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Search Results: 1 - 4 of 4 matches for " Hemraz Palawan "
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Extensively drug resistant tuberculosis (XDR-TB):A potential threat
Anaga Marwar,Nanadal,Ivvala Anand Shaker,Hemraz Palawan
Journal of Basic and Clinical Pharmacy , 2011,
Abstract: Emergence of extensively drug resistant tuberculosis (XDR-TB) has been reported by more than 55 countries. XDR-TB is considered as untreatable and highly fatal disease. In developing countries like India, number of cases of multi-drug resistant tuberculosis (MDR-TB) and XDR-TB are increasing. Emergence of resistance to Isoniazid and Rifampicin, the two most effective and well tolerated agents, coupledwith resistance to second line agents pose limited treatment options for XDR-TB. The present minireview provides information about the seriousness of XDR-TB and the drugs available for its treatment. Although considered a fatal disorder, judicious use of combination of drugs, retaining their antimycobacterial activity, can improve theclinical outcome of XDR-TB. Only such an approach can provide some hope for the patients of XDR-TB.
Research: A STUDY OF LDH ISOENZYME SUBUNIT IN THE DIFFERENTIAL DIAGNOSIS OF CEREBROVASCULAR DISEASE & BRAIN TUMOR
Mriganka Baruah*,I Anand Shaker,Hemraz palwan,Saleem Basha
Pharmacie Globale : International Journal of Comprehensive Pharmacy , 2012,
Abstract: Lactate dehdrogenase (LDH) is a zinc containing enzyme which is present in abundance in brain.This study evaluated the concentration of LDH as well as its isoenzyme subunit ratio (H: M) in the cerebrospinal fluid (CSF) among patients with various neurological and Non neurological cases. Total LDH activity was significantly increased in all the study groups (cerebrovascular accident group, Neurological cases group and brain tumor cases) as compared to Control group (non-neurological cases). Moreover the current study also suggest that the isoenzyme subunit ratio H/M was significantly decreased (p<0.001) in all the study groups as compared to non-neurological Control group. Therefore finding the LDH along with its subunit ratio may be helpful to know the disease progression better and may help in efficient treatment and assessment of neurological disease status.
EVALUATION OF GLYCATED ALBUMIN AND DYSLIPIDEMIA IN TYPE-2 DIABETES MELLITUS
Suresh Babu Kondaveeti, Ivvala Anand Shaker, Aravind Kumar R, Hemraz Palwan, Raja G
International Journal of Bioassays , 2012,
Abstract: Diabetic patients with accompanied (but often unnoticed) dyslipidemia are soft targets of cardiovascular deaths. An early intervention to normalize circulating lipids shown to reduce cardiovascular complications and mortality. Now a day’s Glycated albumin (GA) is a routinely used marker for short-term glycemic control. This investigation is an attempt to evaluate the association between GA and various lipid parameters. Venous blood samples collected from 100 type-2 diabetic patients (46 males, 44 females) and serum analyzed for GA, Fasting blood glucose, Total Cholesterol, Triacylglycerols, HDL-C and LDL-C. L/H risk ratio is also calculated. The levels of GA (%) did not differ significantly between males (8.51 ± 1.17) and females (8.24 ± 1.89), whereas male patients had higher mean values of FBG and various lipid parameters than in females. Patients with GA value >17.0 % showed direct and significant correlation with FBG, TC, LDL-C, L/H risk ratio as compared to patients with GA ≤ 17.0%. There was no significant difference in TG, HDL-C between two groups of glycated albumin. These findings indicate that GA is utilized for screening high risk diabetic patients for early diagnosis of dyslipidemia and timely intervention with lipid lowering drugs.
STUDY OF LIPID PEROXIDATION AND SERUM ASCORBIC ACID LEVELS AS INDICES OF OXIDATIVE STRESS IN VARIOUS LUNG DISORDERS
Ivvala Anand Shaker1*, Suresh Babu Kondaveeti1, Hemraz Palwan2, Dabburu Kumaraswamy3, Raja G1, S Saleem Basha1
International Journal of Bioassays , 2012,
Abstract: The present study was planned to assess the levels of oxidant and antioxidant in various lung disorders and to evaluate the existence of correlation between oxidant-antioxidant levels. Asthma, Bronchitis, COPD and Lung fibrosis well know chronic inflammatory disorders where disturbances in the oxidative system have been observed. To investigate the lipidperoxidation in terms of plasma MDA and antioxidant capacity in terms of ascorbic acid (Vitamin C) were measured. Results revealed statistically significantly Increase serum MDA (P<0.001) and decrease vitamin C (P<0.001) in patients suggestive of oxidative imbalance in various lung disorders was revealed. However there is negative correlation between lipidperoxidation and ascorbic acid levels correlation. The study thus supported the emerging concept of free radical injury in various lung disorders and therefore a thought can be given to whether antioxidant supply could have a beneficial impact on the free radical induced injury and improvement of respiratory reserve in various lung disorders.
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