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Search Results: 1 - 10 of 9320 matches for " Hallack Neto "
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Etoposide e dexametasona como primeira linha em idosos com comorbidades portadores de Linfoma Difuso de Grandes Células B
Costa, Renata O.;Hallack Neto, Abrah?o E.;Chamone, Dalton A. F.;Pereira, Juliana;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009000100015
Abstract: pacientes idosos com linfoma difuso de grandes células b (ldgcb) s?o frequentemente excluídos de estudos clínicos. a utiliza??o de terapias curativas muitas vezes é impossibilitada em virtude das comorbidades apresentadas por esta popula??o ao diagnóstico. nós adotamos um protocolo alternativo de quimioterapia oral combinando um inibidor da topoisomerase ii e dexametasona. apresentamos os resultados parciais com este protocolo em três pacientes portadores de ldgcb com idade superior a 80 anos e comorbidades severas. todos alcan?aram remiss?o completa com baixa toxicidade. esses resultados demonstram que protocolos curativos alternativos devem ser testados em pacientes idosos portadores ldgcb a despeito da presen?a de comorbidades severas.
Primary biliary cirrhosis and myopathy: an uncommon association
Migueletto Bruno Cupertino,Hallack Neto Abrah?o Elias,Domingues Elaine Zamora,Castro Pedro Paulo Neves de
Revista do Hospital das Clínicas , 1999,
Abstract: Primary biliary cirrhosis (PBC) is a cholestatic liver disease, which is characterized by a chronic inflammatory destruction of intrahepatic bile ducts. It is a rare disorder whose precise etiology is still to be elucidated. Even though the liver is the principal target of PBC, other organ systems also might be affected. Muscular involvement has rarely been described in this disease, and in the majority of cases, muscular weakness has been interpreted as polymyositis. We report the case of a 48-year-old woman suffering from classic PBC, in association with a myopathy whose histological features are distinct from the cases reported before. We also performed a MEDLINE research for PBC and concomitant muscular diseases.
Anemia cr?nica no pós-transplante renal: parvovirose B19
Vincens, Natália Calderia Loss;Carminatti, Moisés;Franco, Marcello Fabiano;Hallack Neto, Abra?o Elias;Pinheiro, Hélady Sanders;
Jornal Brasileiro de Nefrologia , 2012, DOI: 10.5935/0101-2800.20120015
Abstract: anemia is frequent in kidney transplant patients, and its prevalence varies according to posttransplant time and the adopted diagnostic criteria. parvovirus b19 (pv b19) infection is an underdiagnosed cause of anemia in this particular population. to illustrate epidemiologic and clinical data regarding it, we present a case of pv b19 infection complicated by pure red cell aplasia (prca), pointing out the pitfalls we encountered in diagnosis and treatment. the use of viral dna detection by polymerase chain reaction (pcr), and correct interpretation of morphological features of bone marrow histology are particularly important for the diagnosis of this condition in kidney transplant patients, who fail to develop a proper humoral response against pv b19, thus importantly decreasing the sensitivity of serological methods in this setting.
Risk stratification for indolent lymphomas
Hallack Neto, Abrah?o Elias;Costa, Renata Oliveira;Atalla, Angelo;Dulley, Frederico Luiz;Chamone, Dalton Alencar Fischer;Pereira, Juliana;
Revista Brasileira de Hematologia e Hemoterapia , 2010, DOI: 10.1590/S1516-84842010000500015
Abstract: indolent b-cell lymphomas account for approximately 40% of all non-hodgkin lymphomas (nhls). advances in technology have contributed to improvements in the diagnosis and classification of indolent non-hodgkin lymphomas. follicular lymphomas are the most common although the frequency varies significantly throughout the world. the description of the follicular lymphoma international prognostic index (flipi) was an important step in identifying patient subgroups, but its use in the clinical practice has not been established yet. the use of a larger number of paraffin active monoclonal antibodies for immunohistochemistry, molecular cytogenetic studies including standard cytogenetics, multi-color fluorescence in-situ hybridization (fish), polymerase chain reaction and locus-specific fluorescence insitu hybridization as well as developments in high-resolution techniquesincluding microarray gene expression profiling allow more accurate diagnosis andprecise definition of biomarkers of value in risk stratification. the identification ofdiseasespecific gene lists resulting from expression profiling provides a number ofpotential protein targets that can be validated using immunohistochemistry. analysesof gene expression profiles or constitutive gene variations may also provide additional insight for prognostication in the near future. a comprehensive understanding of the biology of these distinct lymphoid tumors will allow us to identify novel diseaserelated genes and should facilitate the development of improved diagnosis, outcome prediction, and personalized approaches to treatment.
Aplica??o do índice prognóstico internacional em pacientes com linfoma difuso de grandes células B em uma institui??o brasileira
Hallack Neto, Abrah?o E.;Pereira, Juliana;Dorlhiac-Llacer, Pedro;Beitler, Beatriz;Chamone, Dalton A. F.;
Revista Brasileira de Hematologia e Hemoterapia , 2005, DOI: 10.1590/S1516-84842005000100008
Abstract: diffuse large b-cell lymphomas (dlbcl) correspond to 50% of non-hodgkin's lymphomas. since 1993 the treatment of these patients has been directed by the international prognostic index (ipi), validated in several studies. however, the use of the ipi has not been evaluated in our population and social-economical conditions. in this study, we evaluate the impact of the age-adapted ipi (aipi) in the complete response, overall survival and disease-free survival in under 60-year-old dlbcl sufferers treated in the hematology service of hcfmusp. of the 111 evaluated patients, 60 were classified as aipi low and intermediate risk and 51 as aipi intermediate-high and high risk. the patients with low and intermediate risk were analyzed as a whole with adapted low risk and patients with intermediate-high and high risk with the adapted high risk. we verified that the overall survival and disease-free survival were influenced by the clinic stage, ldh value and patients performance status. we recommend the regular use of ipi in the treatment of the patients with dlbcl in our institution.
Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institution
Santos, Kelli Borges;Hallack Neto, Abrah?o Elias;Silva, Girlene Alves;Atalla, Angelo;Abreu, Marcus Matta;Ribeiro, Luiz Cláudio;
Sao Paulo Medical Journal , 2012, DOI: 10.1590/S1516-31802012000100003
Abstract: context and objective: hematopoietic stem cell transplantation (hsct) has been widely used for treating oncological and hematological diseases. although hsct has helped to improve patient survival, the risk of developing infection during hospitalization is an important cause of morbidity and mortality. this study aimed to analyze the infection profile during hospitalization and the associated risk factors among patients undergoing autologous hsct at the university hospital, universidade federal de juiz de fora. design and setting: this was a cross-sectional study on patients undergoing autologous hsct at a public university hospital. methods: patients with febrile neutropenia between 2004 and 2009 were retrospectively evaluated regarding their infection profile and associated risk factors. results: infection occurred in 57.2% of 112 patients with febrile neutropenia. the main source of infection was the central venous catheter (25.9%). infection was chiefly due to gram-positive bacteria, although gram-negative-related infections were more severe and caused a higher death rate. sex, age, skin color, nutritional status and underlying disease were not associated with the development of infection. patients with severe mucositis (grades iii and iv) had a higher infection rate (p < 0.001). patients who developed pulmonary complications during hospitalization had higher infection rates (p = 0.002). infection was the main cause of death (57.1%) in the study sample. conclusion: strategies aimed at reducing infection-related mortality rates among patients undergoing autologous hsct are necessary.
Sumaya Hallack Sarkis
Psicanálise e Barroco em Revista , 2007,
Abstract: The purpose of this work is to reflect on the difficulty that anyone has to get rid of a symptom. Taking this into accounnt, we propose to make a link between drive and symptom. Then we come to the enjoyment: pulsional satisfaction that symptom contains. This canexplain the difficulty in undoing it, even if it is a source of displeausure and suffering. So the analytical treatment must treat the peculiar form of satisfaction constituted by the symptom,which means the jouissance.
Trombose aguda de prótese mecanica mitral tratada efetivamente com trombólise
Pereira Filho, Wilson Coelho;Hallack Neto, Abrah?o;Pimentel, Leandro Caetano;Bonato, Glauco Resende;Possani, Felipe de Sousa;Caminatti, Moisés;
Arquivos Brasileiros de Cardiologia , 2007, DOI: 10.1590/S0066-782X2007000500024
Abstract: a 61-year-old female patient using a mechanical prosthesis for 11 years was admitted to the hospital with sudden dyspnea, pallor and atrial fibrillation. the diagnostic evaluation included transesophageal echocardiogram, which showed a significantly reduced motion of one of the leaflets of the mitral prosthesis and immobility of the other, in addition to a thickened structure compatible with a thrombus adherent to the valve. the patient was diagnosed with thrombosis of mechanical mitral valve prosthesis. thrombolytic therapy (rtpa) was started successfully. the patient has been followed up for more than one year with a favorable outcome.
Linfoma n?o Hodgkin gástrico
Costa, Renata O.;Hallack Neto, Abrah?o E.;Chamone, Dalton A. F.;Aldred, Vera Lúcia;Pracchia, Luis F.;Pereira, Juliana;
Revista Brasileira de Hematologia e Hemoterapia , 2010, DOI: 10.1590/S1516-84842010005000002
Abstract: extranodal lymphomas account for about 30% of all non-hodgkin lymphomas (nhl), and although they can originate in any tissue, the gastrointestinal tract is the most commonly affected structure with the stomach being the most common subtype. diffuse large b cell lymphoma (dlbcl) and malt (mucosa associated lymphoid tissue) lymphoma account for more than 95% of the cases of gastric lymphoma. the indolent development of malt lymphoma stands out as it is a type of cancer subject to chronic antigen stimulation by the helicobacter pylori bacteria. conversely, diffuse large b cell lymphomas, whose pathogenesis is uncertain, can be a transformation from malt nhl or perhaps a new type of lymphoma. in this study we carried out a review of the literature, stressing the key aspects of these lymphomas in the clinical practice.
Quimioterapia associada à terapia anti-retroviral de alta eficácia no tratamento dos linfomas n?o-Hodgkin agressivos relacionados à Síndrome da Imunodeficiência Adquirida
Pereira, Juliana;Hallack Neto, Abrah?o E;Pracchia, Luís F.;Alcantara, Andréa;Maurino, Beatriz B.;Dorliac-Llacer, Pedro E.;Chamone, Dalton A. F.;
Revista Brasileira de Hematologia e Hemoterapia , 2004, DOI: 10.1590/S1516-84842004000300006
Abstract: non-hodgkin lymphoma is one of the most frequent oncological complications in patients with the acquired immune-deficiency syndrome (aids). in other countries, after the introduction of the highly active antiretroviral therapy (haart), the drop in the incidence of systemic aggressive lymphomas was below expectations, although the survival of these patients rose. in brazil, little is known about the clinical behavior and survival of the patients with lymphoma and aids in the post-haart era. the aim of this study was to retrospectively evaluate 25 patients with lymphomas and aids, treated with the combination of chemotherapy and haart. in agreement with the literature most of the patients were male (20 patients - 80%) with a median age of 39 years. we observed a predominance of the diffuse large b cell lymphoma subtype (13 patients - 52%), advanced stage (15 patients - 60%), with extra-nodal disease (22 patients - 88%) and b symptoms (18 patients - 72%). previous aids diagnosis was present in 14 patients (56%), higher than that reported in other series. fifty-two percent achieved cr, the estimated probability of overall survival and disease-free survival at 3 years were 54% e 42%, respectively. the median overall survival time was 15 months. hematological toxicity and infections were frequently observed, but no toxicity-related deaths were seen. therefore we conclude that the combined chemotherapy-haart treatment is feasible in brazilian patients and can provide similar overall survival than that described for some international groups, with an acceptable toxicity profile.
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