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Association of beta3-adrenergic receptor (ADRB3) Trp64Arg gene polymorphism with obesity and metabolic syndrome in the Balinese: a pilot study
Safarina G Malik, Made R Saraswati, Ketut Suastika, Hidayat Trimarsanto, Sukma Oktavianthi, Herawati Sudoyo
BMC Research Notes , 2011, DOI: 10.1186/1756-0500-4-167
Abstract: A total of 528 Balinese (urban 282, rural 246) were recruited. Body mass index (BMI) and waist circumference (WC) were determined; high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), systolic and diastolic blood pressure (SBP and DBP), and fasting plasma glucose (FPG) were measured using standard procedures. BMI and WC classifications were based on WHO classifications for Asian. Metabolic syndrome (MetS) was defined as described in the Joint Interim Statement. Chi-square test was employed to test the association between the ADRB3 Trp64Arg genotype and disease traits.Urban have higher BMI (p = 2.8 × 10-13), WC ( p < 2.2 × 10-16), TG (p = 0.0028), DBP (p = 1.8 × 10-5), and lower HDL-C (p = 0.0376) when compared to rural. Abdominal obesity and MetS prevalence were significantly higher in urban as compared to rural (both p < 0.001). The Arg64 allele frequency was similar between urban (0.06) and rural (0.05). The Arg64 rural female carriers have higher BMI and WC as compared to their Trp64 counterparts (p = 0.041 for BMI and p = 0.012 for WC), and consequently higher abdominal obesity prevalence (p = 0.007). Comparison between male and female, as well as urban and rural, showed different prevalence of MetS co-morbidities. Abdominal obesity and hypertriglyceridaemia were consistently appeared in all groups, suggesting to play a role as determinant of MetS in both urban and rural.Prevalence of obesity and MetS in urban were two times higher when compared to rural. Abdominal obesity and hypertriglyceridaemia appears to be the key determinant of MetS in both urban and rural Balinese. Our results indicated an association of the ADRB3 Trp64Arg gene polymorphism with obesity in the rural female.Excess bodyweight is one of the most important risk factors contributing to the overall burden of disease worldwide. In 2005, approximately 23.2% adults were classified as overweight, while 9.8% were obese [1]. Average life expectancy was reduced due to the adverse conseque
Uncoupling protein 2 gene polymorphisms are associated with obesity
Sukma Oktavianthi, Hidayat Trimarsanto, Clarissa A Febinia, Ketut Suastika, Made R Saraswati, Pande Dwipayana, Wibowo Arindrarto, Herawati Sudoyo, Safarina G Malik
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-41
Abstract: A total of 603 participants (278 urban and 325 rural subjects) were recruited from Bali Island, Indonesia. Fasting plasma glucose (FPG), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were measured. Obesity was determined based on WHO classifications for adult Asians. Participants were genotyped for G(?866)A and Ala55Val polymorphisms of the UCP2 gene.Obesity prevalence was higher in urban subjects (51%) as compared to rural subjects (23%). The genotype, minor allele (MAF), and heterozygosity frequencies were similar between urban and rural subjects for both SNPs. All genotype frequencies were in Hardy-Weinberg equilibrium. A combined analysis of genotypes and environment revealed that the urban subjects carrying the A/A genotype of the G(?866)A SNP have higher BMI than the rural subjects with the same genotype. Since the two SNPs showed strong linkage disequilibrium (D’?=?0.946, r2?=?0.657), a haplotype analysis was performed. We found that the AT haplotype was associated with high BMI only when the urban environment was taken into account.We have demonstrated the importance of environmental settings in studying the influence of the common UCP2 gene polymorphisms in the development of obesity in a Balinese population.Obesity and type 2 diabetes mellitus (T2DM) have become global health concerns. The International Obesity Task Force estimated that approximately one billion adults are overweight, and 475 million of them are obese [1]. In 2010, it was predicted that 285 million people might suffer from T2DM worldwide [2]. Obesity and T2DM would eventually develop into metabolic disorders and coronary heart disease (CHD), in particular when accompanied with a high serum lipid level. The rapidly increasing prevalence of obesity and T2DM, as well as a high serum lipid level were markedly noticed in developing countries, proposed to be the result of adopting a Western lifestyle, and c
Molecular Surveillance of Dengue in Semarang, Indonesia Revealed the Circulation of an Old Genotype of Dengue Virus Serotype-1
Sukmal Fahri equal contributor,Benediktus Yohan equal contributor,Hidayat Trimarsanto,S. Sayono,Suharyo Hadisaputro,Edi Dharmana,Din Syafruddin,R. Tedjo Sasmono
PLOS Neglected Tropical Diseases , 2013, DOI: 10.1371/journal.pntd.0002354
Abstract: Dengue disease is currently a major health problem in Indonesia and affects all provinces in the country, including Semarang Municipality, Central Java province. While dengue is endemic in this region, only limited data on the disease epidemiology is available. To understand the dynamics of dengue in Semarang, we conducted clinical, virological, and demographical surveillance of dengue in Semarang and its surrounding regions in 2012. Dengue cases were detected in both urban and rural areas located in various geographical features, including the coastal and highland areas. During an eight months' study, a total of 120 febrile patients were recruited, of which 66 were serologically confirmed for dengue infection using IgG/IgM ELISA and/or NS1 tests. The cases occurred both in dry and wet seasons. Majority of patients were under 10 years old. Most patients were diagnosed as dengue hemorrhagic fever, followed by dengue shock syndrome and dengue fever. Serotyping was performed in 31 patients, and we observed the co-circulation of all four dengue virus (DENV) serotypes. When the serotypes were correlated with the severity of the disease, no direct correlation was observed. Phylogenetic analysis of DENV based on Envelope gene sequence revealed the circulation of DENV-2 Cosmopolitan genotype and DENV-3 Genotype I. A striking finding was observed for DENV-1, in which we found the co-circulation of Genotype I with an old Genotype II. The Genotype II was represented by a virus strain that has a very slow mutation rate and is very closely related to the DENV strain from Thailand, isolated in 1964 and never reported in other countries in the last three decades. Moreover, this virus was discovered in a cool highland area with an elevation of 1,001 meters above the sea level. The discovery of this old DENV strain may suggest the silent circulation of old virus strains in Indonesia.
Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination
Rintis Noviyanti?,Farah Coutrier?,Retno A. S. Utami?,Hidayat Trimarsanto,Yusrifar K. Tirta?,Leily Trianty?,Andreas Kusuma?,Inge Sutanto?,Ayleen Kosasih?,Rita Kusriastuti
PLOS Neglected Tropical Diseases , 2015, DOI: 10.1371/journal.pntd.0003739
Abstract: Background Outside of Africa, P. falciparum and P. vivax usually coexist. In such co-endemic regions, successful malaria control programs have a greater impact on reducing falciparum malaria, resulting in P. vivax becoming the predominant species of infection. Adding to the challenges of elimination, the dormant liver stage complicates efforts to monitor the impact of ongoing interventions against P. vivax. We investigated molecular approaches to inform the respective transmission dynamics of P. falciparum and P. vivax and how these could help to prioritize public health interventions. Methodology/ Principal Findings Genotype data generated at 8 and 9 microsatellite loci were analysed in 168 P. falciparum and 166 P. vivax isolates, respectively, from four co-endemic sites in Indonesia (Bangka, Kalimantan, Sumba and West Timor). Measures of diversity, linkage disequilibrium (LD) and population structure were used to gauge the transmission dynamics of each species in each setting. Marked differences were observed in the diversity and population structure of P. vivax versus P. falciparum. In Bangka, Kalimantan and Timor, P. falciparum diversity was low, and LD patterns were consistent with unstable, epidemic transmission, amenable to targeted intervention. In contrast, P. vivax diversity was higher and transmission appeared more stable. Population differentiation was lower in P. vivax versus P. falciparum, suggesting that the hypnozoite reservoir might play an important role in sustaining local transmission and facilitating the spread of P. vivax infections in different endemic settings. P. vivax polyclonality varied with local endemicity, demonstrating potential utility in informing on transmission intensity in this species. Conclusions/ Significance Molecular approaches can provide important information on malaria transmission that is not readily available from traditional epidemiological measures. Elucidation of the transmission dynamics circulating in a given setting will have a major role in prioritising malaria control strategies, particularly against the relatively neglected non-falciparum species.
The Effect of Realistic Mathematic Education on Students’ Conceptual Understanding of Linear Progamming  [PDF]
Riyan Hidayat, Zanaton H. Iksan
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.622251
Abstract: A number of national and international scale surveys showed that the mathematics achievements of Indonesian secondary school students were in the lower level. One of the indicators of this low achievement was the insufficient level of understanding of mathematical concepts of the students. Understanding of mathematical concepts could be integrated through Realistic Mathematics Education (RME). Therefore, the quasi-experimental study was conducted to examine the effectiveness of Realistic Mathematical Education towards the conceptual understanding of linear programming. The study also investigated the relationship between conceptual understanding and mathematics achievement and investigated the misconceptions on linear programming. This study involved 65 students of Madrasah Aliyah Negeri 1 Pekanbaru, Indonesia. Test conceptual understanding programming topics had Cronbach’s alpha reliability of 0.80. The data were collected by using a test question conceptual understanding of linear programming. Quantitative data analysis involved a descriptive and inferential analysis using SPSS 21.0. The descriptive analysis included the percentage, mean and standard deviation while inferential analysis involving independent t-test and Pearson correlation analysis. The results revealed that there were significant differences between the treatment and control groups toward conceptual understanding. There was a significant relationship between conceptual understanding and mathematics achievement of linear programming. Misconception toward linear programming for the treatment group was lower than the control group. The implications of this study were useful for educators to help their students to understand concept of mathematics through open and contextual questions so that the students though through the mathematics, not worked in the mathematics.
Mathematical Modelling Competency for Indonesian Students in Mathematics Education Programmes  [PDF]
Riyan Hidayat, Zanaton H. Iksan
Creative Education (CE) , 2018, DOI: 10.4236/ce.2018.915187
Abstract: Previous studies have documented that students have difficulties in mathematical modeling competency. The current research is an attempt to investigate the issue of student’s mathematical modeling competency in pre-service mathematics teacher in Indonesia and its analysis in term of Cumulative Grade Points Average (CGPA) gap in Riau Province,?Indonesia. The research involved a total of 100 pre-service teacher students?in Universitas Islam Riau?(UIR). A survey design was employed to investigate the students’ mathematical modeling competency using questionnaire of mathematical modeling test. The quantitative data were statistically analyzed using the SPSS 22.0. The descriptive analysis included the percentage, mean and standard deviation while inferential analysis involved Pearson correlation analysis. The results indicated that pre-service mathematics teacher education in Indonesia had moderate level of mathematical modeling competency. However, using graphical representation and interpreting and relating the mathematical solution to the real world context are the most two difficulties in mathematical modeling. At the same time, there was not a significant relationship between CGPA and mathematical modeling competency.
Are there differences between unconditional and conditional demand estimates? implications for future research and policy
Budi Hidayat
Cost Effectiveness and Resource Allocation , 2008, DOI: 10.1186/1478-7547-6-15
Abstract: The demand for outpatient care in three alternative providers was modeled using a multinomial logit regression for samples unconditional on being ill (N = 16485) and conditional on being ill (N = 5055). The ill sample was constructed from two measures of health status – activity of daily living impairments and severity of illness – derived from the second round of panel data from the Indonesian Family Life Survey. The recycling prediction method was used to predict the distribution of utilization rates based on having health insurance and income status, while holding all other variables constant.Both unconditional and conditional estimates yield similar results in terms of the direction of the most covariates. The magnitude effects of insurance on healthcare demand are about 7.5% (public providers) and 20% (private providers) higher for unconditional estimates than for conditional ones. Further, exogenous variables in the former estimates explain a higher variation of the model than that in the latter ones. Findings confirm that health insurance has a positive impact on the demand for healthcare, with the highest effect found among the lowest income group.Conditional estimates do not suffer from statistical selection bias. Such estimates produce smaller demand effects for health insurance than unconditional ones do. Whether to rely on conditional or unconditional demand estimates depends on the purpose of study in question. Findings also demonstrate that health insurance programs significantly improve access to healthcare services, supporting the development of national health insurance programs to address under-utilization of formal healthcare in Indonesia.Several published studies on healthcare demand estimate the probabilities of using healthcare services conditional on being ill sample [1-4]. The ill sample is usually generated from self-assessments of health status. Conditional estimates are the preferred method because an individual's decision to seek treatmen
Pengaruh Kualitas Layanan, Kualitas Produk dan Nilai Nasabah Terhadap Kepuasan dan Loyalitas Nasabah Bank Mandiri
Rachmad Hidayat
Jurnal Manajemen dan Kewirausahaan , 2009,
Abstract: The objectives of this study is to measure customer level of satisfaction and loyalty toward banking service in East Java. This study is categorized as survey research with descriptive analysis method by taking sample from population and using questionnaire as the main data-collecting instrument. The population in this research is all customers of Mandiri Bank in East Java. The respondents are chosen by using probability sampling and systematic random sampling techniques. The research sample is chosen randomly for the first data whereas the following is using certain interval. The results of analysis using Structural Equation Modeling (SEM) model are: (1) Service quality has positive and significant influence on customer satisfaction. (2) Product quality has positive and significant influence on customer satisfaction. (3) Value for customer has positive and significant influence on customer satisfaction. (4) Customer satisfaction has positive, significant influence to customer loyalty. (5) Service quality has negative, significant influence on customer loyalty. (6) Product quality has negative, significant influence on customer loyalty. (7) Value for customer has positive, significant influence on customer loyalty. (8) Theoretical finding leading to the theory developed is service quality has negative, significant influence on customer loyalty. But significant influence on customer satisfaction. And product quality has negative, significant influence on customer loyalty. But positive, significant influence on customer loyalty mediated by customer satisfaction.
Analisis Komitmen (Affective, Continuance dan Normative) Terhadap Kualitas Pelayanan Pengesahan STNK Kendaraan Bermotor (Studi Empiris pada Kantor Bersama Samsat di Propinsi Kalimantan Timur)
Muchtar Hidayat
Jurnal Manajemen dan Kewirausahaan , 2010,
Abstract: Adopting an internal marketing approach, this study attempts to provide a deeper understanding of the organisational commitment – service quality relationship in the service context. This is done by empirically testing the relationships that the three components of organizational commitment (affective, continuance and normative) have with the service quality of customer-contact employees. The hypotheses were framed by critically reviewing the extant literature in the areas of services marketing and human resource management. A large sample comparative study was conducted on employees in Kantor Bersama Samsat Di Propinsi Kaltim. Study explore the important question of how the three components of organizational commitment influence the employee-perceived service quality differently in Kantor Bersama Samsat. The findings indicate that in Kantor Bersama Samsat, both affective commitment and continuance commitment have significant positive impact on service quality while in Kantor Bersama Samsat, only affective commitment is found to affect service quality significantly. Having established the commitment–service quality relationship, the implications for designing internal marketing strategies are further discussed.
The effect of pH on endo-1,4-b-glucanase activity from Bacillus sp. AR 009
Biodiversitas , 2005,
Abstract: The determinination of the suitable pH condition for maximizing the activity of endo-1,4- -glucanase of Bacillus sp. AR 009 had been done. The acidity range of media for examining the enzyme activities were 4, 5, 6, 7, 8, and 9 at 37°C. The experiments show that the value of maximum activity of endo-1,4- -glucanase was 23.068 U/mL at third day incubation with 124.565 mg/L of sugar reduction at pH 7.
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