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Search Results: 1 - 10 of 401082 matches for " Halyna M. Semchyshyn "
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Hormetic Concentrations of Hydrogen Peroxide but Not Ethanol Induce Cross-Adaptation to Different Stresses in Budding Yeast
Halyna M. Semchyshyn
International Journal of Microbiology , 2014, DOI: 10.1155/2014/485792
Abstract: The biphasic-dose response of microorganisms to hydrogen peroxide is a phenomenon of particular interest in hormesis research. In different animal models, the dose-response curve for ethanol is also nonlinear showing an inhibitory effect at high doses but a stimulatory effect at low doses. In this study, we observed the hormetic-dose response to ethanol in budding yeast S. cerevisiae. Cross-protection is a phenomenon in which exposure to mild stress results in the acquisition of cellular resistance to lethal stress induced by different factors. Since both hydrogen peroxide and ethanol at low concentrations were found to stimulate yeast colony growth, we evaluated the role of one substance in cell cross-adaptation to the other substance as well as some weak organic acid preservatives. This study demonstrates that, unlike ethanol, hydrogen peroxide at hormetic concentrations causes cross-resistance of S. cerevisiae to different stresses. The regulatory protein Yap1 plays an important role in the hormetic effects by low concentrations of either hydrogen peroxide or ethanol, and it is involved in the yeast cross-adaptation by low sublethal doses of hydrogen peroxide. 1. Introduction Organisms’ adaptation to environmental stress has become a subject of great interest over the last decades [1–5]. Like other organisms, budding yeast Saccharomyces cerevisiae has developed several strategies to survive stressful changes in their environment. Sudden challenge can result in disturbance of cellular functions or even cell death. Clearly, yeast cells respond rapidly and modify their internal systems to prevent dramatic events. Depending on the intensity and type of stress, many different mechanisms contribute to the development of yeast resistance to stressful changes. It is widely believed that cell exposure to mild stress results in the acquisition of cellular resistance to further lethal stress, what is called “adaptive response” or “preadaptation” [6, 7]. The phenomenon has been observed in various organisms: from bacteria to humans. In many cases, an exposure to mild stress develops tolerance not only to higher doses of the same stressor but also to stress caused by other factors. This phenomenon, known as “cross-protection” or “cross-adaptation” [6, 7], suggests the existence of complex mechanisms, which sense and respond to different kinds of stress. The literature includes data on S. cerevisiae general response, pre-adaptation, and cross-adaptation to extreme temperatures, osmotic shock, and oxidative stress [2, 6, 8–12]. There is information on the increased
On the property of the BBGKY hierarchy solution in cumulant representation
Mykhailo O. Stashenko,Halyna M. Hubal
Opuscula Mathematica , 2009,
Abstract: We consider a one-dimensional nonsymmetric system of particles interacting via the hard-core potential. For this system, we prove that the BBGKY hierarchy solution in a cumulant representation is an equilibrium in the case of equilibrium initial data.
Quasi-Static Problem of Thermoelasticity for Thermosensitive Infinite Circular Cylinder of Complex Heat Exchange  [PDF]
Halyna Harmatij, Marta Król, Vasyl Popovycz
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.34061

Nonlinear nonstationary heat conduction problem for infinite circular cylinder under a complex heat transfer taking into account the temperature dependence of thermophysical characteristics of materials is solved numerically by the method of lines. Directing it to the Cauchy’s problem for systems of ordinary differential equations studied feature which takes place on the cylinder axis. Taken into account the dependence on the temperature coefficient of heat transfer that the different interpretation of its physical content makes it possible to consider both convective and convective-ray or heat ray. Using the perturbation method, the corresponding thermoelasticity problem taking into account the temperature dependence of mechanical properties of the material is construed. The influence of the temperature dependence of the material on the distribution of temperature field and thermoelastic state of infinite circular cylinder made of titanium alloy Ti-6Al-4V by radiant heat transfer through the outer surface has been analyzed.

New Dystrophin/Dystroglycan interactors control neuron behavior in Drosophila eye
April K Marrone, Mariya M Kucherenko, Valentyna M Rishko, Halyna R Shcherbata
BMC Neuroscience , 2011, DOI: 10.1186/1471-2202-12-93
Abstract: Given that disruption of Dys and Dg leads to improper photoreceptor axon projections into the lamina and eye neuron elongation defects during development, we have determined the function of previously screened components and their genetic interaction with the DGC in this tissue. Our study first found that mutations in chif, CG34400, Nrk, Lis1, capt and Cam cause improper axon path-finding and loss of SP2353, Grh, Nrk, capt, CG34400, vimar, Lis1 and Cam cause shortened rhabdomere lengths. We determined that Nrk, mbl, capt and Cam genetically interact with Dys and/or Dg in these processes. It is notable that most of the neuronal DGC interacting components encountered are involved in regulation of actin dynamics.Our data indicate possible DGC involvement in the process of cytoskeletal remodeling in neurons. The identification of new components that interact with the DGC not only helps to dissect the mechanism of axon guidance and eye neuron differentiation but also provides a great opportunity for understanding the signaling mechanisms by which the cell surface receptor Dg communicates via Dys with the actin cytoskeleton.Muscular dystrophies (MDs) are a group of diseases that are characterized by progressive muscular degeneration and concomitant loss of muscular strength ultimately leading to skeletal muscle deterioration and cardiac and/or respiratory failure [1-3]. In addition, MDs are often associated with brain defects. Based upon the clinical symptoms of MDs they are categorized into various subtypes and currently no cures or preventions exist for these diseases, making them a worthwhile field of research. The most severe form of MD is Duchenne MD (DMD), an X-linked fatal disorder that afflicts approximately 1 out of every 3,500 males worldwide. The DMD pathology contains a subset of individuals (about 1 in 3) that suffer from cognitive impairment and mental retardation, and these attributes of the disease appear to be independent from the muscular handicap [4,5].
Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice
Flávia C. Costa,Halyna Fedosyuk,Allen M. Chazelle,Renee Y. Neades,Kenneth R. Peterson
PLOS Genetics , 2012, DOI: 10.1371/journal.pgen.1003155
Abstract: Activation of γ-globin gene expression in adults is known to be therapeutic for sickle cell disease. Thus, it follows that the converse, alleviation of repression, would be equally effective, since the net result would be the same: an increase in fetal hemoglobin. A GATA-1-FOG-1-Mi2 repressor complex was recently demonstrated to be recruited to the ?566 GATA motif of the Aγ-globin gene. We show that Mi2β is essential for γ-globin gene silencing using Mi2β conditional knockout β-YAC transgenic mice. In addition, increased expression of Aγ-globin was detected in adult blood from β-YAC transgenic mice containing a T>G HPFH point mutation at the ?566 GATA silencer site. ChIP experiments demonstrated that GATA-1 is recruited to this silencer at day E16, followed by recruitment of FOG-1 and Mi2 at day E17 in wild-type β-YAC transgenic mice. Recruitment of the GATA-1–mediated repressor complex was disrupted by the ?566 HPFH mutation at developmental stages when it normally binds. Our data suggest that a temporal repression mechanism is operative in the silencing of γ-globin gene expression and that either a trans-acting Mi2β knockout deletion mutation or the cis-acting ?566 Aγ-globin HPFH point mutation disrupts establishment of repression, resulting in continued γ-globin gene transcription during adult definitive erythropoiesis.
Peculiarities of the small businesses interaction to corporate sector of the economy
Sorokivska, Olena,Mashliy, Halyna
Socìal?no-ekonomì?nì Problemì ì Der?ava , 2012,
Abstract: The aim of the present article is to define the role and place of small businesses in the development of the corporate sector, as well as to investigate the possibility of forming small businesses associations with significant participants in the domestic production and business processes. The main tasks of this study is: to analyze the dynamics of the small enterprises number in the total number of the corporate sector enterprises of the economy, identify them a in reasons for the growth of entrepreneurial activity in the small business study of the formation peculiarities partnership relationships between small and large businesses in priority sectors of the economy, the definition of typologies and the main characteristics of companies groups. The results of the study are to determine the influence of small businesses on formation of the corporate sector branch structure the Ukraine economy, the justification features of business associations formation, with the participation of small businesses, determining the types and characteristics of the enterprise groups formation in different categories.
Maintaining the Standard Ukrainian Language: A Challenge for Teachers in Australia
Halyna Koscharsky,Geoffrey Hull
Review of European Studies , 2009, DOI: 10.5539/res.v1n1p16
Abstract: The paper deals with problems of preservation of the Ukrainian language in Australia, based on the 25-year experience of one of the authors, in teaching Ukrainian studies at Macquarie University in Sydney. Against a background of growing assimilation and the dying away of Multiculturalism as a government policy, the authors examine the structure and history of the Ukrainian community in order to explain the characteristics of dialect-influenced spoken Ukrainian, and set up categories for the other main phenomena of linguistic interference in the areas of phonology and morphosyntax. As a parallel concern, they consider a problem with special relevance in the Ukrainian homeland today, at a time when the direction of language planning is an important issue: the gap between modern standard Ukrainian and the different varieties of Ukrainian found in the diaspora.
Slavonic studies at Macquarie University 1983–1998: an experiment in migrant language maintenance
Halyna Koscharsky,Aleksandar Pavkovi?
Australian Slavonic and East European Studies , 2006,
Contours and consequences of the lexical divide in Ukrainian
Geoffrey Hull,Halyna Koscharsky
Australian Slavonic and East European Studies , 2007,
Dystrophin Orchestrates the Epigenetic Profile of Muscle Cells Via miRNAs
Halyna R. Shcherbata
Frontiers in Genetics , 2011, DOI: 10.3389/fgene.2011.00064
Abstract: Mammalian musculature is a very robust and dynamic tissue that goes through many rounds of degeneration and regeneration in an individual’s lifetime. There is a biological program that maintains muscle progenitor cells that, when activated, give rise to intermediate myoblast progeny that consequently differentiate into mature muscle cells. Recent works have provided a picture of the role that microRNAs (miRNAs) play in maintaining aspects of this program. Intriguingly, a subset of these miRNAs is de-regulated in muscular dystrophies (MDs), a group of fatal inherited neuromuscular disorders that are often associated with deficiencies in the Dystrophin (Dys) complex. Apparently, transcriptional expression of many of the muscle specific genes and miRNAs is dependent on chromatin state regulated by the Dys–Syn–nNOS pathway. This puts Dystrophin at the epicenter of a highly regulated program of muscle gene expression in which miRNAs help to coordinate networking between multiple phases of muscle maintenance, degeneration, and regeneration. Therefore, understanding the role of miRNAs in physiology of normal and diseased muscle tissue could be useful for future applications in improving the MD therapies and could open new clinical perspectives.
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