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Search Results: 1 - 10 of 223641 matches for " Hamizah R "
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The effects of short-term, rapid glycemic control on the peroneal nerve function and serum VCAM-1 and AGE in type 2 diabetic patients in Malaysia
Norlinah M,Hamizah R,Md Isa S,Wan Nazaimoon W
Indian Journal of Medical Sciences , 2009,
Abstract: Background : The role of endothelial injury and circulating adhesion molecule in the development and progression of diabetic peripheral neuropathy in the long-term has been established previously. Aims:0 To study the effects of short-term glycemic control using insulin and oral hypoglycemic agent therapy (OHA) on the peroneal nerve function and vascular cell adhesion molecule-1 (VCAM-1) and advanced glycation endproducts (AGE) levels in type 2 diabetic patients. Settings and Design : A randomized controlled study involving poorly controlled (HbA1c, 7.5%-11%) type 2 diabetic patients attending the endocrinology outpatient center in a tertiary hospital in Kuala Lumpur. Materials and Methods Twenty-nine patients were randomized to receive insulin (n=15) or OHA (n=14) for 8 weeks. The glycemic variables (HbA1c, fasting plasma glucose [FPG], fructosamine), VCAM-1, serum AGE and the peroneal motor conduction velocity (PMCV) were measured at baseline and at 4-week intervals. Statistical Analysis Used : Paired ′t′ test or Kruskal Wallis test; and the unpaired ′t′ test or Mann-Whitney U test were used for within-group and between-group analyses, respectively. Correlation was analyzed using Spearman′s correlation coefficient. Results : Within-group analysis showed significant progressive improvement in HbA1c at weeks 4 and 8 in the insulin group. The PMCV improved significantly in both groups by week 8, and by week 4 (P = 0.01) in the insulin group. PMCV correlated negatively with VCAM-1 (P = 0.031) and AGE (P = 0.009) at week 8. Conclusion : Aggressive glycemic control with insulin improves the peroneal nerve function within 4 weeks. Improvement in the serum VCAM-1 and AGE levels correlated significantly with improvement in peroneal nerve conduction velocity only in the insulin group.
A randomized open-label trial on the use of budesonide/formoterol (Symbicort?) as an alternative reliever medication for mild to moderate asthmatic attacks
Keng Chew, Hamizah Kamarudin, Che Hashim
International Journal of Emergency Medicine , 2012, DOI: 10.1186/1865-1380-5-16
Abstract: We performed a randomized, open-label study from March until August 2011 to compare the bronchodilatory effects of Symbicort? vs. nebulized salbutamol in acute exacerbation of mild to moderate asthmatic attack in an emergency department. Initial objective parameters measured include the oxygen saturation, peak expiratory flow rate (PEFR) and respiratory rate. During clinical reassessment, subjective parameters [i.e., Visual Analog Scale (VAS) and 5-point Likert scale of breathlessness] and the second reading of the objective parameters were measured. For the 5-point Likert scale, the patients were asked to describe their symptom relief as 1, much worse; 2, a little worse; 3, no change; 4, a little better; 5, much better.Out of the total of 32 patients enrolled, 17 patients (53%) were randomized to receive nebulized salbutamol and 15 (47%) to receive Symbicort?. For both treatment arms, by using paired t- and Wilcoxon signed rank tests, it was shown that there were statistically significant improvements in oxygen saturation, PEFR and respiratory rate within the individual treatment groups (pre- vs. post-treatment). Comparing the effects of Symbicort? vs. nebulized salbutamol, the average improvement of oxygen saturation was 1% in both treatment arms (p = 0.464), PEFR 78.67 l/min vs. 89.41 l/min, respectively (p = 0.507), and respiratory rate 2/min vs. 2/min (p = 0.890). For subjective evaluation, all patients reported improvement in the VAS (average 2.45 cm vs. 2.20 cm), respectively (p = 0.765). All patients in both treatment arms reported either "a little better" or "much better" on the 5-point Likert scale, with none reporting "no change" or getting worse.This study suggests that there is no statistical difference between using Symbicort? vs. nebulized salbutamol as the reliever for the first 15 min post-intervention.Defined as a chronic inflammatory airway disorder with bronchial hyper-responsiveness to a variety of stimuli, bronchial asthma is often punctuated w
Physicochemical Properties of CuO2 (acac)2 Supported on Functionalized MCM41 Containing Thiourea Ligand
Amirah Ahmad,Hamizah Md. Rasid,Karimah Kassim
International Journal of Chemical Engineering and Applications , 2013, DOI: 10.7763/ijcea.2013.v4.249
Abstract: A new material is prepared by encapsulating functionalized-MCM41 with 2-hydroxy-2-mercaptopyrimidine (2-thiouracil) and copper acetate monohydrate. The functionalized-MCM41 was first synthesized by using Ludox as silica source and cetyltrimethylammonium bromide (CTABr) as template and was modified via co-condensation method using 3-aminopropyltriethoxysilane (APTES). The surface and textural of synthesized material have been characterized by using X-ray diffraction (XRD), N2 adsorption isotherms, BET surface area measurement, FT-IR, elemental analyzer and scanning electron microscopy (SEM). The low-angle XRD results indicated that the CuO2(acac)-Thio-APS-MCM41has similar XRD pattern as the mesoporous MCM41 although the intensity decreases. For high-angle XRD, the results show the presence of monoclinic CuO at 2θ = 35.3 and 38.6° while N2 adsorption and BET results were revealed that the CuO2(acac)-Thio-APS-MCM41 possessed a good mesoporous structural ordering and uniform mesoporosity. FTIR spectra confirmed that the organosilane group still retained in the pore channel of the CuO2(acac)-Thio-APS-MCM41 even after modification and the band of C=S and Cu=O also appeared in CuO2(acac)-Thio-APS-MCM41 spectra with the presence of thiourea ligand and copper. Hence, the characterization results were revealed that the synthesized material has an ordered hexagonal structure, a narrow pore size distribution, a high surface area and thiourea complex were successfully grafted onto the pores of functionalized-MCM41.
Ethnicity association of Helicobacter pylori virulence genotype and metronidazole susceptibility
Hanafiah Alfizah,Awang Hamat Rukman,Ahmad Norazah,Razlan Hamizah
World Journal of Gastroenterology , 2013, DOI: 10.3748/wjg.v19.i8.1283
Abstract: AIM: To characterise the cag pathogenicity island in Helicobacter pylori (H. pylori) isolates by analysing the strains’ vacA alleles and metronidazole susceptibilities in light of patient ethnicity and clinical outcome. METHODS: Ninety-five H. pylori clinical isolates obtained from patients with dyspepsia living in Malaysia were analysed in this study. Six genes in the cagPAI region (cagE, cagM, cagT, cag13, cag10 and cag67) and vacA alleles of the H. pylori isolates were identified by polymerase chain reaction. The isolates’ metronidazole susceptibility was also determined using the E-test method, and the resistant gene was characterised by sequencing. RESULTS: More than 90% of the tested isolates had at least one gene in the cagPAI region, and cag67 was predominantly detected in the strains isolated from the Chinese patients, compared with the Malay and Indian patients (P < 0.0001). The majority of the isolates (88%) exhibited partial deletion (rearrangement) in the cagPAI region, with nineteen different patterns observed. Strains with intact or deleted cagPAI regions were detected in 3.2% and 8.4% of isolates, respectively. The prevalence of vacA s1m1 was significantly higher in the Malay and Indian isolates, whereas the isolates from the Chinese patients were predominantly genotyped as vacA s1m2 (P = 0.018). Additionally, the isolates from the Chinese patients were more sensitive to metronidazole than the isolates from the Malay and Indian patients (P = 0.047). Although we attempted to relate the cagPAI genotypes, vacA alleles and metronidazole susceptibilities to disease outcome, no association was observed. The vacA alleles were distributed evenly among the strains with intact, partially deleted or deleted cagPAI regions. Interestingly, the strains exhibiting an intact cagPAI region were sensitive to metronidazole, whereas the strains with a deleted cagPAI were more resistant. CONCLUSION: Successful colonisation by different H. pylori genotypes is dependent on the host’s genetic makeup and may play an important role in the clinical outcome.
Market Orientation and Performance: A Study of Takaful Performance in Malaysia
Wan Norhayate Wan Daud,Norizan Remli,Hamizah Muhammad
Asian Social Science , 2013, DOI: 10.5539/ass.v9n4p240
Abstract: This empirical study examined the effect of Market Orientation on Organizational Performance from Takaful Business’s perspective in Malaysia. Apparently the framework suggests that Market Orientation has positively effects Performance of the organization. Based on the review of literatures, three hypotheses were developed to guide the study. The sampling frame was top management, middle management, junior management and executives in the Marketing department of six composite Takaful Operators headquarters in Malaysia. A total of 162 questionnaires were distributed and 111 responded in which they were analyzed. Findings from the study found that all of these hypotheses were supported the framework thus providing new ideas for the representative specially Marketing Manager from Takaful industry to increase their level of market penetration which is still low at the present. Several practical implications from the study found are also discussed.
A Proposed Conceptual Framework for Market Orientation and Innovation towards Takaful Performance in Malaysia
Norizan Remli,Wan Norhayate Wan Daud,Fakhrul Anwar Zainol,Hamizah Muhammad
International Journal of Business and Management , 2013, DOI: 10.5539/ijbm.v8n7p100
Abstract: This paper aims to propose a conceptual framework to study the relationship between Market Orientation and Organizational Performance from Takaful Business’s standpoint in Malaysia. The Innovation was added in this research to represents the mediating factor. Apparently the framework suggests that Market Orientation has positively effects Performance of the organization. Considering Innovation as the catalyst within the relationship, the mediating effect of it is to be investigated. From the review of literatures, hypotheses were developed to suggest the relationship between the Market Orientation, Innovation and Performance by choosing the Takaful Operators in Malaysia as the research sample. The findings of this research are expected to provide new ideas for the representative specially Marketing Manager from Takaful industry to increase their level of market penetration which is still low at the present.
Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease
Hamizah Razlan,Nurhayaty Muhamad Marzuki,Mei-Ling Sharon Tai,Azhar-Shah Shamsul,Tze-Zen Ong,Sanjiv Mahadeva
Gastroenterology Research and Practice , 2011, DOI: 10.1155/2011/235796
Abstract: The accuracy of the 13C-methacetin breath test (13C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the 13C-MBT in various stages of chronic liver diseases. Diagnostic accuracy of the breath test was determined by sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve analysis. Seventy-seven patients (47 men/30 women, mean age years) were recruited. Forty-seven patients had liver cirrhosis (Child Pugh A = 11, Child Pugh B = 15, and Child Pugh C = 21), 21 had fibrosis, and 9 had chronic inflammation. The sensitivity and positive predictive value for liver fibrosis, cirrhosis (all stages), Child-Pugh A, Child-Pugh B, and Child-Pugh C were 65% and 56%, 89% and 89%, 67% and 42%, 40% and 40%, and 50% and 77%, respectively. Area under curve values for fibrosis was 0.62 (0.39–0.86), whilst that for cirrhosis (all stages) was 0.95 (0.91–0.99). The 13C-methacetin breath test has a poor predictive value for liver fibrosis but accurately determines advanced cirrhosis. 1. Background The prognosis and management of chronic liver diseases usually requires knowledge of the stage and progression of disease. Liver biopsy, which is the gold standard in determining liver fibrosis and cirrhosis, is invasive and is associated with morbidity and mortality risks [1]. Furthermore, sampling variability can be found in 15%–30% of biopsies [2], and it is not used repeatedly to follow-up patients. Therefore, there is an increasing need for alternative noninvasive methods to diagnose liver fibrosis and cirrhosis. Several quantitative liver function tests have been proposed to measure the functional hepatic mass [3]. However, these tests, although accurate, are cumbersome to perform and impractical in clinical settings. The Child-Pugh [4, 5] classification still remains the most widely used parameter of liver function. However, this classification does not strictly reflect the quantitative functional liver reserve, and its usefulness is limited by concomitant therapy with albumin, for example, and subjectivity on the degree of ascites and hepatic encephalopathy in an individual patient. Currently, several 13C breath tests based on the use of labeled substrates selectively metabolized within the liver are available to noninvasively assess hepatocellular function. Amongst the various substrates utilized to evaluate quantitative liver function, the 13C methacetin breath test (MBT) has shown to be most promising [6–8].
Power Aware Routing Protocol (PARP) for Wireless Sensor Networks  [PDF]
R. Prema, R. Rangarajan
Wireless Sensor Network (WSN) , 2012, DOI: 10.4236/wsn.2012.45019
Abstract: Several wireless sensor network applications ought to decide the intrinsic variance between energy efficient communication and the requirement to attain preferred quality of service (QoS) such as packet delivery ratio, delay and to reduce the power consumption of wireless sensor nodes. In order to address this challenge, we propose the Power Aware Routing Protocol (PARP), which attains application-specified communication delays at low energy cost by dynamically adapting transmission power and routing decisions. Extensive simulation results prove that the proposed PARP attains better QoS and reduced power consumption.
Studies on Dissolution Behaviour of Nanoparticulate Curcumin Formulation  [PDF]
R. Ravichandran
Advances in Nanoparticles (ANP) , 2013, DOI: 10.4236/anp.2013.21010

Curcumin is the main biologically active phytochemical compound of turmeric that has been widely used by ancient cultures throughout Asia. However the dissolution rate limited absorption and pre-absorption degradation limits its use as a potential therapeutic. In this study an attempt has been made to overcome the above limitations by curcumin delivery through nanotechnology. Nanocurcumin solid dosage formulations were prepared and studied for its dissolution behaviour. Considerable improvement in the dissolution behavior was observed in the drug nanocrystal-loaded solid dosage forms. This is expected to enhance the bioavailability of poorly soluble medicinal herbs such as turmeric in the body.

Pharmacokinetic Study of Nanoparticulate Curcumin: Oral Formulation for Enhanced Bioavailability  [PDF]
R. Ravichandran
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.43037

Curcumin, a bioactive component of turmeric, which is a commonly used spice and nutritional supplement, is isolated from the rhizomes of Curcuma longa Linn. (Zingiberaceae). In recent years, the potential pharmacological actions of Curcumin in inflammatory disorders, cardiovascular disease, cancer, Alzheimer’s disease and neurological disorders have been shown. However, the clinical application of Curcumin is severely limited by its main drawbacks such as instability, low solubility, poor bioavailability and rapid metabolism. Multifarious nanotechnology-based drug delivery systems for Curcumin including liposomes, polymeric nanoparticles, solid lipid nanoparticles, micelles, nanogels, nanoemulsions, complexes and dendrimer/dimer, have been attempted to enhance the oral bioavailability, biological activity or tissue-targeting ability of Curcumin. We attempted the nanosuspensions based delivery of curcumin. Nanonisation renders curcumin completely dispersible in aqueous media. To enhance the curcumin absorption by oral administration, nanoparticulate solid oral formulation of curcumin was prepared by us and the resulting capsule was then examined for its efficiency on bioavailability in Male Wistar rats at a dose of 100 mg curcumin/kg body weight and the pharmacokinetic parameters were compared to those of normal curcumin powder and a commercial curcumin capsule CUR-500. The bio-distribution of curcumin in organs of rat was also studied. Nanoparticulation significantly raised the curcumin concentration in selective organs in the body. The results obtained provide promising results for nanoparticulate Curcumin to improve its biological activities. Enhanced bioavailability of curcumin in the form of nanoparticle is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease. The available information also strongly suggests that nano-formulation of ingredients such as curcumin may be used as a novel nutrient delivery system too.

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