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Search Results: 1 - 10 of 1493 matches for " Hendrik Marks "
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Disabling hip osteoarthritis: gender, body mass, health and functional status correlates  [PDF]
Ray Marks
Health (Health) , 2010, DOI: 10.4236/health.2010.27106
Abstract: Objective: To examine gender differences in self-reported pain and function before and after hip replacement surgery and the extent to which overweight, comorbidities and muscular status impact pain and function in adults with disabling end-stage hip joint osteoarthritis. Setting: Orthopedic Hospital Setting on the East Coast of the United States. Study Design: Cross-sectional retrospective chart review. Methods: The desired demographic, physical and psychological attributes of 1040 adults with end-stage hip osteoarthritis hospitalized for hip surgery were recorded and subjected to comparison and correlational analyses. These data included gender, self-reported weight, height, numbers and nature of physical and psychological comorbidities, pain intensity, ambulatory capacity and discharge destination. Sub-group analyses of 808 candidates hospitalized for primary unilateral surgery were also conducted using SPSS 16. Results: There were significant (p < 0.05) associations between gender, pain scores, comorbidity numbers and ambulatory capacity. Specifically, women who exhibited higher comorbid disease rates than men, exhibited higher pre-surgery pain levels and greater functional limitations in walking ability before and after surgery than men with the same condition. In sub-group analyses of men and women with the same mean age, comorbid prevalence rates, and body mass indices, women were found to have significantly higher ideal weights on average than men, and those with higher ideal weights recovered more slowly after surgery (p < 0.05). Conclusion: The presentation of hip joint osteoarthritis is not uniform, and may be impacted differentially by gender. Women with high ideal body weights, may be specifically impacted. Whether genetic or other factors account for gender differences in pain and function among adults with disabling hip osteoarthritis observation needs to be examined.
Information Systems Development Methodolgies in Developing Higher Education  [PDF]
Adam Marks
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.31019
Abstract: Studies concerned with the status of Information Systems Development Methodologies usage in many developing countries including the factors that influence and motivate their use, current trends, difficulties, and barriers to adoption are lacking, especially within the higher education sector. This paper examines these identified gaps in a developing country, namely the United Arab Emirates. The initial findings reveal that there is limited knowledge and understanding of the concept of ISDM in federal higher education institutions in the UAE. This is reflected in the quality of the software products being developed and released. However, the analysed data also reveals a trend whereby federal higher education institutions in the UAE are gradually moving towards increased ISDM adoption and deployment.
Osteoarthritis and Articular Cartilage: Biomechanics and Novel Treatment Paradigms  [PDF]
Ray Marks
Advances in Aging Research (AAR) , 2014, DOI: 10.4236/aar.2014.34039

Background: Osteoarthritis is a widespread highly painful disabling age-related disease with no known cure. Although novel strategies for ameliorating osteoarthritic damage abound, it is likely that none will be successful over time if the entire spectrum of the disease and the effects of joint biomechanics on joint tissues are not carefully considered. Objectives: 1) To detail the structure of healthy articular cartilage, the key tissue affected by osteoarthritis. 2) To detail what aspects of cartilage damage best characterize osteoarthritis. 3) To consider the role of biomechanical factors in developing solutions to treat osteoarthritic joint damage. Methods: Literature sources from 1980 onwards that have contributed to our knowledge of the topics relevant to this paper were accessed and retrieved. The data were categorized into four predominant themes and conclusions about the state of our knowledge and future directives were formulated. Conclusions: Osteoarthritis prevalence remains high, and a cure appears elusive. A rich body of data has helped us to better understand the key tissue involved, and suggests a repair process might be feasible, if the basic collective information on the role of biomechanics in mediating or moderating articular cartilage integrity and function is forthcoming.

Non-Operative Management of Hip Osteoarthritis  [PDF]
Ray Marks
Pain Studies and Treatment (PST) , 2015, DOI: 10.4236/pst.2015.32002
Abstract: This paper reviews several non-operative and non-pharmacologic management strategies advocated for alleviating the pain and disability experienced by people with hip osteoarthritis. It analyzes whether painful debilitating hip osteoarthritis, which has no effective cure and is often progressive, may be affected positively by non-operative interventions designed to control osteoarthritis pain. Finally, it provides an integrated plan of management for ameliorating hip osteoarthritis pain and disability in light of this knowledge.
The Marginal Propensity to Import in China and the Composition of Australia’s Exports: Some Interesting Revelations  [PDF]
Andrew Marks
Modern Economy (ME) , 2017, DOI: 10.4236/me.2017.87063
Abstract: The marginal propensity to import manufacturing products is rising more rapidly than the marginal propensity to import primary products in China, yet Australia’s exports to this country are concentrated in primary products thereby leading to large export revenue and hence output and employment losses. The over-reliance on primary product exports to China has also led to fluctuations export revenue and hence output and employment growth. These problems have been compounded due to these products dominating the export base. Adopting industry policy to stimulate manufacturing exports and thus broaden the export base has the potential to alleviate the losses and fluctuations in export revenue and hence output and employment growth when Australia trades with China and the rest of the world.
In silico identification of putative promoter motifs of White Spot Syndrome Virus
Hendrik Marks, Xin-Ying Ren, Hans Sandbrink, Mari?lle CW van Hulten, Just M Vlak
BMC Bioinformatics , 2006, DOI: 10.1186/1471-2105-7-309
Abstract: The collective information shows that the upstream region of early WSSV genes, containing a TATA box and an initiator, is similar to Drosophila RNA polymerase II core promoter sequences, suggesting utilization of the cellular transcription machinery for generating early transcripts. The alignment of the 5' ends of known well-established late genes, including all major structural protein genes, identified a degenerate motif (ATNAC) which could be involved in WSSV late transcription. For these genes, only one contained a functional TATA box. However, almost half of the WSSV late genes, as previously assigned by microarray analysis, did contain a TATA box in their upstream region.The data may suggest the presence of two separate classes of late WSSV genes, one exploiting the cellular RNA polymerase II system for mRNA synthesis and the other generating messengers by a new virus-induced transcription mechanism.White Spot Syndrome Virus (WSSV), type species of the virus family Nimaviridae (genus whispovirus), is a pathogen of major economic importance in cultured penaeid shrimp [1,2]. Histopathological studies on WSSV infected shrimp have shown that the virus mainly infects tissues of ectodermal and mesodermal origin, such as the stomach, gills, heart, gut, muscle tissue and hematopoietic tissue [3-5]. Infected cells within these tissues are characterized by the appearance of homogeneous hypertrophied nuclei and chromatin margination [1,5,6]. WSSV particles have been mainly detected in the nuclei of infected cells, indicating that transcription, replication and virion assembly probably occur in the nucleus [5-8]. It is not clear how the virions are released from the nucleus of an infected cell, but this most likely occurs by budding or by rupture of the nuclear envelope and/or the cell membrane.The circular ds DNA genome of three WSSV isolates, originating from Taiwan (WSSV-TW), China (WSSV-CN) and Thailand (WSSV-TH), have been completely sequenced [9-11]. The genome of W
An RNA-Seq Strategy to Detect the Complete Coding and Non-Coding Transcriptome Including Full-Length Imprinted Macro ncRNAs
Ru Huang, Markus Jaritz, Philipp Guenzl, Irena Vlatkovic, Andreas Sommer, Ido M. Tamir, Hendrik Marks, Thorsten Klampfl, Robert Kralovics, Hendrik G. Stunnenberg, Denise P. Barlow, Florian M. Pauler
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027288
Abstract: Imprinted macro non-protein-coding (nc) RNAs are cis-repressor transcripts that silence multiple genes in at least three imprinted gene clusters in the mouse genome. Similar macro or long ncRNAs are abundant in the mammalian genome. Here we present the full coding and non-coding transcriptome of two mouse tissues: differentiated ES cells and fetal head using an optimized RNA-Seq strategy. The data produced is highly reproducible in different sequencing locations and is able to detect the full length of imprinted macro ncRNAs such as Airn and Kcnq1ot1, whose length ranges between 80–118 kb. Transcripts show a more uniform read coverage when RNA is fragmented with RNA hydrolysis compared with cDNA fragmentation by shearing. Irrespective of the fragmentation method, all coding and non-coding transcripts longer than 8 kb show a gradual loss of sequencing tags towards the 3′ end. Comparisons to published RNA-Seq datasets show that the strategy presented here is more efficient in detecting known functional imprinted macro ncRNAs and also indicate that standardization of RNA preparation protocols would increase the comparability of the transcriptome between different RNA-Seq datasets.
Tolerance of Ambiguity: A Review of the Recent Literature  [PDF]
Adrian Furnham, Joseph Marks
Psychology (PSYCH) , 2013, DOI: 10.4236/psych.2013.49102

This review paper attempts to update the literature on tolerance of ambiguity (TA) and related concepts since a previous review (Furnham & Ribchester, 1995). Various related concepts like Uncertainly Avoidance and In/Tolerance of Uncertainly are reviewed. Both correlational and experimental studies of TA are reviewed and tabulated. Further, an attempt was made to identify and critique various different questionnaires design to measure TA. Recommendations for the use of these tests in research are made. The reasons for progress and lack of progress in this field are highlighted.

Airport Information Systems—Airside Management Information Systems  [PDF]
Adam Marks, Kees Rietsema
Intelligent Information Management (IIM) , 2014, DOI: 10.4236/iim.2014.63016

Research on the intersection of the areas of aviation and management of information systems is scarce. Airports, more than ever before need to align their information systems to gain a competitive advantage and become more efficient in their operations. A proper classification is a prerequisite to systems alignment. The purpose of this paper is to provide descriptions of some of the airport management information systems, connections to or interoperability with other systems, and the key uses and users of each system. There are many types of management information systems and they can be organized or classified in a number of different ways. Furthermore, each system may or may not be necessary for a particular airport depending on the business goals and objectives and the certificate which the airport is operating under. Consequently, the system classification schema presented in this paper is neither all-inclusive nor exclusive; however, a number of leading aviation practitioners, business professionals, and educators in the industry were instrumental in both proposing and validating the schema. The study used interviews, documentation, and observation as the primary sources of data.

Epigenetic Regulation of Learning and Memory by Drosophila EHMT/G9a
Jamie M. Kramer,Korinna Kochinke,Merel A. W. Oortveld,Hendrik Marks,Daniela Kramer,Eiko K. de Jong,Zoltan Asztalos,J. Timothy Westwood,Hendrik G. Stunnenberg,Marla B. Sokolowski,Krystyna Keleman,Huiqing Zhou,Hans van Bokhoven,Annette Schenck
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1000569
Abstract: The epigenetic modification of chromatin structure and its effect on complex neuronal processes like learning and memory is an emerging field in neuroscience. However, little is known about the “writers” of the neuronal epigenome and how they lay down the basis for proper cognition. Here, we have dissected the neuronal function of the Drosophila euchromatin histone methyltransferase (EHMT), a member of a conserved protein family that methylates histone 3 at lysine 9 (H3K9). EHMT is widely expressed in the nervous system and other tissues, yet EHMT mutant flies are viable. Neurodevelopmental and behavioral analyses identified EHMT as a regulator of peripheral dendrite development, larval locomotor behavior, non-associative learning, and courtship memory. The requirement for EHMT in memory was mapped to 7B-Gal4 positive cells, which are, in adult brains, predominantly mushroom body neurons. Moreover, memory was restored by EHMT re-expression during adulthood, indicating that cognitive defects are reversible in EHMT mutants. To uncover the underlying molecular mechanisms, we generated genome-wide H3K9 dimethylation profiles by ChIP-seq. Loss of H3K9 dimethylation in EHMT mutants occurs at 5% of the euchromatic genome and is enriched at the 5′ and 3′ ends of distinct classes of genes that control neuronal and behavioral processes that are corrupted in EHMT mutants. Our study identifies Drosophila EHMT as a key regulator of cognition that orchestrates an epigenetic program featuring classic learning and memory genes. Our findings are relevant to the pathophysiological mechanisms underlying Kleefstra Syndrome, a severe form of intellectual disability caused by mutations in human EHMT1, and have potential therapeutic implications. Our work thus provides novel insights into the epigenetic control of cognition in health and disease.
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