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Search Results: 1 - 10 of 410595 matches for " Hala M El-Gendy "
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Homocysteine, an indicator of methylation pathway alternation in Down syndrome and its regulation by folic acid therapy
Hala M El-Gendy,Hala M Mokhtar
Journal of Research in Medical Sciences , 2007,
Abstract: BACKGROUND: Down syndrome (DS) is a complex genetic disease. Some clinical features of patients with this syndrome could be related to functional folate deficiency. The purpose of this study was to evaluate the total homocysteine (T-Hcy) metabolism in DS children and to determine whether the supplementation with folic acid therapy would shift the genetically induced metabolic imbalance or not. METHODS: Thirty-five infants with DS, with the mean age of 17.66 ± 12.24 months were included in this study. They were selected from those attending the Genetic Outpatients Clinic in Children hospital. RESULTS: Our results revealed that Down syndrome children had a significant decrease in serum plasma T-Hcy level after the treatment with folic acid [11.79 ± 0.92 vs. 14.41 ± 4.93 μmol/L]. A significant negative correlation was found between T-Hcy and folic acid serum levels [r = -0.112; P<0.05].CONCLUSIONS: We concluded that the regulation of methylation pathways in Down syndrome patients becomes important in the light of possible normalization of the metabolic imbalance and the detection of increased sensitivity to therapeutic interventions. KEY WORDS: Down syndrome, hyperhomocysteine, folic acid, vitamin B-12.
Amelioration of aluminium - intake oxidative stress by some antioxidants in malealbino rats
Ahkam M. El-Gendy
Egyptian Journal of Hospital Medicine , 2011,
Abstract: Aluminum is potentially toxic to humans. The Agency for Toxics Substances and Disease Registry (ATSDR) reported that aluminum accumulates mainly in the bone, liver, testes, kidneys and brain. The goal of the present study was to assess in rats the pro-oxidant effects induced by Al3+ exposure, as well as the protective role of exogenous melatonin (M), vitamin E (vit. E) or N-acetylcystiene (NAC). The effect of aluminium (Al) alone or combined with antioxidants (M), (vit. E) or (NAC) on some physiological parameters and antioxidants in male albino rats were studied. Material and methods: The animals were assigned to 5 groups: control (group I); Al3+-intake (53.5 mg AlCl3/litre drinking water , group II) ; 5 mg melatonin/kg b.wt. plus AlCl3 (group III); , or vitamin E(100 mg/kg b.w.) plus AlCl3 (group IV)or 100mg N-acetylcystien plus AlCl3 (group V). Rats were orally administered their respective doses daily for 30 days. At the end of the treatment period, blood was obtained. Thereafter, brain, liver, kidney and testes were removed. These tissues were processed to examine oxidative stress markers: reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSHpx) and lipid peroxidation end products {malondialdhyde(MDA) + 4- hydroxynonenal (4- HNE)}. Samples of these tissues were also used to determine Al3+ concentrations. Results : In Al- toxicated group ,serum glucose and total cholesterol levels, liver enzyme activities (ASAT and ALAT), as well as, lipid peroxidation end products {malondialdhyde (MDA) + 4- hydroxynonenal (4- HNE)} were elevated significantly in the brain , liver ,kidney and testes tissues when compared with control group. On the other hand, serum triglycerides and tissue (liver, kidney and testes) intracellular antioxidants glutathione (GSH) and superoxide dismutase (SOD) and liver glutathione peroxidase (GSHpx) activity decreased significantly. Brain GSH also decreased but SOD showed no significant changes. Melatonin, vit. E and NAC improved the levels of the different changed parameters when combined with Al. The most improved correction was recorded when Al3+ combined with vit. E followed by M ,then NAC. Serum Al3+ levels were increased in Al3+ treated group as well as groups exposed to Al3+ combined with vit. E, M or NAC when compared with control group. Al3+ could not be detected in tissues by atomic spectrophotometer (aluminium metal concentrations were below the limit of detection by AAS). Conclusion: The results show that Al3+ exposure promotes oxidative stress in different tissues while melatonin, vitamin E an
The Beneficial Effect Of Trifolium Flower Extracts
Ahkam M. El-Gendy
Egyptian Journal of Hospital Medicine , 2012,
Abstract: Acetaminophen known as paracetamol (P) overdose can cause severe hepatotoxicity and even liver failure and hepatic centrilobular necrosis in experimental animals and humans. Material and methods: The male rats (n=36) were allocated into 6 groups (each group n=6 rats). Group I was kept as control. All animals in groups II-VI were given paracetamol at 2 g /kg bw by gastric gavage on days 3 post Trifolium alixanderanum (T alixanderanum) flower extracts (TEs) or N-acetylcystiene (NAC) treatments. Group III, IV and V were treated for three days by hexane extract (THE + P), ethanol extract (TEE + P) and water extract (TWE + P). Group VI received 100 mg/kg bw of antidote N-acetylcystiene (NAC + P). Results: Paracetamol induced a significant rise in Liver weight and hepatosomatic index, serum aspartate amino transferase (ASAT), alanine amino transferase (ALAT), alkaline phosphatase (ALP), total bilirubin (T bili), liver lipid peroxides (MDA+ 4-HDNE) with a reduction of liver glutathione (GSH), glutathione peroxidase (GSHpx) and superoxide dismutase (SOD) enzymes activities. The plant extracts showed a remarkable hepatoprotective and antioxidant activity against paracetamol induced hepatotoxicity as judged from the serum marker enzymes and antioxidant levels in liver tissues.Conclusion: The present investigation indicated that paracetamol damaged liver cells and TEs prevented this damage when compared with control group.Trifolium flower hexane extract was the most effective superior to TEE, TWE and NAC.
Adult Intussusception in Patients with Peutz-Jeghers Syndrome: Case Series and Review of Literature  [PDF]
Mohamed A. Mlees, Tamer A. El-Bakary, Magdy M. El-Gendy, Ahmed A. Darwish
Surgical Science (SS) , 2017, DOI: 10.4236/ss.2017.82014
Abstract: Background: Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by gastrointestinal hamartomatous polyps and mucocutaneous pigmentations in the mouth, facial skin, hands & feet. Small bowel obstruction, intussusception, bleeding, intestinal and extra-intestinal malignancies are the major complications of PJS. The aim of this study is to analyze the clinical characteristics, preoperative diagnosis, and surgical management of PJS associated-intussusception in adults. Patients and Methods: This study included 5 cases with intussusception in PJS patients presented to Surgical Oncology Unit, General Surgery Department, Tanta University Hospital, Egypt and Hamad General Hospital, Hamad Medical Corporation, Qatar, between October 2011 and March 2016. Patients’ demographics were collected. After thorough clinical examination, abdominal X-ray, US, & CT scan were done. All the patients were submitted to midline laparotomy with resection anastomosis of the affected bowel segment. Results: The mean age was 28.4 years. Female: male ratio was 3:2. Abdominal pain was the most common presenting complaint with or without intestinal obstruction manifestations. Palpable abdominal mass was found in 3 patients (60%). Intussusception was proved pre-operatively in all the cases by abdominal ultrasound and CT scan. The intussusception was found in the jejunum in 3 patients, ileum in 1 patient, & in 1 patient, there was double intussusception (one jejunal & one ileo-cecal). Histopathological examination revealed the presence of typical Peutz-Jeghers hamartomatous polyp. No morbidity or mortality was reported at a mean follow-up period of 32 months. Conclusion: Family history, physical examination, abdominal ultrasound and CT scan were important in the diagnosis of acute intussusception caused by PJS. Surgical management of PJS associated intussusception is the recommended treatment to relieve patient’s symptoms and to avoid missing underlying malignancy. Patients with PJS should be followed up throughout their lives because of the increased risk of malignant changes.
A Secured Communication Based On Knowledge Engineering Technique
M. W. Youssef,Hazem El-Gendy
International Journal of Advanced Computer Sciences and Applications , 2012,
Abstract: Communication security has become the keynote of the "e" world. Industries like eComm, eGov were built on the technology of computer networks. Those industries cannot afford security breaches. This paper presents a methodology of securing computer communication based on identifying typical communication behavior of each system user based on the dominant set of protocols utilized between the network nodes.
Imipenem Resistance and BLAIMP Gene among Hospital Strains of Pseudomonas aeruginosa at University Hospital in Egypt
Fatma A. Amer,1 Eman M. El-Behedy,1 Heba A. Mohtady,1 Hala E. Zanfaly,2 Dalal E. M. Soud,2 Tarek M. El-Behedy,3 Eman El-Gendy.3
Journal of Infection in Developing Countries , 2007,
Abstract: Background: Imipenem (IMP) is considered the last resort for treatment of infections caused by resistant Gram negative bacteria in our setting. However, in recent times, multi-drug resistant strains of P. aeruginosa which are also imipenem (IMP) resistant have been isolated in our hospital. This study was conducted to determine the occurrence of IMP resistance among P. aeruginosa strains isolated in our setting as well as assess for the presence of blaIMP gene among these IMP-resistant strains. Methods: The study was conducted at the Zagazig University Hospital, Egypt between February 2003-January 2004. All P. aeruginosa strains isolated from patients with nosocomial infections were studied. Disk diffusion method was used to determine susceptibility to IMP and other antimicrobials. The minimum inhibitory concentration (MIC) for IMP was determined by broth microdilution method and phenotypic screening for metallo-β-lactamases (MBL) was by E-test. Carriage of the blaIMP gene was detected by PCR. Results: Of the 261 P. aeruginosa strains studies 31 (11.9%), were IMP resistant, mostly from Intensive Care Unit patients. The IMP MIC range for resistant isolates was 8 - >128 μg/ml (MIC50:16 μg/ml and MIC90:32 μg/ml). These IMP-resistant strains were also resistance to multiple antimicrobial agents. Ten IMP-resistant strains were MBL-positive with only 8 demonstrating carriage of the blaIMP gene Conclusions: Our findings indicate the emergence of IMP-resistant Pseudomonas isolates in our locality and represents the first reported detection of blaIMP gene from Egyptian isolates of P. aeruginosa.
Bioethanol Production from Rice Straw Enzymatically Saccharified by Fungal Isolates, Trichoderma viride F94 and Aspergillus terreus F98  [PDF]
Mervate A. Abo-State, Ahmed M. E. Ragab, Nour Sh. EL-Gendy, Laila A. Farahat, Hekmat R. Madian
Soft (Soft) , 2014, DOI: 10.4236/soft.2014.32003
Abstract:

Egypt faces a high population growth rate nowadays, which demands for an increase in agricultural production efficiency. Consequently, agricultural field residues will increase. Rice straw is one of the main agriculture residues in Egypt. So this study was performed on rice straw as a resource for production of bioethanol. Eight microbial isolates, five yeasts and three fungi were isolated from rice straw. Yeast isolates were selected for their ability to utilize different sugars and cellulose. Chipped and grinded rice straw was subjected to different pretreatment methods physically through steam treatment by autoclaving and different doses of gamma γ irradiation (50 and 70 Mrad). Autoclaved pretreated rice straw was further enzymatically treated throughout solid state fermentation process by different fungal isolates; F68, F94 and F98 producing maximum total reducing sugars of 12.62, 13.58, 17.00 g/L, respectively. Bioethanol production by separate microbial hydrolysis and fermentation (SHF) process of rice straw hydrolysate was performed by the two selected fungal isolates; Trichoderma viride F94 and Aspergillus terreus F98 and two yeast isolates (Y26 and Y39). The two yeast isolates have been identified by 18S, RNA as Candida tropicalis Y26 and Saccharomyces cerevisiae Y39. SHF processes by F94 and Y26 produced 45 gallon/ton rice straw while that of F98 and Y39 produced 50 gallon/ton rice straw.

The Influence of Marine Pollution on Distribution and Abundance of Polychaetes
A. El-Gendy,S. Al-Farraj,S. Al-Kahtani,M. El-Hedeny
Current Research Journal of Biological Sciences , 2012,
Abstract: Polychaetes are the most abundant taxon recorded in benthic communities of many habitats of Alexandria, Egypt. In the study, six stations were chosen along the Mediterranean coast of Alexandria. In each station water quality variables were measured. A total of 25 polychaete species were encountered. The most common families were Capitellidae and Spionidae both in term of abundance and species richness. Capitella capitata, Minuspio cirrifera, Polydora capensis and Heteromastus filiformis were the most abundant and omnipresent polychaete species in the study area, indicating their tolerance and adaptability to various degrees of pollution. Statistical analyses of polychaete data were used to determine the level of environmental degradation in various stations of coast. Shannon’s index (H') varied spatially from 1.43 to 2.52, Margalef richness index (d) from 0.50 to 2.59, and evenness index (J) from 0.81 to 0.97 indicating poor polychaete diversity. Comparing with control sites, the impacted stations (1-4) had lower species richness and diversity indicating poor environment that is confirmed with low pH and dissolved oxygen values. Moreover, they displayed high nutrient levels due to the high organic matter input in the area. The poorest environment for polychaetes was in the Eastern Abu Quir "station #1" (S = 5, N = 2275, H' = 1.50, d = 0.51 and J = 0.93). The present data can form a baseline for future monitoring programmers in the area.
Heterogeneity of Campylobacter species isolated from serial stool specimens of Egyptian children using pulsed field gel electrophoresis
Atef M. El-Gendy,Momtaz O. Wasfy,Adel M. Mansour,Buhari Oyofo
African Journal of Laboratory Medicine , 2013,
Abstract: Background: The genus Campylobacter spp. is a common cause of human acute bacterial enteritis and travellers f diarrhoea worldwide.Objective: To determine whether multiple serial isolations of Campylobacter spp., when obtained from a single child, represented the same or a different organism.Methods: In a birth cohort study conducted in Egypt, numerous children showed serialisolations of Campylobacter spp. Of these, 13 children were selected from different households based on the successive isolation of six or more Campylobacter isolates from stool samples.Results: Eighty isolates were recovered and identified as either Campylobacter coli (n = 25) or Campylobacter jejuni (n = 55). Pulsed-field gel electrophoresis (PFGE) revealed the presence of 38 unique C. jejuni and 24 C. coli profiles at a similarity level of . 90%. Although no seriallyidentical isolates were detected in six children, others demonstrated at least one identical couple of isolates; all identified serially between one to six weeks. Two children demonstrated > 80% similar couples of isolates that appeared seven months apart. PFGE could be a useful tool for differentiating reinfection, relapse and convalescent excretion phases.Conclusion: Our data suggest that Campylobacter infection in children is a complex process;children are exposed to multiple species in endemic environments and strains of the samebacterium appear to be shed serially between one to six weeks after the first exposure. Isolates that persisted for longer periods were relatively less similar, as shown from the results of this study.
The potential therapeutic effect of melatonin in gastro-esophageal reflux disease
Tharwat S Kandil, Amany A Mousa, Ahmed A El-Gendy, Amr M Abbas
BMC Gastroenterology , 2010, DOI: 10.1186/1471-230x-10-7
Abstract: 36 persons were divided into 4 groups (control subjects, patients with reflux disease treated with melatonin alone, omeprazole alone and a combination of melatonin and omeprazole for 4 and 8 weeks) Each group consisted of 9 persons. Persons were subjected to thorough history taking, clinical examination, and investigations including laboratory, endoscopic, record of esophageal motility, pH-metry, basal acid output and serum gastrin.Melatonin has a role in the improvement of Gastro-esophageal reflux disease when used alone or in combination with omeprazole. Meanwhile, omeprazole alone is better used in the treatment of GERD than melatonin alone.The present study showed that oral melatonin is a promising therapeutic agent for the treatment of GERD. It is an effective line of treatment in relieving epigastric pain and heartburn. However, further studies are required to confirm the efficacy and long-term safety of melatonin before being recommended for routine clinical use.QA13NCT00915616Gastro esophageal reflux Disease (GERD) is defined as a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications [1]. Symptoms of GERD occur in approximately 14 to 20% of the population on at least a weekly basis. Symptoms of GERD may result in a large burden on employers through increased absenteeism and decreased performance while remaining at work impaired by health problems [2].Even though over 50 years have passed since the discovery of melatonin, the knowledge on its physiological function is still not complete. The results of the researches have provided the evidence that melatonin is synthesized not only in the pineal gland, but also in different organs. A special attention has been directed to the digestive tract where total quantity of melatonin is considerably greater than in the pineal gland [3]. It was calculated that the gastrointestinal tract contains at least 400 times melatonin than the pineal gland [4]. Although pinea
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