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Search Results: 1 - 10 of 2003 matches for " Harald Niederegger "
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CenH3/CID Incorporation Is Not Dependent on the Chromatin Assembly Factor CHD1 in Drosophila
Valerie Podhraski,Beatriz Campo-Fernandez,Hildegard W?rle,Paolo Piatti,Harald Niederegger,Günther B?ck,Dmitry V. Fyodorov,Alexandra Lusser
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010120
Abstract: CHD1 is a SNF2-related ATPase that is required for the genome-wide incorporation of variant histone H3.3 in the paternal pronucleus as well as in transcriptionally active nuclei in Drosophila embryos. The S. pombe and vertebrate orthologs of CHD1 have been implicated in the assembly of the centromeric histone H3 variant CenH3CENP-A, which occurs in a DNA replication-independent manner. Here, we examined whether CHD1 participates in the assembly of CenH3CID in Drosophila. In contrast to the findings in fission yeast and vertebrate cells, our evidence clearly argues against such a role for CHD1 in Drosophila. CHD1 does not localize to centromeres in either S2 cells or developing fly embryos. Down-regulation of CHD1 in S2 cells by RNAi reveals unchanged levels of CenH3CID at the centromeres. Most notably, ablation of functional CHD1 in Chd1 mutant fly embryos does not interfere with centromere and kinetochore assembly, as the levels and localization of CenH3CID, CENP-C and BubR1 in the mutant embryos remain similar to those seen in wild-type embryos. These results indicate that Drosophila CHD1 has no direct function in the incorporation of the centromeric H3 variant CenH3CID into chromatin. Therefore, centromeric chromatin assembly may involve different mechanisms in different organisms.
Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury
Christian M K?hler, Jutta Wechselberger, Wolfgang Hilbe, Andreas Gschwendtner, Daniela Colleselli, Harald Niederegger, Eva-Maria Boneberg, Gilbert Spizzo, Albrecht Wendel, Eberhard Gunsilius, Josef R Patsch, Jürg Hamacher
Respiratory Research , 2007, DOI: 10.1186/1465-9921-8-50
Abstract: Ex vivo generated, characterized and cultivated rat bone marrow-derived EPC were investigated for proliferation and vasculogenic properties in vitro. EPC were tested for their homing in a left-sided rat lung transplant model mimicking a severe acute lung injury. EPC were transplanted into the host animal by peripheral administration into the femoral vein (106 cells). Rats were sacrificed 1, 4 or 9 days after lung transplantation and homing of EPC was evaluated by fluorescence microscopy. EPC were tested further for their involvement in vasculogenesis processes occurring in subcutaneously applied Matrigel in transplanted animals.We demonstrate the integration of intravenously injected EPC into the tissue of the transplanted left lung suffering from acute lung injury. EPC were localized in vessel walls as well as in destructed lung tissue. Virtually no cells were found in the right lung or in other organs. However, few EPC were found in subcutaneous Matrigel in transplanted rats.Transplanted EPC may play an important role in reestablishing the endothelial integrity in vessels after severe injury or at inflamatory sites and might further contribute to vascular repair or wound healing processes in severely damaged tissue. Therapeutic applications of EPC transplantation may ensue.Aimed at a huge surface between blood and ambient air to accomplish the optimal external breathing, the lung is a high-throughput blood spongue that has matched its endothelial surface virtually to the same size as the alveolar space [1]. Endothelial cells (EC) regulate the transport of nutrients and mediators, the traffic of inflammatory cells, and regulate the vascular tone, density and selectivity of the blood-interstitial barrier [2]. In many pathophysiologic processes, e.g. during haemostasis, inflammation and angiogenesis they thus are suggested to play a key role [3].Due to the lung's serial position in the blood circulation the whole amount of cardiac output has to pass through the pulmo
Different typologies of workplace conflict and their connections with post traumatic embitterment disorder (PTED)  [PDF]
Harald Ege
Health (Health) , 2010, DOI: 10.4236/health.2010.23033
Abstract: Reported is an empirical study which shows that Post-Traumatic Embitterment Disorder (PTED) is the most appropriate psychological diagnosis for victims of workplace conflicts, particularly bullying. A group of 118 people all reporting conflict at work were evaluated with the LIPT questionnaire, the PTED self-rating scale and a guided psychological interview. 91.5% proved to be affected by a PTED, the slight majority males, aged between 31 and 40 years and subjected to bullying. The evidence suggests that some workplace conflict victims who are presently diagnosed and treated as depression or phobia can be in fact cases of PTED. The treatment may be adjusted and the PTED scale may be used as a screening in-strument similar to scales for anxiety and depressive disorders.
On a New Mechanism for Separating two Components in a Stationary Flow through Mesopores  [PDF]
Harald Morgner
American Journal of Analytical Chemistry (AJAC) , 2011, DOI: 10.4236/ajac.2011.25070
Abstract: When simulating the behavior of fluids in a stationary flow through mesopores we have observed a phenomenon that may prove useful in some cases as basis for separating fluid components. The scheme works at constant temperature which makes it energy efficient as are other schemes like (molecular) sieves or chromatography. Sieves rely on differences in molecular size and chromatography on different affinity of components to the solid material of the ‘packing’. The scheme presented here may sometimes complement the established techniques in that it is based on a different mechanism. The fluids to be separated can have the same molecular size and the same affinity to solid material they are in contact with. The only requirement for the scheme to work is that the miscibility behavior varies somewhat with pressure or density. From literature it is known that virtually any mixture reacts on strong variations of pressure. Even a mixture that behaves almost ideally at ambient pressure will show slight deviations from ideal miscibility when exposed to extreme pressure. The strong differences in pressure are not created by external means but by exploiting the spontaneous behavior of fluids in mesopores. If the experiment is designed correctly, strong pressure gradients show up in mesopores that are far beyond any gradient that could be established by technical means. Our simulations are carried out for situations where pressure inside the pores varies between a few hundred bar positive pressure and a few hundred bar negative pressure while the pressure in the gas phase outside the pores amounts to ca.170 mbar.
From Thaer and Thünen until Today: Past and Future of Agricultural Landscape Use in Germany  [PDF]
Harald Kaechele, Sunil Nautiyal
Natural Resources (NR) , 2010, DOI: 10.4236/nr.2010.12006
Abstract: This article intends to present the historical development of German agriculture sector in last two centuries and underlined the benefit of the advancement in agriculture sector to fulfil the growing food demand. At the same time the article discussed the ecological and socio-economic perspectives of rapid technological development of agriculture sector in Germany. This article would facilitate the debate on technological development in agriculture sector, which rapidly growing throughout the world, in view point of sustainable socio-ecological development.
Matrix Metalloproteinase MMP-9 Promotes K/BxN Serum Induced Arthritis in Mice  [PDF]
Narendiran Rajasekaran, Harald Illges
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2014, DOI: 10.4236/ojra.2014.41003
Abstract: Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that are over-expressed in joints of rheumatoid arthritis (RA) patients. However, the contribution of specific MMPs for the development of arthritic joints is unknown. This study is aimed at studying the role of matrix metalloproteinase-9 (MMP-9) in mice, using the K/BxN serum-transfer model of RA. Arthritis was induced in Balb/c mice by injecting K/BxN serum. Development of arthritis was followed in these mice by measuring ankle thickness and clinical index score. MMP-9 expression in the joints of mice killed at various time points during the disease progression was determined by gelatin zymography using ankle lysates. We found that MMP-9 expression increased with the severity of arthritis. Importantly MMP-9 deficient mice injected with K/BxN serum showed a milder form of arthritis in comparison to the control C57BL/6 mice injected with K/BxN serum. We therefore conclude that MMP-9 promotes arthritis in mice.
Quantum theory and consciousness: an overview with selected examples
Harald Atmanspacher
Discrete Dynamics in Nature and Society , 2004, DOI: 10.1155/s102602260440106x
Abstract: It is widely accepted that consciousness or, in other words, mental activity is in some way correlated to the behavior of the brain or, in other words, material brain activity. Since quantum theory is the most fundamental theory of matter that is currently available, it is a legitimate question to ask whether quantum theory can help us to understand consciousness. Several approaches answering this question affirmatively, proposed in recent decades, will be surveyed. It will be pointed out that they make different epistemological assumptions, refer to different neurophysiological levels of description, and adopt quantum theory in different ways. For each of the approaches discussed, these imply both problematic and promising features which will be indicated.
Neurotrophins in bronchial asthma
Harald Renz
Respiratory Research , 2001, DOI: 10.1186/rr66
Abstract: BA is a complex disease with several clinically well-defined pathogenic components, including recurrent reversible airway obstruction, chronic airway inflammation and development of airway hyperresponsiveness [1]. The constituents of the inflammatory component have, in recent years, been relatively well characterized and defined. There is now overwhelming evidence that T cells play a central role in, particularly, allergic BA. Strong evidence supports the notion that T-helper 2 cells orchestrate allergic inflammation and control many important aspects of the effector phase response, including recruitment, activation and survival of eosinophils, activation of mast cells and IgE production. Reversible airway obstruction is pathogenetically related to mucus hypersecretion, development of local tissue edema as a consequence of acute inflammatory responses, and constriction of airway smooth muscle. Nonspecific bronchial hyperresponsiveness may be defined as an increase in the ease and degree of airway narrowing in response to a wide range of bronchoconstrictor stimuli. The development of airway hyperresponsiveness is mediated by multiple independent and additive pathways working in concert, which can be clinically tested using stimuli such as methacholine, histamine, exercise, cold air, capsaicin, and so on. Constriction of airway smooth muscle is largely controlled by sensory and motor neurons innervating the airways and the lung. The autonomic nerves that regulate many aspects of airway function, including airway smooth muscle tone, mucus secretion and bronchial microcirculation, can be functionally subdivided into cholinergic, adrenergic and nonadrenergic noncholinergic pathways.Sensory and motor neurons exhibit drastic functional changes in BA. These changes are defined by the term 'neuronal plasticity' [2]. Increased levels of neuropeptides including substance P have been detected in the lungs of asthmatic patients [3,4]. Increased levels of Neurokinin A have been d
50 anos de pesquisas em limnologia na Amaz?nia
Sioli, Harald;
Acta Amazonica , 2006, DOI: 10.1590/S0044-59672006000300001
Abstract: this present work is a complete transcription of a talk given by dr. harald sioli (1910-2004) at the seminária da amaz?nia, on 10 august 1990. the occasion was his last trip to amazonas, when his collogues paid him homage on completing 80 years of age. on that occasion, inpa invited him to speak about the "50 years of limnology research in amazonia", which, according to his own words, were "the most decisive days of his life". the text can be divided into two parts: the first refers to his personal history, namely, from his arrival in brazil, his discovery of amazonia and his survival in the backwoods of amazonas and pará to the 2nd world war, until he became a researcher at inpa and setting up the inpa/max planck working agreement; the second speaks of his limnology research, interacting with research, with brazilian and foreign researchers of the past and present, and with backwoodsmen (caboclos) who, in his mind, "live with the forest and not against the forest". the transcription was made by elci silva and antonio alvarez, and kept by terezinha soares of the assessoria de tecnologia extens?o - aste, which, at the time, organized the seminária da amaz?nia. dr. sioli personally authorized the publication in 2000 by correspondence in which he declares: "i would satisfy me very much, if i could still be useful in the fight for the survival of amazonia which is my second country". now, at last, it is being published. although harald sioli is no longer with us, this publication is homage of the acta amazonica to the memory of one who dedicated so many years to the knowledge and preservation of amazonia.
Isospin Mass Differences of Heavy Baryons
Fritzsch, Harald
High Energy Physics - Phenomenology , 2008,
Abstract: We discuss the mass differences for isospin multiplets of the charmed and b-flavored baryons. The mass of the neutral b-flavored sigma baryon, which is not measured, is calculated. We point out, that the measurements of the mass differences between the charmed sigma and chi baryons might be wrong.
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