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Protective effect of Wormwood extract on lead induced neurotoxicity and cognitive disorder
Kharoubi O,Slimani M,Hamadouche N,Krouf D
International Journal of Green Pharmacy , 2010,
Abstract: Lead is a ubiquitous and a potent neurotoxicant causes several neurophysiological and behavioural alterations. Considering the vulnerability of the developing brain to Pb neurotoxicity, this study was carried out to investigate the effects of Pb exposure on brain regions acetylcholinesterase (AchE) and monoamino oxidase (MAO) enzymes activities and on behavioural changes. Wister rat were exposed to 750 ppm of lead acetate in the drinking water for 11-weeks after weaning, and treated by Artemisia Absinthium L. (wormwood) extract (200 mg.kg-1 body weight) for 4 weeks. The activities of AchE and MAO were determined in the hypothalamus, hippocampus, cortex and striatum of male rat; and general/ Locomotors activity was evaluated in the open-field test. Results indicated a significant decrease in AchE activity in intoxicated group (Pb) compared to untreated group (as contral) (hypothalamus: -12%, hippocampus: -57%, cerebral cortex: -18% and striatum: -43%) and in MAO activity (hypothalamus: -29%, hippocampus: -41%, cerebral cortex: -28% and striatum: -51%) respectively, with decrease crossing test score and increase sniffing test score. After, wormwood extract administration, the activity of AchE and MAO were significantly increased in all brain region compared to Pb group, but were significantly lower than control. The locomotors activity was reduced compared to Pb group. These data suggest that administration of wormwood extract for 4 weeks protect against the lead acetate-induced change in behavioural and neurobiochemical parameters changes.
Holderian Version of Donsker-Prohorov's Invariance Principle
Hamadouche Djamel,Taleb Youcef
IAENG International Journal of Applied Mathematics , 2009,
Abstract:
A New Adaptive Linear Combined Cfar Detector in Presence of Interfering Targets
Boualem Magaz;Adel Belouchrani;M'hamed Hamadouche
PIER B , 2011, DOI: 10.2528/PIERB11012603
Abstract: In this paper, a new radar constant false alarm rate detector to perform adaptive threshold target detection in presence of interfering targets is proposed. The proposed CFAR detector, referred to as Adaptive Linear Combined CFAR, ALC-CFAR, employs an adaptive composite approach based on the well-known cell averaging CFAR, CA-CFAR, and the ordered statistics, OS-CFAR, detectors. Data in the reference window is used to compute an adaptive weighting factor employed in the fusion scheme. Based on this factor, the ALC-CFAR tailors the background estimation algorithm. The conducted Monte Carlo simulation results demonstrate that the proposed detector provides low loss CFAR performance in an homogeneous environment and also performs robustly in presence of interfering targets. The performances of the ALC-CFAR detector have been evaluated and compared with that of the CA-CFAR and the OS-CFAR detectors. The obtained results are presented and discussed in this paper.
Automatic Threshold Selection in Os-Cfar Radar Detection Using Information Theoretic Criteria
Boualem Magaz;Adel Belouchrani;M'hamed Hamadouche
PIER B , 2011, DOI: 10.2528/PIERB10122502
Abstract: This paper proposes a new approach for efficiently determining the unwanted interfering samples in the reference window, for the ordered statistics constant false alarm rate detector, based on the application of the information theoretic criteria principle. The proposed processor termed as Forward Automatic Order Selection Ordered Statistics Detector (FAOSOSD) does not require any prior information about the number of interfering targets. The proposed design aims to improve the Ordered Statistics Constant False Alarm Rate detector performance under severe interference situations. The number of interfering targets is obtained by minimizing the information theoretic criteria. Simulation results that illustrate the performance of the proposed method versus the classical OS-CFAR, the AND-CFAR and the OR-CFAR detectors are presented and discussed.
Beneficial Effect Administration of Vitamin C in Amelioration of Lead Hepatotoxicity
Nadia AIT HAMADOUCHE,Miloud SLIMANI,Abdelkader AOUES
Notulae Scientia Biologicae , 2012,
Abstract: Previous human and experimental studies have demonstrated that lead exposure may modify the metabolism of lipid. Oxidative stress with subsequent lipid peroxidation has been postulated as one mechanism for lead toxicity. The protective action of vitamins C against lead affects lipid hydroperoxide level and liver functions in male rats has been studied. Experiments were performed on male waster rats with body weights of 120-160 g. Male wistar rats were exposed to 3 g/l lead acetate in drinking water for 5 weeks and treated thereafter with vitamin C (500 mg/kg, orally) for 28 days. One day after the feeding was over, venous blood samples, under chloroform anesthesia, were collected. The animals were killed by exsanguinations and the liver was excise for determination the metal content and histopathological changes. Similarly, the tissue lipid (lipid peroxidation) and the enzyme fraction (superoxide dismutase (SOD), catalase (CAT), alkaline phosphatase (ALP), acid phosphatase (ACP) and glutathione (GSH) were also measured in the liver. Metal content in blood and liver was determined by means of atomic absorption spectrophotometry. Administration of lead acetate (3 g/l) in drinking water for 5 weeks induced a significant increase in the levels of hepatic ALP, ACP and lipid peroxidation. Lead acetate exposure also produced detrimental effects on the redox status of the liver indicated by a significant decline in the levels of liver antioxidants such SOD, CAT and GSH. Further, there was a significant increase in the levels of lead in blood and liver of animals exposed to lead. However, oral administration of vitamin C at dose level of 500 mg/kg body weight reduced the alterations in the previous parameters. Histological examination of the liver also revealed pathophysiological changes in lead acetate-exposed group and treatment with vitamin C improved liver histology. The result of this study strongly indicate that vitamin C has got a potent antioxidant action against lead acetate induced hepatic damage in rats.
Oestrogen deficiency modulates particle-induced osteolysis
Christophe Nich, Jean Langlois, Arnaud Marchadier, Catherine Vidal, Martine Cohen-Solal, Hervé Petite, Moussa Hamadouche
Arthritis Research & Therapy , 2011, DOI: 10.1186/ar3381
Abstract: Polyethylene (PE) particles were implanted onto the calvaria of normal controls, sham-ovariectomized (OVX), OVX mice and OVX mice supplemented with oestrogen (OVX+E). After 14 days, seven skulls per group were analyzed using a high-resolution micro-computed tomography (micro-CT) and histomorphometry, and for tartrate-specific alkaline phosphatase. Five calvariae per group were cultured for the assay of IL-1β, IL-6, TNF-α and receptor activator of the nuclear factor κB (RANKL) secretion using quantitative ELISA. Serum IL-6 concentrations were obtained. The expression of RANKL and osteoprotegerin (OPG) mRNA were evaluated using real-time PCR.As assessed by μCT and by histomorphometry, PE particles induced extensive bone resorption and an intense inflammatory reaction in normal controls, sham-OVX and OVX+E mice, but not in the OVX mice group. In normal controls, sham-OVX and OVX+E mice, PE particles induced an increase in serum IL-6, in TNF-α and RANKL local concentrations, and resulted in a significant increase in RANKL/OPG messenger RNA (mRNA) ratio. Conversely, these parameters remained unchanged in OVX mice after PE implantation.Oestrogen privation in the osteolysis murine model ultimately attenuated osteolytic response to PE particles, suggesting a protective effect. This paradoxical phenomenon was associated with a down-regulation of pro-resorptive cytokines. It is hypothesized that excessive inflammatory response was controlled, illustrated by the absence of increase of serum IL-6 in OVX mice after PE implantation.Aseptic loosening of total joint replacements develops as a consequence of periprosthetic osteolysis, caused by a macrophage-mediated inflammatory reaction [1,2]. Although it is well established that generation of polyethylene (PE) particles by the bearing couple is correlated with the risk for revision due to aseptic loosening [3], great variations in the degree of osteolysis are sometimes observed in clinical practice. This suggests that patient-rela
Comparison of Patient and Surgeon Expectations of Total Hip Arthroplasty
Claire Jourdan, Serge Poiraudeau, Stéphane Descamps, Rémy Nizard, Moussa Hamadouche, Philippe Anract, Stéphane Boisgard, Myriam Galvin, Philippe Ravaud
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030195
Abstract: Objectives Analysis of discrepancies between patient and surgeon expectations before total hip arthroplasty (THA) should enable a better understanding of motives of dissatisfaction about surgery, but this question has been seldom studied. Our objectives were to compare surgeons' and patients' expectations before THA, and to study factors which affected surgeon-patient agreement. Methods 132 adults (mean age 62.8+/?13.7 years, 52% men) on waiting list for THA in three tertiary care centres and their 16 surgeons were interviewed to assess their expectations using the Hospital for Special Surgery Total Hip Replacement Expectations Survey (range 0–100). Patients' and surgeons' answers were compared, for the total score and for the score of each item. Univariate analyses tested the effect of patients' characteristics on surgeons' and patients' expectations separately, and on surgeon-patient differences. Results Surgeon and patient expectations' mean scores were high (respectively 90.9+/?11.1 and 90.0+/?11.6 over 100). Surgeons' and patients' expectations showed no systematic difference, but there was little agreement on Bland and Altman graph and correlation coefficient was low. Patients had higher expectations than surgeons for sports. Patients rated their expectations according to trust in physician and mental quality of life, surgeons considered disability. More disabled patients and patients from a low-income professional category were often “more optimistic” than their surgeons. Conclusion Surgeons and patients often do not agree on what to expect from THA. More disabled patients expect better outcomes than their surgeons.
Implementation of a Higher Quality dc Power Converter  [PDF]
N. N. Barsoum
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2010, DOI: 10.4236/jemaa.2010.22012
Abstract: Many single and three-phase converters are well developed, and covered up in most of electric markets. It is used in many applications in power systems and machine drives. However, an exact definite output signal from the dc side still not recognized. The waveforms of output voltage and current demonstrate an imperfect dc signal and constitute losses, harmonic distortion, low power factor, and observed some ripples. An approximately perfect rectifier bridge is the aim of this research. Perhaps it gives the ability to identify the parameters of the converter to obtain, as much as possible, a perfect dc signal with less ripple, high power factor and high efficiency. Design is implemented by simulation on Power Simulator PSIM, and practically, a series regulator LM723 is applied to provide regulating output voltage. Comparisons of both simulation and hardware results are made to observe differences and similarities.
Estimation of Sensitivity of the DS/AHP Method While Solving Foresight Problems with Incomplete Data  [PDF]
N. Pankratova, N. Nedashkovskaya
Intelligent Control and Automation (ICA) , 2013, DOI: 10.4236/ica.2013.41011
Abstract:

The paper provides mathematical analysis of sensitivity of different combination rules in the DS/AHP method when an alternative is added to the set of decision alternatives while solving foresight problems. Different cases of rank reversals are defined and two sets of conditions for these cases using the method DS/AHP are considered. Rank reversals are illustrated when the DS/AHP method is used to solve practical problem of critical technologies of energy conservation and power efficiency evaluation in Ukraine. It is shown that the DS/AHP method is not sensitive to exclusion (or addition) of an irrelevant decision alternative from (or to) the set of decision alternatives.

Change of the Microorganisms Quantity in Irrigative Gleyey-Yellow under Vegetable Soils  [PDF]
N. ?. Orudzheva
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.312213
Abstract: The results of the long-term investigations in dynamics for study of the conditions of taxonomic groups of microorganisms of irrigated gleyey-yellow soils of the subtropical zone under vegetable crops in rotation with the continuous growing of these cultures have been presented. The results of the researches study demonstrated an important vibration of the microorganisms quantity under growing cultures happens. The most quantity of microorganisms, consuming organic nitrogen is observed in irrigative gleyey-yellow soils of the humid subtropical zone. Intensity of mineralization of organic matters was lower in irrigative gleyey-yellow soils. A quantity of microorganisms was lower, but a coefficient of mineralization was higher under continuous cultures as compared the analogous soils under crop rotation. These data show that a type of the soil influence on the rhizosphere microflora insignificantly, while plant shows a significant effect on its quantity and compositions.
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