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Parotid lymph node
(LN) metastasis occurs most commonly from cutaneous squamous cell carcinoma
(CSCC) of the head and neck, but rarely from
oral squamous cell carcinoma (OSCC). Here, we present a rare case of
metastasis to the parotid LN in a patient with tongue cancer. Although usual
extent of modified radical neck dissection that includes resection of the tail
of the parotid gland is below the line of the mandibular angle and the mastoid
process was performed, the parotid LN metastasis occurred. The patient was
treated with partial parotidectomy and chemoradiotherapy. One year and two
months later, there was no evidence of local recurrence, although multiple lung
metastases were observed. We also review the literature on parotid LN
metastasis from OSCC.
Continued advancement of protein array, bioelectrode, and biosensor technologies will necessitate development of methods that allow for increased protein immobilization capacity and more control over protein orientation. Toward these ends, we developed a method involving modification of chitosan with nitrilotriacetic acid (NTA) to achieve immobilization of a larger amount of His-tagged protein than is possible with current methods. The immobilization capacity of our method was evaluated using His-tagged GFP (Green Fluorescent Protein) as a model protein. The average immobilization density on modified glass was about 32 ng/mm2. Our method is suitable for use on a variety of solid surfaces, including glassy carbon, silicon wafers, polycarbonate, and beaten gold.