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Primary pancreatic Non-Hodgkin's lymphoma in a young man with abdominal pain and hypersplenism: a case report
Noorian SE,Beigi AA,Safaee M,Heshmat-Ghahdarijani K
Tehran University Medical Journal , 2013,
Abstract: Background: Primary pancreatic lymphoma is really rare and comprising about 0.2-4.9% of all pancreatic malignancies. The diagnosis of this lymphoma is very difficult because the clinical symptoms and signs resemble those of pancreatic adenocarcinoma. Case presentation: A 30-year old man was admitted to the hospital with the complaint of left upper abdominal pain. Because of his splenomegaly and pancytopenia he was candidate for splenectomy but during operation a large mass was found in the pancreas and biopsy was taken from it. Pathology reported lymphoblastic lymphoma of pancreas.Conclusion: It is important to differentiate between primary lymphoma and the adenocarcinoma of the pancreas as prognosis and treatment of them differ significantly. Primary pancreatic lymphoma should be considered in differential diagnosis of pancreatic tumors and an attempt to obtain tissue diagnosis is always necessary before radical surgery, especially in young patients.
Solvent effect on 14N NMR shielding of glycine, serine, leucine, and threonine: comparison between chemical shifts and energy versus dielectric constant
M. Monajjemi, M. Heshmat, H. Aghaei, R. Ahmadi, K. Zare
Bulletin of the Chemical Society of Ethiopia , 2007,
Abstract: The polarizable continuum model (PCM) is employed to describe the system in the condensed phase. The performance of DFT and PCM in describing high order nonlinear mixed electric and magnetic effects in condensed phase are described. In this paper we consider the effect of 10 solvents with a wide range of dielectric constants on 4 amino acids. NMR shielding values (ppm), isotropic and anisotropic effects, energy interaction between solute and solvent, and the effect of hydrogen bond on shielding are described. Direct and indirect solvent effects on shielding are also calculated. The observed solvent-induced shielding variation is more strongly related to the intensity of the solvent reaction field rather than on the change of molecular geometry induced by the solvent. KEY WORDS: Solvent effect, 14N NMR shielding, Solvent-induced shielding, Polarizable continuum model, Amino acids Bull. Chem. Soc. Ethiop. 2007, 21(1), 111-116.
Vitamin D Deficiency in Iran: A Multi-center Study among Different Urban Areas
R Heshmat,K Mohammad,SR Majdzadeh,MH Forouzanfar
Iranian Journal of Public Health , 2008,
Abstract: "nBackground: Recent studies have reported different prevalence of vitamin D deficiency in different sex and age groups in de-veloping countries. In the present survey, we elucidated the prevalence of vitamin D deficiency in a multi-center study among Iranian population. "nMethods: In a random cluster sample of healthy men and women (ranged 20 to 69 years old), a number of 5232 subjects from five urban metropolitans' cities (Tehran, Tabriz, Mashhad, Shiraz and Booshehr) were recruited in 2001. Fasting blood sam-ple was taken from participants and sent to the laboratory for measurement of 25-hydroxy vitamin D level. Meta-analy-sis was performed using fixed effect method for estimation of vitamin D deficiency prevalence in a national level. "nResults: Moderate to severe vitamin D deficiency was estimated in urban areas (except for Booshehr because of its heterogene-ity) equal to 47.2, 45.7 and 44.2% in age groups of <50, 50-60 and 60≤ years, respectively among men and 54.2, 41.2 and 37.5 percent among women in the same age groups. The highest prevalence of moderate to severe vitamin D defi-ciency in men was observed in Tehran. Mashhad and Booshehr had also the lowest prevalence of moderate to severe vita-min D deficiency among men and women."nConclusion: Iran is a country with high prevalence of moderate to severe vitamin D deficiency and the prevalence of this defi-ciency is more evident in Tehran, capital of Iran. Therefore, consideration of main predictors for vitamin D deficiency in all age groups especially in Tehran is recommended.
Vitamin D Deficiency in Iran: A Multi-center Study among Different Urban Areas
R Heshmat,K Mohammad,SR Majdzadeh,MH Forouzanfar
Iranian Journal of Public Health , 2008,
Abstract: "nBackground: Recent studies have reported different prevalence of vitamin D deficiency in different sex and age groups in de-veloping countries. In the present survey, we elucidated the prevalence of vitamin D deficiency in a multi-center study among Iranian population. "nMethods: In a random cluster sample of healthy men and women (ranged 20 to 69 years old), a number of 5232 subjects from five urban metropolitans' cities (Tehran, Tabriz, Mashhad, Shiraz and Booshehr) were recruited in 2001. Fasting blood sam-ple was taken from participants and sent to the laboratory for measurement of 25-hydroxy vitamin D level. Meta-analy-sis was performed using fixed effect method for estimation of vitamin D deficiency prevalence in a national level. "nResults: Moderate to severe vitamin D deficiency was estimated in urban areas (except for Booshehr because of its heterogene-ity) equal to 47.2, 45.7 and 44.2% in age groups of <50, 50-60 and 60≤ years, respectively among men and 54.2, 41.2 and 37.5 percent among women in the same age groups. The highest prevalence of moderate to severe vitamin D defi-ciency in men was observed in Tehran. Mashhad and Booshehr had also the lowest prevalence of moderate to severe vita-min D deficiency among men and women."nConclusion: Iran is a country with high prevalence of moderate to severe vitamin D deficiency and the prevalence of this defi-ciency is more evident in Tehran, capital of Iran. Therefore, consideration of main predictors for vitamin D deficiency in all age groups especially in Tehran is recommended.
Intravenous Semelil (ANGIPARSTM) as a novel therapy for pressure Ulcers: A randomized clinical trial
Shamimi Nouri K,Heshmat R,Karimian R,Nasli E
DARU : Journal of Pharmaceutical Sciences , 2008,
Abstract: The prevalence of pressure ulcers of the foot is a major health care problem in frail elderly patients. A pressure sore dramatically increases the cost of medical and nursing care, and effective treatment has always been an essential nursing concern. Management options for pressure ulcers include local wound care; surgical repair and, more recently, topical application of growth factors.The main goal of this study was to examine the effects of intravenous treatment of Semelil (ANGIPARSTM), a new herbal extract in patients with severe, noninfected pressure ulcers of the foot.As a randomized clinical trial, 18 patients with pressure ulcers were recruited from Vali-e-Asr hospital, Medical Sciences/ University of Tehran, Iran. Nine patients received intravenous Semelil (ANGIPARSTM) besides to conventional therapy and nine received only conventional treatment.At the baseline, the treatment and control groups did not differ across demographic variables, clinical characteristics, and functional measures. The mean surface areas of the ulcers were reduced 43.2 ± 57.4 cm2 (80.3%) and 2.8± 6.2 cm2 (6.3%) in the treatment and control groups, respectively (p=0.000). The average reduction in pressure ulcer area at four weeks was statistically and clinically greater in the treatment group than in the control group So, intravenous Semelil (ANGIPARSTM) can be recommended as an effective treatment for patients with severe pressure ulcers.
Assessment of maximum tolerated dose of a new herbal drug, Semelil (ANGIPARSTM) in patients with diabetic foot ulcer: A Phase I clinical trial
Heshmat R,Mohammad K,Mohajeri Tehrani MR,Tabatabaie Malazy O
DARU : Journal of Pharmaceutical Sciences , 2008,
Abstract: Background and the purpose of the study: In many cases of diabetic foot ulcer (DFU) management, wound healing is incomplete, and wound closure and epithelial junctional integrity are rarely achieved. Our aim was to evaluate the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of Semelil (ANGIPARSTM), a new herbal compound for wound treatment in a Phase I clinical trial.Methods: In this open label study, six male diabetic patients with a mean age of 57±7.6 years were treated with escalating intravenous doses of Semelil, which started at 2 cc/day to 13.5 cc/day for 28 days. Patients were assessed with a full physical exam; variables which analyzed included age, past history of diabetes and its duration, blood pressure, body temperature, weight, characteristics of DFU, Na, K, liver function test, Complete Blood Count and Differential(CBC & diff), serum amylase, HbA1c, PT, PTT, proteinuria, hematuria, and side effects were recorded. All the measurements were taken at the beginning of treatment, the end of week 2 and week 4. We also evaluated Semelil's side effects at the end of weeks 4 and 8 after ending therapy.Results and major conclusions: Up to the drug dose of 10 cc/day foot ulcer dramatically improved. We did not observe any clinical or laboratory side effects at this or lower dose levels in diabetic patients. With daily dose of 13.5 cc of Semelil we observed phlebitis at the infusion site, which was the only side effect. Therefore, in this study we determined the MTD of Semelil at 10 cc/day, and the only DLT was phlebitis in injection vein. The recommended dose of Semelil I.V. administration for Phase II studies was 4 cc/day.
Changes of Proline Content and Activity of Antioxidative Enzymes in Two Canola Genotype under Drought Stress
Heshmat Omidi
American Journal of Plant Physiology , 2010,
Abstract: The aim of present study was to get further information on the ability of drought stress applied to retard senescence and to frustrate inhibitory effects of drought-stress via comparing two canola genotypes differing in drought tolerance. The objective of this work was to evaluate the effects of the drought stress (control, -0.5, -1 and -1.5 Mpa) on two canola genotypes (Okapi and RGS). The experiment was factorial with four replications at experimental greenhouse at Center of Agriculture Research-Shahed, Iran, during 2006-2007. Morphological parameters of root and shoot dry weight, proline content osmolyte and enzyme activities of Ascorbate peroxidase (APx), Guaiacol peroxidase (GAx) and Catalase (Cat) in shoot and root of tissues canola genotypes were highly significant differences for main and interaction effects of two factors (Drought (D) and Genotype (G)) studied. Drought decreased the roots and shoots dry weight of canola plants and this effect was particularly significant at high level of stress. So, results indicated that proline content, ascorbate peroxidase (APx) and Guaiacol peroxidase (GAx) and Catalase (Cat) activity in root and shoot increased with enhancement of drought stress in the two genotypes. Of course, the proline content and antioxidant activities in Okapi genotype were more than RGS genotype. These results showed that Okapi genotype tolerated drought stress than RGS with increasing of proline content and antioxidant activities including GAx and APx. Shoot always maintained higher level of free Catalase (CAT) contents than the root. Therefore, the evaluation of both antioxidant enzymes and proline content can be suggested for Mechanisms of drought stress tolerance.
Libraries Usage of On-line Electronic Information Resources
Heshmat Qassem
Cybrarians Journal , 2004,
Abstract:
Effect of Preheating Temperature on the Mechanical and Fracture Properties of Welded Pearlitic Rail Steels  [PDF]
Heshmat A. Aglan, Sudan Ahmed, Kaushal R. Prayakarao, Mahmood Fateh
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.511101
Abstract:

The effect of preheating temperature on the mechanical and fracture behavior, hardness, and the microstructure of slot welded pearlitic rail steel were studied. Railhead sections with slots were preheated to 200℃, 300℃, 350℃ and 400℃ before gas metal arc filling to simulate defects repair. Another sample, welded at room temperature (RT) with no preheat, was studied in comparison. The parent rail steel has ultimate strength, yield strength and strain to failure of 1146 MPa, 717 MPa and 9.3%, respectively. Optimum values of these properties for the welded rail steels were found to be 1023 MPa, 655 MPa and 4.7%, respectively, for the 200℃ preheat temperature. On this basis, the optimum weld efficiency was found to be 89.2%. The average apparent fracture toughness KI for the parent rail was 127 MPa.m0.5, while that for the optimum welded joint (200℃ preheat) was 116.5 MPa.m0.5. In addition, the average hardness values of the weld, fusion zone, and heat affected zone (HAZ) were 313.5, 332 and 313.6 HB, respectively, while that for parent rail steel was about 360 HB. Dominance of bainite and acicular ferrite phase in the weld microstructure was observed at 200℃ preheat.

Noise Removal in Speech Processing Using Spectral Subtraction  [PDF]
Marc Karam, Hasan F. Khazaal, Heshmat Aglan, Cliston Cole
Journal of Signal and Information Processing (JSIP) , 2014, DOI: 10.4236/jsip.2014.52006
Abstract:

Spectral subtraction is used in this research as a method to remove noise from noisy speech signals in the frequency domain. This method consists of computing the spectrum of the noisy speech using the Fast Fourier Transform (FFT) and subtracting the average magnitude of the noise spectrum from the noisy speech spectrum. We applied spectral subtraction to the speech signal “Real graph”. A digital audio recorder system embedded in a personal computer was used to sample the speech signal “Real graph” to which we digitally added vacuum cleaner noise. The noise removal algorithm was implemented using Matlab software by storing the noisy speech data into Hanning time-widowed half-overlapped data buffers, computing the corresponding spectrums using the FFT, removing the noise from the noisy speech, and reconstructing the speech back into the time domain using the inverse Fast Fourier Transform (IFFT). The performance of the algorithm was evaluated by calculating the Speech to Noise Ratio (SNR). Frame averaging was introduced as an optional technique that could improve the SNR. Seventeen different configurations with various lengths of the Hanning time windows, various degrees of data buffers overlapping, and various numbers of frames to be averaged were investigated in view of improving the SNR. Results showed that using one-fourth overlapped data buffers with 128 points Hanning windows and no frames averaging leads to the best performance in removing noise from the noisy speech.

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