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Search Results: 1 - 10 of 175809 matches for " Hans E. Fj?sne "
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Feasibility of MR Metabolomics for Immediate Analysis of Resection Margins during Breast Cancer Surgery
Tone F. Bathen, Brigitte Geurts, Beathe Sitter, Hans E. Fjsne, Steinar Lundgren, Lutgarde M. Buydens, Ingrid S. Gribbestad, Geert Postma, Guro F. Giske?deg?rd
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061578
Abstract: In this study, the feasibility of high resolution magic angle spinning (HR MAS) magnetic resonance spectroscopy (MRS) of small tissue biopsies to distinguish between tumor and non-involved adjacent tissue was investigated. With the current methods, delineation of the tumor borders during breast cancer surgery is a challenging task for the surgeon, and a significant number of re-surgeries occur. We analyzed 328 tissue samples from 228 breast cancer patients using HR MAS MRS. Partial least squares discriminant analysis (PLS-DA) was applied to discriminate between tumor and non-involved adjacent tissue. Using proper double cross validation, high sensitivity and specificity of 91% and 93%, respectively was achieved. Analysis of the loading profiles from both principal component analysis (PCA) and PLS-DA showed the choline-containing metabolites as main biomarkers for tumor content, with phosphocholine being especially high in tumor tissue. Other indicative metabolites include glycine, taurine and glucose. We conclude that metabolic profiling by HR MAS MRS may be a potential method for on-line analysis of resection margins during breast cancer surgery to reduce the number of re-surgeries and risk of local recurrence.
Predictive and Prognostic Impact of TP53 Mutations and MDM2 Promoter Genotype in Primary Breast Cancer Patients Treated with Epirubicin or Paclitaxel
Ranjan Chrisanthar,Stian Knappskog,Erik L?kkevik,Gun Anker,Bj?rn ?stenstad,Steinar Lundgren,Terje Risberg,Ingvil Mjaaland,Gudbrand Skj?nsberg,Turid Aas,Ellen Schlichting,Hans E. Fjsne,Arne Nysted,Johan Richard Lillehaug,Per Eystein L?nning
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019249
Abstract: TP53 mutations have been associated with resistance to anthracyclines but not to taxanes in breast cancer patients. The MDM2 promoter single nucleotide polymorphism (SNP) T309G increases MDM2 activity and may reduce wild-type p53 protein activity. Here, we explored the predictive and prognostic value of TP53 and CHEK2 mutation status together with MDM2 SNP309 genotype in stage III breast cancer patients receiving paclitaxel or epirubicin monotherapy.
Effect of α+-thalassaemia on episodes of fever due to malaria and other causes: a community-based cohort study in Tanzania
Jacobien Veenemans, Esther JS Jansen, Amrish Y Baidjoe, Erasto V Mbugi, Ay?e Y Demir, Rob J Kraaijenhagen, Huub FJ Savelkoul, Hans Verhoef
Malaria Journal , 2011, DOI: 10.1186/1475-2875-10-280
Abstract: In Tanzania, in children aged 6-60 months and height-for-age z-score < -1.5 SD (n = 612), rates of fevers due to malaria and other causes were compared between those with heterozygous or homozygotes α+-thalassaemia and those with a normal genotype, using Cox regression models that accounted for multiple events per child.The overall incidence of malaria was 3.0/child-year (1, 572/526 child-years); no differences were found in malaria rates between genotypes (hazard ratios, 95% CI: 0.93, 0.82-1.06 and 0.91, 0.73-1.14 for heterozygotes and homozygotes respectively, adjusted for baseline factors that were predictive for outcome). However, this association strongly depended on age: among children aged 6-17 months, those with α+-thalassaemia experienced episodes more frequently than those with a normal genotype (1.30, 1.02-1.65 and 1.15, 0.80-1.65 for heterozygotes and homozygotes respectively), whereas among their peers aged 18-60 months, α+-thalassaemia protected against malaria (0.80, 0.68-0.95 and 0.78, 0.60-1.03; p-value for interaction 0.001 and 0.10 for hetero- and homozygotes respectively). No effect was observed on non-malarial febrile episodes.In this population, the association between α+-thalassaemia and malaria depends on age. Our data suggest that protection by α+-thalassaemia is conferred by more efficient acquisition of malaria-specific immunity.Alpha+-thalassaemia is a common genetic trait in malaria-endemic areas in sub-Saharan Africa, Asia and Melanesia, and may protect against the decline in haemoglobin concentration that is associated with asymptomatic Plasmodium infection [1].Case-control studies [2-4] and two cohort studies [5,6] have consistently shown that α+-thalassaemia is associated with reduced risks of severe malaria. Reports on its effect on uncomplicated malaria are inconsistent. A study in Vanuatu showed that, among children aged < 5 years, homozygous (but not heterozygous) α+-thalassaemia was associated with an increased incidence of unco
Spectral entropy and haemodynamic response to surgery during sevoflurane anaesthesia
FJ Smith, E Dannhauser
Southern African Journal of Anaesthesia and Analgesia , 2006,
Abstract:
Searching and oviposition behavior of aphidophagous hoverflies (Diptera: Syrphidae): a review
Raki A.,Verheggen FJ.,Haubruge E.
Biotechnologie, Agronomie, Société et Environnement , 2009,
Abstract: Aphidophagous hoverflies forage according two different host-finding mechanisms: they forage for suitable food sources (for their energy-expensive hovering flight, and for protein to mature their reproductive system), and for suitable oviposition sites. Syrphids are highly mobile, enabling them to lay eggs over large areas, and to locate aphid colonies earlier in the season than other aphidophaga. The result is that most syrphid eggs tend to be laid close to aphid colonies. The choice of oviposition sites may be crucial for offspring performance because the neonate larvae have limited dispersal ability. Selection of aphid patches should therefore reflect nutritional value, risk of predation and competition pressure. Several factors are known to affect the choice of oviposition site: habitat, host plant, aphid species, aphid availability, semiochemicals, the presence of intra- or interspecific competitors and female age. We review here the available information on these factors in order to understand the mechanisms of decision-making by syrphid females during their egg-laying behavior, a crucial aspect of their effective use in strategies of the biological control of aphids.
Biosensors in forensic sciences
Frederickx, C.,Verheggen, FJ.,Haubruge, E.
Biotechnologie, Agronomie, Société et Environnement , 2011,
Abstract: A biosensor is a device that uses biological materials to detect and monitor the presence of specific chemicals in an area. Traditional methods of volatile detection used by law enforcement agencies and rescue teams typically consist of reliance on canine olfaction. This concept of using dogs to detect specific substances is quite old. However, dogs have some limitations such as cost of training and time of conditioning. Thus, the possibility of using other organisms as biosensors including rats, dolphins, honeybees, and parasitic wasps for detecting explosives, narcotics and cadavers has been developed. Insects have several advantages unshared by mammals. Insects are sensitive, cheap to produce and can be conditioned with impressive speed for a specific chemical-detection task. Moreover, insects might be a preferred sensing method in scenarios that are deemed too dangerous to use mammals. The purpose of this review is to provide an overview of the biosensors used in forensic sciences.
Die Radiusfraktur als unerkannte Erstmanifestation der Osteoporose
Seibert FJ,Giessau C,Sagmeister-Skrabal E,Sampl E
Journal für Mineralstoffwechsel , 2012,
Abstract: Die Radiusfraktur loco typico ist die h ufigste Fraktur, welche einer unfallchirurgischen Betreuung bedarf. Die Osteoporose des lteren Patienten mit der Zunahme der lteren Bev lkerungsgruppe wird in Zukunft die osteoporoseinduzierten Frakturen (Wirbels ule, Becken, Oberarm usw.) an Zahl deutlich ansteigen lassen und die medizinischen und pflegerischen Kosten erheblich steigern. Da der zweite Altersgipfel der Speichenfrakturen bei etwa 50 Jahren und somit deutlich vor Frakturen anderer Regionen zu finden ist, liegt es auf der Hand, Patienten mit Radiusfraktur nach Low-Energy-Trauma verd chtig auf Fragility Fracture frühzeitig einer Abkl rung und wenn n tig Therapie eines gest rten Mineralstoffwechsels zuzuführen. Die Bedeutung eines Fracture- Liaison-Dienstes wird ebenso diskutiert. Das Bewusstsein gegenüber m glicher Osteoporose und die Einleitung zu einem Sturzpr ventionstraining k nnten der Schlüssel zu einer m glichen Senkung der unfallchirurgischen Kosten in der Zukunft sein.
Reduced Dicer expression in the cord blood of infants admitted with severe respiratory syncytial virus disease
Christopher S Inchley, Tonje Sonerud, Hans O Fj?rli, Britt Nakstad
BMC Infectious Diseases , 2011, DOI: 10.1186/1471-2334-11-59
Abstract: The cord blood of 2108 newborns was collected. 51 had a positive nasopharyngeal aspirate for RSV <1 year, and were grouped according to disease severity. 37 had sufficient cord blood RNA of good quality. Dicer gene expression was assessed by qPCR analysis of cord blood using a TaqMan low-density array and compared to control infants who did not present with RSV disease using the Mann-Whitney test.There was significant downregulation of Dicer in the severe disease group: relative quantity 0.69 (95% CI: 0.56 - 0.87), p = 0.002. There was no significant downregulation in the mild disease group.We demonstrate reduced Dicer expression in the cord blood of infants with severe RSV disease, prior to RSV exposure. We theorize that this may predispose to RSV disease by disruption of leukocyte gene regulation or direct anti-viral RNA interference mechanisms.Bronchiolitis and other lower respiratory tract diseases are amongst the most common causes of pediatric admissions [1,2]. In epidemiological studies the most important pathogen causing bronchiolitis has consistently been respiratory syncytial virus (RSV) [1,3-7]. The yearly epidemics of RSV lead to a significant increase in admissions to pediatric wards across the globe during the winter and spring months. Infantile RSV bronchiolitis is associated with later development of asthma in childhood [8], and is therefore a major cause of ongoing disease burden to patients and significant health costs to society [5].69% of US children are infected with RSV in the first year of life, and almost all by the age of two years [6]. The majority are asymptomatic or have only mild symptoms. International studies estimate the annual incidence of RSV bronchiolitis requiring hospital admission to 22 - 31/1000 amongst infants < 1 year [2,6,9,10].Why so few children exposed to RSV should develop symptoms requiring hospital admission is yet to be adequately explained, although research has provided important clues in the last 10 years. Some gen
Mechanical ventilation in the ICU- is there a gap between the time available and time used for nurse-led weaning?
Britt Hansen, Wenche Fj?lberg, Odd Nilsen, Hans Lossius, Eldar S?reide
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2008, DOI: 10.1186/1757-7241-16-17
Abstract: This retrospective study was performed in a 12-bed general ICU at a university hospital. Weaning data were collected from 68 adult patients on MV and recorded in terms of ventilator-shifts. One ventilator-shift was defined as an 8-hour nursing shift for one MV patient.Of the 2000 ventilator-shifts analysed, 572 ventilator-shifts were available for weaning. We found that only 46% of the ventilator shifts available for weaning were actually used for weaning. While physician prescription of weaning was associated with increased weaning activity (p < 0.001), a large amount (22%) of weaning took place without physician prescription. Both increased nursing workload and night shifts were associated with reduced weaning activity. During the study period there was a significant increase in performed weaning, both when prescribed or not (p < 0.001).Our study identified a significant gap between the time available and time actually used for weaning. While various patient and systemic factors were linked to weaning activity, the most important factor in our study was whether the intensive care nurses made use of the time available for weaning.Mechanical ventilation (MV) is a key component in the care of critically ill and injured patients. Almost half the time patients spend on mechanical ventilation is devoted to weaning [1]. Delays in weaning the patient from MV increase the number of complications and may lead to increased expenditure [2]. Consequently, weaning constitutes a major challenge for the intensive care staff. It is important to wean the patient from MV as expeditiously as possible. Several studies [3-6] indicate that the implementation of nurse-led, protocol-directed weaning reduces the amount of time spent on MV, the length of ICU stay, and associated costs.The introduction of nurse-led weaning under a protocol constitutes a systematic approach to weaning with less freedom for the individual clinician to decide if and how weaning should be performed [1,7]. This a
Heat transport between antiferromagnetic insulators and normal metals
Arne Brataas,Hans Skarsv?g,Erlend G. Tveten,Eirik L?haugen Fj?rbu
Physics , 2015, DOI: 10.1103/PhysRevB.92.180414
Abstract: Antiferromagnetic insulators can become active spintronics components by controlling and detecting their dynamics via spin currents in adjacent metals. This cross-talk occurs via spin-transfer and spin-pumping, phenomena that have been predicted to be as strong in antiferromagnets as in ferromagnets. Here, we demonstrate that a temperature gradient drives a significant heat flow from magnons in antiferromagnetic insulators to electrons in adjacent normal metals. The same coefficients as in the spin-transfer and spin-pumping processes also determine the thermal conductance. However, in contrast to ferromagnets, the heat is not transferred via a spin Seebeck effect which is absent in antiferromagnetic insulator-normal metal systems. Instead, the heat is transferred via a large staggered spin Seebeck effect.
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