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Search Results: 1 - 10 of 1437 matches for " Hiroaki Shintani "
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Physiological Effects of Salmon Milt Nucleoprotein on Movement, Stress Tolerance and Lifespan of C. elegans  [PDF]
Hiroaki Shintani, Tsubasa Furuhashi, Hiroyuki Hano, Masaji Matsunaga, Koji Usumi, Norimasa Shudo, Kazuichi Sakamoto
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.31009
Abstract: In recent years, various physiological functions of salmon milt extract, which consists of nucleic acid and nucleoprotein, have been reported. The objective of this study is to analyze the physiological function and its mechanism of salmon milt extract (NG) on nematodes (C. elegans). The wild type nematode N2 strain was bred on the plate containing of NG for four days, and its body length increased depending on NG concentration. When nematodes were bred with NG for a longer period, average lifespan was increased, and survival rate was increased by up to 20%. Generally, the movement of nematodes decreases with longer breeding period (i.e. aging). Analysis of movement (both gross thrashing movement and local pumping movement) showed that NG suppressed this decrease f movement with aging. Furthermore, the deease of survival rate by heat stress and oxidative stress was suppressed by NG administration. Nile Red staining analysis showed that fat accumulation varied depending on the concentration of NG. RT-PCR analysis revealed that the mRNA expression levels of the stress resistance genes sod-3 and sod-4 were increased. These results indicated that NG administration increased the expression of stress-tolerance-related genes, promoted stress tolerance, increased movement and prolonged lifespan in nematode.
Conformal fixed point of SU(3) gauge theory with 12 fundamental fermions
Tatsumi Aoyama,Hiroaki Ikeda,Masafumi Kurachi,C. -J. David Lin,Hideo Matsufuru,Kenji Ogawa,Hiroshi Ohki,Tetsuya Onogi,Eigo Shintani,Takeshi Yamazaki
Physics , 2011,
Abstract: We study the infrared properties of SU(3) gauge theory coupled to 12 massless Dirac fermions in the fundamental representation. The renormalized running coupling constant is calculated in the Twisted Polyakov loop scheme on the lattice. From the step-scaling analysis, we find that the infrared behavior of the theory is governed by a non-trivial fixed point.
The Infrared behavior of SU(3) Nf=12 gauge theory -about the existence of conformal fixed point-
Kenji Ogawa,Tatsumi Aoyama,Hiroaki Ikeda,Etsuko Itou,Masafumi Kurachi,C. -J. David Lin,Hideo Matsufuru,Hiroshi Ohki,Tetsuya Onogi,Eigo Shintani,Takeshi Yamazaki
Physics , 2011,
Abstract: Incorporated with twisted boundary condition, Polyakov loop correlators can give a definition of the renormalized coupling. We employ this scheme for the step scaling method (with step size s = 2) in the search of conformal fixed point of SU(3) gauge theory with 12 massless flavors. Staggered fermion and plaquette gauge action are used in the lattice simulation with six different lattice sizes, L/a = 20, 16, 12, 10, 8 and 6. For the largest lattice size, L/a = 20, we used a large number of Graphics Processing Units (GPUs) and accumulated 3,000,000 trajectories in total. We found that the step scaling function sigma (u) is consistent with u in the low-energy region. This means the existence of conformal fixed point. Some details of our analysis and simulations will also be presented.
A 7-Year-Old Boy with Light Cupula of the Horizontal Semicircular Canal  [PDF]
Hiroaki Ichijo
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2014, DOI: 10.4236/ijohns.2014.32018

Report of childhood positional vertigo is very rare. We present a 7-year-old boy who revealed persistent direction-changing geotropic positional nystagmus. In the supine position, horizontal nystagmus toward the left continued as long as the position was maintained. However, it ceased when the head was turned to the right side by 45°. With greater head turn (right-ear-down), nystagmus toward the right lasted for more than 1 minute. In the left-ear-down position, horizontal nystagmus toward the left occurred and lasted for more than 1 minute. After the disappearance of positional nystagmus, we detected canal paresis of the right ear by caloric test. We considered that the pathophysiology of the persistent type of geotropic nystagmus is a result of light debris cupulolithiasis of the horizontal canal.

Determination of Shear Center of Arbitrary Cross-Section  [PDF]
Hiroaki Katori
World Journal of Mechanics (WJM) , 2016, DOI: 10.4236/wjm.2016.68020
Abstract: In structural analysis, it is often necessary to determine the geometrical properties of cross section. The location of the shear center is greater importance for an arbitrary cross section. In this study, the problems of coupled shearing and torsional were analyzed by using the finite element method. Namely, the simultaneous equations with respect to the warping, shear deflection, angle of torsion and Lagrange’s multipliers are derived by finite element approximation. Solving them numerically, the matrix of the shearing rigidity and torsional rigidity is obtained. This matrix indicates the coupled shearing and torsional deflection. The shear center can be obtained determining the coordinate axes so as to eliminate the non-diagonal terms. Several numerical examples are performed and show that the present method gives excellent results for an arbitrary cross section.
Inverse Problems for an Euler-Bernoulli Beam: Identification of Bending Rigidity and External Loads  [PDF]
Hiroaki Katori
World Journal of Mechanics (WJM) , 2018, DOI: 10.4236/wjm.2018.85014
Abstract: We present a method for identifying the flexural rigidity and external loads acting on a beam using the finite-element method. We used mixed beam elements possessing transverse deflection and the bending moment as the primary degrees of freedom. The first step is to determine the bending moment from the transverse deflection and boundary conditions. The second step is to substitute the bending moment into the final equations with respect to the unknown parameters (flexural rigidity or external load). The final step solves the resulting system of equations. We apply this method to some inverse beam problems and provide an accurate estimation. Several numerical examples are performed and show that present method gives excellent results for identifying bending stiffness and distributed load of beam.
Vestibular Rehabilitation for the Patients with Intractable Vestibular Neuritis  [PDF]
Hiroaki Ichijo
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2018, DOI: 10.4236/ijohns.2018.76035
Abstract: Objective: To clarify whether vestibular rehabilitation is effective in improving spontaneous nystagmus in patients with intractable vestibular neuritis. Methods: The subjects were 8 patients (6 females and 2 males) with vestibular neuritis who revealed long-lasting (more than 2 months since the onset) horizontal spontaneous nystagmus toward the healthy side. We used thumbs-up head shaking for vestibular rehabilitation. This exercise involves active head shaking (1 Hz) while staring at one’s thumb nail. One set is 10 cycles. We asked the patient to do 3 sets (morning, afternoon, and night) every day. Results: The mean value of the slow-phase velocity of spontaneous nystagmus before treatment was 4.1°/s, and that 3 months after vestibular rehabilitation was 4.1°/s. No improvement was observed. Conclusion: Vestibular rehabilitation is not always effective in improving spontaneous nystagmus in patients with intractable vestibular neuritis. Therefore, clinicians should consider the possibility of long-term incomplete central compensation.
Review of literature: Role of 5-aminolevulinic acid and sleep  [PDF]
Michael H. Perez, Beatriz L. Rodriguez, Terry T. Shintani, Terry T. Shintani, Rosanne C. Harrigan
World Journal of Neuroscience (WJNS) , 2013, DOI: 10.4236/wjns.2013.34042

Objective: To determine if current peer-reviewed literature supports the existence of a relationship between the administration of dietary supplements containing 5-Aminolevulinic Acid (5-ALA) and sleep. Methods: Conceptual analysis of a systematically defined group of data is based on publications in referred journals. Constant comparative analyses were used to analyze the data. Detailed analyses were used to identify trends that led to qualifying relationships between the use of 5-ALA and heme. In addition, the relationship among heme, melatonin, and sleep were explored. Since there were no published data related to 5-ALA and sleep, an analysis of what is known about 5-ALA and heme was undertaken. Results: Currently, within the scope of this review, no literature available directly connecting 5-ALA and sleep was found. Research indicates that 5-ALA has an indirect relationship with intra-cellular energy production, which could result in a wide range of effects fromcellular to endocrine to neurologic to behavioral. In addition, there is evidence that 5-ALA may influence tryptophan and serotonin levels. Conclusion: While there are no studies on 5-ALA and sleep were found, current research suggests several potential mechanisms by which 5-ALA could influence sleep. The mechanisms suggest the potential for 5-ALA to assist in the adjustment of a person’s circadian cycle, endocrine function, or neurologic function in order to allow for better sleep in a natural way. In doing so, it may provide for a safer alternative to currently available sleep medication. Further research is needed to explore this possibility.

Differential effects of dexamethasone on the chondrogenesis of mesenchymal stromal cells: Influence of microenvironment, tissue origin and growth factor
N Shintani,EB Hunziker
European Cells and Materials (ECM) , 2011,
Abstract: nchymal stromal cells (MSCs), which reside within various tissues, are utilized in the engineering of cartilage tissue. Dexamethasone (DEX) – a synthetic glucocorticoid – is almost invariably applied to potentiate the growth-factor-induced chondrogenesis of MSCs in vitro, albeit that this effect has been experimentally demonstrated only for transforming-growth-factor-beta (TGF-β)-stimulated bone-marrow-derived MSCs. Clinically, systemic glucocorticoid therapy is associated with untoward side effects (e.g., bone loss and increased susceptibility to infection). Hence, the use of these agents should be avoided or limited. We hypothesize that the influence of DEX on the chondrogenesis of MSCs depends upon their tissue origin and microenvironment [absence or presence of an extracellular matrix (ECM)], as well as upon the nature of the growth factor. We investigated its effects upon the TGF-β1- and bone-morphogenetic-protein 2 (BMP-2)-induced chondrogenesis of MSCs as a function of tissue source (bone marrow vs. synovium) and microenvironment [cell aggregates (no ECM) vs. explants (presence of a natural ECM)]. In aggregates of bone-marrow-derived MSCs, DEX enhanced TGF-β1-induced chondrogenesis by an up-regulation of cartilaginous genes, but had little influence on the BMP-2-induced response. In aggregates of synovial MSCs, DEX exerted no remarkable effect on either TGF-β1- or BMP-2-induced chondrogenesis. In synovial explants, DEX inhibited BMP-2-induced chondrogenesis almost completely, but had little impact on the TGF-β1-induced response. Our data reveal that steroids are not indispensable for the chondrogenesis of MSCs in vitro. Their influence is context dependent (tissue source of the MSCs, their microenvironment and the nature of the growth-factor). This finding has important implications for MSC based approaches to cartilage repair.
Chiral symmetry breaking in lattice QED model with fermion brane
E. Shintani,T. Onogi
Physics , 2012,
Abstract: We propose a novel approach to the Graphene system using a local field theory of 4 dimensional QED model coupled to 2+1 dimensional Dirac fermions, whose velocity is much smaller than the speed of light. Performing hybrid Monte Carlo simulations of this model on the lattice, we compute the chiral condensate and its susceptibility with different coupling constant, velocity parameter and flavor number. We find that the chiral symmetry is dynamically broken in the small velocity regime and obtain a qualitatively consistent behavior with the prediction from Schwinger-Dyson equations.
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