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Search Results: 1 - 10 of 401300 matches for " Harden Lois M "
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Interleukin-10 modulates the synthesis of inflammatory mediators in the sensory circumventricular organs: implications for the regulation of fever and sickness behaviors
Harden Lois M,Rummel Christoph,Luheshi Giamal N,Poole Stephen
Journal of Neuroinflammation , 2013, DOI: 10.1186/1742-2094-10-22
Abstract: Background Whereas the role played by interleukin (IL)-10 in modulating fever and sickness behavior has been linked to it targeting the production of pro-inflammatory cytokines in the circulation, liver and spleen, it is not known whether it could directly target the local production of pro-inflammatory cytokines within the sensory circumventricular organs (CVOs) situated within the brain, but outside the blood–brain barrier. Using inactivation of IL-10, we, therefore, investigated whether IL-10 could modulate the synthesis of pro-inflammatory cytokines within the sensory CVOs, in particular the organum vasculosum laminae terminalis (OVLT) and area postrema (AP). Findings Primary OVLT and AP microcultures were established from topographically excised rat pup brain tissue. The microcultures were pretreated with either IL-10 antibodies (AB) (10 μl/350 μl medium) or phosphate-buffered saline (PBS) (10 μl/350 μl medium) before being incubated with lipopolysaccharide (LPS) (100 μg/ml) or PBS in complete medium for 6 h. Supernatants were removed from the microcultures after 6 h of incubation with LPS and used for the determination of IL-6 and tumor necrosis factor (TNF)-α. Pre-treating the OVLT and AP microcultures with IL-10 antibodies significantly enhanced the LPS-induced increase in TNF-α and IL-6 in the supernatant obtained from the microcultures. Conclusions Our results show for the first time that the LPS-induced release of pro-inflammatory cytokines in cells cultured from the AP and OVLT can be modulated in the presence of IL-10 antibodies. Thus, we have identified that the sensory CVOs may have a key role to play in both the initiation and modulation of neuroinflammation.
Abstract from the International Medical Education Conference 2007: Keynote Address
Ronald M Harden
International e-Journal of Science, Medicine & Education , 2007,
Abstract: The IMU story represents one of the most exciting andsignificant experiments in medical education in recent years.The educational strategies implemented at IMU, the learningopportunities made available to IMU students, theeducational climate created and elements of the assessmentprocess could all be highlighted as significant contemporarydevelopments in medical education. Two aspects of the IMUstory, however, merit special attention and in themselvesmake the IMU story a unique one and one that needs to betold for the significant messages it offers medical education.The first unique feature is the transnational approach tomedical education. The second is a professionalism in thedelivery of education. These features have even moresignificance today than when IMU was created as theIMC 15 years ago. How this transnational approach andprofessionalism in education have been developed at IMUwill be reviewed and their significance for the short and longterm future of medical education internationally will behighlighted.
Role of 3-Dimentional Computed Tomography Scan in Video Assisted Major Pulmonary Resection in Patient with Situs Inversus Totalis  [PDF]
Adnan Raza, Stephen Harden, Lukacs Veres, Khalid M. Amer
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.68070
Abstract: The aim of this case report is to raise awareness about the use of 3-Dimentional Computed Tomography (3D-CT) virtual reality imaging as a routine pre-operative tool for evaluation of unusual anatomy such as Situs Inversus Totalis (SIT). We present a case of presumed lung cancer in a 58 years old lady with SIT successfully treated by VATS lobectomy via an anterior approach. She presented with an incidental solitary pulmonary nodule in her right lower lobe, which had moderate FDG uptake on the PET scan. The nodule was too deep to permit safe wedge biopsy, due to proximity of a large pulmonary arterial branch. 3D-CT images were invaluable in pre-operative assessment of the anatomy and were the key to safe completion of right VATS lower lobectomy. Sectioning the lung after retrieval of the specimen suggested a chondroid hamartoma; therefore, systemic nodal dissection (SND) was not contemplated. The final histology confirmed the diagnosis of chondroid hamartoma. In an unusual anatomy such as SIT, 3D-CT allows construction of virtual reality models that can be viewed and manipulated before and during the operation to understand the anatomy better, highlight caveats around target structures and enable localisation of lesions unlikely to be palpated intra-operatively.
Experiential Learning in Graduate Education: Development, Delivery, and Analysis of an Evidence-Based Intervention  [PDF]
Samantha M. Harden, Kacie C. Allen, Clarice N. Chau, Serena L. Parks, Ashley L. Zanko
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.35095
Abstract: Certain expectations are outlined for a young professional with a recently earned doctoral degree. In academia, it is anticipated that graduates will demonstrate the ability to obtain funding, actively engage in an interdisciplinary work environment, and value experiences with critical thinking and problem solving. This paper outlines a unique learning experience of five graduate research students who progressed from the initial stage of research question conceptualization to dissemination of research results. The process included a written research design proposal, grant review process, physical activity program development, intervention delivery, data analysis, and publication of findings. Challenges overcome by these young investigators throughout the research process (i.e. intervention recruitment, development and delivery) are included within the manuscript, as well as other important findings from this process evaluation. The first-hand account of their learning experiences demonstrates the value of promoting internal competition (i.e., within a department, college, university), while working as a collaborative research team to prepare graduate students for ‘real-world’ research and work-related scenarios. Graduate student faculty mentors should incorporate more opportunities for their students to glean research experience described here.
Force networks and the dynamic approach to jamming in sheared granular media
Gregg Lois,Jean M. Carlson
Physics , 2006, DOI: 10.1209/0295-5075/80/58001
Abstract: Diverging correlation lengths on either side of the jamming transition are used to formulate a rheological model of granular shear flow, based on the propagation of stress through force chain networks. The model predicts three distinct flow regimes, characterized by the shear rate dependence of the stress tensor, that have been observed in both simulations and experiments. The boundaries separating the flow regimes are quantitatively determined and testable. In the limit of jammed granular solids, the model predicts the observed anomalous scaling of the shear modulus and a new relation for the shear strain at yield.
The Rhetorical Turn to Otherness: Otherwise than Humanism
Ronald C Arnett,Janie Harden Fritz,Annette M Holba
Cosmos and History : the Journal of Natural and Social Philosophy , 2007,
Abstract: While offering a public welcome of communicative participation, a communicative dark side of the moderate Enlightenment project emerged. Moderate Enlightenmentrsquo;s corollary companion to wresting power from a limited few is the staggering sense of confidence in the universal ground of assurance that is ldquo;bad faithrdquo; mdash;we fib to ourselves that we can stand above history and affect the future. Absolute conviction of universal access to truth propels through methodological confidence, undergirding the era of ldquo;the rationalrdquo; pursuit of truth, transporting the individual into an ethereal delusionmdash;that one can stand above the historical moment of engagement and cast judgment. This essay calls into question the common assumption that communication begins with the individual. We offer a critique of this assumption in accordance with radical enlightenment scholarship, calling forth a return to Otherness that renders the construct of individual secondary to that which is met.br /
Visual Thinking: Art Students Have an Advantage in Geometric Reasoning  [PDF]
Caren M. Walker, Ellen Winner, Lois Hetland, Seymour Simmons, Lynn Goldsmith
Creative Education (CE) , 2011, DOI: 10.4236/ce.2011.21004
Abstract: We investigated whether individuals with training in the visual arts show superior performance on geometric reasoning tasks, given that both art and geometry entail visualization and mental manipulation of images. Two groups of undergraduates, one majoring in studio art, the other majoring in psychology, were given a set of geometric reasoning items designed to assess the ability to mentally manipulate geometric shapes in two- and three-dimensional space. Participants were also given a verbal intelligence test. Both training in the arts and verbal intelligence were strong predictors of geometric reasoning, but training in the arts was a significant predictor even when the effects of verbal intelligence were removed. These correlational findings lend support to the hypothesis that training in the visual arts may improve geometric reasoning via the learned cognitive skill of visualization.
Poliomielitis en chile: Frecuencia, distribución geográfica y caracteres del agente
Revista chilena de pediatría , 1958,
La enfermedad reumática como problema colectivo
Revista chilena de pediatría , 1958,
Apuntes de radiología práctica de peque os animales No 8
M.V. Angel Augusto Lois
REDVET , 2010,
Abstract: ResumenApuntes de radiología práctica de peque os animales No 8
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