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Preparation and characterization of mucoadhesive microcapsules of salbutamol sulfate
Patil Pradnya,Raghavendra Rao N,Hiremath Doddayya
Asian Journal of Pharmaceutics , 2010,
Abstract: Salbutamol sulfate microcapsules with a coat consisting of sodium alginate and mucoadhesive polymer such as sodium carboxy methyl cellulose (NaCMC), methyl cellulose (MC), carbopol-934, and hydroxy propyl methyl cellulose (HPMC) were prepared by ionotropic gelation technique and were evaluated for morphological characters, drug content, loading efficiency, drug-polymer interactions, swelling ratio, mucoadhesive properties, and in vitro release. The resulting microcapsules were discrete, spherical, and free-flowing, and microencapsulation efficiency was 51.28-96.70%. The microcapsules prepared with alginate alone (A4) have exhibited good mucoadhesive property in the in vitro washoff test. The swelling ratio of microcapsules was enhanced with increased alginate concentration. Salbutamol sulfate release from these mucoadhesive microcapsules was slow and extended over a period of 8 h and depends upon the concentration of the alginate. The drug release from alginate-HPMC/carbopol microcapsules followed diffusion-controlled first-order kinetics. The release rate of alginate-HPMC microcapsules (A4H) was higher than other formulations and comparable with commercially available controlled-release capsules. Microcapsules with alginate alone (A4) followed diffusion mechanism. In conclusion, alginate-HPMC/carbopol mucoadhesive microcapsules could be promising vehicle for oral controlled release of salbutamol sulfate.
DESIGN AND CHARACTERIZATION OF TRANSMUCOSAL DRUG DELIVERY SYSTEM OF GLIBENCLAMIDE
Sarfaraz Md,P Venubabu,Hiremath Doddayya,Udupi R H
International Research Journal of Pharmacy , 2011,
Abstract: Buccal drug delivery has been considered as an alternative to oral route for compounds subjected to degradation in the gastrointestinal tract or hepatic first pass metabolism. Glibenclamide, an oral hypoglycemic agent of the sulphonylurea group is frequently prescribed for the treatment of late-onset (non-insulin dependent) diabetes mellitus. In the present investigation, an attempt was made to develop mucoadhesive buccal tablets of glibenclamide by direct compression method using bioadhesive polymers like Carbopol 934P, HPMC K4M and NaCMC. Preformulation and micromeritic studies were carried out. The physical characteristics, surface pH, in-vitro bioadhesion strength, swelling index and in-vitro release of formulated tablets were dependent on characteristics and composition of bioadhesive materials used. The formulation F2 containing Carbopol 934P, HPMC K4M and mannitol was found to be promising and exhibited an in vitro drug release of 95.94% in 8 hrs along with satisfactory bioadhesion strength (3.68 gms). Short-term stability studies on the promising formulation indicated no significant changes in drug content and in vitro dissolution characteristics. The n values of all formulations were in the range of 1.327 – 1.518, indicating non-Fickian super case II type transport mechanism. FT-IR and DSC studies revealed absence of any chemical interaction between drug and polymers used.
TRIMETAZIDINE HYDROCHLORIDE TRANSDERMAL PATCH: FORMULATION AND IN-VITRO EVALUATION
Sarfaraz Md,Reddy Jayendra A,Hiremath Doddayya,Udupi R. H.
International Research Journal of Pharmacy , 2012,
Abstract: The present study was carried out to formulate and evaluate matrix-type transdermal formulations containing trimetazidine hydrochloride with polymers such as carboxymethyl chitosan and hydroxypropylmethylcellulose (HPMC 5cps) by solvent evaporation technique with glycerin, as plasticizer. The prepared patches were tested for their physicochemical characteristics such as thickness, weight variation, drug content uniformity, folding endurance and tensile strength. The partition coefficient study was performed using n-octanol as the organic phase and phosphate buffer pH 7.4 as an aqueous phase and it was found to be 1.01. In-vitro release studies of trimetazidine hydrochloride-loaded patches in phosphate buffer (pH, 7.4) exhibited drug release in the range of 89.40 to 92.10 % in 24 hrs. The parameter flux (J) was calculated and it was in the range of 1.325 to 2.898 mg/cm2/hr. Based on optimization studies, patches containing carboxymethyl chitosan patches were chosen as optimized formulation. Skin irritation studies were performed on optimized transdermal patch and were found to be free of irritation. The patches were subjected to short term stability studies and were found stable. FTIR studies revealed no interactions between drug and excipients. Data of in vitro release from optimized patches were fit in to different equations and kinetic models such as zero order, first-order, Higuchi and Korsmeyer-Peppas models to explain release kinetics.
3D Face Recognition Using Radon Transform and Symbolic PCA
P. S. Hiremath,Manjunath Hiremath
International Journal of Electronics and Computer Science Engineering , 2012,
Abstract: Three Dimensional (3D) human face recognition is emerging as a significant biometric technology. Research interest into 3D face recognition has increased during recent years due to availability of improved 3D acquisition devices and processing algorithms. A 3D face image is represented by 3D meshes or range images which contain depth information. Range images have several advantages over 2D intensity images and 3D meshes. Range images are robust to the change of color and illumination, which are the causes for limited success in face recognition using 2D intensity images. In the literature, there are several methods for face recognition using range images, which are focused on the data acquisition and preprocessing stage only. In this paper, a new 3D face recognition technique based on symbolic Principal Component Analysis approach is presented. The proposed method transforms the 3D range face images using radon transform and then obtain symbolic objects, (i.e. interval valued objects) termed as symbolic 3D range faces. The PCA is employed to symbolic 3D range face image dataset to obtain symbolic eigen faces which are used for face recognition. The proposed symbolic PCA method has been successfully tested for 3D face recognition using Texas 3D Face Database. The experimental results show that the proposed algorithm performs satisfactorily with an average accuracy of 97% as compared to conventional PCA method and is efficient in terms of accuracy and detection time.
FUZZY FACE MODEL FOR FACE DETECTION USING EYES AND MOUTH FEATURES
HIREMATH P.S. and MANJUNATH HIREMATH
International Journal of Machine Intelligence , 2011,
Abstract: Face detection is a necessary first-step in face recognition systems, with the purpose of localizing and extractingthe face region from the background. It also has several applications in areas such as content-based image retrieval, videocoding, video conferencing, crowd surveillance, and intelligent human–computer interfaces. In this paper, we propose a novelapproach for the detection of human face in a digital image based on the fuzzy spatial interrelationships of only the prominentfacial features of the face, namely, eyes and mouth. A fuzzy face model is constructed for the face detection algorithm. Theexperimentation has been done using several face databases. The experimental results show that the proposed algorithm performssatisfactorily with an average accuracy of 96.10% and is efficient in terms of accuracy and detection time despite the exclusion ofother facial features, namely, nose, eyebrows and ears.
VISUAL DATA MINING USING UNSUPERVISED CLASSIFICATION OF LULC SATELLITE IMAGERY
KODGE BG AND HIREMATH PS
International Journal of Machine Intelligence , 2011,
Abstract: This study presents a new visualization tool using unsupervised classification of LUCL satellite imagery.Visualization of feature space allows exploration of patterns in the image data and insight into the classification process andrelated uncertainty. Visual Data Mining provides added value to image classifications as the user can be involved in theclassification process providing increased confidence in and understanding of the results. In this study, we present a prototypevisualization tool for visual data mining (VDM) of satellite imagery into volume visualization. This volume based representationdivides feature space into cubes or voxels. The visualization tool is showcased in an unsupervised classification study of highresolutionimageries of Latur district in Maharashtra state of India.
EVALUATION OF PHYSICOCHEMICAL & PHYTOCHEMICAL PARAMETERS OF AMARANTHUS CAUDATUS LEAVES
Hiremath G. Urmila
International Research Journal of Pharmacy , 2012,
Abstract: The present study was carried out to provide physicochemical and phytochemical detail about the plant Amaranthus caudatus. The physicochemical results obtained can be used for the identification of the powdered drugs. In the phytochemical screening different type of extracts were prepared to find the presence of secondary metabolites. The results revealed the presence of carbohydrates, glycosides, saponins, proteins, amino acids, tannins, and phenolic compounds in the plant. Amaranthus caudatus belongs to the family Amaranthaceae .The Amaranthus plants are spread throughout the world, growing under a wide range of climatic conditions and they are able to produce grains and leaves edible vegetables. Traditionally it has been used nutritionally for infants, children, pregnant and lactating woman, as it is comparable to the properties of milk; it was also used in countering heavy menstrual bleeding and vaginal discharge. It helps control dysentery and diarrhea. The roots were used to cure kidney stones, leaves used to cure cuts, leprosy, boils, burns, fever and decoction of the stem used in jaundice. The plant has cooling effect, laxative, diuretic, stomachic and antipyretic, anti-diarrheal, anti-hemorrhagic. The leaves, roots, bark, stem, seeds have medicinal value.
LINGAYAT POLITICAL ELITE: A CASE STUDY
SUMANTH S. HIREMATH
Indian Streams Research Journal , 2013,
Abstract: The term 'Elite' is that in every society there are people who possess in a marked degree the qualities of intelligence, character, skill and capacity of whatever kind. The present study is to draw an outline of 'Lingayat Political Elite' group on the base of some previous empirical studies and inquiries. Of this Elite group, some data are presented on the socio- economic background characteristics, political or professional career and role perceptions of the respondents. This serves as a, ladder to political assent, by providing the activists, an opportunity to learn, the technique and rules of the political game.
Preparation and in vitro characterization of paclitaxel-loaded injectable microspheres
Hiremath Jagadeesh,Devi V
Asian Journal of Pharmaceutics , 2010,
Abstract: The main objective of this study was to develop paclitaxel loaded poly (caprolactone) injectable microspheres prepared by solvent evaporation method. Mircoparticles were characterized in terms of particle size and size distribution, surface morphology, drug physical state, and crystalline nature by using master size analyzer, scanning electron microscope, differential scanning calorimetry, and X-ray diffraction. Paclitaxel loading over different concentrations was analyzed by high-performance liquid chromatography. In vitro drug release studies were performed in phosphate buffer saline. Best formulation was selected for in vitro cytotoxic studies by using MCF-7 breast cancer cell lines.
Preparation and in vitro characterization of poly (epsilon-caprolactone)-based tamoxifen citrate-loaded cylindrical subdermal implant for breast cancer
Hiremath Jagadeesh,Devi V
Asian Journal of Pharmaceutics , 2011,
Abstract: In the present study cylindrical poly(epsilon-caprolactone) (PCL)-based biodegradable polymeric tamoxifen citrate-loaded subdermal implants were prepared by laboratory-based modified melt extrusion technique. The prepared implants were evaluated for their physicochemical parameters. Drug content in implants by high-performance liquid chromatographic (HPLC) method, differential scanning calorimetry (DSC), X-ray diffraction (XRD) and scanning electron microscope (SEM) studies of tamoxifen citrate-loaded implants. Determination of in vitro hydrolytic degradation of polymeric and tamoxifen citrate-loaded implants and in vitro drug release was carried out by using indigenously developed dissolution apparatus. DSC and XRD studies proved that the drug is entrapped in the implant. The highest rate of hydrolytic degradation (weight loss) was observed in blank implants when compared to tamoxifen citrate-loaded implants. The studies proved that the developed method have potential in terms of industrial feasibility.
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