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Search Results: 1 - 10 of 8490 matches for " Hamish Scott "
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What transcripts are found in a human cell?
Hamish Scott
Genome Biology , 2000, DOI: 10.1186/gb-2000-1-1-reports031
Abstract: A total of 3.5 million transcripts was analyzed from 19 tissues (both normal and diseased, mainly cancer cell lines or primary tumor samples). From this, the number of genes in the human genome was estimated at around 84,000. The average number of different but related transcripts corresponding to each gene is 1.6 (134,135 transcripts total, mainly due to differences in polyadenylation). More than 43,000 transcripts were expressed in a single cell type (colorectal cancer cell lines) with expression levels ranging from 0.3 to 9,417 copies of the transcript per cell. Of the transcripts, 83% were present at levels as low as one copy per cell; 55 transcripts present at over 500 copies per cell made up 18% of the cellular mRNA mass (Figure 1a); and the most highly expressed 633 genes accounted for 45% of the cellular mRNA. Most unique transcripts were produced at low levels, with just under 25% of the cellular mRNA mass being made up of 94% of the unique transcripts (Figure 1b). Approximately 9,000 genes of known function and 63,000 genes of unknown function were matched to the transcripts; the remaining transcript tags, mainly from genes expressed at a low level (46%), had no matches in existing (public) databases (Figure 1c). Differences in gene expression between different cell types were greater than the changes in gene expression observed in different physiological states of a given cell type. Expression levels of tissue-specific transcripts present at more than ten copies per cell ranged from 0.05% to 1.76% (as a percentage of total cellular mRNA), and 50% of these transcripts had no database match. Approximately 1,000 'ubiquitously' expressed transcripts were detected and may be viewed as a minimal transcriptome.More information about SAGE is available from the Serial analysis of gene expression homepage and the SAGEmap site at the National Center for Biotechnological Information (NCBI). For information on cDNA microarray technology visit the Gene Chips (DNA Micro
The homeomorphism problem for closed 3-manifolds
Peter Scott,Hamish Short
Mathematics , 2012, DOI: 10.2140/agt.2014.14.2431
Abstract: We give a more geometric approach to an algorithm for deciding whether two hyperbolic 3-manifolds are homeomorphic. We also give a more algebraic approach to the homeomorphism problem for geometric, but non-hyperbolic, 3-manifolds.
Linguistic Brilliance: Rule of Law with Chinese Characteristics  [PDF]
Hamish McCardle
Beijing Law Review (BLR) , 2019, DOI: 10.4236/blr.2019.102017
Abstract: Rule of law discourse has been excited in recent years with China’s reemergence as a state with global influence and its own interpretation of rule of law; a socialist rule of law with Chinese characteristics. If rule of law is to become a main theme of China’s socialist justice system building in the next ten-year period, then some of the changes will necessarily reach well beyond China’s internal system, potentially internationally. In terms of China’s approach, it is possible to understand that developments of rule of law are being made with due recognition of exactly how much implementation work is actually required to shift the country forward. China’s progress towards a socialist rule of law with Chinese characteristics will almost certainly be slow, measured and most importantly completed on China’s terms, not the West’s terms.
A realistic assessment of the CTA sensitivity to dark matter annihilation
Hamish Silverwood,Christoph Weniger,Pat Scott,Gianfranco Bertone
Physics , 2014, DOI: 10.1088/1475-7516/2015/03/055
Abstract: We estimate the sensitivity of the upcoming CTA gamma-ray telescope to DM annihilation at the Galactic centre, improving on previous analyses in a number of significant ways. First, we perform a detailed analyses of all backgrounds, including diffuse astrophysical emission for the first time in a study of this type. Second, we present a statistical framework for including systematic errors and estimate the consequent degradation in sensitivity. These errors may come from e.g. event reconstruction, Monte Carlo determination of the effective area or uncertainty in atmospheric conditions. Third, we show that performing the analysis on a set of suitably optimised regions of interest makes it possible to partially compensate for the degradation in sensitivity caused by systematics and diffuse emission. To probe dark matter with the canonical thermal annihilation cross-section, CTA systematics like non-uniform variations in acceptance over a single field of view must be kept below the 0.3% level, unless the dark matter density rises more steeply in the centre of the Galaxy than predicted by a typical Navarro-Frenk-White or Einasto profile. For a contracted $r^{-1.3}$ profile, and systematics at the 1% level, CTA can probe annihilation to $b\bar{b}$ at the canonical thermal level for dark matter masses between 100 GeV and 10 TeV.
Investigating dark matter substructure with pulsar timing: I. Constraints on ultracompact minihalos
Hamish A. Clark,Geraint F. Lewis,Pat Scott
Physics , 2015,
Abstract: Small-scale dark matter structure within the Milky Way is expected to affect pulsar timing. The change in gravitational potential induced by a dark matter halo passing near the line of sight to a pulsar would produce a varying delay in the light travel time of photons from the pulsar. Individual transits produce an effect that would either be too rare or too weak to be detected in 30-year pulsar observations. However, a population of dark matter subhalos would be expected to produce a detectable effect on the measured properties of pulsars if the subhalos constitute a significant fraction of the total halo mass. The effect is to increase the dispersion of measured period derivatives across the pulsar population. By statistical analysis of the ATNF pulsar catalogue, we place an upper limit on this dispersion of $\log \sigma_{\dot{P}} \leq -17.05$. We use this to place strong upper limits on the number density of ultracompact minihalos within the Milky Way. These limits are completely independent of the particle nature of dark matter.
A Validated Model of Serum Anti-Müllerian Hormone from Conception to Menopause
Thomas W. Kelsey, Phoebe Wright, Scott M. Nelson, Richard A. Anderson, W. Hamish B Wallace
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0022024
Abstract: Background Anti-Müllerian hormone (AMH) is a product of growing ovarian follicles. The concentration of AMH in blood may also reflect the non-growing follicle (NGF) population, i.e. the ovarian reserve, and be of value in predicting reproductive lifespan. A full description of AMH production up to the menopause has not been previously reported. Methodology/Principal Findings By searching the published literature for AMH concentrations in healthy pre-menopausal females, and using our own data (combined ) we have generated and robustly validated the first model of AMH concentration from conception to menopause. This model shows that 34% of the variation in AMH is due to age alone. We have shown that AMH peaks at age 24.5 years, followed by a decline to the menopause. We have also shown that there is a neonatal peak and a potential pre-pubertal peak. Our model allows us to generate normative data at all ages. Conclusions/Significance These data highlight key inflection points in ovarian follicle dynamics. This first validated model of circulating AMH in healthy females describes a transition period in early adulthood, after which AMH reflects the progressive loss of the NGF pool. The existence of a neonatal increase in gonadal activity is confirmed for females. An improved understanding of the relationship between circulating AMH and age will lead to more accurate assessment of ovarian reserve for the individual woman.
Prevalence and Prognostic Significance of Left Ventricular Dysfunction in Patients Presenting Acutely with Atrial Fibrillation
Chin Lin, Colin Edwards, Guy P. Armstrong, Anthony Scott, Hitesh Patel, Hamish Hart and Jonathan P. Christiansen
Clinical Medicine Insights: Cardiology , 2012, DOI: 10.4137/CMC.S4106
Abstract: Condensed Abstract: The prevalence and prognostic importance of CM occurring as a consequence of AF is poorly defined. This study investigated the incidence of CM in patients with AF, its clinical features and long-term outcomes. We demonstrated that CM is common in patients presenting acutely with newly diagnosed rapid AF, and carries a worse long-term prognosis. Systolic dysfunction was reversible in an important proportion of patients, suggesting a greater prevalence of rate-related CM in AF than has previously been postulated. This underscores the importance of appropriate rhythm management strategies and repeat imaging studies. Summary Background: Atrial fibrillation (AF) may precipitate LV dysfunction, potentially leading to cardiomyopathy (CM). The prevalence and prognostic importance of CM occurring as a consequence of AF is poorly defined. We investigated the incidence of CM in patients with AF, its clinical features and long-term outcomes. Methods: We reviewed 292 consecutive patients (average age 72 ± 13yrs) presenting acutely with AF and tachycardia over a 3 year period from June 2004. Clinical details were obtained from medical records. CM was defined as ejection fraction (EF) ≤ 50% on index admission. Results: Echo was performed 93% of patients at index admission, and 69 (24%) had CM (average EF% = 37 ± 11), 60 of which were newly diagnosed. Patients with CM had significantly higher presenting heart rate (141 ± 19 vs. 132 ± 23 bpm), larger end-diastolic (5.7 vs. 5.2 cm) and end-systolic (4.5 vs. 3.2 cm) dimensions, and larger left atrial size (4.6 vs. 4.3 cm) (P < 0.05 for all). They were also statistically more likely (P < 0.05) to be male, present with breathlessness, have a history of coronary disease, and be treated with digoxin and warfarin. Follow-up echo between 6 and 12 months was performed in 46% of patients with new CM, and average EF rose to 53 ± 12%. At an average follow-up of 2.5 years, there was a significant increase in mortality in CM patients (16% vs. 9.5%, P < 0.05). Conclusion: CM is common in patients presenting acutely with newly diagnosed rapid AF, and carries a worse long-term prognosis. Systolic dysfunction was reversible in an important proportion of patients, suggesting a greater prevalence of rate-related CM in AF than has previously been postulated. This underscores the importance of appropriate rhythm management strategies and repeat imaging studies.
Listening to the Learner: A Qualitative Investigation of Motivation for Embracing or Avoiding the Use of Self-Access Centres
Hamish Gillies
Studies in Self-Access Learning Journal , 2010,
Abstract: This paper reports on a follow-up study to Gillies (2007), in which a survey was conducted to investigate how tertiary-level Japanese EFL students understand and interpret their use or non-use of their institution’s self-access centre (SAC). The survey data revealed general trends regarding the factors which motivate the students’ use of the SAC as well as reasons why students choose not to use it, while also suggesting four types of students, via cluster analysis. Employing Dornyei’s (2005) L2 Motivational Self System as a theoretical framework, the current paper attempts to probe deeper into the survey data, and specifically tease out the factors influencing the use or non-use of the SAC. It reports on a set of semi-structured interviews with a purposeful sample of nine students from amongst the survey respondents. The interviewees included representatives of each of the four clusters identified in the survey data. The interview transcripts were then subjected to coding and labelling, and key themes in the data emerged: the SAC as an environment; the SAC as a community of selves; the SAC as contrasted with the classroom. Related to these themes, it was found that in the first year of university, identities are forged, distinguishing regular SAC users and rare SAC users. The SAC is an attractive environment for students with strong ideal L2 selves, while being uncomfortable for less confident students. The former type of student is more likely to see the classroom environment as restrictive, while the latter views it as sheltered and supportive. Meanwhile, the level of English proficiency is not in itself predictive of SAC use, but rather the level of L2 motivation, in particular the strength of the learner’s ideal L2 self. The paper discusses these themes and findings, and concludes with implications for the SAC, and suggestions for making the centre accessible and appealing to a wider cross-section of the overall student body.
Hamish Williams
Akroterion , 2012, DOI: 10.7445/52-0-58
Abstract: The paper judged to be the best student essay submitted to Akroterion by November 30, preceding publication of the volume for that specific year, is published annually as the CASA / KVSA Essay. The competition, which is sponsored by the Classical Association of South Africa, is open to undergraduate students every year and to Honours students in even-numbered years. The winner receives a cash prize of R500.
Anthropology : a science of the non-event?
Morgan, Hamish
Cultural Studies Review , 2010,
Abstract: This essay explores the notion of the ‘event’ and it relevance to ethnography and community. It has developed from research work with Aboriginal people, especially the Jackman family, in central Western Australia. The essay sketches the possibility of developing another kind of ethnographic writing, one attuned to the relation with others, one that involves being-in-common with others. It focuses on developing a writing practice that is exposed to interruption, to fragments, to little happenings and encounters, to those shared events that happen in community. The essay sees community as the place of interruption: that to be with others is to be taken off, shown something else, exposed to unique turnings of the world that others give light to trace.
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