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Search Results: 1 - 10 of 2137 matches for " Hirak Jyoti Chakraborty "
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Identification of regulatory sequence signatures in microRNA precursors implicated in neurological disorders  [PDF]
Sayak Ganguli, Sasti Gopal Das, Hirak Jyoti Chakraborty, Sohini Gupta, Abhijit Datta
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.45A003
Abstract:

MicroRNAs have emerged as one of the major classes of non-coding RNAs. Recent reports have placed them in high abundance in the nervous system, having key roles in development. Neurological disorders such as Parkinson’s disease, Alzheimer’s disease as well as Huntington disease have also been studied and several microRNAs associated with diseases pathogenesis have been identified. Various such findings indicate differential expression levels of many of these microRNAs. Such changes in the expression levels not only indicate towards a control of the biogenesis of these microRNAs but also indicate towards critical yet unelucidated roles of regulatory proteins, which probably act in concert to control the production or maturation of these molecules. In this work, a collection of overrepresented regulatory motif signatures were identified in the DNA and RNA sequences of the precursor microRNAs. The identification of such regulatory sequence signatures promises to provide new insights into many facets of microRNA regulation and neurological disorders.

Structural analysis and molecular modeling of Human dopamine receptor 5 (DRD5)
Raja Chakraborty,Sayak Ganguli,Hirak Jyoti Chakraborty,Abhijit Datta
International Journal of Bioinformatics Research , 2010,
Abstract: Dopamine has been shown to play a key role in the Central Nervous System. Any imbalance indopamine production and dopamine receptor activity has been implicated widely in the pharmacology, of anumber of neurobehavioral disorders existing today. The dopamine receptors interact with G-proteins totransduce dopamine stimulation into intracellular responses. In this work a 3D structure of DRD5 based onthe template of High resolution crystal structure of human -2 adrenergic receptor (PDB code 2RH1A) wasgenerated. The model was assessed using MOLPROBITY. The results revealed that 94% of the residueswere found in the favoured region of Ramachandran’s plot. Active site analysis showed that predictedbinding sites included all the seven transmembrane helices. Our work demonstrates that in silico modelingof proteins has been shown to play an important role in determining protein structure and provides apromising area in possible drug discovery
Structural analysis of Leucocine – an essential bacteriocin
Hirak Jyoti Chakraborty,Sayak Ganguli,Protip Basu,Paushali Roy
International Journal of Bioinformatics Research , 2010,
Abstract: Bacterial peptides of low molecular weight displaying antagonism towards other bacterialmembers are referred to as bacteriocins. Bacteriocins are an essential member of the broadly classifiedgroup of lantibiotics which finds several commercial uses. This work comprises of the determination ofstructure of the most important class of bacteriocins – the leucocin group. Structure elucidation wasperformed using homology modelling approach and the modeled structure was validated using theirRamachandran calculations. Ligand interaction pockets were identified by calculating the Delaunaytriangulation number and structural properties of amino acids were documented. Structure elucidations ofsuch lantibiotics are important for future endeavours towards analyses of protein - protein interactions.
Phylogenetic signatures of functional conservedness in lantibiotics- an in-silico regulomics study
Protip Basu, Hirak Jyoti Chakraborty, Sayak Ganguli, Paushali Roy, and Abhijit Datta
International Journal of Microbiology Research , 2010,
Abstract: The name Lantibiotics was introduced in 1988 as an abbreviation for "Lanthionine-containingpeptide antibiotics". In spite of this naming, Lantibiotics are not classed as antibiotics. The first structures ofthese antimicrobial agents were produced by pioneering work by Gross and Morell in the late sixties andearly seventies, thus marking the formal introduction of Lantibiotics. Since then Lantibiotics such as Nisinhave been for food preservation and have yet to encounter significant bacterial resistance. These attributesof lantibiotics have led to more detailed research into them
PSEUDOKNOTS IN HUMAN SNRNPS
SANJAY KUMAR DEY, SAYAK GANGULI, PAUSHALI ROY, PROTIP BASU, HIRAK JYOTI CHAKRABORTY AND ABHIJIT DATTA
International Journal of Bioinformatics Research , 2011,
Abstract: Snurps or small nuclear ribonucleoproteins (snRNPs), are RNA-protein complexes that combine withunmodified pre-mRNA and various other proteins to form a Spliceosome, comprising of five small nuclear RNAs(snRNAs)—U1, U2, U4, U5, and U6 snRNA—as well as many protein factors, upon which splicing of pre-mRNAoccurs. While, RNA pseudoknots play crucial role in protein synthesis by helping in internal ribosome entry,frameshifting, stop codon readthrough in many viral species and the 3’NCR pseudoknots helps viral RNAs to replicate,has been reported by a number of investigators, its presence in human snurps has not yet been done. The present insilico study reveals the presence of pseudoknots in the mRNAs of the proteins associated with human Spliceosome. Itnot only emphasizes their significance as catalytic RNA world relics but also opens the scope of research in thefunctional and structural associations of RNA pseudoknots in eukaryotic gene regulation.
Macroeconomic Link to Indian Capital Market: A Post-Liberalization Evidence  [PDF]
Hirak Ray, Joy Sarkar
Modern Economy (ME) , 2014, DOI: 10.4236/me.2014.54028
Abstract:

The present paper attempts to investigate the dynamic relation between the stock market and the select macroeconomic variables at log-levels, in India, for the period 1991:01 to 2008:04. Findings of the study show that the long-run stock market behavior is positively related to output and exchange rate, and negatively related to short- and long-term interests, money supply and inflation. The results of the causality and innovation analysis suggest that the stock market influences the economic activities, more specifically the industrial activities and the market is expected to be more sensitive to the shocks of itself over the projected period of the study.

Challenges in Retention of Patients in Continuum of HIV-Care in Delhi— Experience of a Decade & Way Ahead  [PDF]
Anil Kumar Gupta, Vandana Dabla, Bipin Chandra Joshi, Sabyasachi Chakraborty, Jiban Jyoti Baishya, Abhinav Gupta
World Journal of AIDS (WJA) , 2014, DOI: 10.4236/wja.2014.44046
Abstract: Retention of the patients in HIV-care is critical for success of Anti Retroviral Treatment (ART) programme to reduce HIV-related morbidity & mortality and prevent emergence of drug resistance. In last decade in Delhi (April 2004 to March 2014), overall 24% HIV-positive patients were lost-to-follow-up (LTFU) at step-1 (testing to enrolment into HIV-care), 7.8% at step-2 (enrolment to ART eligibility), 23.7% at step-3 (eligibility to initiation of ART) and 16.6% at step-4 (initiation to lifelong ART) of retention cascade. About 2/3rd losses at step-4 were within 1st year and 80% within 2 years. The retention of the patients in pre-ART care was 3 times lower than those initiated ART. Only 27.4% patients were in active pre-ART care during 2013. The intensified LTFU tracking (ILT) undertaken during November, 2013 through March, 2014 was not successful in tracking 97% pre-ART LTFU clients due to incomplete addresses/or migration since address proof of patients on enrolment into HIV-care was not mandatory prior to 2009. Amongst patients tracked, 1.5% were alive, 0.24% had disengaged from care while 1.2% had died. After ILT overall “On ART” and “Pre-ART” LTFU rate in the last decade was 15.5% and 45.2%, respectively. The retention cascade of last year from April 2013 to March 2014 showed improvement through strategies adopted in Third Phase of National AIDS Control Programme (NACP-III; 2007-2013), and “On ART” and “Pre-ART” LTFU rates declined to 9.4% and 7.4%, respectively. However, desired at least 90% retention at various steps of the cascade could not be achieved. National Policy of delivering ART services through limited number of standalone ART centers in India, despite its significant success, has limitation of leaky treatment cascade and calls for policy makers to decentralize the programme by its appropriate integration with general health services and task shifting to improve continuum of care.
Unique carbon-nano-structure for high quality electron-emitter to be employed in a variety of applications
Hiraki, Akio;Hirak, Hirohisa;
Revista mexicana de física , 2008,
Abstract: there have been many trials to employ nano-carbon materials, such as carbon-nano-tubes and nano-diamond films, as electron-emitter. several reasons exist why the nano-carbon materials are good for the emitter. they are, in addition to (a) unique morphological shapes of the materials good for the emitter- the high aspect ratio of the carbon-nano-tube is a good example-, (b) sturdiness(they can even be formed in a plasma), (c) high thermal conductivity (current density in the electron-emitting-nano-structure is high, thus it is vital to provide effective joule-heat dissipation), and (d) easiness of the fabrication of the electron-emitting carbon materials. in order to fabricate good electron emitters, we have long been trying to employ a variety of fabrication cvd methods and fabricating conditions (starting cvd gas, pressure, temperature, substrate materials and so on).then recently our emitters have shown a world-top-ranking property: very low turn-on- voltage(0.5v/μm induce 10μa/cm2 of emission current) and high current at low applied voltage with gap distance of 1mm(1ma/cm2 at 1.1v/μm and 100/ at 2v/μm). this excellent property comes from a carbon-nano-structure which we call cnx(carbon-nano-exit). in addition, these emitter can be formed on a variety of substrates(ni, ni-cr, sus or others), in forms of wire or pipe, very quickly. namely, by one reactor, it is possible to fabricate 50100 km of "wire or pipe type emitter" per month. the wire type emitter is good for both high field concentration and avoiding the so-called "edge-effect".then using these emitters, we are able to fabricate mercury-free fluorescence lamps with high efficiency (601m/watt) and high brightness of more than 105cd/m2(white-light).
Unique carbon-nano-structure for high quality electron-emitter to be employed in a variety of applications
Akio Hiraki,Hirohisa Hirak
Revista mexicana de física , 2008,
Abstract: There have been many trials to employ nano-carbon materials, such as carbon-nano-tubes and nano-diamond films, as electron-emitter. Several reasons exist why the nano-carbon materials are good for the emitter. They are, in addition to (a) unique morphological shapes of the materials good for the emitter- the high aspect ratio of the carbon-nano-tube is a good example-, (b) sturdiness(they can even be formed in a plasma), (c) high thermal conductivity (current density in the electron-emitting nano-structure is high, thus it is vital to provide effective Joule-heat dissipation), and (d) easiness of the fabrication of the electron-emitting carbon materials. In order to fabricate good electron emitters, we have long been trying to employ a variety of fabrication CVD methods and fabricating conditions (starting CVD gas, pressure, temperature, substrate materials and so on).Then recently our emitters have shown a world-top-ranking property: very low turnon- voltage(0.5V/1m induce 101A/cm2 of emission current) and high current at low applied voltage with gap distance of 1mm(1mA/cm2 at 1.1V/1m and 100/ at 2V/1m). This excellent property comes from a carbon-nano-structure which we call CNX(Carbon-Nano-eXit). In addition, these emitter can be formed on a variety of substrates(Ni, Ni-Cr, SUS or others), in forms of wire or pipe, very quickly. Namely, by one reactor, it is possible to fabricate 50>100 km of "wire or pipe type emitter" per month.The wire type emitter is good for both high field concentration and avoiding the so-called "edge-effect".Then using these emitters, we are able to fabricate Mercury-free fluorescence lamps with high efficiency (>60lm/watt) and high brightness of more than 105cd/m2(white-light).
Unicentric Castleman’s Disease Masquerading Pancreatic Neoplasm
Saurabh Jain,Souvik Chatterjee,Jyoti Ranjan Swain,Pritha Rakshit,Partha Chakraborty,Santanu Sinha
Case Reports in Oncological Medicine , 2012, DOI: 10.1155/2012/793403
Abstract: Castleman’s disease is a rare nonclonal proliferative disorder of the lymph nodes with an unknown etiology. Common locations of Castleman’s disease are mediastinum, neck, axilla, and abdomen. Castleman’s disease of a peripancreatic location masquerading as pancreatic neoplasm is an even rarer entity. On search of published data, we came across about 17 cases published on peripancreatic Castleman’s disease until now. Here we are reporting a case of retropancreatic Castleman's disease masquerading as retroperitoneal neoplasm in a 46-year-old male patient.
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