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Search Results: 1 - 10 of 1209 matches for " Hervé Watier "
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Lability of IgE Levels Early in Life
Koffi N'guessan,David Ternant,Fran?ois Labarthe,Hervé Watier
Journal of Allergy , 2011, DOI: 10.1155/2011/547389
Abstract: We report a case of a very fast and intriguing decrease in IgE concentrations after exclusion from the diet of any CM lysate in an unusual clinical presentation of cow's milk allergy in an infant. Analysis of IgE kinetics after allergen elimination suggests rapid cessation of IgE biosynthesis and a short IgE half-life. 1. Introduction An unusual clinical presentation of cow's milk allergy (CMA) in an infant gave us the opportunity to observe a very fast and intriguing decrease of IgE concentrations after allergen withdrawal, raising new questions about IgE production and metabolism in newborns and infants. 2. Case Report A 17-day-old neonate, born to atopic parents at full term, was hospitalized in the children hospital of Tours (France) for poor feeding and increasing diarrhoea for 4 days, associated with a severe metabolic acidosis, after a symptom-free interval of 2 weeks. The diarrhoea ceased soon after admission. Erythema and a pustular rash of the face as well as a “gloves and socks-” type skin rash were noted at 18 days of age, leading to the finding of very high concentrations of total IgE (1298?kIU/L) and IgE specific to cow’s milk (CM) (83?kAU/L, Phadia) (Figure 1). First-stage formula milk had been introduced on day 11 in addition to breastfeeding according to the mother, although it is possible that this had been given since birth. Although the clinical presentation was very unusual and severe [1, 2], the diagnosis of CMA was confirmed by a rapid regression of all symptoms after withdrawal of CM proteins. Seven days later, total IgE fell to 121?kIU/L and specific IgE to 1.44?kAU/L, and total IgE returned to within the normal range (10.5?kIU/L) (Figure 1) five days later. Figure 1: Evolution of total IgE (●) and CM-specific IgE (■). IgE levels were measured on D19, D26, and D31. Predicted IgE kinetics are indicated as a black bold line. Extrapolated IgE kinetics are shown as grey lines (median in bold, 5 and 95% CI as normal lines). With only two values available, calculations were not performed for specific IgE. 3. Discussion The IgE detected in the newborn had been self-produced since IgE did not cross the placenta and his mother had no CM-specific IgE (not shown). This IgE immune response thus probably reflected a rapid maturation of IgE+ B cells into plasmablasts, as recently evidenced in mice [3]. No less spectacular was the 100-fold decrease in IgE concentrations 12 days later (Figure 1), following exclusion of any CM lysate from the diet. High levels of both specific and total IgE are regularly observed in infant cow’s milk allergy [4]
Bounds for Goal Achieving Probabilities of Mean-Variance Strategies with a No Bankruptcy Constraint  [PDF]
Alexandre Scott, Francois Watier
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.312A278

We establish, through solving semi-infinite programming problems, bounds on the probability of safely reaching a desired level of wealth on a finite horizon, when an investor starts with an optimal mean-variance financial investment strategy under a non-negative wealth restriction.

Antibodies toward infliximab are associated with low infliximab concentration at treatment initiation and poor infliximab maintenance in rheumatic diseases
Emilie Ducourau, Denis Mulleman, Gilles Paintaud, Delphine Miow Lin, Francine Lauféron, David Ternant, Hervé Watier, Philippe Goupille
Arthritis Research & Therapy , 2011, DOI: 10.1186/ar3386
Abstract: All patients with rheumatoid arthritis (RA) or spondyloarthritis (SpA) receiving infliximab beginning in December 2005 were retrospectively followed until January 2009 or until infliximab discontinuation. Trough serum infliximab and ATI concentrations were measured at each visit. The patients were separated into two groups: ATIpos if ATI were detected at least once during the follow-up period and ATIneg otherwise. Repeated measures analysis of variance was used to study the association of infliximab concentration at treatment initiation and the development of ATI. Maintenance of infliximab in the two groups was studied by using Kaplan-Meier curves.We included 108 patients: 17 with RA and 91 with SpA. ATI were detected in 21 patients (19%). The median time to ATI detection after initiation of infliximab was 3.7 months (1.7 to 26.0 months). For both RA and SpA patients, trough infliximab concentration during the initiation period was significantly lower for ATIpos than ATIneg patients. RA patients showed maintenance of infliximab at a median of 19.5 months (5.0 to 31.0 months) and 12.0 months (2.0 to 24.0 months) for ATIneg and ATIpos groups, respectively (P = 0.08). SpA patients showed infliximab maintenance at a median of 16.0 months (3.0 to 34.0 months) and 9.5 months (3.0 to 39.0 months) for ATIneg and ATIpos groups, respectively (P = 0.20). Among SpA patients, those who were being treated concomitantly with methotrexate had a lower risk of developing ATI than patients not taking methotrexate (0 of 14 patients (0%) vs. 25 of 77 patients (32%); P = 0.03).High concentrations of infliximab during treatment initiation reduce the development of ATI, and the absence of ATI may be associated with prolonged maintenance of infliximab. Thus, trough serum infliximab concentration should be monitored early in patients with rheumatic diseases.Infliximab, a chimeric mAb targeting TNFα, is used to treat rheumatoid arthritis (RA), spondyloarthritis (SpA) and inflammatory bowel di
Imported Episodic Rabies Increases Patient Demand for and Physician Delivery of Antirabies Prophylaxis
Zélie Lardon,Laurence Watier,Audrey Brunet,Claire Bernède,Maryvonne Goudal,Laurent Dacheux,Yolande Rotivel,Didier Guillemot equal contributor,Hervé Bourhy equal contributor
PLOS Neglected Tropical Diseases , 2010, DOI: 10.1371/journal.pntd.0000723
Abstract: Background Imported cases threaten rabies reemergence in rabies-free areas. During 2000–2005, five dog and one human rabies cases were imported into France, a rabies-free country since 2001. The Summer 2004 event led to unprecedented media warnings by the French Public Health Director. We investigated medical practice evolution following the official elimination of rabies in 2001; impact of subsequent episodic rabies importations and national newspaper coverage on demand for and delivery of antirabies prophylaxis; regular transmission of epidemiological developments within the French Antirabies Medical Center (ARMC) network; and ARMC discussions on indications of rabies post-exposure prophylaxis (RPEP). Methodology/Principal Findings Annual data collected by the National Reference Center for Rabies NRCR (1989–2006) and the exhaustive database (2000–2005) of 56 ARMC were analyzed. Weekly numbers of patients consulting at ARMC and their RPEP- and antirabies-immunoglobulin (ARIG) prescription rates were determined. Autoregressive integrated moving-average modeling and regression with autocorrelated errors were applied to examine how 2000–2005 episodic rabies events and their related national newspaper coverage affected demand for and delivery of RPEP. A slight, continuous decline of rabies-dedicated public health facility attendance was observed from 2000 to 2004. Then, during the Summer 2004 event, patient consultations and RPEP and ARIG prescriptions increased by 84%, 19.7% and 43.4%, respectively. Moreover, elevated medical resource use persisted in 2005, despite communication efforts, without any secondary human or animal case. Conclusions Our findings demonstrated appropriate responsiveness to reemerging rabies cases and effective newspaper reporting, as no secondary case occurred. However, the ensuing demand on medical resources had immediate and long-lasting effects on rabies-related public health resources and expenses. Henceforth, when facing such an event, decision-makers must anticipate the broad impact of their media communications to counter the emerging risk on maintaining an optimal public health organization and implement a post-crisis communication strategy.
Switch-When-Safe Multiperiod Mean-Variance Strategies
Rene Ferland,Francois Watier
International Journal of Statistics and Probability , 2013, DOI: 10.5539/ijsp.v2n2p59
Abstract: In this work, we study the goal-achieving probabilities of a multiperiod mean-variance financial strategy under a emph{switch-when-safe} stopping time rule. This stopping time is defined as the first moment, if it occurs, where the investor's cumulative wealth, at this point, can be safely reinvested in a simple bank account in order to meet his financial objective at the end of the investment horizon.
Estimation of first passage time densities of diffusions processess through time-varying boundaries
Imene Allab,Francois Watier
Mathematics , 2013,
Abstract: In this paper, we develop a Monte Carlo based algorithm for estimating the FPT density of a time-homogeneous SDE through a time-dependent frontier. We consider Brownian bridges as well as localized Daniels curve approximations to obtain tractable estimations of the FPT probability between successive points of a simulated path of the process. Under mild assumptions, a (unique) Daniels curve local approximation can easily be obtained by explicitly solving a non-linear system of equations.
Molecular gastronomy is a scientific discipline, and note by note cuisine is the next culinary trend
Hervé This
Flavour , 2013, DOI: 10.1186/2044-7248-2-1
Abstract: In 1988, a new scientific discipline, molecular gastronomy, was defined as ‘looking for the mechanisms of phenomena occurring during dish preparation and consumption’ [1,2]. This new definition presented the opportunity to discuss the precise content of molecular gastronomy and its relationship with other existing fields of science.There has always been much confusion between science and technology when it comes to food, including over exactly what food is. Dictionaries give the definition: ‘any substance that can give to living beings the elements necessary for their growth or for their preservation’ [3]. However, one has to recognize that human beings very seldom eat non-transformed tissues or natural products; raw materials are transformed so that chemical and physical changes determine the final composition of all food as well as its ‘bioactivity’, a term which we propose to describe the sensory effects, nutritional value, eventual toxic effects, and so on, of the various compounds released by food systems [4].During food preparation, plant or animal tissues are at least washed and cut, and most food are thermally processed. For example, even for a simple carrot salad, which requires no thermal processing, there is a big difference between the raw product in the field and what is consumed - that is, grated carrots on a plate: this is because cutting the tissue triggers enzymatic reactions [5] and because compounds get transferred between the dressing and the plant tissue [6]. This analysis leads to the conclusion that reagents and products of ‘culinary transformations’ (transformations performed in the kitchen) should not both be called food. The specific transformation occurring from the raw materials to the final prepared dish is worth studying, both for scientific and technological reasons.Making the difference between science and technology clear is particularly important for molecular gastronomy because of the confusion between science and cooking (see, for
LVDC: An Efficient Energy Solution for On-Grid Photovoltaic Applications  [PDF]
Anis Ammous, Hervé Morel
Smart Grid and Renewable Energy (SGRE) , 2014, DOI: 10.4236/sgre.2014.54007

In this paper some photovoltaic, PV, conversion chains architectures for on-grid applications have been proposed and the advantage of the direct use of a Low Voltage Direct Current (LVDC) bus for the DC loads has been shown. The evaluation of the efficiency of the proposed chains compared to the classical one was performed. It is shown that LVDC use instead of standard AC plugs, in numerous applications, is promising in future. The registered annual saved energy can exceed 25% of the PV generated energy. This important rate, the need of better services at lower economic cost and environmental burden will incite to make reflection about industry and supplies’ future standards.

Why African Companies Are Absent on the Bond Market? An Explanation through Companies Listed on the BRVM  [PDF]
Ndoume Essingone Hervé
Modern Economy (ME) , 2019, DOI: 10.4236/me.2019.101015

This research provides some answers to the question of the limited presence of African companies in the bond markets. Indeed, from a sample of companies listed on the BRVM and panel models tested by the Generalized Moment Method (GMM) developed by Blundell and Bond [1], we study the behavior of the variables usually retained in the work on the determinants of bond issues. We show that the reputation, renegotiability and maturity of the debt, as well as the level of wealth created, determine the debt behavior of companies. Also, any financing strategy by bond issues should take into account these determinants.

Jimmy Gautier,Laurent Baly,Pier-Giorgio Zanone,Bruno Watier
Journal of Sports Science and Medicine , 2004,
Abstract: Finswimming is a sport of speed practiced on the surface or underwater, in which performance is based on whole-body oscillations. The present study investigated the undulatory motion performed by finswimmers at the surface. This study aiming to analyze the influence of the interaction of gender, practice level, and race distance on selected kinematic parameters. Six elite and six novices finswimmers equipped with joints markers (wrist, elbow, shoulder, hip, knee, and ankle) were recorded in the sagittal plane. The position of these anatomical marks was digitized at 50 Hz. An automated motion analysis software yielded velocity, vertical amplitude, frequency, and angular position. Results showed that stroke frequency decreased whereas the mean amplitude of all joints increased with increasing race distance (p < 0.01). Mean joint amplitude for the upper limbs (wrist, elbow and shoulder) was smaller for experts than for novices. Whereas that of the ankle was larger, so that the oscillation amplitude increased from shoulder to ankle. Elite male finswimmers were pitching more acutely than female. Moreover, elite male finswimmers showed a smaller knee bending than novices and than elite females (p < 0.01). This indicated that elite male finswimmers attempt to reduce drag forces thanks to a weak knee bending and a low upper limbs pitch. To sum up, gender, expertise, and race distance affect the performance and its kinematics in terms frontal drag. Expertise in finswimming requires taking advantage of the mechanical constraints pertaining to hydrodynamic constraints in order to optimize performance
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