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Search Results: 1 - 6 of 6 matches for " Haniffa Rashan "
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Developing a clinically relevant classification to predict mortality in severe leptospirosis
Rajapakse Senaka,Rodrigo Chaturaka,Haniffa Rashan
Journal of Emergencies, Trauma and Shock , 2010,
Abstract: Background : Severe leptospirosis requires critical care and has a high mortality. We reviewed the literature to identify factors predicting mortality, and such predictors were classified according to the predisposition, infection, response, organ dysfunction (PIRO) concept, which is a risk stratification model used in severe sepsis. Material and Methods : PUBMED was searched for all articles (English), with the key word "leptospirosis" in any field, within the last 20 years. Data were collected from 45 relevant papers and grouped into each component of the PIRO model. Results : The following correlated with increased mortality: predisposition - increasing age and chronic alcoholism; infection - leptospiraemic burden; response - hemodynamic disturbances, leukocytosis; organ dysfunction - multiple organ dysfunction syndrome, pulmonary involvement and acute renal failure. Conclusions : Further research is needed to identify the role of infecting serovars, clinical signs, inflammatory markers, cytokines and evidence of hepatic dysfunction as prognostic indicators. It is hoped that this paper will be an initiative to create a staging system for severity of leptospirosis based on the PIRO model with an added component for treatment-related predictors.
Initial Management Of Patients With Community-Acquired Pneumonia In A Tertiary Hospital In Sri Lanka
Rashan Haniffa,Hemal Ariyaratne,Shyam Fernando,Senaka Rajapakse
Sri Lanka Journal of Critical Care , 2009,
Abstract: Introduction: We studied the choice of antibiotic/s prescribed on admission and microbiological investigations, in patients hospitalised with community-acquired pneumonia, and compared such choice with published consensus guidelines.Methods: Adult patients admitted to medical wards of the National Hospital of Sri Lanka with clinical features of pneumonia, with subsequent radiological confirmation, were eligible for inclusion (n=112). Patients who had been in hospital within 10 days of admission, and those with diagnoses of lung malignancy, lung fibrosis, bronchiectasis or tuberculosis were excluded. We obtained data from the patients' case records regarding indicators of severity, the antibiotic prescribed on admission, and route of administration. The microbiological investigations performed were also recorded. We compared the practices with guidelines for management of community-acquired pneumonia published by the British Thoracic Society in 2001.Results: The respiratory rate, a core clinical adverse prognostic feature, was documented in only 13% of case records. Oral amoxicillin was the most common antibiotic prescribed on admission, with 29% of hospitalized patients receiving it. Erythromycin was included in the drug regimen in only 18% of all patients. Intravenous antibiotics were started for 44% of cases without any documented adverse prognostic features on admission. Sputum was sent for acid-fast bacilli staining in 48% of patients and for bacterial culture in 11%. Blood culture was performed in 5% of patients.Conclusion: Documentation of severity criteria is often incomplete. There is inadequate utilization of oral macrolide antibiotics to cover atypical pathogens. Intravenous antibiotics are overused in hospitalized patients with community-acquired pneumonia.
Generation of dexamethasone and vitamin D3-treated human monocyte-derived dendritic cells with tolerogenic properties
Bethan Sayers, Muzlifah Haniffa, Julie Diboll, John Isaacs, Catharien Hilkens
Arthritis Research & Therapy , 2007, DOI: 10.1186/ar2237
Abstract: Cellular therapies are being explored as treatment for autoimmune diseases including rheumatoid arthritis. DexVitD3 DC have potential for future use in this field as well as being a useful tool to elucidate mechanisms of immune regulation.
Effect of Dietary Administration of Efinol FG on Growth and Enzymatic Activities of Channa striatus (Bloch, 1793)
R. Arthi Manju,M.A. Haniffa,S.V. Arun Singh,C. Muthu Ramakrishnan,M. Dhanaraj,B. Xavier Innocent,S. Seetharaman,A. Jesu Arockiaraj
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2011.796.801
Abstract: The probiotic Efinol FG was added to basal diet (control) in four concentrations viz., T1-103 cells g-1 incorporated diet; T2-104, T3-105 and T4-106 cells g-1 and supplied to the striped snakehead Channa striatus. C. striatus fed with probiotic diet showed significantly better growth performance (p<0.05) than those fed on basal diet alone. The total heterotrophic gut bacterial count in T4 was higher 7.7±1.89x108 CFU g-1 when compared to that of the other 3 trials as well as control diet. The mean digestive enzyme activity of all probiotic treatments was significantly different (p<0.05) from that of the control. The protease activity of 2, 3 and T4 was significantly >T1 and the control. Among the different probiotic trials no significant difference was noticed between 3 and T4. The amylase activity of T4 was the highest 68.71±5.23 U mg-1 and significantly different (p<0.05) from that of the control 47.83±3.75 U mg-1 and T1 49.97±3.98 U mg-1. All the probiotic treated C. striatus showed higher lipase activity than that of the control 78.93±5.31 U g-1.
Selective Susceptibility of Human Skin Antigen Presenting Cells to Productive Dengue Virus Infection
Daniela Cerny,Muzlifah Haniffa,Amanda Shin,Paul Bigliardi,Bien Keem Tan,Bernett Lee,Michael Poidinger,Ern Yu Tan,Florent Ginhoux,Katja Fink
PLOS Pathogens , 2014, DOI: doi/10.1371/journal.ppat.1004548
Abstract: Dengue is a growing global concern with 390 million people infected each year. Dengue virus (DENV) is transmitted by mosquitoes, thus host cells in the skin are the first point of contact with the virus. Human skin contains several populations of antigen-presenting cells which could drive the immune response to DENV in vivo: epidermal Langerhans cells (LCs), three populations of dermal dendritic cells (DCs), and macrophages. Using samples of normal human skin we detected productive infection of CD14+ and CD1c+ DCs, LCs and dermal macrophages, which was independent of DC-SIGN expression. LCs produced the highest viral titers and were less sensitive to IFN-β. Nanostring gene expression data showed significant up-regulation of IFN-β, STAT-1 and CCL5 upon viral exposure in susceptible DC populations. In mice infected intra-dermally with DENV we detected parallel populations of infected DCs originating from the dermis and migrating to the skin-draining lymph nodes. Therefore dermal DCs may simultaneously facilitate systemic spread of DENV and initiate the adaptive anti-viral immune response.
Unraveling a 146 Years Old Taxonomic Puzzle: Validation of Malabar Snakehead, Species-Status and Its Relevance for Channid Systematics and Evolution
Allen Benziger, Siby Philip, Rajeev Raghavan, Palakkaparambil Hamsa Anvar Ali, Mithun Sukumaran, Josin C. Tharian, Neelesh Dahanukar, Fibin Baby, Reynold Peter, Karunakaran Rema Devi, Kizhakke Veetil Radhakrishnan, Mohamed AbdulKather Haniffa, Ralf Britz, Agostinho Antunes
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021272
Abstract: Background The Malabar snakehead Channa diplogramma is one of the most enigmatic and least understood species within the family Channidae, which comprise one of the most important groups of freshwater food fish in tropical Asia. Since its description from peninsular India in 1865, it has remained a taxonomic puzzle with many researchers questioning its validity, based on its striking similarity with the South East Asian C. micropeltes. In this study, we assessed the identity of the Malabar snakehead, C. diplogramma, using morphological and molecular genetic analyses, and also evaluated its phylogenetic relationships and evolutionary biogeography. Methodology/Principal Findings The morphometric and meristic analysis provided conclusive evidence to separate C. diplogramma and C. micropeltes as two distinct species. Number of caudal fin rays, lateral line scales, scales below lateral line; total vertebrae, pre-anal length and body depth were the most prominent characters that can be used to differentiate both the species. Channa diplogramma also shows several ontogenic color phases during its life history, which is shared with C. micropeltes. Finally, the genetic distance between both species for the partial mitochondrial 16S rRNA and COI sequences is also well above the intra-specific genetic distances of any other channid species compared in this study. Conclusions/Significance The current distribution of C. diplogramma and C. micropeltes is best explained by vicariance. The significant variation in the key taxonomic characters and the results of the molecular marker analysis points towards an allopatric speciation event or vicariant divergence from a common ancestor, which molecular data suggests to have occurred as early as 21.76 million years ago. The resurrection of C. diplogramma from the synonymy of C. micropeltes has hence been confirmed 146 years after its initial description and 134 years after it was synonymised, establishing it is an endemic species of peninsular India and prioritizing its conservation value.
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