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Search Results: 1 - 10 of 10 matches for " Helli Merica "
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The Neuronal Transition Probability (NTP) Model for the Dynamic Progression of Non-REM Sleep EEG: The Role of the Suprachiasmatic Nucleus
Helli Merica, Ronald D. Fortune
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023593
Abstract: Little attention has gone into linking to its neuronal substrates the dynamic structure of non-rapid-eye-movement (NREM) sleep, defined as the pattern of time-course power in all frequency bands across an entire episode. Using the spectral power time-courses in the sleep electroencephalogram (EEG), we showed in the typical first episode, several moves towards-and-away from deep sleep, each having an identical pattern linking the major frequency bands beta, sigma and delta. The neuronal transition probability model (NTP) – in fitting the data well – successfully explained the pattern as resulting from stochastic transitions of the firing-rates of the thalamically-projecting brainstem-activating neurons, alternating between two steady dynamic-states (towards-and-away from deep sleep) each initiated by a so-far unidentified flip-flop. The aims here are to identify this flip-flop and to demonstrate that the model fits well all NREM episodes, not just the first. Using published data on suprachiasmatic nucleus (SCN) activity we show that the SCN has the information required to provide a threshold-triggered flip-flop for timing the towards-and-away alternations, information provided by sleep-relevant feedback to the SCN. NTP then determines the pattern of spectral power within each dynamic-state. NTP was fitted to individual NREM episodes 1–4, using data from 30 healthy subjects aged 20–30 years, and the quality of fit for each NREM measured. We show that the model fits well all NREM episodes and the best-fit probability-set is found to be effectively the same in fitting all subject data. The significant model-data agreement, the constant probability parameter and the proposed role of the SCN add considerable strength to the model. With it we link for the first time findings at cellular level and detailed time-course data at EEG level, to give a coherent picture of NREM dynamics over the entire night and over hierarchic brain levels all the way from the SCN to the EEG.
PROBLEMS OF BIOFOULING ON FISH–CAGE NETS IN AQUACULTURE
Merica Sli?kovi?,Gorana Jeli?
Ribarstvo : Croatian Journal of Fisheries , 2002,
Abstract: Biofouling on fish–cage netting is a serious technical and economical problem to aquaculture worldwide. Compensation for the effects of biofouling must be included in cage system design and planning, as fouling can dramatically increase both weight and drag. Settlements of sessile plants and animals, with accumulation of the detritus diminish the size of mesh and can rapidly occlude mesh. Negative effect of smaller mesh size is changing in water flow trough the cages. Biofouling problems necessitating purchase of a second sets of nets or more, and frequent cleaning and changing of biofouling. Changing and cleaning frequency depend on many factors such as: location of cages (near the coast or off shore), productivity of that location, time of the year, time period in which the cages are placed on that location (cause of loading of phosphorus and nitrogen from the unconsumed food in the sediment). Net changing and cleaning procedures are labor and capital intensive. Process of the cleaning of the nets is inadequate, especially when there isn t adequate equipment available as it is case in smaller aquaculture industry. Chemical control of biofouling e. g. use of antifoulants is questioningly cause of their possible negative effects on breeding species and environment.
Macroalgae fouling community as quality element for the evaluation of the ecological status in Vela Luka Bay, Croatia
Gorana Jelic Mrcelic,Merica Sliskovic,Boris Antolic
Acta Societatis Botanicorum Poloniae , 2012, DOI: 10.5586/asbp.2012.028
Abstract: One year qualitative and quantitative study of communities of three major taxonomic groups has been carried out at test panles placed in the upper infarlittoral zone of coastal area of Vela Luka Bay, Croatia. A list of 44 taxa was recorded. Chaetomorpha sp., Ulva sp., Fosliella farinosa, Sphacelaria cirrosa, Polysiphonia scopulorum were the most frequent dominant taxa. Among 27 algal taxa with noticeable presence only three were classified as ESG (Ecological State Groups) I. Low diversity and species richness together with massive presence of the green algae (as Ulva sp.) and negligible presence of ESG I taxa, may lead to erroneous conclusion that Vela Luka Bay is eutrophicated area. Low values of biomass and R/P (Rhodophyceae by Phaeophyceae ratio) Index together with dominance of Phaeophyta also support conclusion that there is no negative impact of nutrient enrichment on macrophyta fouling community in Vela Luka Bay.
RECRUITMENT AND RECRUITMENT MODELS IN FISHERY SCIENCE
Merica Sli?kovi?,Gordana Jeli? Mr?eli?
Ribarstvo : Croatian Journal of Fisheries , 2006,
Abstract: Recruitment and growth of individuals bring the most to enlargement of fish stock biomass. Recruitment can be independent on stock size during the development of the fishery, but experience has showed that many fisheries have come to the point when recruitment decreases due to over fishing. Large parental stock does not give large number of juveniles because large number of individuals influences survival of juveniles (competition for food). In period between 1984 and 1987 this phenomenon was recorded in sardine population in the Adriatic Sea, when large biomass of parental stock resulted in twice less recruitment. In the period between 1993 and 2000 there was no significant recruitment of the sardine population in the Adriatic Sea and it reflected on biomass of the sardine. Large recruitment was recorded in 2001 and 2002. There are numerous mathematical models which give relation between stock and recruitment. Beverton–Holt’s and Ricker’s models are usually used. Beverton–Holt’s model assumes that recruitment depends on the density of population. Ricker’s model is based on assumption that all resources are evenly distributed among the individuals; therefore the rise in density causes the exhaustion of resources. This model is suitable for species as the sardine, which migrates in the breeding area.
FOULING AS INDICATOR OF AQUACULTURE INFLUENCE ON ENVIRONMENT
Merica Sli?kovi?,Gorana Jeli?,Zvonko Hell
Ribarstvo : Croatian Journal of Fisheries , 2003,
Abstract: By ecological awarening of the whole community and by the broadening of the aquacultural activity on the Adriatic, the influence of the aquaculture on the environment is more questionable. The opholding of the ecological protection of the natural environment is pointed out as one of the basic goals in the by–coastal aquaculture. The processes of the net fouling, which are used for the construction of the cages, is present to a certain degree at all locations of the fish breeding. By periodical investigation of the fouling organisms it is possible, with the earlier set monitoring (chemisms of the sediments, chemisms of the water, benthic biotes and phytoplankton) to follow the influence of the existing aquacultural activity on the environment. Qualitative and quantitative constitution of the fouling organisms can indicate certain changes in the environment. There are also species that can indicate changes by their presence, i. e. they can be used as indicators of the ecological changes.
SYSTEM DYNAMIC MODEL OF WASTE GENERATED FROM MARICULTURE FARMING
Ivan ?ula,Merica Sli?kovi?,Gorana Jeli? Mr?eli?
Ribarstvo : Croatian Journal of Fisheries , 2012,
Abstract: The aim of this paper is to present a model of mariculture waste in the marine environment. The model can help determine the sustainability of mariculture in the area. It is divided into four sub-systems (organic matter, dissolved oxygen, dissolved nitrogen and algae-phytoplankton subsystem) and is defined by six basic variables connected by cause-effect relationships. Each of these variables is defined by one or several functions of state. The basic input into the system is the amount of waste generated by mariculture entering the observed water environment.
THE INFLUENCE OF FISHING ON DEMERSAL FISH POPULATIONS – TWO CASE STUDIES
Gorana Jeli? Mr?eli?,Merica Sli?kovi?,Tereza Alaburi?
Ribarstvo : Croatian Journal of Fisheries , 2012,
Abstract: This paper shows the trends in fish populations from demersal systems in two areas. The contrast between the Georges Bank/Gulf of Maine area and the North Sea illustrates how similar systems can respond differently.
Anxiolytic-like and sedative effects of Kyllinga brevifolia in mice
María del Carmen Hellión-Ibarrola,Yenny Montalbetti,Olga Y. Heinichen,María L. Kennedy
Revista Brasileira de Farmacognosia , 2012,
Abstract: Kyllinga brevifolia Rottb., Cyperaceae, rhizomes have been widely used in the Paraguayan folk medicine as digestive, diuretic, sedative, tonic, antispasmodic and sudorific. The purpose of this study is to characterize the putative sedative, anxiolytic effects of the crude hydro-ethanolic extract (CEKb) and fractions of the rhizome of K. brevifolia, in male mice. The behaviour of mice was assessed in the open field, hole board, rota-rod and elevated plus-maze (EPM) test. Oral treatment with single doses of 10, 100 and 1000 mg/kg of CEKb and 10 mg/kg of ethyl acetate fraction (KbF-ethyl-ac) increased the duration of the sleeping time induced by pentobarbital. Oral administration of 1, 10 and 100 mg/kg of CEKb and 0.1, 1 and 10 mg/kg of KbF-ethyl-ac also significantly increased the time-spent and arm entries into open arms of the elevated plus maze (EPM) versus control group. These findings indicate that K. brevifolia exerts a weak sedative and an interesting anxiolytic-like effect in mice and suggest its potential usefulness for the treatment of anxiety in humans.
IMP3 can predict aggressive behaviour of lung adenocarcinoma
Renata Beljan Perak, Merica Durdov, Vesna Capkun, Veljka Ivcevic, Antonia Pavlovic, Violeta Soljic, Mari Peric
Diagnostic Pathology , 2012, DOI: 10.1186/1746-1596-7-165
Abstract: In retrospective study, consecutive series of 105 patients with advanced lung adenocarcinoma diagnosed from 2006 to 2009 in Clinical Hospital Center Split, Croatia, were analysed. Clinical data were collected from the Pulmology Department and time of death from the Mortality Registry. Paraffin blocks of bronchoscopic biopsies were collected from the Institute of Pathology and 15 cases excluded from the analysis due to insufficient material. Expression of IMP3, Napsin A and TTF-1 were analysed by indirect enzyme immunohistochemistry. Statistical analysis was performed and P values less than 0.05 considered significant.Of 90 patients, 71 (78%) were males and 19 (22%) females. Median age for males was 61.5 years (min-max 43–83) and for females 61 years (min-max 44–86). Pleural effusion was found in 15 (16.6%) and distant metastases in 45 (50%) cases. According to histological subtypes, there were 34 acinar, 2 lepidic, 2 papillary and 52 solid subtypes. IMP3 overexpression was found in 63 cases (70%) and was correlated with solid subtype (P?=?0.002) and negative/weak Napsin A expression (P?=?0.004). Strong Napsin A expression correlated with TTF-1 expression (P?=?0.003) and lower histological grades (P?=?0.031). Patients with IMP3 overexpression more often had distant metastases than patients with negative IMP3, 55.5% versus 33.3% (P?=?0.033). Non solid subtypes with IMP3 overexpression developed distant metastasis more common than non solid subtypes with negative IMP3, 72% versus 35% (P?=?0.028).Expression of IMP3 correlates with solid subtype and with distant metastases regardless of histological subtype of lung adenocarcinoma.http://www.diagnosticpathology.diagnomx.eu/vs/1966211581795258 webciteDas Lungenkarzinom kommt meistens als nicht resektabler Tumor vor und die Diagnose kann nur in kleinen Biopsaten oder zytologisch gestellt werden. In der Gruppe der nicht kleinzelligen Lungenkarzinome kann der nicht anders spezifizierte Adenokarzinom Ph?notyp mit Hilfe der Ant
THE PROCEDURE AND THE CRITERIA FOR FISH CAGES ALLOCATION
Valentina Andri?,Gordana Jeli? Mr?eli?,Merica Sli?kovi?,Ivana Mileti?
Ribarstvo : Croatian Journal of Fisheries , 2010,
Abstract: In the Republic of Croatia, fish cage farming is one of the most important economic activities. Fish cage farms inevitably influence the quality of marine environment. Environment protection measures are established in order to minimize negative effects on the stability of ecosystem. The aim of this paper is to give an overview on the procedure of fish cage farm allocation, environment protection measures, as also as program of monitoring before, during and after fish farming allocation.
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