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Search Results: 1 - 10 of 7587 matches for " Himanshu Gupta "
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Launch of the special issue of JPBS on CBRN disaster management
Gupta Himanshu
Journal of Pharmacy and Bioallied Sciences , 2011,
Abstract:
Graduate pharmacy aptitude test
Gupta Himanshu
Journal of Pharmacy and Bioallied Sciences , 2010,
Abstract:
Ion activated bioadhesive in situ gel of clindamycin for vaginal application
Himanshu Gupta,Aarti Sharma
International Journal of Drug Delivery , 2011,
Abstract: Vaginal preparations, although generally perceived as safer most , still they are associated with a number of problems, including multiple days of dosing, dripping, leakage and messiness, causing discomfort to users and expulsion due to the self-cleansing action of the vaginal tract. These limitations lead to poor patient compliance and failure of the desired therapeutic effects. For effective vaginal delivery of antimicrobial agents, the drug delivery system should reside at the site of infection for a prolonged period of time. In our present work, we have developed and optimized a chitosan (bioadhesive and permeation enhancer) and gellan gum (ion activated gelling polymer) based in situ gel system of clindamycin for vaginal application. The developed formulation was characterized for various in-vitro parameters e.g. clarity, refractive index, pH, isotonicity, sterility, viscosity, drug release profile, statistical release kinetics, bioadhesive force, retention time, microbial efficacy, irritation test and stability studies. To simulate vaginal conditions, a synthetic membrane (cellophane hydrated with modified simulated vaginal fluid) and sheep vaginal mucosa were used as model membranes. The developed formulation was found to be non irritant, bioadhesive with good retention properties. Developed formulation shows matrix model release kinetic by PCP disso software. The developed formulation is thus a viable alternative to conventional vaginal dosage forms. Keywords: sol-to-gel system; chitosan; gellan gum; vaginal; clindamycin
Analog Circuits Design Using Ant Colony Optimization
Himanshu Gupta,Bahniman Ghosh
International Journal of Electronics, Computer and Communications Technologies , 2012,
Abstract: In this paper, we present, Ant Colony Optimization (ACO) algorithm, as a tool to design analog circuits, for given output specifications. ACO is a swarm intelligence algorithm, which was first proposed in early nineties, to solve the problems of combinatorial optimization. In this paper, a modified version of this algorithm, (for continuous domain) has been implemented to optimize transistor sizes. In this work, widths of transistors are found for three analog circuits, to achieve the given specifications. Also, ACO has been tested on an Analog to Digital (ADC) Converter. Performance of the ADC is improved by optimizing the widths of the transistors, to minimize the error in the output of the ADC. In the past, one of the most popular evolutionary algorithms, Genetic Algorithm (GA) has been found to be effective in optimizing transistor sizes. Therefore, to examine the solutions achieved by ACO, all the circuits are optimized by GA also. Results show that ACO is better than GA in finding transistor sizes. Also, ACO takes less time in optimization process. In this work, Perl code of algorithms has been coupled with HSPICE to do circuit simulations. All circuits are simulated using BSIM3v3 MOSFET models in 0.13μm, 0.18μm or 0.35μm CMOS processes.
MICROWAVE ASSISTED, SOLVENT-FREE SYNTHESIS OF SOME NOVEL IMIDAZOLES OF BIOLOGICAL INTEREST
Rohit Kumar* and Himanshu Gupta
International Journal of Bioassays , 2013,
Abstract: In the present study we have made an attempt to synthesize novel imidazoles and evaluate them as potential therapeutic agent for its anthelmintic and free radical scavenging activity. First, sulfanilamide was condensed with heteryl aldehydes to afford corresponding Schiff’s base. The Schiff’s base further on treatment with ammonium acetate and acetylated / benzoylated isatin using silica gel as solid support yielded corresponding imidazoles. The synthesized compounds were analyzed by physical and analytical data. The synthesized compounds were evaluated for their anthelmintic and free radical scavenging activity. All the synthesized substituted imidazoles have shown moderate to good anthelmintic activity while compound 1b, 2b, 8b, 9b and 10b showed most significant free radical scavenging activity.
Recent trends in protein and peptide drug delivery systems
Gupta Himanshu,Sharma Aarti
Asian Journal of Pharmaceutics , 2009,
Abstract: With the discovery of insulin in 1922, identification and commercialization of potential protein and peptide drugs have been increased. Since then, research and development to improve the means of delivering protein therapeutics to patients has begun. The research efforts have followed two basic pathways: One path focused on noninvasive means of delivering proteins to the body and the second path has been primarily aimed at increasing the biological half-life of the therapeutic molecules. The search for approaches that provide formulations that are stable, bioavailable, readily manufacturable, and acceptable to the patient, has led to major advances in the development of nasal and controlled release technology, applicable to every protein or peptide. In several limited cases, sustained delivery of peptides and proteins has employed the use of polymeric carriers. More successes have been achieved by chemical modification using amino acid substitutions, protein pegylation or glycosylation to improve the pharmacodynamic properties of certain macromolecules and various delivery systems have been developed like the prolease technology, nano-particulate and microparticulate delivery systems, and the mucoadhesive delivery of peptides. The needle and syringe remain the primary means of protein delivery. Major hurdles remain in order to overcome the combined natural barriers of drug permeability, drug stability, pharmacokinetics, and pharmacodynamics of protein therapeutics. In our present review we have tried to compile some recent advances in protein and peptide drug delivery systems.
Molecular Modelling
Aarti Sharma,Himanshu Gupta
Journal of Pharmacy and Bioallied Sciences , 2009,
Abstract: The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and the exponential growth of the knowledge of protein structures have made it possible for organic compounds to tailored to decrease harmful side effects and increase the potency. This article provides a detailed description of the techniques employed in molecular modeling. Molecular modelling is a rapidly developing discipline, and has been supported from the dramatic improvements in computer hardware and software in recent years.
Molecular modeling
Sharma Aarti,Gupta Himanshu
Journal of Pharmacy and Bioallied Sciences , 2009,
Abstract: The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and the exponential growth of the knowledge of protein structures have made it possible for organic compounds to be tailored to decrease the harmful side effects and increase the potency. This article provides a detailed description of the techniques employed in molecular modeling. Molecular modeling is a rapidly developing discipline, and has been supported by the dramatic improvements in computer hardware and software in recent years.
Isolation and purification of fungal pathogen (Macrophomina phaseolina) induced chitinase from moth beans (Phaseolus aconitifolius)
Garg Neelima,Gupta Himanshu
Journal of Pharmacy and Bioallied Sciences , 2010,
Abstract: Objective : Chitinase (EC 3.2.1.14) is one of the major pathogenesis-related proteins, which is a polypeptide that accumulates extracellularly in infected plant tissue. An attempt was made to isolate and purify the chitanase enzyme using moth beans as an enzyme source. Materials and Method : The enzyme was isolated and purified from moth beans against the fungal pathogen Macrophomina phaseolina strain 2165. The isolation and purification was done in both in vitro and in vivo conditions. Purification of chitinase was carried out to obtain three fractions, viz. 50°C heated, ammonium sulfate precipitated and sephadex G-25 column-eluted fractions. The molecular mass of Chitinase was directly estimated by sodium dodecyl sulfate-polyacryamide gel electroresis (SDS-PAGE). Result : The yield is sufficient for initial characterization studies of the enzyme. The molecular study of the enzyme shows the possibility of generating the defense mechanism in plants in which it cannot occur. Chitinase was purified by gel filtration chromatography with 20.75-fold and 32.78-fold purification in the in vitro and in vivo conditions, respectively. The enzyme shows a maximum activity after 90 min with 0.1 ml of colloidal chitin as a substrate and 0.4 ml of crude chitinase extract. The optimum pH of 5.0 and an optimum temperature of 40°C was found for maximal activity. The molecular weight of purified chitinase was estimated to be 30 kDa by SDS-PAGE. Conclusion : The chitinase isolated in both in vitro and in vivo conditions is stable andactive.
ε-Net Approach to Sensor k-Coverage
Giordano Fusco,Himanshu Gupta
EURASIP Journal on Wireless Communications and Networking , 2010, DOI: 10.1155/2010/192752
Abstract: Wireless sensors rely on battery power, and in many applications it is difficult or prohibitive to replace them. Hence, in order to prolongate the system's lifetime, some sensors can be kept inactive while others perform all the tasks. In this paper, we study the k-coverage problem of activating the minimum number of sensors to ensure that every point in the area is covered by at least k sensors. This ensures higher fault tolerance, robustness, and improves many operations, among which position detection and intrusion detection. The k-coverage problem is trivially NP-complete, and hence we can only provide approximation algorithms. In this paper, we present an algorithm based on an extension of the classical ε-net technique. This method gives an O(log M)-approximation, where M is the number of sensors in an optimal solution. We do not make any particular assumption on the shape of the areas covered by each sensor, besides that they must be closed, connected, and without holes.
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