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Search Results: 1 - 10 of 10383 matches for " Hee Kyoung Kang "
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A Study on Development of Balanced Scorecard for Management Evaluation Using Multiple Attribute Decision Making  [PDF]
Kwang Mo Yang, Young Wook Cho, Seung Hee Choi, Jae Hyun Park, Kyoung Sik Kang
Journal of Software Engineering and Applications (JSEA) , 2010, DOI: 10.4236/jsea.2010.33032
Abstract: Recently, most businesses have introduced a system for improving their responsibility to the customers in terms of job improvement. For example, small-quantity batch production increases cost but improve efficiency of management. Companies have been introduced the balanced scorecard to evaluate their management as part of improvement, while they suffer from many trials and errors. Many businesses still have difficulty in introducing balance scorecard concept in their process, but we suggest a method to successfully introduce the balance scorecard. This study aims to suggest a new performance measurement model reflecting relative importance of the key performance indicators for each factor. Our model is applied to several companies in real-world to validate the new model. Also, our study proposes a methodology for an adequate performance measurement using multiple attribute decision making.
Marine Peptides and Their Anti-Infective Activities
Hee Kyoung Kang,Chang Ho Seo,Yoonkyung Park
Marine Drugs , 2015, DOI: 10.3390/md13010618
Abstract: Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. However, the treatments available for many infectious diseases caused by bacteria, fungi, and viruses are limited. Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored. In this review, we will present the structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present.
Fermented fish oil suppresses T helper 1/2 cell response in a mouse model of atopic dermatitis via generation of CD4+CD25+Foxp3+ T cells
Han Sang-Chul,Kang Gyeoung-Jin,Ko Yeong-Jong,Kang Hee-Kyoung
BMC Immunology , 2012, DOI: 10.1186/1471-2172-13-44
Abstract: Background Allergic skin inflammation such as atopic dermatitis (AD), which is characterized by pruritus and inflammation, is regulated partly through the activity of regulatory T cells (Tregs). Tregs play key roles in the immune response by preventing or suppressing the differentiation, proliferation and function of various immune cells, including CD4+ T cells. Recent studies report that fermentation has a tremendous capacity to transform chemical structures or create new substances, and the omega-3 polyunsaturated fatty acids (n-3 PUFAs) in fish oil can reduce inflammation in allergic patients. The beneficial effects of natural fish oil (NFO) have been described in many diseases, but the mechanism by which fermented fish oil (FFO) modulates the immune system and the allergic response is poorly understood. In this study, we produced FFO and tested its ability to suppress the allergic inflammatory response and to activate CD4+CD25+Foxp3+ Tregs. Results The ability of FFO and NFO to modulate the immune system was investigated using a mouse model of AD. Administration of FFO or NFO in the drinking water alleviated the allergic inflammation in the skin, and FFO was more effective than NFO. FFO treatment did increase the expression of the immune-suppressive cytokines TGF-β and IL-10. In addition, ingestion of FFO increased Foxp3 expression and the number of CD4+CD25+Foxp3+ Tregs compared with NFO. Conclusions These results suggest that the anti-allergic effect of FFO is associated with enrichment of CD4+CD25+ Foxp3+ T cells at the inflamed sites and that FFO may be effective in treating the allergic symptoms of AD.
Antioxidant Effects of the Ethanol Extract from Flower of Camellia japonica via Scavenging of Reactive Oxygen Species and Induction of Antioxidant Enzymes
Mei Jing Piao,Eun Sook Yoo,Young Sang Koh,Hee Kyoung Kang,Junoh Kim,Yong Jin Kim,Hak Hee Kang,Jin Won Hyun
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12042618
Abstract: The aim of this study was to investigate the antioxidant properties of the ethanol extract of the flower of Camellia japonica ( Camellia extract). Camellia extract exhibited 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species (ROS) scavenging activity in human HaCaT keratinocytes. In addition, Camellia extract scavenged superoxide anion generated by xanthine/xanthine oxidase and hydroxyl radical generated by the Fenton reaction (FeSO 4 + H 2O 2) in a cell-free system, which was detected by electron spin resonance spectrometry. Furthermore, Camellia extract increased the protein expressions and activity of cellular antioxidant enzymes, such as superoxide dismutase, catalase and glutathione peroxidase. These results suggest that Camellia extract exhibits antioxidant properties by scavenging ROS and enhancing antioxidant enzymes. Camellia extract contained quercetin, quercetin-3- O-glucoside, quercitrin and kaempferol, which are antioxidant compounds.
Hydrologic Response Unit Routing in SWAT to Simulate Effects of Vegetated Filter Strip for South-Korean Conditions Based on VFSMOD
Youn Shik Park,Jeong Hee Park,Won Seok Jang,Ji Chul Ryu,Hyunwoo Kang,Joongdae Choi,Kyoung Jae Lim
Water , 2011, DOI: 10.3390/w3030819
Abstract: The Soil and Water Assessment Tool (SWAT) model has been used worldwide for many hydrologic and Non-Point Source (NPS) Pollution analyses on a watershed scale. However, it has many limitations in simulating the Vegetative Filter Strip (VFS) because it considers only ‘filter strip width’ when the model estimates sediment trapping efficiency and does not consider the routing of sediment with overland flow which is expected to maximize the sediment trapping efficiency from upper agricultural subwatersheds to lower spatially-explicit filter strips. Therefore, the SWAT overland flow option between landuse-subwatersheds with sediment routing capability was enhanced by modifying the SWAT watershed configuration and SWAT engine based on the numerical model VFSMOD applied to South-Korean conditions. The enhanced SWAT can simulate the VFS sediment trapping efficiency for South-Korean conditions in a manner similar to the desktop VFSMOD-w system. Due to this enhancement, SWAT is applicable to simulate the effects of overland flow from upper subwatersheds to reflect increased runoff volume at the lower subwatershed, which occurs in the field if no diversion channel is installed. In this study, the enhanced SWAT model was applied to small watersheds located at Jaun-ri in South-Korea to simulate a diversion channel and spatially-explicit VFS. Sediment can be reduced by 31%, 65%, and 68%, with a diversion channel, the VFS, and the VFS with diversion channel, respectively. The enhanced SWAT should be used in estimating site-specific effects on sediment reduction with diversion channels and VFS, instead of the currently available SWAT, which does not simulate sediment routing in overland flow and does not consider other sensitive factors affecting sediment reduction with VFS.
Anti-Tumor Effect of Adipose Tissue Derived-Mesenchymal Stem Cells Expressing Interferon-β and Treatment with Cisplatin in a Xenograft Mouse Model for Canine Melanoma
Jin ok Ahn, Hee woo Lee, Kyoung won Seo, Sung keun Kang, Jeong chan Ra, Hwa young Youn
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074897
Abstract: Adipose tissue-derived mesenchymal stem cells (AT-MSCs) are attractive cell-therapy vehicles for the delivery of anti-tumor molecules into the tumor microenvironment. The innate tropism of AT-MSCs for tumors has important implications for effective cellular delivery of anti-tumor molecules, including cytokines, interferon, and pro-drugs. The present study was designed to determine the possibility that the combination of stem cell-based gene therapy with low-dose cisplatin would improve therapeutic efficacy against canine melanoma. The IFN-β transduced canine AT-MSCs (cAT-MSC-IFN-β) inhibited the growth of LMeC canine melanoma cells in direct and indirect in vitro co-culture systems. In animal experiments using BALB/c nude mouse xenografts, which developed by injecting LMeC cells, the combination treatment of cAT-MSC-IFN-β and low-dose cisplatin significantly reduced tumor volume compared with the other treatment groups. Fluorescent microscopic analysis with a TUNEL (terminal deoxynucleotidyl transferase-mediated nick-end labeling) assay of tumor section provided evidence for homing of cAT-MSC-IFN-β to the tumor site and revealed that the combination treatment of cAT-MSC-IFN-β with low-dose cisplatin induced high levels of cell apoptosis. These findings may prove useful in further explorations of the application of these combined approaches to the treatment of malignant melanoma and other tumors.
Acanthamoeba Protease Activity Promotes Allergic Airway Inflammation via Protease-Activated Receptor 2
Mi Kyung Park, Min Kyoung Cho, Shin Ae Kang, Hye-Kyung Park, Dong-Hee Kim, Hak Sun Yu
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0092726
Abstract: Acanthamoeba is a free-living amoeba commonly present in the environment and often found in human airway cavities. Acanthamoeba possesses strong proteases that can elicit allergic airway inflammation. To our knowledge, the aeroallergenicity of Acanthamoeba has not been reported. We repeatedly inoculated mice with Acanthamoeba trophozoites or excretory-secretory (ES) proteins intra-nasally and evaluated symptoms and airway immune responses. Acanthamoeba trophozoites or ES proteins elicited immune responses in mice that resembled allergic airway inflammation. ES proteins had strong protease activity and activated the expression of several chemokine genes (CCL11, CCL17, CCL22, TSLP, and IL-25) in mouse lung epithelial cells. The serine protease inhibitor phenyl-methane-sulfonyl fluoride (PMSF) inhibited ES protein activity. ES proteins also stimulated dendritic cells and enhanced the differentiation of naive T cells into IL-4-secreting T cells. After repeated inoculation of the protease-activated receptor 2 knockout mouse with ES proteins, airway inflammation and Th2 immune responses were markedly reduced, but not to basal levels. Furthermore, asthma patients had higher Acanthamoeba-specific IgE titers than healthy controls and we found Acanthamoeba specific antigen from house dust in typical living room. Our findings suggest that Acanthamoeba elicits allergic airway symptoms in mice via a protease allergen. In addition, it is possible that Acanthamoeba may be one of the triggers human airway allergic disease.
An Ethanol Extract Derived from Bonnemaisonia hamifera Scavenges Ultraviolet B (UVB) Radiation-Induced Reactive Oxygen Species and Attenuates UVB-Induced Cell Damage in Human Keratinocytes
Mei Jing Piao,Yu Jae Hyun,Suk Ju Cho,Hee Kyoung Kang,Eun Sook Yoo,Young Sang Koh,Nam Ho Lee,Mi Hee Ko,Jin Won Hyun
Marine Drugs , 2012, DOI: 10.3390/md10122826
Abstract: The present study investigated the photoprotective properties of an ethanol extract derived from the red alga Bonnemaisonia hamifera against ultraviolet B (UVB)-induced cell damage in human HaCaT keratinocytes. The Bonnemaisonia hamifera ethanol extract (BHE) scavenged the superoxide anion generated by the xanthine/xanthine oxidase system and the hydroxyl radical generated by the Fenton reaction (FeSO 4 + H 2O 2), both of which were detected by using electron spin resonance spectrometry. In addition, BHE exhibited scavenging activity against the 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species (ROS) that were induced by either hydrogen peroxide or UVB radiation. BHE reduced UVB-induced apoptosis, as shown by decreased apoptotic body formation and DNA fragmentation. BHE also attenuated DNA damage and the elevated levels of 8-isoprostane and protein carbonyls resulting from UVB-mediated oxidative stress. Furthermore, BHE absorbed electromagnetic radiation in the UVB range (280–320 nm). These results suggest that BHE protects human HaCaT keratinocytes against UVB-induced oxidative damage by scavenging ROS and absorbing UVB photons, thereby reducing injury to cellular components.
Effect of Dieckol, a Component of Ecklonia cava, on the Promotion of Hair Growth
Jung-Il Kang,Sang-Cheol Kim,Min-Kyoung Kim,Hye-Jin Boo,You-Jin Jeon,Young-Sang Koh,Eun-Sook Yoo,Sung-Myung Kang,Hee-Kyoung Kang
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13056407
Abstract: This study was conducted to evaluate the effect of Ecklonia cava, a marine alga native to Jeju Island in Korea, on the promotion of hair growth. When vibrissa follicles were cultured in the presence of E. cava enzymatic extract (which contains more than 35% of dieckol) for 21 days, E. cava enzymatic extract increased hair-fiber length. In addition, after topical application of the 0.5% E. cava enzymatic extract onto the back of C57BL/6 mice, anagen progression of the hair-shaft was induced. The treatment with E. cava enzymatic extract resulted in the proliferation of immortalized vibrissa dermal papilla cells (DPC). Especially, dieckol, among the isolated compounds from the E. cava enzymatic extract, showed activity that increased the proliferation of DPC. When NIH3T3 fibroblasts were treated with the E. cava enzymatic extract and the isolated compounds from the E.?cava enzymatic extract, the E. cava enzymatic extract increased the proliferation of NIH3T3 fibroblasts, but the isolated compounds such as eckol, dieckol, phloroglucinol and triphlorethol-A did not affect the proliferation of NIH3T3 fibroblasts. On the other hand, the E. cava enzymatic extract and dieckol significantly inhibited 5α-reductase activity. These results suggest that dieckol from E. cava can stimulate hair growth by the proliferation of DPC and/or the inhibition of 5α-reductase activity.
The Promoting Effect of Ishige sinicola on Hair Growth
Jung-Il Kang,Eun-JI Kim,Min-Kyoung Kim,You-Jin Jeon,Sung-Myung Kang,Young-Sang Koh,Eun-Sook Yoo,Hee-Kyoung Kang
Marine Drugs , 2013, DOI: 10.3390/md11061783
Abstract: This study was conducted to evaluate the promoting effect of Ishige sinicola, an alga native to Jeju Island, Korea, on hair growth. When vibrissa follicles were cultured in the presence of I. sinicola extract for 21 days, I. sinicola extract increased hair-fiber length. After topical application of I. sinicola extract onto the back of C57BL/6 mice, anagen progression of the hair shaft was induced. The I. sinicola extract significantly inhibited the activity of 5α-reductase. Treatment of immortalized vibrissa dermal papilla cells (DPCs) with I. sinicola extract resulted in increase of cell proliferation, which was accompanied by the increase of phospho-GSK3β level, β-catenin, Cyclin E and CDK2, whereas p27 kip1 was down-regulated. In particular, octaphlorethol A, an isolated component from the I. sinicola extract, inhibited the activity of 5α-reductase and increased the proliferation of DPCs. These results suggest that I. sinicola extract and octaphlorethol A, a principal of I. sinicola, have the potential to treat alopecia via the proliferation of DPCs followed by the activation of β-catenin pathway, and the 5α-reductase inhibition.
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