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Search Results: 1 - 10 of 620 matches for " Hannes Pichler "
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Photonic Quantum Circuits with Time Delays
Hannes Pichler,Peter Zoller
Physics , 2015,
Abstract: We study the dynamics of photonic quantum circuits consisting of nodes coupled by quantum channels. We are interested in the regime where time delay in communication between the nodes is significant. This includes the problem of quantum feedback, where a quantum signal is fed back on a system with a time delay. We develop a matrix product state approach to solve the Quantum Stochastic Schr\"odinger Equation with time delays, which accounts in an efficient way for the entanglement of nodes with the stream of emitted photons in the waveguide, and thus the non-Markovian character of the dynamics. We illustrate this approach with two paradigmatic quantum optical examples: two coherently driven distant atoms coupled to a photonic waveguide with a time delay, and a driven atom coupled to its own output field with a time delay as an instance of a quantum feedback problem.
Heating dynamics of bosonic atoms in a noisy optical lattice
Hannes Pichler,Johannes Schachenmayer,Andrew J. Daley,Peter Zoller
Physics , 2013, DOI: 10.1103/PhysRevA.87.033606
Abstract: We analyze the heating of interacting bosonic atoms in an optical lattice due to intensity fluctuations of the lasers forming the lattice. We focus in particular on fluctuations at low frequencies below the band gap frequency, such that the dynamics is restricted to the lowest band. We derive stochastic equations of motion, and analyze the effects on different many-body states, characterizing heating processes in both strongly and weakly interacting regimes. In the limit where the noise spectrum is flat at low frequencies, we can derive an effective Master equation describing the dynamics. We compute heating rates and changes to characteristic correlation functions both in the perturbation theory limit, and using a full time-dependent calculation of the stochastic many-body dynamics in 1D based on time-dependent density-matrix-renormalization-group methods.
Quantum Spin Dimers from Chiral Dissipation in Cold-Atom Chains
Tomás Ramos,Hannes Pichler,Andrew J. Daley,Peter Zoller
Physics , 2014, DOI: 10.1103/PhysRevLett.113.237203
Abstract: We consider the non-equilibrium dynamics of a driven dissipative spin chain with chiral coupling to a 1D bosonic bath, and its atomic implementation with a two-species mixture of cold quantum gases. The reservoir is represented by a spin-orbit coupled 1D quasi-condensate of atoms in a magnetized phase, while the spins are identified with motional states of a separate species of atoms in an optical lattice. The chirality of reservoir excitations allows the spins to couple differently to left and right moving modes, which in our atomic setup can be tuned from bidirectional to purely unidirectional. Remarkably, this leads to a pure steady state in which pairs of neighboring spins form dimers that decouple from the remainder of the chain. Our results also apply to current experiments with two-level emitters coupled to photonic waveguides.
An entropy perspective on the thermal crossover in a fermionic Hubbard chain
Lars Bonnes,Hannes Pichler,Andreas M. L?uchli
Physics , 2013, DOI: 10.1103/PhysRevB.88.155103
Abstract: We study the Renyi entropy in the finite temperature crossover regime of a Hubbard chain using quantum Monte Carlo. The ground state entropy has characteristic features such as a logarithmic divergence with block size and $2\kF$ oscillations that are a hallmark of its Luttinger liquid nature. The interplay between the (extensive) thermal entropy and the ground state features is studied and we analyze the temperature induced decay of the amplitude of the oscillations as well as the scaling of the purity. Furthermore, we show how the spin and charge velocities can be extracted from the temperature dependence of the Renyi entropy, bridging our findings to recent experimental proposals on how to implement the measurement of Renyi entropies in cold atom system. Studying the Renyi mutual information, we also demonstrate how constraints such as particle number conservation can induce persistent correlations visible in the mutual information even at high temperature.
Dressed, noise- or disorder- resilient optical lattices
Hannes Pichler,Johannes Schachenmayer,Jonathan Simon,Peter Zoller,Andrew J. Daley
Physics , 2012, DOI: 10.1103/PhysRevA.86.051605
Abstract: External noise is inherent in any quantum system, and can have especially strong effects for systems exhibiting sensitive many-body phenomena. We show how a dressed lattice scheme can provide control over certain types of noise for atomic quantum gases in the lowest band of an optical lattice, removing the effects of lattice amplitude noise to first order for particular choices of the dressing field parameters. We investigate the non-equilibrium many-body dynamics for bosons and fermions induced by noise away from this parameter regime, and also show how the same technique can be used to reduce spatial disorder in projected lattice potentials.
Thermal vs. Entanglement Entropy: A Measurement Protocol for Fermionic Atoms with a Quantum Gas Microscope
Hannes Pichler,Lars Bonnes,Andrew J. Daley,Andreas M. L?uchli,Peter Zoller
Physics , 2013, DOI: 10.1088/1367-2630/15/6/063003
Abstract: We show how to measure the order-two Renyi entropy of many-body states of spinful fermionic atoms in an optical lattice in equilibrium and non-equilibrium situations. The proposed scheme relies on the possibility to produce and couple two copies of the state under investigation, and to measure the occupation number in a site- and spin-resolved manner, e.g. with a quantum gas microscope. Such a protocol opens the possibility to measure entanglement and test a number of theoretical predictions, such as area laws and their corrections. As an illustration we discuss the interplay between thermal and entanglement entropy for a one dimensional Fermi-Hubbard model at finite temperature, and its possible measurement in an experiment using the present scheme.
Quantum Hall Physics with Cold Atoms in Cylindrical Optical Lattices
Mateusz ??cki,Hannes Pichler,Antoine Sterdyniak,Andreas Lyras,Vassilis E. Lembessis,Omar Al-Dossary,Jan Carl Budich,Peter Zoller
Physics , 2015,
Abstract: We propose and study various realizations of a Hofstadter-Hubbard model on a cylinder geometry with fermionic cold atoms in optical lattices. The cylindrical optical lattice is created by copropagating Laguerre-Gauss beams, i.e.~light beams carrying orbital angular momentum. By strong focusing of the light beams we create a real space optical lattice in the form of rings, which are offset in energy. A second set of Laguerre-Gauss beams then induces a Raman-hopping between these rings, imprinting phases corresponding to a synthetic magnetic field (artificial gauge field). In addition, by rotating the lattice potential, we achieve a slowly varying flux through the hole of the cylinder, which allows us to probe the Hall response of the system as a realization of Laughlin's thought experiment. We study how in the presence of interactions fractional quantum Hall physics could be observed in this setup.
T cell receptor variable β20-1 harbors a nucleotide binding pocket in the CDR2β loop  [PDF]
Stephan Watkins, Werner J. Pichler
Open Journal of Immunology (OJI) , 2013, DOI: 10.4236/oji.2013.33021

Novel aspects of T cells containing TCRVβ20-1 are numerous, ranging from pathogen specific reactivity to specific tissue homing, or possible T cell subsets. Recently, it was demonstrated that TCR itself could become reactive by binding to small molecules free of the pHLA interface. Our work here was to identify a natural ligand binding to an identified pocket on the CDR2β loop of these TCR. Using docking of suspected ligands, we were able to show Guanine and Adenine diand tri-nucleotides readily bind to the identified site. Comparing these with small molecule sites found on other TCR types, we show this interaction is novel. With further molecular dynamic simulations, these sites are shown to be plausible by conducting simple computational based solubility tests as cross validation. Combined with simple proliferative responses, the identified nucleotides are also shown to have functional consequences by inducing T cell proliferation for CD4/Vβ20-1 + T cells, while failing to induce proliferation in other T cell isolates. Merging computational and simple cell assays, this work establishes a role of nucleotides in T cells found to contain this TCR subtype.

Activating interactions of sulfanilamides with T cell receptors  [PDF]
Stephan Watkins, Werner J. Pichler
Open Journal of Immunology (OJI) , 2013, DOI: 10.4236/oji.2013.33019

Activation and expansion of drug reactive T cells are key features in drug hypersensitivity reactions. Drugs may interact directly with immune receptors such as the human leukocyte antigens (HLA) or the T-cell receptors (TCR) itself, the pharmacological interaction [p-i] concept. To analyze whether the drug sulfamethoxazole (SMX) interacts directly with the TCR and thereby contributing to signaling and T cell activation, we analyze two SMX specific T cell clones (TCC “1.3”and “H13”). Proliferation to SMX and 11 related sulfanilamides, Ca++ influx in drug stimulated T-cells and the inhibitory effect of non-reactive sulfanilamides on SMX stimulation were analyzed. In silico docking of SMX and related sulfanilamide to the TCR were used to identify possible drug binding sites, and correlated to in vitro data to find the correct docking. In Ca++ influx assays, reactions occurred as early as 14 sec after adding SMX to TCC and APC. The broadly reactive clone (“H13”) was stimulated by 5 additional sulfanilamide, while one TCC (“1.3”) was reactive exclusively with SMX but not other sulfanilamides. Competition experiments with sulfanilamide inhibited SMX induced Ca++ influx and proliferation of the TCC1.3 ina dose dependent way. Docking experiments with SMX and related sulfanilamides confirmed and explained the in vitro data as docking localized binding sites for SMX and the 5 stimulating sulfanilamides on the CDR2β domain of the clone H13, while the 6 non-stimulatory SA failed to bind. In TCC 1.3, SMX could be docked on the CDR3α of the TCR. The other, non-stimulatory but inhibitory SA could also be docked to the same site. The combined analysis of in vitro and in silico

Book Review: Pye, O. & Bhattacharya, J. (Eds.) (2013). The Palm Oil Controversy in Southeast Asia. A Transnational Perspective.
Melanie Pichler
ASEAS : ?sterreichische Zeitschrift für Südostasienwissenschaften , 2012,
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