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Sero-epidemiological Study of Herpes simplex virus type 1 infections in outpatient population referred to clinical laboratories in Gorgan, IRAN 2006
Hedayat Mofidi,M,Moradi, A.,Saeedi, M.,Behnampoor,N
Medical Laboratory Journal , 2008, DOI: http://www.goums.ac.ir/mljgoums/index.php?&slct_pg_id=10&sid=1&slc_lang=en
Abstract: Backgrounds and objectives: Herpes simplex virus type 1 (HSV-1) infections are mostly shown as a Herpes disease, but It causesconjunctivitis, genital herpes, encephalitis and newborn herpes.This study was conducted to determine the sero-epidemiologicprevalence of herpes simplex virus type 1 in cases referred toclinical laboratories of Gorgan, Iran.Material and methods: In this cross sectional study, we didrandom blood sampling on 406 cases referred to the Gorgan city'sclinical laboratories. These samples were analyzed for HSV-1Immunoglobulin G and M antibodies using type- specific enzymelinkedImmunoassays (ELISA).Results: Of 406 participants, the HSV-1 seroprevalence is 49%(44.3% and 4.7% for IgG and IgM respectively). There is notsignificant relationship between seropositive HSV-1 and gender,ethnicity, age and marital status.Conclusion: Sero-epidemiological of HSV-1 in Gorgan is the sameof the other places in Iran, but it is higher than European and lowerthan African countries. It seems that the people’s culture is veryimportant. Therefore; it needs to be investigated more.Keywords: HSV-1, Antibody, Gorgan
The Association Between High Blood Pressure and Cognitive Impairment in Elderly: A Brief Report
Mahmudi MJ,Hedayat M,Sharifi F,Edalat B
Tehran University Medical Journal , 2012,
Abstract: Background: Epidemiological studies have reported positive, negative, U-shaped or J-shaped association between high blood pressure and cognitive function as well as dementia whereas other studies have not reported any significant association. The aim of this study was to examine the association between hypertension and cognitive impairment in the elderly residents of Kahrizak Charity Foundation (KCF). Methods: This cross sectional study was done in Kahrizak Charity Foundation in suburban areas of Tehran, Iran during 2008. The data were collected over one week. Among the 850 elderly residents of the Foundation who were ≥ 65 years old, 185 individuals were chosen randomly. The Mini-Mental State Examination (MMSE) was completed for all. Mean of all blood pressure readings were recorded while anthropometric and biochemical measurements were performed. Results: The findings indicated that in participants with cognitive impairment, systolic blood pressure, diastolic and mean blood pressures were higher than people with normal cognitive function but the differences were not significant statistically. The odds ratio of cognitive impairment in patients with and without hypertension was 1.52 and 1.58, respectively (P>0.05). Conclusion: This study did not show any significant association between hypertension and cognitive impairment in the elderly residents of Kahrizak Charity Foundation.
Reduction of Left Ventricular Hypertrophy by Sirolimus in Kidney Transplant Recipients: A Nonrandomized Clinical Trial
Sedghipour M,Tabatabaei SAH,Sadadi F,Kamal Hedayat D
Tehran University Medical Journal , 2012,
Abstract: Background: Persistence of left ventricular hypertrophy (LVH) in renal transplant recipients is associated with unfavorable outcomes. Calcineurin-inhibitor (CNI) nephrotoxicity is a major cause of morbidity and mortality after kidney transplantation. In this study we compared sirolimus (SRL) with calcineurin-inhibitor as primary immunosuppressants for the attenuation of left ventricular hypertrophy in renal transplantation recipients. Methods: In this prospective cohort study done in Shariati Hospital in 2010, we evaluated the effects of sirolimus and CNI on LVH of 55 renal transplant recipients. The cases (19) received sirolimus while the controls (36) received CNI while being matched for age and duration of transplantation. Data regarding blood pressure (BP), hemoglobin, serum creatinine, uric acid and lipid concentrations were assessed and changes in left ventricular (LV) mass were evaluated by echocardiography over a one-year follow-up. Results: Left ventricular mass significantly decreased (P=0.0001) in the SRL group but blood pressure did not differ between the two groups. LV mass and LV mass index both decreased significantly (P≤0.05) but the difference was not associated with changes in BP. The difference in interventricular septal thickness at end diastole (IVSD) and posterior wall diameter (PWD) were significant (P≤0.05) in the SRL group but the difference in end diastolic diameter (EDD) was not significant. Conclusion: Conversion from CNI to SRL-based immunosuppressive therapy in RTRs is safe and SRL may decrease LVH. SRL seems to be safe and improve renal function without cardiac compromise in kidney transplant recipients.
Diagnostic value of frozen section study for thyroid nodules in patients referred to Shariati Hospital 1997-2000
"Shirzad M,Hedayat A,Kamalian N,Larijani B
Tehran University Medical Journal , 2001,
Abstract: Frozen section is a useful method in the diagnosis of different malignancies including those of thyroid origin. However, there are still controversies about its application, sensitivity and specificity for thyroid neoplasm. In this study, diagnostic value of frozen section (FS) was compared with permanent histopathologic and Fine Needle Aspiration (FNA). In this study, which was conducted in process research method, permanent sample, FNA, and frozen section results in 214 patients was compared. All of these 214 patients had been seeking medical evaluation for thyroid nodules between years 1997 and 1999 in Shariati hospital. All pathologic evaluations were performed by pathology staff of this hospital. Permanent pathology was considered as the gold standard; so the specificity, sensitivity and diagnostic precision of FNA and FS were evaluated on the basis of its results. We use Macnemar test for this purpose. The number of patients during this period were 214 (160 women and 54 men). Mean age of our patients was 42.3±5.4 and their age ranged between 12 to 84 years. Pathologic results revealed that 163 of the patients (76 percent) had benign lesions, and 51 of them (24 percent) had malignant lesions. Thyroid malignancies comparised papillary carcinoma (70 percent), follicular carcinoma (13.5 percent), papilofollicular carcinoma (6 percent), medulary carcinoma (6 percent), Hurtle cell carcinoma (4 percent) and anaplastic carcinoma (5 percent). FNA was done in all of the patients before surgery and was able to determine the status of nodules in 150 patients. Sensitivity, specificity and precision of FNA in these 150 patients were 72, 96 and 90 percents respectively. When FNA was unable to determine the status of a nodule (64 remaining patients), FS was applied to do the job. A sensitivity of 36 percent, specificity of 85 percent and precision of 73 percent was found in this group of patients. Macnemar test showed that there is no significant difference between FNA and FS methods. This study showed: when FNA is not conclusive, FS will not bring any further benefit. It seems that only in suspicious cases of papillary, undifferentiated and medulary carcinomas, FS can be useful in certifying the results of FNA and choosing the appropriate surgical plan. We should wait for permanent sample reports in the case of follicular or Hurtle cell carcinoma.
Decrease Rate In PTH Level After Parathyroidectomy In Primary Hyperthyroidism (Shariati Hospital, 2000 - 2001)
Hedayat A,Bastan Hagh M H,Bavandi F
Tehran University Medical Journal , 2003,
Abstract: Intra-operative measurement of intact Parathyroid hormone (iPTH) using a rapid assay technique is useful as an aid in determining adequacy of resection and leads to reduce re-operative cases."nMaterials and Methods: In a prospective case series study, PTH level determined before and after (intra-operative and one day after) Parathyroidectomy in 34 patients with primary hyperthyroidism that refer to Shariati hospital during 18 months between year 2000 and 2001."nResults: The average PTH levels before and after parathyroidectomy were 563 pgr/lit and 121 pgr/lit. All patients had significant decrease in PTH levels after Parathroidectomy (mean = 78%). One day after operation, this level decreased to 42 pgr/lit (mean = 87% decrease compared with before operation)"nConclusion: In this study, like the same other studies from other countries there was significant decrease in PTH levels in rapid intra-operative assay that can demonstrate the reliability of PTH monitoring for intra-operative management and overall operative success rates.
OSLER'S NODE IN A PATIENT WITH BRUCELLA ENDOCARDITIS
HASSAN AREFI,M.D,DARIUSH KAMAL-HEDAYAT
Acta Medica Iranica , 1987,
Abstract:
Comparative Study of Cytomegalovirus, Listeria monocytogen and Toxoplasma gondii infections in successful and non-successful pregnancy in Gorgan
Saeedi, M,Bakhshandeh Nosrat, S,Moradi, A,Hedayat Mofidi, SM
Medical Laboratory Journal , 2009, DOI: http://www.goums.ac.ir/mljgoums/index.php?&slct_pg_id=10&sid=1&slc_lang=en
Abstract: Background and objectives: Infection has a Leading role in pregnancy.Cytomegalovirus (CMV), listeria and Toxoplasma are the most commoncauses of infection in human. Based on the previous researches, about 15-25percent of being infected during pregnancy leads to some complications suchas abortion, fetal death, early labor and etc. This study was designed todetermine the seroprevalence of Cytomegalovirus (CMV), Toxoplasmagondii and Listeria moncytogenes among pregnant women in Gorgan, northof Iran (2005-2006).Material and Methods: we conducted this Simple randomized study on118 unsuccessful pregnant woman and 99 successful ones referred to Dezianihospital in Gorgan. We assayed both IgG and IgM antibodies for CMV andToxo by Elisa and IFA method for Listeria. In addition, we fill out a Checklist and then use SPSS soft ware, chi square to analyze the data.Results: The frequency of IgG for CMV and Toxo is 89.9% and 45.5% insuccessful pregnant women and 77.1% and 44.1% for unsuccessful pregnantwomen (P=0.41, P=0.01). IgM frequency for CMV and Toxo is 14.1% and46.5% in successful women and 30.5 and 21.7% in unsuccessful ones.(P=0.003, P=0.002)Total frequency (IgG, IgM) for Listeria is 7.62% and%3.03 in successful and unsuccessful women, respectively. There is asignificant relation between abortion and IgM titer against Toxoplasma insuccessful and unsuccessful groups. (P=0.003).This relation is true for totalantibody titer against Listeria (P=0.003).Conclusion: Because of high titer of antibodies against CMV, Toxo andListeria in unsuccessful pregnant women, suffering from these agents duringpregnancy may result in abortion and fetal death. Hence, we recommend tohold some preventive and educational program and also to assayantibodies against theses agents.Key words: Listeria moncytogenes, Cytomegalovirus (CMV), Toxoplasmagondii, success and non-success pregnancy, Serology, Gorgan
Large liver abscess: Unusual presentation of fascioliasis: Case report and literature review
Riazi Hedayat
Saudi Journal of Gastroenterology , 2001,
Abstract:
Estimation of Basal Area in West Oak Forests of Iran Using Remote Sensing Imagery  [PDF]
Loghman Ghahramany, Parviz Fatehi, Hedayat Ghazanfari
International Journal of Geosciences (IJG) , 2012, DOI: 10.4236/ijg.2012.32044
Abstract: The objective of this study is to evaluate the capability of satellite imagery for the estimation of basal area in Northern Zagros Forests. The data of the high resolution geometric (HRG) sensor of SPOT-5 satellite dated in July 2005 were used. Investigation of the quality of Satellite images shows that these images have no radiometric distortion. Overlaying of geocoded images with the digital topographic maps indicated that the images have high geometric precision. A number of 319 circular plots (0.1 ha) were established using systematic random method in the study area. All trees having diameter at breast height (DBH) (i.e. 1.3 m above ground) greater than 5 cm were callipered in each plot. Basal area in each plot was determined using field data. Main bands, artificial bands such as vegetation indices and principle component analysis (PCA) were studied. Digital numbers related to each plot were extracted from original and artificial bands. All plots were ordinated by major geographic aspects and the best fitted regression models were determined for both the study area without consideration of aspects and with consideration of major geographic aspects by multiple regression analysis (step wise regression). The results from regression analysis indicated that the square root of basal area without consideration of aspects has a high correlation with band B1 (r = –0.60). The consideration of aspects resulted in correlation of different indices with square root of basal area such that in northern forests, band B1 had higher correlation coefficient(r = –0.67) among other indices. In Eastern forests, the same band showed correlation of basal area with different correlation coefficient (r = –0.65). In southern and western forests, the square root of basal area had higher correlation (r = –0.68) with RVI. The use of the square root of basal area as a dependent variable in multivariate linear regression improved the results. The assessment of model validity indicated that the proposed models are properly valid.
Implantation of octacalcium phosphate enhances long bones repair in rats
F. Sargolzaei,M.R. Arab,S.A. Sarani,A. Hedayat Pour
Tehran University Medical Journal , 2006,
Abstract: Background: This study was designed to investigate the process of bone formation caused by implantation of octa calcium phosphate (OCP) in rat tibiae. Methods: We used 25 young male Sprague-Dawley rats. A full thickness standardized trephine defect, 3-mm in diameter, was surgically created on the superior end of right and left tibia. Amount of 6-mg synthetic Octa calcium Phosphate was implanted into a bony defect on the right tibia as a experimental group. No OCP particles were implanted in the left tibia as a control group that was otherwise treated identically. Bone formation was examined histologically on 7th, 10th, 14th, 21st, 28th days after implantation. Results: In the experimental group, on the 7th day after implantation, a few clusters of cartilage cells were observed between the OCP particles near the defects margin. Osteogenesis was initiated locally between the OCP particles in central position of the defects on 10th day after implantation. By 14th day after implantation, Alcian blue staining showed hypertrophic chondrocytes that replaced by new bone. In addition to bone formation locally around the OCP particles, more apposition of new bone was observed near the defects margin on 14th and 21st days after implantation. At the end of study implanted OCP was surrounded by newly formed bone. In the control group, at the end of study, bone formation was observed only along and near the defects margin. Conclusion: These results demonstrate that octa calcium phosphate could be used in the repair of the long bone defects.
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