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Search Results: 1 - 10 of 3772 matches for " Hiroaki Yoshida "
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Stochastic Process Optimization Technique  [PDF]
Hiroaki Yoshida, Katsuhito Yamaguchi, Yoshio Ishikawa
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.519293
Abstract: The conventional optimization methods were generally based on a deterministic approach, since their purpose is to find out an accurate solution. However, when the solution space is extremely narrowed as a result of setting many inequality constraints, an ingenious scheme based on experience may be needed. Similarly, parameters must be adjusted with solution search algorithms when nonlinearity of the problem is strong, because the risk of falling into local solution is high. Thus, we here propose a new method in which the optimization problem is replaced with stochastic process based on path integral techniques used in quantum mechanics and an approximate value of optimal solution is calculated as an expected value instead of accurate value. It was checked through some optimization problems that this method using stochastic process is effective. We call this new optimization method “stochastic process optimization technique (SPOT)”. It is expected that this method will enable efficient optimization by avoiding the above difficulties. In this report, a new optimization method based on a stochastic process is formulated, and several calculation examples are shown to prove its effectiveness as a method to obtain approximate solution for optimization problems.
Improving the Effective Potential, Multi-Mass Problem and Modified Mass-Dependent Scheme
Hiroaki Nakano,Yusuke Yoshida
Physics , 1993, DOI: 10.1103/PhysRevD.49.5393
Abstract: We present a new procedure for improving the effective potential by using renormalization group equation (RGE) in the presence of several mass scales. We propose a modification of the mass-dependent (MD) renormalization scheme, MDbar scheme, so that the scalar mass parameter runs at most logarithmically on the one hand and the decoupling of heavy particles is naturally incorporated in the RGE's on the other. Thanks to these properties, the procedure in MDbar scheme turns out to be very simple compared with the regionwise procedure in MSbar scheme proposed previously. The relation with other schemes is also discussed both analytically and numerically.
New limit theorems related to free multiplicative convolution
Noriyoshi Sakuma,Hiroaki Yoshida
Mathematics , 2011,
Abstract: Let $\boxplus$, $\boxtimes$ and $\uplus$ be the free additive, free multiplicative, and boolean additive convolutions, respectively. For a probability measure $\mu$ on $[0,\infty)$ with finite second moment, we find the scaling limit of $(\mu^{\boxtimes N})^{\boxplus N}$ as $N$ goes to infinity. The $\mathcal{R}$--transform of the limit distribution can be represented by the Lambert's $W$ function. We also find similar limit theorem by replacing the free additive convolution with the boolean convolution.
Development of a High-PerformanceFlexible Substrate for Flexible Electronics:Joining TAC Films and an Ultra-Thin Glassby Using TEOS-DAC Synthesized by the Sol-Gel Method  [PDF]
Tomoji Ohishi, Hiroaki Kawada, Tsutomu Yoshida, Takeshi Ohwada
Materials Sciences and Applications (MSA) , 2015, DOI: 10.4236/msa.2015.612109
Abstract: A new flexible substrate for flexible electronics has been developed. The developed substrate consists of an ultra thin glass and TAC (triacethyl cellulose) film. An ultra thin glass and TAC film were joined with TEOS-DAC (TEOS: tetraethyl orthosilicate, DAC: diacethy cellulose) adhesive resin synthesized by sol-gel method by means of thermo-compression bonding. This substrate has high transparency in visible-light region (90%), high flexibility (torsion strength and bending strength) and high gas barrier characteristics due to an ultra thin glass. The newly-developed substrate is superior to the substrates fabricated with commercially available adhesive resin in the same way in characteristics of heat resistance, transparency and flexibility.
An Integral Representation of the Relative Entropy
Miku Hirata,Aya Nemoto,Hiroaki Yoshida
Entropy , 2012, DOI: 10.3390/e14081469
Abstract: Recently the identity of de Bruijn type between the relative entropy and the relative Fisher information with the reference moving has been unveiled by Verdú via MMSE in estimation theory. In this paper, we shall give another proof of this identity in more direct way that the derivative is calculated by applying integrations by part with the heat equation. We shall also derive an integral representation of the relative entropy, as one of the applications of which the logarithmic Sobolev inequality for centered Gaussian measures will be given.
Correction: In Vivo Robustness Analysis of Cell Division Cycle in Saccharomyces cerevisiae
Hisao Moriya,Yuki Shimizu-Yoshida,Hiroaki Kitano
PLOS Genetics , 2006, DOI: 10.1371/journal.pgen.0020218
In Vivo Robustness Analysis of Cell Division Cycle Genes in Saccharomyces cerevisiae
Hisao Moriya ,Yuki Shimizu-Yoshida,Hiroaki Kitano
PLOS Genetics , 2006, DOI: 10.1371/journal.pgen.0020111
Abstract: Intracellular biochemical parameters, such as the expression level of gene products, are considered to be optimized so that a biological system, including the parameters, works effectively. Those parameters should have some permissible range so that the systems have robustness against perturbations, such as noise in gene expression. However, little is known about the permissible range in real cells because there has been no experimental technique to test it. In this study, we developed a genetic screening method, named “genetic tug-of-war” (gTOW) that evaluates upper limit copy numbers of genes in a model eukaryote Saccharomyces cerevisiae, and we applied it for 30 cell-cycle related genes (CDC genes). The experiment provided unique quantitative data that could be used to argue the system-level properties of the cell cycle such as robustness and fragility. The data were used to evaluate the current computational model, and refinements to the model were suggested.
An Efficient and Compact Difference-Frequency-Generation Spectrometer and Its Application to 12CH3D/12CH4 Isotope Ratio Measurements
Kiyoshi Tsuji,Hiroaki Teshima,Hiroyuki Sasada,Naohiro Yoshida
Sensors , 2010, DOI: 10.3390/s100706612
Abstract: We have developed an efficient and compact 3.4 μm difference-frequency-generation spectrometer using a 1.55 μm distributed feedback (DFB) laser diode, a 1.06 μm DFB laser diode, and a ridge-waveguide periodically poled lithium niobate. It is continuously tunable in the 30 cm–1 span and is applied to 12CH3D/12CH4 isotope ratio measurements. The suitable pair of 12CH3D n4 pP(7,6) and 12CH4 ν2+ν4 R(6) F1(1) lines enabled us to determine their isotope ratio with a precision repeatability of 0.8‰ using a sample and a working standard of pure methane with an effective signal averaging time of 100 ms.
Successful adjuvant bi-weekly gemcitabine chemotherapy for pancreatic cancer without impairing patients’ quality of life
Toyama Yoichi,Yoshida Seiya,Saito Ryota,Kitamura Hiroaki
World Journal of Surgical Oncology , 2013, DOI: 10.1186/1477-7819-11-3
Abstract: Background Although adjuvant gemcitabine (GEM) chemotherapy for pancreatic cancer is standard, the quality of life (QOL) in those patients is still impaired by the standard regimen of GEM. Therefore, we studied whether mild dose-intensity adjuvant chemotherapy with bi-weekly GEM administration could provide a survival benefit with acceptable QOL to the patients with pancreatic cancer. Methods After a phase I trial, an adjuvant bi-weekly 1,000 mg/m2 of GEM chemotherapy was performed in 58 patients with pancreatic cancer for at least 12 courses (Group A). In contrast, 36 patients who declined the adjuvant bi-weekly GEM chemotherapy underwent traditional adjuvant 5FU-based chemotherapy (Group B). Careful periodical follow-ups for side effects of GEM and disease recurrence, and assessment of patients’ QOL using the EORTC QOL questionnaire (QLQ-C30) and pancreatic cancer-specific supplemental module (QLQ-PAN26) were performed. Retrospectively, the degree of side effects, patients’ QOL, compliance rate, disease-free survival (DFS), and overall survival (OS) in Group A were compared with those in Group B. Results No severe side effects (higher than Grade 2 according to the common toxicity criteria of ECOG) were observed, except for patients in Group B, who were switched to the standard GEM chemotherapy. Patients’ QOL was better in Group A than B (fatigue: 48.9 ± 32.1 versus 68.1 ± 36.3, nausea and vomiting: 26.8 ± 20.4 versus 53.7 ± 32.6, diarrhea: 21.0 ± 22.6 versus 53.9 ± 38.5, difficulty gaining weight: 49.5 ± 34.4 versus 67.7 ± 40.5, P < 0.05). Compliance rates in Groups A and B were 93% and 47%. There was a significant difference in the median DFS between both groups (Group A : B =12.5 : 6.6 months, P < 0.001). The median OS of Group A was prolonged markedly compared with Group B (20.2 versus 11.9 months, P < 0.005). For OS between both groups, univariate analysis revealed no statistical difference in 69-year-old or under females, and T1–2 factors, moreover, multivariate analysis indicated three factors, such as bi-weekly adjuvant GEM chemotherapy, T2 or less, and R0. Conclusions Adjuvant chemotherapy with bi-weekly GEM offered not only the advantage of survival benefits but the excellent compliance with acceptable QOL for postoperative pancreatic cancer patients.
A 7-Year-Old Boy with Light Cupula of the Horizontal Semicircular Canal  [PDF]
Hiroaki Ichijo
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2014, DOI: 10.4236/ijohns.2014.32018

Report of childhood positional vertigo is very rare. We present a 7-year-old boy who revealed persistent direction-changing geotropic positional nystagmus. In the supine position, horizontal nystagmus toward the left continued as long as the position was maintained. However, it ceased when the head was turned to the right side by 45°. With greater head turn (right-ear-down), nystagmus toward the right lasted for more than 1 minute. In the left-ear-down position, horizontal nystagmus toward the left occurred and lasted for more than 1 minute. After the disappearance of positional nystagmus, we detected canal paresis of the right ear by caloric test. We considered that the pathophysiology of the persistent type of geotropic nystagmus is a result of light debris cupulolithiasis of the horizontal canal.

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