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Search Results: 1 - 10 of 13435 matches for " Halima El Omri "
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Acquired pure megakaryocytic aplasia successfully treated with cyclosporine
Halima El Omri,Firyal Ibrahim,Ruba Yasin Taha,Riham Hassan Negm
Turkish Journal of Hematology , 2010,
Abstract: Acquired pure megakaryocytic aplasia is a rare hematological disorder characterized by thrombocytopenia with absent or markedly reduced megakaryocytes in the bone marrow. We report a case of a 25-year-old male diagnosed as acquired pure megakaryocytic aplasia. Treatment with prednisone and intravenous immunoglobulin failed, but he was successfully treated with cyclosporine, with complete remission after 90 days and normal platelet count maintained thereafter.
Diagnostic Delay and Associated Clinical Features of Tuberculosis among Adult Patients with Acute Myeloid Leukemia in Doha, Qatar  [PDF]
Halima El Omri, Ruba Taha, Wanis Ibrahim, Nancy Kassem, Lajos Szabados, Hesham El Sabah, Fatma Ben Abid, Amna Gamiel, Aisha Al Khinji, Wojciech Szmeigielski, Saba Hasan, Ibrahim Al Hijji
Journal of Tuberculosis Research (JTR) , 2018, DOI: 10.4236/jtr.2018.61005
Abstract: Background: Tuberculosis is currently the world’s leading cause of death arising from a single infectious condition. While T cell mediated immunity is recognized to have a major contribution to tuberculosis activation, the present investigation confirmed that TB was more prevalent among patients with acute myeloid rather than lymphoid leukemia and such association was frequently overlooked. The primary objective of this study is to estimate the diagnostic delay of tuberculosis among patients with acute myeloid leukemia (AML) and compare it to the general population in Qatar. Secondary objective is to study the clinical and epidemiologic characteristics of tuberculosis in patients with AML. Methods: This is a retrospective study of tuberculosis cases diagnosed in subjects with AML during the period from January 2008 till December 2016. Results: Among 215 subjects with AML identified during the study period, 12 (5.58%) received the diagnosis of tuberculosis. The estimated incidence of tuberculosis among AML cases was 7.14 cases per 1000 per year. The mean delay in diagnosis of tuberculosis was 64.2 days (95% CI: 26.8 - 101.5) and the median was 45 days (interquartile range; Q1 - Q3, 29.5 - 97.5). Prolonged fever was the most common presentation (100% of cases). Parenchymal lung involvement was the most common radiologic abnormality (83.3% of cases). Three patients (25%) died and 8 patients completed 9 to 12 months of anti-tuberculous treatment with clinical and radiological remission. Conclusion: Infections caused by Mycobacterium tuberculosis are not uncommon in patients with AML especially in patients from tuberculosis endemic regions. It constitutes a diagnostic challenge so high index of suspicion is of paramount importance.
Mantle Cell Lymphoma: A Report of a Case with a Blend of Atypical Features
Firyal A. Ibrahim, Halima El Omri, Ruba Y. Taha, Ibrahim Al Hijji, Mohamad ElKhalifa and Ahmad Al Sabbagh
Indian Journal of Clinical Medicine , 2012, DOI: 10.4137/IJCM.S10608
Abstract: Mantle cell lymphoma is an aggressive B-cell neoplasm with special clinical and pathological characteristics. As the morphological variants of mantle cell lymphoma are currently acknowledged, a practical challenge for achieving the correct diagnosis is encountered especially when the cytogenetic/molecular data are not widely available. Here we describe a case of mantle cell lymphoma (MCL) presented with a blend of atypical clinical, morphological, and immunophenotypic features that led to an incorrect diagnosis of B-cell prolymphocytic leukemia (B-PLL).
Fatal Strongyloides stercoralis hyper-infection in a patient with multiple myeloma
Yassin, Mohamed A;El Omri, Halima;Al-Hijji, Ibrahim;Taha, Ruba;Hassan, Reham;Aboudi, Kamal Al;El-Ayoubi, Hanadi;
Brazilian Journal of Infectious Diseases , 2010, DOI: 10.1590/S1413-86702010000500019
Abstract: strongyloides stercoralis (s.s.) is a human intestinal parasite, which may lead to complicated strongyloidiasis. we report a case of disseminated strongyloidiasis following the treatment of myeloma. the patient developed skin lesions, respiratory distress, aseptic meningitis and bacterial and fungal sepsis. the diagnosis of strongyloidiasis was established through endotracheal tube secretions. despite the treatment with ivermectin and albendazole, the outcome was fatal. the value of screening for strongyloidiasis is unclear but may be of benefit in patients with hematological malignancies from high endemic areas
Molecular study of the perforin gene in familial hematological malignancies
Rim El Abed, Violaine Bourdon, Ilia Voskoboinik, Halima Omri, Yosra Youssef, Mohamed Laatiri, Laetitia Huiart, Fran?ois Eisinger, Laetitia Rabayrol, Marc Frenay, Paul Gesta, Liliane Demange, Hélène Dreyfus, Valérie Bonadona, Catherine Dugast, Hélène Zattara, Laurence Faivre, Monia Zaier, Saloua Jemni, Testsuro Noguchi, Hagay Sobol, Zohra Soua
Hereditary Cancer in Clinical Practice , 2011, DOI: 10.1186/1897-4287-9-9
Abstract: Perforin is a Ca2+ dependent pore forming protein stored as an active protein in specialized secretory lysosomes (known as lytic granules) of Cytotoxic T lymphocyte (CTL) and Natural Killer cells (NK). Upon recognition of the target cells, lytic granules polarize and release their contents at the immunologic synapse, which triggers apoptosis [1,2]. Cytotoxic granules also contain a group of serine proteases called granzymes in a proteoglycan matrix [3,4]. Perforin is the only molecule that is able to deliver granzymes into the target cell.Perforin is encoded by PRF1, a highly conserved gene, which is crucial to the function of the granzymes involved in triggering caspase dependent and caspase independent target cell death after the formation of an immunological synapse [5]. Perforin-mediated cellular cytotoxicity is a highly preserved mechanism responsible for killing virus-infected and neoplastic cells.PRF1 mutations were first described in familial hemophagocytic lymphohistiocytosis (FHL) [6,7]. These mutations include nonsense, frameshift and missense mutations disrupting perforin activity [8-15]. FHL is a life threatening disease usually occurring in childhood, which is associated with profound immune derangement and characterized by impaired T-cell and NK cell granule-mediated cytotoxic activity. The fact that these mutations were described in homozygous and compound heterozygous states suggests that autosomal recessive transmission processes are involved. Patients with FHL caused by biallelic perforin mutations are severely immunocompromised [7,16].Inherited PRF1 mutations were subsequently described in various types of lymphomas [17-19], which suggests that PRF1 protein is involved in the immune surveillance mechanisms preventing tumor growth and/or development.Escape from immune surveillance is thought to be the main mechanism possibly explaining the role of some predisposing genetic mutations in the development of leukemia and lymphoma[20-23].The key role o
Comparison of Different Regularized and Shrinkage Regression Methods to Predict Daily Tropospheric Ozone Concentration in the Grand Casablanca Area  [PDF]
Halima Oufdou, Lise Bellanger, Amal Bergam, Angélina El Ghaziri, Kenza Khomsi, El Mostafa Qannari
Advances in Pure Mathematics (APM) , 2018, DOI: 10.4236/apm.2018.810049
Abstract: Tropospheric ozone (O3) is one of the pollutants that have a significant impact on human health. It can increase the rate of asthma crises, cause permanent lung infections and death. Predicting its concentration levels is therefore important for planning atmospheric protection strategies. The aim of this study is to predict the daily mean O3 concentration one day ahead in the Grand Casablanca area of Morocco using primary pollutants and meteorological variables. Since the available explanatory variables are multicollinear, multiple linear regressions are likely to lead to unstable models. To counteract the multicollinearity problem, we compared several alternative regression methods: 1) Continuum Regression; 2) Ridge & Lasso Regressions; 3) Principal component regression (PCR); 4) Partial least Square regression & sparse PLS and; 5) Biased Power Regression. The aim is to set up a good prediction model of the daily ozone in the Grand Casablanca area. These models are fitted on a training data set (from the years 2013 and 2014), tested on a data set (from 2015) and validated on yet another data set data (from 2015). The Lasso model showed a better performance for the prediction of ozone concentrations compared to multiple linear regression and its other alternative methods.
Chromosomal aberrations and nucleic acids systems affected by some Egyptian medicinal plants used in treating female pregnant diabetic rats  [PDF]
Halima S . Abdou, Sherifa H. Salah, Amira Abd El Raouf, E.A. Abdel-Rahim
American Journal of Molecular Biology (AJMB) , 2011, DOI: 10.4236/ajmb.2011.11004
Abstract: The influences of medicinal plants Juniperus Phoenicea (Araar), Hyphaene thebaica (Doum), An-astatica hierochuntica (Kafta) and Cleome droserifolia (Sammo) as antidiabetic agents were investigated using female pregnant albino rats. Female rats were injected with 60 mg/kg b.w. alloxan to induce diabe-tes. Diabetic rats treated orally with the methanol extracts of tested plants till the 19 day of gestation. The present studies include the frequencies of chro-mosomal aberrations and nucleic acid system of liver in the female pregnant rats and their embryos. The results showed that injection of alloxan caused highly significant increase in chromosomal aberrations as well as in blood glucose levels as a result of diabetes in pregnant females. It also caused a high incidence of chromosomal deviation in embryos and decreased the liver soluble protein contents of female rats and their embryos. These effects in alloxanized animals were treated and improved by ingestion of the methanol extracts of the tested plants (Araar, Doum, Kafta and Somma) in which under their treatments, the inceased level of blood glu-cose of diabetic rats was deceased. Ingestion with the plants methanolic extracts improved and normalized the effects of diabetes in nucleic acids values of liver tissues. These were accompanied with nucleases (RNAase and DNAase) activities. The inhibited ac-tivities of both DNA ase and RNA ase of pregnant rats and their embryos were stimulated and read-justed around the normal values. Also administration of the plants methanol extracts decreased the per-centage of chromosomal aberrations in the female rats and embryos. It is concluded that there are some biochemical dynamics which might occur in the metabo-lism of glucose, nucleic acids and proteins in order to prevent or to reduce the oxidative stress of diabetes by flavonoides treatment.
Enthalpy of Dissolution and Dehydration of Two Moroccan Clays  [PDF]
Jabrane Maissara, Halima Karym, Mohammed El Mahi Chbihi, Mohammed Moutaabbid, Mohamed Abatal, Said Benmokhtar
World Journal of Engineering and Technology (WJET) , 2018, DOI: 10.4236/wjet.2018.61007
Abstract: This work aims to characterize and determine the dehydroxylation enthalpy variations of two natural Moroccan clays from the Nador region (denoted K1) and the Settat region (denoted by K2). The variations of dissolution enthalpies were determined by dissolving clays in hydrofluoric acid. They have a minimum value for dehydroxylation of clays made between 600°C and 700°C. The analysis of the two clays shows that they consist of kaolinite in significant proportion. The optimum calcination parameters, for which dehydroxylation is total, are 700°C with a heating time of 6 H. The conversion of the kaolinite to metakaolinite was confirmed by IR analyses of the starting and thermally treated kaolin samples. The result confirms previous observations about obtaining metakaolinite with optimum reactivity when hydrated with calcium hydroxide as chemical activator.
The antioxidative effects of some medicinal plants as hypoglycemic agents on chromosomal aberration and abnormal nucleic acids metabolism produced by diabetes stress in male adult albino rats  [PDF]
Sherifa H. Salah, Halima S. Abdou, Amal S. Abd El Azeem, E.A. Abdel-Rahim
Journal of Diabetes Mellitus (JDM) , 2011, DOI: 10.4236/jdm.2011.11002
Abstract: The objectives of the present study are to evaluate the chromosomal aberrations in somatic and germ cells of alloxanized diabetic rats treated with methanolic extracts of Cleome droserifolia (Sammo), Anastatica hierochuntica (Kafta), Juniperus phoencea (Araar) and Hyphaene thebaica (Doum) as well as their effects on blood glucose, liver and testes total soluble protein, DNA and RNA contents and also nucleases (RNAase and DNAase) activity. The material and Methods: The study was performed in six groups. The first group was the normal healthy control; the second group was rats injected with alloxan (diabetic control). Every one of the other four groups (diabetic rats) was ingested with each of the methanolic extracts of Kafta, Doum, Sammo and Araar (individually). The results: The results of chromosomal analysis showed that, diabetic rats had a highly significant increase of chromosomal aberrations compared to that of normal healthy control. Animals which treated with the four plants methanolic extracts showed significant improvements in the frequencies of chromosomal aberrations. In case of biochemical analysis, blood glucose level was significantly increased but immunoglobulins levels were decreased in diabetic albino rats. Diabetes increased serum total lipids, cholesterol, triglycerides and LDL but serum HDL was decreased. RNA and DNA as well as inhibited the nucleases (RNAase and DNAase) activity of both organs (liver and testes) tissue. The conclusions: It is concluded that diabetes is much harmful in the animal body, whilst the induction of flavonoids extract (by methanol) of Kafta, Somma, Araar and Doum reduced these harmful of diabetes.
Microbial analysis of raw ground beef marketed in Fez (Morocco)
Oumokhtar bouchra,Berrada Halima,Ameur Najia,El Fakir Samira
Technologies de Laboratoire , 2008,
Abstract: The ground meat is highly perishable product. This foodstuff constitutes a potential risk for the consumer since it is mostly consumed while insufficiently cooked. The aim of the present study was to evaluate the bacterial quality of ground beef marketed in Fes. Forty samples of ground meat were collected randomly from butcheries during three months in Fez (Morocco). The samples were analyzed for the presence and counts of various bacteria. Results indicated that faecal coliforms and Escherichia coli were particularly high in all the samples analysed. The coagulase-positive Staphylococcus and anaerobic sulphite-reducing charges were not homogeneous. When Salmonella, and Shigella were detected respectively in 17,5 % and 2,5% of the ground beef samples. The ground beef samples contained 80% of bacteria above the maximum limits established by the Moroccan regulatory standards. These high levels of microbial contamination and occurrence of pathogenic bacteria reflect the poor hygienic quality of ground beef production and transport conditions.
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