducible G-protein activator, activator of G-protein signaling 8 (AGS8), which regulates Gβγ signaling and plays a key role in the hypoxia-induced apoptosis of cardiomyocytes. Here, we attempted to intervene in the AGS8-Gβγ signaling process and protect cardiomyocytes from hypoxia-induced apoptosis with a peptide that disrupted the AGS8-Gβγ interaction. Synthesized AGS8-peptides, with amino acid sequences based on those of the Gβγ-binding domain of AGS8, successfully inhibited the association of AGS8 with Gβγ. The AGS8-peptide effectively blocked hypoxia-induced apoptosis of cardiomyocytes, as determined by DNA end-labeling and an increase in cleaved caspase-3. AGS8-peptide also inhibited the change in localization/permeability of channel protein connexin 43, which was mediated by AGS8-Gβγ under hypoxia. Small compounds that inhibit a wide range of Gβγ signals caused deleterious effects in cardiomyocytes. In contrast, AGS8-peptide did not cause cell damage under normoxia, suggesting an advantage inherent in targeted disruption of the AGS8-Gβγ signaling pathway. These data indicate a pivotal role for the interaction of AGS8 with Gβγ in hypoxia-induced apoptosis of cardiomyocytes, and suggest that targeted disruption of the AGS8-Gβγ signal provides a novel approach for protecting the myocardium against ischemic injury.
Novos tempos, novos rumos para a RBO
Riuitiro Yamane
Revista Brasileira de Oftalmologia , 2008, DOI: 10.1590/s0034-72802008000100001
Revista Brasileira de Oftalmologia recebe selo de qualidade da Thomson Reuters sendo indexada nas Bases de Dados "Science Citation Index e Journal Citation Report"
Riuitiro Yamane
Revista Brasileira de Oftalmologia , 2008, DOI: 10.1590/s0034-72802008000500001
Labor Market Discrimination: Vietnamese Immigrants
Linus Yamane
Journal of Southeast Asian American Education and Advancement , 2012,
Abstract: Vietnamese and East European immigrants face similar obstacles in the U.S. labor market. This provides for an interesting test of racial discrimination in the labor market. Does it make any difference if an immigrant is Asian or White? When Vietnamese immigrants are compared to East European immigrants, Vietnamese men earn 7-9% less than comparable East European men, with more discrimination among the less educated, and in the larger Vietnamese population centers like California. Vietnamese women earn as much as comparable East European women. Vietnamese immigrants, male and female, are much less likely to hold managerial and supervisory positions than comparable East European immigrants.
Long-Time Asymptotics for the integrable discrete nonlinear Schr?dinger equation: The Focusing Case
Hideshi Yamane
Physics , 2015,
Abstract: We investigate the long-time asymptotics for the focusing integrable discrete nonlinear Schr\"odinger equation by using the nonlinear steepest descent method. The leading term is a multi-soliton.
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