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Search Results: 1 - 10 of 8380 matches for " Hans Petter Eikesdal "
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Endogenous Matrix-Derived Inhibitors of Angiogenesis
Malin Sund,Pia Nyberg,Hans Petter Eikesdal
Pharmaceuticals , 2010, DOI: 10.3390/ph3103021
Abstract: Endogenous inhibitors of angiogenesis are proteins or fragments of proteins that are formed in the body, which can inhibit the angiogenic process. These molecules can be found both in the circulation and sequestered in the extracellular matrix (ECM) surrounding cells. Many matrix-derived inhibitors of angiogenesis, such as endostatin, tumstatin, canstatin and arresten, are bioactive fragments of larger ECM molecules. These substances become released upon proteolysis of the ECM and the vascular basement membrane (VBM) by enzymes of the tumor microenvironment. Although the role of matrix-derived angiogenesis inhibitors is well studied in animal models of cancer, their role in human cancers is less established. In this review we discuss the current knowledge about these molecules and their potential use as cancer therapeutics and biomarkers.
Clinical Sociology and Moral Hegemony  [PDF]
Hans Petter Sand
Advances in Applied Sociology (AASoci) , 2013, DOI: 10.4236/aasoci.2013.37034
Abstract: The article presents a critique of a dominant way of analysing gang conflict in Norwegian sociology. The research in question uses a rather crude Marxist analysis that could somehow fit any gang conflict in the country. However, this kind of analysis was gradually put in question first by professor Ottar Brox and his criticism of the moral hegemony by a group of Marxists gathered around the publication “Klassekampen” (“Class Struggle”). Then the analysis was challenged by gang-researchers who reached back to the classical study of Frederic M. Thrasher, finding the latter more fruitful for analysis. Antonio Gramsci (1891- 1937) who coined the term cultural hegemony used it to describe how a social class can manipulate the system of values in a society to establish a ruling class world-view. In my context the term moral hegemony is used to show how an intellectual group came to dominate the discourse on relations between Norwegians and immigrants, labelling other views as “racist”.
Applied Social Anthropology in the Researcher’s Own Society  [PDF]
Hans Petter Sand
Advances in Applied Sociology (AASoci) , 2014, DOI: 10.4236/aasoci.2014.42009

Professor Arne Martin Klausen (1927-) is the only social anthropologist in Norway who has tried to analyse the culture of the country as a whole. In doing this, he has explored several central themes of the country’s culture; like egalitarianism, the class journey, the strong tradition for development aid to poor countries, connected to a so-called humanitarian super-power which in its turn was an extension of Christian mission, the very wide-spread newspaper reading; however self-centered to national and local issues and finally, the collision between an elitist Olympic culture with Norwegian egalitarianism. Klausen also tried to tie some threads together in editing a collection of essays on Norwegian culture.

Norwegian Sociology and the Recognition of the Saami Minority  [PDF]
Hans Petter Sand
Advances in Applied Sociology (AASoci) , 2014, DOI: 10.4236/aasoci.2014.45017

At a time when the Saami ethnic minority got little attention by the Norwegian public and the political authorities of the country, sociologists did much to raise public awareness about the conditions of this ethnic minority. In the postwar period of the 1950s and 1960s, sociologists of Norway focused to a large degree on social groups that fell outside the emerging welfare state. Norwegian sociology has been characterized by an approach named “problem-oriented empirism” and also by sociologists playing a vital role as public intellectuals. Sociology professor Vilhelm Aubert (1922- 88) coined the term “problem-oriented empirism” to characterize Norwegian sociology from the end of the Second World War to around 1975. Empirism refers to the importance of sociology being close to social reality. Problem-orientation refers to the importance of choosing research questions that are not only scientifically interesting, but also relevant to society. Vilhelm Aubert was also a leading figure among sociologists playing the role of public intellectuals in this period. Problem-oriented empirism and sociologists as public intellectuals have in particular been the case with regard to Saami research.

L’enseignement du fran ais en Norvège
Hans Petter Helland
Synergies Pays Scandinaves , 2011,
Abstract: La situation des langues étrangères dans le système éducatif en Norvège montre que le fran ais maintient sa position comme quatrième langue étrangère, bien devancée par l’allemand, l’espagnol et l’anglais. Il y a un manque général d’enseignants du fran ais au niveau national, ce qui a pour résultat qu’on ne peut pas proposer le fran ais comme matière à option dans tous les départements du pays. Il y a également un manque de compétences en langues étrangères, notamment en fran ais, dans la vie des entreprises et dans la vie des finances. En même temps, on constate une perte d’étudiants au niveau universitaire, ce qui entra ne une réduction des ressources pour l’enseignement. Il faudra ainsi renforcer le statut du fran ais comme langue étrangère à la fois au niveau du système scolaire et au niveau universitaire.
Prevention of White-Collar Crime by Knowledge and Learning in Business Organizations: An Empirical Study of Chief Financial Officer Management
Petter Gottschalk,Hans Solli-Soether
International Journal of Management, Knowledge and Learning , 2012,
Abstract: Knowledge and learning are important in combating financial crime generallyand white-collar crime in particular. The purpose of this research is to generateinsights into prevention approaches in practice that may reflect on acontingent approach. The five hundred largest business companies in termsof annual turnover were identified in Norway for our empirical study of whitecollarcrime. A paper letter was mailed to the chief financial officer (CFO)asking him or her to fill in the questionnaire to be found on a web site usinga password found in the letter. The open-ended question in the questionnaireto CFOs about prevention of white-collar crime was formulated as follows:How can white-collar crime best be prevented in your company? Survey resultsindicate an even distribution of respondents emphasizing control and respondentsemphasizing influence. This empirical research steps back from manybest practice articles and provides insights into preferences of chief financialofficers on how to prevent white-collar crime in the company.
Differences in Stage of Integration between Business Planning and Information Systems Planning according to Value Configurations
Petter Gottschalk,Hans Solli-S?ther
Informing Science The International Journal of an Emerging Transdiscipline , 2001,
Abstract: Integration between business planning and information systems (IS) planning is considered an important enabler of business - IS alignment. A con-tent analysis of IS plans was conducted to identify stages of integration between business and IS planning. The companies studied were also classified according to value configurations and eras of IS growth. Empirical results indicate that companies classified as value networks are at a higher stage of integration than value shops and chains probably because they are in the network era rather than the data processing or information technology eras.
Er prenatale eller postnatale forhold viktigst for voksen helse? Eksemplet forh yet blodtrykk
Hans Magne Gravseth,Petter Kristensen,Rannveig Nordhagen
Norsk Epidemiologi , 2009,
Abstract: Artikkelen tar utgangspunkt i to forskjellige forklaringsmodeller for voksen sykdom: programmering og livsl pstiln rming. Programmering inneb rer en p virkning i en tidlig kritisk fase som resulterer i en varig skade, mens en livsl pstiln rming er studien av langsiktige effekter av p virkninger gjennom alle livsfaser. Disse to m tene forklare voksen sykdom p blir demonstrert ved bruke eksemplet forh yet blodtrykk. Vi oppsummerer funn i nyere studier som belyser hvordan determinanter i ulike livsfaser, s rlig i de f rste leve r, kan p virke senere blodtrykk. Man finner gjennomg ende en svak invers sammenheng mellom f dselsvekt og senere blodtrykk, og det er vist en svak gunstig effekt p blodtrykket av bli brystern rt. Tidlig innhentingsvekst er hovedsakelig vist ha en uheldig virkning p senere blodtrykk; det kan imidlertid v re fordelaktig i utviklingsland. BMI er sterkt assosiert med blodtrykk hos b de voksne og barn. Enkelte har ogs funnet en interaksjon mellom f dselsvekt og voksen BMI, med sterkest invers sammenheng mellom f dselsvekst og senere blodtrykk hos de med en h y voksen BMI. Siden b de blodtrykk og BMI sporer fra barndom til voksen alder, er tidlig forebygging viktig. Blant voksne er det tendens til en sosial gradient i blodtrykket, i hovedsak mediert gjennom tradisjonelle risikofaktorer. Ensidig fokusering p s vel programmering som p voksenlivets risikofaktorer har ofte begrenset forklaringsverdi. I en livsl pstiln rming, som har kommet som en respons p dette, tar man hensyn til b de programmering, livsstilsfaktorer og sosiale forhold. The paper describes two different explanation models for adult disease: programming and the life course approach. In programming, there is a stimulus or insult at an early critical period of development that has lasting significance, whereas a life course approach is the study of long-term effects of exposures during all stages of life. These two ways of explaining adult disease are demonstrated by using elevated blood pressure as an example. We summarize findings in newer studies on how determinants in different stages of life, especially during the earliest years, may influence later blood pressure. In general, a weak inverse association between birth weight and later blood pressure is found. Breast-feeding is shown to have a weak favourable effect on blood pressure. Early catch-up growth is generally seen having an adverse effect on later blood pressure; it could have some benefits in developing countries, however. BMI is at all ages strongly associated with blood pressure. An interaction
Evidence of Two Distinct Dynamic Critical Exponents in Connection with Vortex Physics
Petter Minnhagen,Beom Jun Kim,Hans Weber
Physics , 2001, DOI: 10.1103/PhysRevLett.87.037002
Abstract: The dynamic critical exponent $z$ is determined from numerical simulations for the three-dimensional (3D) lattice Coulomb gas (LCG) and the 3D XY models with relaxational dynamics. It is suggested that the dynamics is characterized by two distinct dynamic critical indices $z_0$ and $z$ related to the divergence of the relaxation time $\tau$ by $\tau\propto \xi^{z_0}$ and $\tau\propto k^{-z}$, where $\xi$ is the correlation length and $k$ the wavevector. The values determined are $z_0\approx 1.5$ and $z\approx 1$ for the 3D LCG and $z_0\approx 1.5$ and $z\approx 2$ for the 3D XY model. It is argued that the nonlinear $IV$ exponent relates to $z_0$, whereas the usual Hohenberg-Halperin classification relates to $z$. Possible implications for the interpretation of experiments are pointed out. Comparisons with other existing results are discussed.
Clinical Efficacy and Safety of Bevacizumab Monotherapy in Patients with Metastatic Melanoma: Predictive Importance of Induced Early Hypertension
Cornelia Schuster, Hans P. Eikesdal, Hanne Puntervoll, Jürgen Geisler, Stephanie Geisler, Daniel Heinrich, Anders Molven, Per E. L?nning, Lars A. Akslen, Oddbj?rn Straume
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038364
Abstract: Background VEGF driven angiogenesis plays a key role in cancer progression. We determined the clinical efficacy of bevacizumab monotherapy in patients with metastatic melanoma. Methods and Findings Thirty-five patients with metastatic melanoma in progression were enrolled in this phase II, single arm clinical trial. Each patient received bevacizumab monotherapy 10 mg/kg q14 d until intolerable toxicity or disease progression occurred. Clinical efficacy was evaluated as objective response, disease control (DC), and survival. We observed one complete (3%) and 5 partial (14%) responses. In addition, 5 patients experienced stable disease >6 months (14%) while 24 patients had progressive disease (PD, 69%), corresponding to a total DC at 6 months in 11 out of 35 patients (31%). Median progression free survival (PFS) was 2.14 months and median overall survival (OS) was 9 months (1.12–49). Seven of the 11 patients experiencing DC developed early hypertension (<2 months) compared to 3/24 of patients with PD (P = 0.001), and hypertension was associated with PFS (P = 0.005) and OS (P = 0.013). Conclusion Bevacizumab monotherapy demonstrated promising clinical efficacy in patients with metastatic melanoma with disease control in 31% of the patients. Induced early hypertension was a marker for clinical efficacy of bevacizumab. Trial Registration ClinicalTrials.gov NCT00139360.
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