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Excitatory and inhibitory effects of nitric oxide on weight, size, and histological changes of rat cerebellum
Karambaksh A,Noori Mougahi SMH,Hassan Zadeh GR,Tak Zaree N
Tehran University Medical Journal , 2013,
Abstract: Background: Nitric oxide (NO) is produced in different body organs in mammals and numerous physiological and pathological properties are attributed to this small molecule. The precursor of this substance in the body, L-arginine, is synthesized by the enzyme nitric oxide synthase (NOS), and it is catalyzed, and is inhibited by a substance called L-NG-nitroarginine methyl ester (L-NAME). In this study we investigated the qualitative and quantitative effects of nitric oxide on cerebellar histopathology in vivo environment via increasing and decreasing its production.Methods: Forty Wister rats, weighing 200- 250 gr with a mean age of 8 weeks, were divided into 5 groups after making sure the rats were pregnant. Except the control group, the other pregnant groups, respectively received: 2 ml/kg normal saline, 200 mg/kg L-arginine, 20 mg/kg L-NAME and a mixture of the same doses of L-arginine and L-NAME on the third, fourth and fifth days of pregnancy. On day 18 of pregnancy, we anesthetized the rats, excised the cerebellum after craniotomy and fixed the organs in 10% formalin. We later prepared 5 to 6-micron in thickness tissue sections and dyed them by the routine Hematoxylin and eosin (HE) and Masson's Trichrom staining methods before studying them by light microscopy.Results: There was a significant difference between the rats receiving L-arginine and the rats in other groups (P<0.01). Conclusion: This study showed that L-NAME is capable of significantly decreasing the injury caused by nitric oxides in rat cerebellum.
Giant linear syringocystadenoma papilliferum on scalp
Yaghoobi Reza,Zadeh Sara,Zadeh Abdoul Hassan
Indian Journal of Dermatology, Venereology and Leprology , 2009,
Abstract:
CA Based Path Planning Method for Mobile Robots Enhanced by ant Colony Inspired Mechanis
Adel Akbarimajd,Akbar Hassan Zadeh
Intelligent Systems in Electrical Engineering , 2011,
Abstract: In path planning of mobile robots dealing with concave obstacles is a major challenge. More specifically in real-time planning where there is no complete representation of the environment, this challenge would be much more problematic. In such cases local minimums and high computations cost are the most important problems. In this paper, in order to reduce computational cost, cellular automata as a distributed computational method with parallel processing properties is employed as tool for path planning purposes. The environment of the robot is modeled as a two dimensional cellular automata with four states. Evolutionary rules of the automata are proposed to perform the planning task. The proposed method is appropriate for single robot systems as well as multi robot systems. The proposed method is afterwards extended to be employed for concave obstacles using a ant colony inspired technique. The most superior advantage of the proposed method is its capability of real-time path planning of mobile robots with no need to prior representation of the environment.
Prevalence of Bacterial Resistance to Commonly Used Antimicrobials among Escherichia coli Isolated from Chickens in Kerman Province of Iran
Gholamreza Sepehri,Hassan Abbass- Zadeh
Journal of Medical Sciences , 2006,
Abstract: The objective of this study was to determine antimicrobial resistance rate of Escherichia coli isolates from chickens against commonly used antimicrobials in veterinary medicine. A total of 200 faecal samples of chickens were analyzed for pathogenic E. coli. Isolates were subjected to antimicrobial resistance testing by the disc diffusion method. The microbial resistance of tylosin, oxytetracycline, linco-spectin, neomycin, sulfadiazine/trimethoprim, enrofloxacin, difloxacin, flumequine and forphenical were determined. Out of 200 bacterial isolates 96% were identified as E. coli. A high prevalence of resistance were observed in E. coli for commonly used antibiotics in poultry medicine, tylosin (100%), oxytetracycline (94.8%), sulfadiazine/trimethprim (80.7%), flumequine (79.7%), neomycin (79.2%), difloxacin (78.7%), enrofloxacin (65.5%). The least resistance rate of E. coli isolates were observed for florphenicol (4.2%) and linco-spectin (4.2%). Findings from this study indicates high resistance rate of E. coli to commonly used antibiotics, therefore, the use of antimicrobial agents should be restricted to treating infections and call for banning of antimicrobials as growth promoters in poultry industry.
Three Dimensional Seepage Analyses in Mollasadra Dam after Its Impoundments
GR Rakhshandehroo, M Vaghefi, ARH Zadeh
Journal of Applied Sciences and Environmental Management , 2011,
Abstract: Mollasadra dam is an earth fill dam with a clayey core and a height of 72 m from river bed, constructed on Kor River. pore water pressure in the dam was investigated following its construction and first and second impoundments. The dam was modeled by a finite element mesh. After the first and second dam impoundments, the overall trend in monitored pore water pressure was well modeled by the transient analysis. The result showed the six month time period between impoundments was long enough for the pore water pressure to reach equilibrium everywhere throughout the core, except where considerable initial constructioninduced pore water pressure was observed. High values of construction-induced pore water pressure at elevation 2050 m did not dissipate completely during the 6 month period of almost constant reservoir level (el. 2098.3 m) and the pore pressures were still at the transient state throughout the core. Therefore, it was concluded that pore pressures in the core of earth fill dams may not achieve steady state conditions even several months after the dam construction and impoundments.
Effect of various surfactants and their concentration on controlled release of captopril from polymeric matrices
Ali Nokhodchi, , Davoud Hassan-Zadeh, Farnaz Monajjem-Zadeh, Nita Taghi-Zadeh
Acta Pharmaceutica , 2008, DOI: 10.2478/v10007-008-0004-5
Abstract: Various methods are available to formulate water soluble drugs into sustained release dosage forms by retarding the dissolution rate. One of the methods used to control drug release and thereby prolong therapeutic activity is to use hydrophilic and lipophilic polymers. In this study, the effects of various polymers such as hydroxypropyl methylcellulose (HPMC), ethylcellulose (EC) and sodium carboxymethylcellulose (CMC) and surfactants (sodium lauryl sulphate, cetyltrimethylammonium bromide and Arlacel 60) on the release rate of captopril were investigated. The results showed that an increase in the amount of HPMC K15M resulted in reduction of the release rate of captopril from these matrices. When HPMC was partly replaced by NaCMC (the ratio of HPMC/NaCMC was 5:1), the release rate of the drug significantly decreased. However, there was no significant difference in release rate of captopril from matrices produced with ratios of 5:1 and 2:1 of HPMC/NaCMC. The presence of lactose in matrices containing HPMC and NaCMC increased the release rate of captopril. It was interesting to note that although partial replacement of HPMC by EC reduced the release rate of the drug (ratio of HPMC/EC 2:1), the release rate was increased when the ratio of HPMC/EC was reduced to 1:1. The effects of various surfactants on the release rate of captopril from HPMC/EC (1:1) matrices were also investigated. The results showed that the surfactants did not significantly change the release rate of the drug. Release data were examined kinetically and the ideal kinetic models were estimated for the drug release. The kinetic analysis of drug release data from various formulations showed that incorporation of surfactants in HPMC/EC matrices did not produce a zero-order release pattern.
CFD analysis of helical nozzles effects on the energy separation in a vortex tube
Pourmahmoud Nader,Zadeh Hassan Amir,Moutaby Omid,Bramo Abdolreza
Thermal Science , 2012, DOI: 10.2298/tsci110531085p
Abstract: In this article computational fluid dynamics (CFD) analysis of a three-dimensional steady state compressible and turbulent flow has been carried out through a vortex tube. The numerical models use the k-ε turbulence model to simulate an axisymmetric computational domain along with periodic boundary conditions. The present research has focused on the energy separation and flow field behavior of a vortex tube by utilizing both straight and helical nozzles. Three kinds of nozzles set include of 3 and 6 straight and 3 helical nozzles have been investigated and their principal effects as cold temperature difference was compared. The studied vortex tubes dimensions are kept the same for all models. The numerical values of hot and cold outlet temperature differences indicate the considerable operating role of helical nozzles, even a few numbers of that in comparing with straight nozzles. The results showed that this type of nozzles causes to form higher swirl velocity in the vortex chamber than the straight one. To be presented numerical results in this paper are validated by both available experimental data and flow characteristics such as stagnation point situation and the location of maximum wall temperature as two important facts. These comparisons showed reasonable agreement.
Release of Steroids from Plastibase Semisolid Bases
D.Hassan-Zadeh S.Kararayar
DARU : Journal of Pharmaceutical Sciences , 1991,
Abstract: The present research is carried out in order to study the possibility of replacing the classic semisolid bases in steroidal commercial products with Plastibase."nAs regard to its high lipophilic properties, the plastibase alone is not a suitable base for hydrocortisone acetate and f.luocinolone acetonide. Addition of 5 and 7.5% of Propylene glycol to plastibase can increase the rate of drug release from vehicle. This change in drug release is related to decrease in drug-vehicle interaction and consequently increasing its partition coefficient. It seems that these considerations can be applied to betamethasone and clobetasole ointments, which are the most utilized in Iranian commerce .
GROWTH RATE AND IDENTIFICATION OF YEASTS IN THREE DIFFERENT MEDIA: FLOUR, SPROUT OF CEREALS AND COMMERCIAL MEDIA
P DEHGHAN,SH SHADZI,M ,MOVAHED MOHAMMADI,A HASSAN ZADEH
Journal of Research in Medical Sciences , 2002,
Abstract: Introduction. The yeasts are a large group of fungi. In addition to their different uses in food industries and pharmacology they can also cause human and animal infections under predisposing factors. For investigating the yeast"s growth phases and diagnosis of the species, they should culture in media from natural sources like the seeds on the commercial media. According to yeast"s nutritinal requierments and considering the various nutritional materials of seeds like wheat, rice, barney and better use of these seed"s compounds during sprouting, this research was done with the aim of measurment of growth rate and yeasts characterization in such media. Methods. For making seeds media, a fixed quantity of seed"s flour or sprout"s flour was added to a certain amount of agar in acidotic condition (pH=5.8). The germination of seeds was done by Hus method and for colony counting Mc, Farland tubes were used and microscopic and macroscopic characteristics were investigated and compared in both synthetic and seed media Results. The results showed that the rate of yeasts growth in all germinated seeds was more than the seeds themeselves. Statistical analysis showed no significal difference between the growth rate of yeasts in both wheat and barney sprout compared to the commercial media. In the microscopic studies, the species of Candida albicans in wheat flour has produced more chlamydoconidia than the synthetic medium of corn meal agar. Also production of the capsule in C.neoformans in the seed"s media has been better than the synthetic media. Discussion. According to the promising results obtained from the present study regard to the growth rate and differentiation of the fungal species in such media, standardization and mass production of them in our country would seem to be an productive step towards self sufficiency.
Heterogeneity of Variance for Milk Traits at Climitical Regions in Holstein Dairy Cattle in Iran and the Best Method(s) for Data Transformation
Sheyda Varkoohi,Hassan Mehrabani-Yeganeh,Seyed Reza Miraei-Ashtiani,Navid Ghavi Hossein-Zadeh
Pakistan Journal of Biological Sciences , 2007,
Abstract: In this research, heterogeneity of variance components in cattle populations at climatical regions in the first three lactations was studied. The data set included the following: 161328 records of first, 123369 records of second and 81013 records of third lactations, which was collected by Animal Breeding Center of Iran from 1983 to 2004. Records of three lactations were divided in the base of Domarten method. Bartlett test for heterogeneity of variance components was significant among all subgroups. In order to decrease the heterogeneity of variance components, we used several data transformation methods including Logarithmic, Square root and Arc sin transformations. Logarithmic transformation decreased the heterogeneity of variance components in the three lactations and other methods had not effect for removing the heterogeneity in any group. Genetic parameters and heritability were estimated for three lactations by MATVEC program, using animal model. Results showed that the heritability estimates of milk yield were decreased from the first lactation to the third; also the heritability estimates of transformed data were slightly higher than the original data. Comparison between estimated parameters in single trait and two traits analysis, before and after data transformation, showed that there were not significant differences between derived results.
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