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Search Results: 1 - 10 of 230 matches for " Harpreet Walia "
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Thrombotic thrombocytopenic purpura treated with vincristine in a Jehovah′s witness
Walia Sandeep,Walia Manmeet,Walia Harpreet
Asian Journal of Transfusion Science , 2011,
Abstract:
Ocular Manifestations of Systemic Lupus Erythematosus: A Review of the Literature
Neal V. Palejwala,Harpreet S. Walia,Steven Yeh
Autoimmune Diseases , 2012, DOI: 10.1155/2012/290898
Abstract: About one-third of patients suffering from systemic lupus erythematosus have ocular manifestations. The most common manifestation is keratoconjunctivitis sicca. The most vision threatening are retinal vasculitis and optic neuritis/neuropathy. Prompt diagnosis and treatment of eye disease is paramount as they are often associated with high levels of systemic inflammation and end-organ damage. Initial management with high-dose oral or IV corticosteroids is often necessary. Multiple “steroid-sparing” treatment options exist with the most recently studied being biologic agents. 1. Introduction Systemic lupus erythematosus (SLE) is a chronic, autoimmune, connective tissue disorder affecting multiple organ systems often with a relapsing and remitting clinical course. Prevalence, clinical manifestations, and morbidity vary significantly between the developing and industrialized worlds. While SLE is more common in people of African and Asian descent, thrombotic complications are more common in Caucasian patients [1]. The highest prevalence has been reported in Italy, Spain, Martinique, and the UK Afro-Caribbean population [2]. The median age of onset is between the late teens and early 40s with a 9 times higher incidence in women compared to men. Ocular manifestations—occurring in up to one third of patients—can be associated with significant morbidity and also a marker for overall systemic disease activity. 2. Genetic Considerations Concordance rates for SLE among monozygotic and dizygotic twins are 25% and 2%, respectively, suggesting a significant genetic contribution [3]. Major histocompatibility complex genes, such as HLA-A1, B8, and DR3 [4], as well as alleles that cause deficiency in complement components—C1q, C2, and C4 [5]—have all been linked to lupus. 3. Mechanism of Disease SLE is a complex disease process demonstrating dysregulation of the immune system at multiple levels. Autoantibodies against double-stranded DNA were first isolated from kidney specimens in patients with lupus nephritis in 1967 [6]. Other autoantibodies that have been implicated in disease include anti-Ro, La, Sm, nucleosome, NMDA receptor, phospholipid, and α-actinin. Two major theories exist on how these autoantibodies cause tissue damage. The first model suggests that anti-double-stranded DNA antibodies bind to circulating nucleosomes to form immune complexes that then get deposited in end-organ capillary beds such as the renal glomerulus and activate immune/inflammatory responses [7]. The second hypothesizes that these autoantibodies cross-react with normal renal proteins
Leiomyoma cutis: A clinicopathological series of 37 cases
Malhotra Purnima,Walia Harpreet,Singh Avninder,Ramesh V
Indian Journal of Dermatology , 2010,
Abstract: Background: Cutaneous leiomyomas are benign smooth muscle tumors that comprise three distinct types such as piloleimyoma, angioleiomyoma, and genital leiomyoma. Aim: The objective of this study was to report a series of cases seen in last 8 years in a tertiary care hospital in north India and to discuss their clinicopathologic findings. Material and Methods: Paraffin-embedded blocks of cases reported as cutaneous leiomyoma from 1999 to 2007 were retrieved from the Institute of Pathology, New Delhi, and their clinical parameters were noted. Their histopathological features were reviewed on hematoxylin-eosin stained slides. Immunohistochemistry was performed where necessary. Results: Twenty-seven cases of piloleiomyoma, three cases of angioleiomyoma, five breast leiomyomas, and two scrotal leiomyomas were seen in patients ranging from 21 to 65 years of age, with an average of 38.2 years at presentation. There was a male predominance with 26 males and 11 females (M:F = 2.2:1). Solitary lesions (n = 21) were more common than multiple ( n = 16). The trunk and upper limbs were involved most commonly, comprising 23 of 37 (62.2%) cases. This was followed by lower limb, face, breast, and scrotum. Conclusion: Cutaneous leiomyomas are rare lesions and form an important clinical differential diagnosis of painful papulonodules. These must be biopsied in order to differentiate them from other spindle cell lesions.
Comparative analysis of antioxidant and phenolic content of chloroform extract/fraction of Terminalia chebula
Harpreet Walia,Saroj Arora1,Subodh Kumar
Journal of Basic and Clinical Pharmacy , 2011,
Abstract: In the present study, two chloroform extracts of fruits of Terminalia chebula viz. “CHL1” and “CHL 2” prepared by maceration and sequential method respectively was compared for their antioxidant efficacy and phenolic content. The extraction procedure of plant material plays an important role in the activity of phytochemicals. Also, the assessment of antioxidant capacity of phytochemicals cannot be executed precisely by any single method due to complex nature of phytochemicals as multiple reaction characteristics and mechanisms can be involved. So, no single assay could accurately reflect comparison in a mixed or complex system. Therefore in the present study the comparison of extracts was done by using most widely used assays viz. DPPH, deoxyribose, reducing power, chelating power and lipid peroxidation assay. Furthermore, the UV-Vis spectrum of both extracts and the correlation between total phenolic content was examined in order to give an orientation to the search of phytochemicals responsible for their activity. From the results, it was concluded that antioxidant activity and phenolic compounds were predominant in the ‘CHL 2’ prepared by sequential method. The present study enlightening the useful extraction procedure of plant material.
Comparative analysis of antioxidant and phenolic content of chloroform extract/fraction of Terminalia chebula
Harpreet Walia,Saroj Arora,Subodh Kumar2
Journal of Basic and Clinical Pharmacy , 2011,
Abstract: In the present study, two chloroform extracts of fruits of Terminalia chebula viz.“CHL1” and “CHL 2” prepared by maceration and sequential method respectively was compared for their antioxidant efficacy and phenolic content. The extraction procedure of plant material plays an important role in the activity of phytochemicals.Also, the assessment of antioxidant capacity of phytochemicals cannot be executed precisely by any single method due to complex nature of phytochemicals as multiple reaction characteristics and mechanisms can be involved. So, no single assay couldaccurately reflect comparison in a mixed or complex system. Therefore in the present study the comparison of extracts was done by using most widely used assays viz.DPPH, deoxyribose, reducing power, chelating power and lipid peroxidation assay.Furthermore, the UV-Vis spectrum of both extracts and the correlation between totalphenolic content was examined in order to give an orientation to the search of phytochemicals responsible for their activity. From the results, it was concluded that antioxidant activity and phenolic compounds were predominant in the ‘CHL 2’ prepared by sequential method. The present study enlightening the useful extraction procedureof plant material.
An Aggressive Sphenoid Wing Meningioma Causing Foster Kennedy Syndrome
Harpreet S. Walia,F. Lawson Grumbine,Gagan K. Sawhney,David S. Risner,Neal V. Palejwala,Matthew E. Emanuel,Sandeep S. Walia
Case Reports in Ophthalmological Medicine , 2012, DOI: 10.1155/2012/102365
Abstract: Foster Kennedy syndrome is a rare neurological condition with ophthalmic significance that can manifest as acute visual loss. It is classically characterised by unilateral optic nerve atrophy and contralateral papilledema resulting from an intracranial neoplasm. Physicians should consider Foster Kennedy syndrome in patients who present with visual loss and who have a history of intracranial neoplasm. In addition to ophthalmologic examination, neuroimaging is essential for the diagnosis of Foster Kennedy syndrome.
An Aggressive Sphenoid Wing Meningioma Causing Foster Kennedy Syndrome
Harpreet S. Walia,F. Lawson Grumbine,Gagan K. Sawhney,David S. Risner,Neal V. Palejwala,Matthew E. Emanuel,Sandeep S. Walia
Case Reports in Ophthalmological Medicine , 2012, DOI: 10.1155/2012/102365
Abstract: Foster Kennedy syndrome is a rare neurological condition with ophthalmic significance that can manifest as acute visual loss. It is classically characterised by unilateral optic nerve atrophy and contralateral papilledema resulting from an intracranial neoplasm. Physicians should consider Foster Kennedy syndrome in patients who present with visual loss and who have a history of intracranial neoplasm. In addition to ophthalmologic examination, neuroimaging is essential for the diagnosis of Foster Kennedy syndrome. 1. Introduction Foster Kennedy syndrome is a rare condition that classically involves optic nerve atrophy ipsilateral to an intracranial neoplasm with concomitant contralateral papilledema. As few as 37 cases have been completely documented between 1909 and 1989 [1]. We review the pathogenesis and common clinical manifestations of Foster Kennedy syndrome and highlight the role of neuroimaging in diagnosis. 2. Case History A 72-year-old white female with a medical history of an aggressive left sphenoid wing meningioma, initially treated with resection and subsequently with radiotherapy for a recurrence four years, presented complaining of acute visual loss in her left eye. She also endorsed an associated left-sided retroorbital headache; she denied nausea, vomiting, or gait abnormalities. On physical exam, the patient had stable vital signs and was in no acute distress. Ophthalmologic exam revealed visual acuity of 20/50 in the right eye and finger counting in the left eye. A relative afferent pupillary defect was present in the left eye. Confrontation visual fields were full in the right eye but revealed significant generalized constriction in all four quadrants in the left eye. Slit lamp exam was remarkable for only moderate nuclear sclerotic cataracts in both eyes. On funduscopic exam, the right eye revealed a hyperemic, edematous optic disc with tortuous and dilated vessels and scattered drusen in the macula without subretinal fluid, and the left eye revealed a pale optic disc with scattered drusen in the macula without subretinal fluid. Given her history of known sphenoid wing meningioma, neuroimaging with MRI was obtained. Axial MRI scans revealed a large mass in the left cavernous sinus extending into the left optic nerve and optic chiasm (see Figures 1 and 2). A coronal MRI scan confirmed infiltration into the sella turcica and sphenoid sinus (Figure 3). A lumbar puncture confirmed elevated intracranial pressure at 22?mmHg and did not show any signs of infection. Other diagnostic tests including complete blood count, complete metabolic
Dermatitis artefacta: Three case reports
Walia N
Indian Journal of Dermatology , 2006,
Abstract: Three cases of dermatitis artefacta are reported for their varied presentation, diagnostic indicators and complex management. A 21-year-old soldier had multiple painful erosions on dorsum of both forearms of three weeks duration normal with inbetween skin. By occlusive bandaging dressing lesions healed without recurrence. A 28-year-old mechanic had recurrent blisters with non healing wounds on the right knee without surrounding inflammation. Histopathology was nonspecific. A young soldier had multiple asymphomatic nodular lesion in linear distribution on right forearm of two years induration. Biopsy showed features of scar. Psychiatric evaluation and follow-up was essential in all cases.
ACHIEVEMENT IN RELATION TO MATHEMATICAL CREATIVITY OF EIGHTH GRADE STUDENTS
Pooja Walia
Indian Streams Research Journal , 2012,
Abstract: The present study was conducted to examine the relationship of mathematical creativity with achievement and differences between boys and girls with regard to their mathematical creativity (along with its dimensions) and achievement. Simple random sampling was used to select the participants. Participants (N= 180, boys = 99 and girls = 81) completed creativity test. Mathematical creativity was measured using the Creative Ability in Mathematics Test developed by Balka (1974). Pearson's Product Moment Correlation analysis indicated that mathematical creativity (along with its dimensions) is related to achievement in mathematics of eighth grade students. No significant difference was found between boys and girls with regard to their achievement and mathematical creativity (along with its dimensions). However, girls were found better than boys on one dimension of mathematical creativity i.e. flexibility.
Tensor factorization and Spin construction for Kac-Moody algebras
Rajeev Walia
Mathematics , 2007,
Abstract: In this paper we discuss the "Factorization phenomenon" which occurs when a representation of a Lie algebra is restricted to a subalgebra, and the result factors into a tensor product of smaller representations of the subalgebra. We analyze this phenomenon for symmetrizable Kac-Moody algebras (including finite-dimensional, semi-simple Lie algebras). We present a few factorization results for a general embedding of a symmetrizable Kac-Moody algebra into another and provide an algebraic explanation for such a phenomenon using Spin construction. We also give some application of these results for semi-simple finite dimensional Lie algebras. We extend the notion of Spin functor from finite-dimensional to symmetrizable Kac-Moody algebras, which requires a very delicate treatment. We introduce a certain category of orthogonal $\g$-representations for which, surprisingly, the Spin functor gives a $\g$-representation in Bernstein-Gelfand-Gelfand category $\O$. Also, for an integrable representation $\Spin$ produces an integrable representation. We give the formula for the character of Spin representation for the above category and work out the factorization results for an embedding of a finite dimensional semi-simple Lie algebra into its untwisted affine Lie algebra. Finally, we discuss classification of those representations for which $\Spin$ is irreducible.
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