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Search Results: 1 - 10 of 303702 matches for " Hans-Jürgen Scheruhn "
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Managing Business Processes in Distributed Systems: Requirements, Models, and Implementation
Evaristo Colomina,Burkhardt Funk,Peter Niemeyer,Hans-Jürgen Scheruhn
IBIMA Business Review , 2010,
Abstract: This paper describes a case study for teaching purposes which enables students of Business Informatics and Economics to jointly work on B2B processes from modeling to implementation and execution. The teaching materials are based on a practical example and show how B2B processes can be integrated using a business process management system. Special focus is given to the goal of making the business processes as realistic as possible. An introduction to the technologies used (Simulated SAP Environment, modeling software ARIS Design Platform, workflow management system SAP Business Workflow and the SAP Exchange Infrastructure) is part of the teaching material.
Treatment of chronic vulvovaginal candidiasis with posaconazole and ciclopiroxolamine  [PDF]
Hans-Jürgen Tietz
Health (Health) , 2010, DOI: 10.4236/health.2010.26077
Abstract: Therapy of chronic recurrent vulvovaginal can- didiasis (VVC) caused by Candida glabrata is still rare in comparison to C. albicans infection, but therapy remains more difficult. Combination therapy with topical antifungals may improve therapy outcome, but still standard agents as fluconazole or itraconazole often fail. Posaconazole is a new systemic triazole with a wide antifungal spectrum including rare Candida species. Up to now, no clinical trials with posa- conazole in chronic recurrent VVC have been undertaken. Here, first results of the application of a new therapy regimen consisting of oral posaconazole in combination with topical ciclopiroxolamine are presented. 15 patients with chronic recurrent VVC caused by C. glabrata have been treated. 14 of these patients experienced successful therapy, clinical and mycological cure 30 days after begin of therapy has been observed. Long-term results are promising, as in 4 patients clinical and mycologic cure persists for more than 1 year up to now.
Raltegravir in the management of HIV-infected patients
Hans-Jürgen Stellbrink
Drug Design, Development and Therapy , 2008, DOI: http://dx.doi.org/10.2147/DDDT.S3337
Abstract: ltegravir in the management of HIV-infected patients Review (5518) Total Article Views Authors: Hans-Jürgen Stellbrink Published Date December 2008 Volume 2008:2 Pages 281 - 288 DOI: http://dx.doi.org/10.2147/DDDT.S3337 Hans-Jürgen Stellbrink ICH and IPM Study Center Hamburg, Hamburg, Germany Abstract: Raltegravir has recently been licensed for the treatment of HIV-1 infection. Currently its use is limited to treatment-experienced patients and subjects with resistant virus. In addition to its activity in the setting of resistance and treatment failure, it appears to have great potential for first-line therapy and as a switch option for subjects with intolerance to other agents, as well. Overall tolerability in clinical trials was excellent, and the toxicity profile is non-overlapping with other agents, with no clear neuropsychiatric, gastrointestinal, or metabolic toxicity. Its metabolization occurs mainly via UGT1A1 rather than by the CYP450 system, resulting in a relatively unproblematic drug interaction profile. The independence of the compound from “boosting” of drug levels with ritonavir is an attractive feature for many patients suffering from ritonavir-associated side effects. However, it has to be dosed twice daily. The unique effect of raltegravir on the establishment of viral latency makes it a logical component of treatment attempts aiming at reducing and controlling this viral sanctuary. This review summarizes the clinical view on the role of this novel compound in HIV therapy.
Etravirine (TMC-125): The evidence for its place in the treatment of HIV-1 infection
Hans-Jürgen Stellbrink
Core Evidence , 2009, DOI: http://dx.doi.org/10.2147/CE.S6009
Abstract: ravirine (TMC-125): The evidence for its place in the treatment of HIV-1 infection Review (3930) Total Article Views Authors: Hans-Jürgen Stellbrink Published Date July 2009 Volume 2009:4 Pages 149 - 158 DOI: http://dx.doi.org/10.2147/CE.S6009 Hans-Jürgen Stellbrink Infektionsmedizinisches Centrum Hamburg (iCH), Hamburg, Germany Introduction: Etravirine is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) specifically designed to suppress the replication of viruses resistant to the three currently approved NNRTIs efavirenz, nevirapine, and delavirdine. Aims: To assess the evidence for the place of etravirine in the treatment of HIV-1 infection. Evidence review: In combination with a ritonavir-boosted protease inhibitor etravirine has demonstrated high antiviral activity against strains exhibiting up to three NNRTI resistance mutations. The drug appears to be well tolerated, with only nausea and rash occuring significantly more frequently with etravirine compared with placebo. Of note, neuropsychologic side effects that frequently limit the use of efavirenz were not reported more frequently with etravirine. Place in therapy: Given its high activity against most NNRTI-resistant strains and its very good tolerability, etravirine is of high value for pretreated patients with NNRTI resistance and protease inhibitor exposure. Efforts should be made to demonstrate activity in switching strategies (due to toxicity) and earlier lines of failure or in the setting of primary NNRTI resistance in order to explore the potential of the drug beyond salvage therapy.
Zur Zukunftsf higkeit der (qualitativen) Psychologie The Future Prospects for (Qualitative) Psychology Perspectivas futuras de la psicología (cualitativa)
Hans-Jürgen Seel
Forum : Qualitative Social Research , 2000,
Abstract: Versucht man, die Zukunftschancen für die Psychologie zehn Jahre nach Gründung der "Neuen Gesellschaft für Psychologie (NGfP)" einzusch tzen, so haben wir einen st ndig wachsenden Bedarf an professioneller psychologischen Dienstleistungen zu konstatieren. Solche Dienstleistungen werden jedoch nicht automatisch von PsychologInnen nachgefragt werden. Der gegenw rtige Zustand der psychologischen Wissenschaft in Deutschland als eine nomothetische Wissenschaft stellt keine optimale Grundlage für die Ausbildung professioneller BeraterInnen z.B. im psychosozialen und im Management – Bereich dar, weil praktisch arbeitende PsychologInnen meistens mit Einzelf llen zu tun haben, was wesentlich eine qualitative Arbeitsweise erfordert. Deshalb wird die Zukunft der Psychologie nicht zuletzt von der Elaboration qualitativer methodologischer Konzepte innerhalb einer pluralistischen psychologischen Wissenschaft abh ngen. Vorbedingung für eine Sicherung der Identit t des Fachs ist die Etablierung eines wissenschaftlichen Meta-Diskurses, der unterschiedliche methodologische Zugangsweisen zum wissenschaftlichen Objekt akzeptiert. Ein solcher sich der Alltagssprache bedienender Diskurs wird Protopsychologie genannt. Protopsychologie muss sich auseinandersetzen mit der Zuordnung unterschiedlicher methodologischer Zugangsweisen zu speziellen Typen von Situationen gesellschaftlicher Praxis in einer pluralistischen Gesellschaft und dabei die Nützlichkeit wissenschaftlichen psychologischen Wissens nachweisen. Auf der Grundlage dieser Argumentation muss ebenfalls die Struktur der wissenschaftlichen Produktion überdacht werden, weil in der Zukunft psychologisches Wissen mehr in praktisch-psychologischer T tigkeit als in wissenschaftlichen Labors geschaffen werden muss; anderenfalls kann es nicht übertragen werden auf die Arbeitssituation praktisch t tiger PsychologInnen und keine Grundlage abgeben für eine Beteiligung von PsychologInnen an gesellschaftskritischen Diskursen. URN: urn:nbn:de:0114-fqs0002240 If we attempt to assess the future prospects for psychology ten years after the founding of the "Neue Gesellschaft für Psychologie" (NGfP), we find a steadily increasing demand for professional psychological services. However, such services will not automatically be sought from psychologists. The current state of psychology in Germany as a nomothetic science is not an ideal basis for the training of professional counsellors in the psychosocial and management fields for example, since practising psychologists mostly handle individual cases, which essentially calls for a qualitative
Heterogeneity: multilingualism and democracy
Hans-Jürgen Krumm
Utbildning & Demokrati : Tidsskrift f?r Didaktik och Utbildningspolitik , 2004,
Abstract: Linguistic diversity and multilingualism on the part of individuals are aprerequisite and a constitutive condition of enabling people to live togetherin a world of growing heterogeneity. Foreign language teaching plays animportant part in democratic education because it can be seen as a trainingin respecting otherness and developing an intercultural, non-ethnocentricperception and attitude. This is all the more important because of the neces-sity of integrating children from migrant families into school life.My article argues that language education policy has to take this per-spective into account, i.e., of establishing a planned diversification so thatpupils (and their parents) will not feel satisfied with learning English only,but also become motivated to learn languages of their own neighbourhood,such as migrant and minority languages. However, in order to make use ofthe linguistic resources in the classroom, relating it to the democratic impetusof foreign language education, it is necessary to revise existing languagepolicies and to develop a multilingual perspective for all educational institutions.
Editor's Note
Hans-Jürgen Grabbe
American Studies Journal , 2007,
Abstract: In September of 1960, English teachers in the state (Land) of Baden-Württemberg received a small publication consisting of some 20 mimeographed and stapled pages that contained news and articles about the United States of America. It was entitled American Newsletter and was distributed four times a year by the Cultural Affairs Unit of the United States Information Service (USIS) in Stuttgart.
GOOD GOVERNANCE AND TRANSFORMATION
Hans-Jürgen WAGENER
Revista Romana de Economie , 2005,
Abstract: Transformation of a totalitarian, basically administratively coordinated system into a democratic one that is coordinated predominantly by markets and competition has been triggered by, among others, the perception of a serious deficit in welfare and happiness. Public policy has a special task transforming the economic order by liberalisation, privatisation, stabilisation and the installation of institutions that are supportive for competition. After 15 years since transformation began, there are sufficiently differentiated success stories to test the hypothesis: it was good governance that is responsible for success and bad governance for failure. The empirical results support the “Lorenzetti hypothesis”: where freedom, security and trust prevail, the economy flourishes, where they are lacking, the costs of long-term investment are too high. The initial conditions of transition countries seem to be quite similar, nevertheless, even there one can discern good and bad governance. The extent of socialist lawfulness, planning security, cronyism and corruption differed widely between East Berlin and Tashkent. And a good deal of such variations can be found in the pre-socialist history of these countries. However, the main conclusion is that the co-evolution hypothesis states that both, welfare and good governance, go together.
Professionalization of Counseling – Questions and Theses
Hans-Jürgen Seel
Journal für Psychologie , 2009,
Abstract: The importance of counseling as a central kind of communication in the reflective modern society is increasing, some indications of an advanced professionalization can be identified, but some problems and lacks can be seen, too, which make further professionalization difficult. After an overview over the status of professionalization the as problematic estimated emerging fragmentation in different counseling professions and the problem of generating knowledge in and for counseling are mentioned and ideas of solving the problems are outlined.
Editorial
Hans-Jürgen Seel
Journal für Psychologie , 2009,
Abstract:
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