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The effect of Isosorbide Dinitrate on vascular endothelial growth factor production by human leukemic cell lines in vitro
Hajighasemi F,Mirshafiey A
Tehran University Medical Journal , 2009,
Abstract: "nBackground: Vascular endothelial growth factor (VEGF) has mitogenic effect for endothelial cells and is an important mediator of tumor expansion, metastasis and angiogenesis in vivo. Isosorbide dinitrate, as a nitric oxide donor, has been widely used in treatment of many cardiovascular diseases such as congestive heart failure and acute coronary syndromes. Furthermore this drug was found to have inhibitory effect on angiogenesis, tumor growth and metastasis in vivo. In the present study we evaluated the isosorbide effect on the VEGF production using some human leukemic cell lines. "nMethods: Human leukemic MOLT-4, JURKAT and U937 cells were cultured in complete RPMI medium. The cells at the exponential growth phase were then incubated with different concentrations of Isosorbide (4′10-7 -4′10-4 M) in the presence or absence of PMA (25ng/ml) for 24 hours. The VEGF concentrations in the culture supernatants were measured by enzyme immunoassay kits (R&D systems) according to the manufacturer's instructions. "nResults: The level of VEGF produced by the human leukemic cell lines which was treated with different concentrations of isosorbide, did not show any significant difference with untreated control cells. "nConclusions: The results of this study showed that isosorbide had no significant effect on VEGF production. Our findings suggest that anti-angiogenesis effect of isosorbide could be mediated through VEGF-independent mechanism(s). Further studies are warranted to determine definite isosorbide effect on VEGF and other angiogenic factors production in patients as well as animal models.
The Effects of Isosorbide Dinitrate on in Vitro Proliferation of WEHI-164 Cells and Peripheral Blood Mononuclear Cells
Hajighasemi F,Resvan Madani FZ
Tehran University Medical Journal , 2012,
Abstract: Background: Isosorbide dinitrate has been broadly used in the treatment of various ischemic heart diseases. Isosorbide is a nitric oxide donor which increases blood flow to tumors through vasodilatation and consequently accelerates the access of chemo-drugs to them. Furthermore, this drug has inhibitory effects on angiogenesis, tumor growth and metastasis in vivo. Moreover, its ant-inflammatory effects have also been reported. In the present study we evaluated the effects of isosorbide on the proliferative activity of fibrosarcoma WEHI-164 cell line and peripheral blood mononuclear cells (PBMCs). Methods: WEHI-164 fibrosarcoma cells and human PBMCs were cultured in complete Roswell Park Memorial Institute (RPMI) 1640 medium with 10% fetal bovine serum and 2×104 cells/mL for WEHI-164 and 2×105 cells/mL for PBMCs. The cells were then incubated at the exponential growth phase with different concentrations of isosorbide (4×10-6-1.6×10-3 M) for 24, 48 and 72 hours. Subsequently, isosorbide effects on proliferation of the cells were evaluated by trypan blue dye exclusion (TB) test and MTT assay. Statistical comparisons between groups were made by analysis of variance. Results: The proliferative activity of WEHI-164 fibrosarcoma cells and human PBMCs treated with different concentrations of isosorbide, did not show any significant difference with untreated control cells. Conclusion: The results of this study showed that isosorbide neither had any significant effects on the proliferative activity of fibrosarcoma WEHI-164 cells nor on human PBMCs. Our findings suggest that anti-tumoral effects of isosorbide reported by other investigators may be mediated through non-cytotoxic mechanisms.
CLINICAL AND HORMONAL MILIEU OF 9 PATIENTS WITH PRIMARY GROWTH HORMONE INSENSITIVITY SYNDROME AND THEIR RESPONSE TO IGF-I GENERATION TEST
M. Razzaghy-Azar,M. Nourbakhsh F. Hajighasemi
Acta Medica Iranica , 2006,
Abstract: Primary growth hormone insensitivity syndrome (GHIS) is a rare entity which can be due to defects in growth hormone (GH) receptor that is called type 1 Laron syndrome (T1LS) or post receptor defects (type 2 Laron syndrome ). The aim of study was determining the clinical and hormonal milieu of the patients with primary GHIS and their response to IGF-I (insulin like growth factor-I) generation test (IGT). GH, IGF-I, IGF-II, IGF binding protein 1 and 3 (BP-1 and BP-3), GH binding protein (GHBP) and anti-GH antibody were detected by ELISA and RIA methods. IGF-I and BP-3 were measured before and after IGT. Nine patients (8 males, 1 female) (mean age ± SD, 6.4 ± 5 years) with severe short stature and high GH level were studied. Height SDS was - 8.5 ± 2.6. In 7 patients GHBP was zero, IGF-I and BP-3 were low and did not increase after IGT, so they had T1LS. Two brothers did not show the hormonal milieu of GH receptor defect, and were called non Laron syndrome (NLS). Birth weight in patients with T1LS and NLS was 3.65 ± 0.2 Kg and 1.65 ± 0.2 Kg, respectively (P = 0.001). All of the patients had typical clinical feature of GH-deficiency, but nasal bridge depression and microphallus were not seen in NLS. GH treatment of NLS, normalized their growth velocity, but without catch up growth. In conclusion IGT can differentiate Laron syndrome from other types of short stature. GH and IGF-I of fetus have no role in intrauterine growth.
Sensitivity of Monocytic Cell Lines to Verapamil in vitro
Fatemeh Hajighasemi,Neda Kakadezfuli
Research Journal of Biological Sciences , 2012, DOI: 10.3923/rjbsci.2012.209.214
Abstract: Verapamil as a calcium channel blocker broadly used in therapy of many cardiovascular diseases such as hypertension and arrhythmia. Moreover, the anti-tumor effect of several chemotherapeutic agents has been increased by verapamil. Also, the inhibitory effect of some calcium channel blockers on tumor cell growth and invasion has been reported. Moreover, induction of apoptosis in leukemia cells by a Ca2+ channel blocker has been revealed. The present study was conducted to evaluate the verapamil cytotoxicity in two human monocytic cell lines in vitro. The human monocytic U937 and THP1 cells were cultured in complete RPMI medium. Then, the cells at logarhytmic growth phase were incubated with different concentrations of verapamil (0.01-2 mM) for 24, 48 and 72 h periods. Next, the cell viability was assessed with trypan blue dye exclusion and MTT 3-(4, 5-dimethyl thiazol-2, 5-diphenyltetrazoliumbromide) methods. Verapamil significantly decreased the proliferation of U937 and THP1 cells dose and time dependently. This cytotoxic effect after 24, 48 and 72 h incubation time was shown at ≥1, 0.2 and 0.1 mM concentration for U937 and at ≥1, 1 and 0.2 mM concentration for THP1 cells, respectively. In U937 cells verapamil cytotoxicity at 0.2 mM concentration, significantly increased with time in this order 72>48 h (p<0.05). According to the results of this study, verapamil showed a dose and time-dependent cytotoxic effect on human U937 and THP1 cells. Moreover, the sensitivity of U937 and THP1 cells to verapamil was somewhat different. So, the anti-tumor effects of verapamil reported by several investigations may be in part due to its direct cytotoxic effects. Thus, verapamil with potential inhibitory effect on leukemic U937 and THP1 cells growth might be useful as an anti-proliferative agent in leukemia.
Investigating the Effect of Fundamental Accounting Variables on the Stock Prices Variations
Mahmood Moein Aldin,Hassan Dehghan Dehnavi,Mohammadreza Hajighasemi,Ali Hajighasemi
International Journal of Economics and Finance , 2012, DOI: 10.5539/ijef.v4n10p125
Abstract: Preparing financial statements mainly aims at providing users with the required information in order to help them make economic decisions. Current and potential investors are regarded as information users which are composed of diverse aspects. Investors seek to predict the future stock yields and this can be done through investigating the future stock prices. Hence, predicting future stock price is an essential aspect considered by potential investors. The present paper explores the relationship between changes in fundamental accounting variables with stock price variations of 70 firms listed on Tehran Stock Exchange in a period covering five years from 2006 to 2010 employing Correlation coefficient, adjusted R2 and multiple regressions. The fundamental accounting variables include assets, liabilities, owner's equity, sale, operating income, net income, operating cash flow and investment cash flow. The empirical results reveal that there is a significant relationship between fundamental accounting variables and stock price variations of firms listed on Tehran Stock Exchange. That's why investors should have a special attention to fundamental accounting variables when predicting stock prices and making financial decisions.
Pattern of Coronary Artery Disease Risk Factors in Population Younger than 55 Years and Above 55 Years: A Population Study of 31999 Healthy Individuals
Zinat Nadia Hatmi,Mitra Mahdavi-Mazdeh,Seyed Saeid Hashemi-Nazari,Ebrahim Hajighasemi
Acta Medica Iranica , 2011,
Abstract: More than eighty percent of patients with coronary heart diseases (CHD) have conventional risk factors. Prevalence of well known risk factors seems to show a different pattern in younger patients and individual above 55 years. To evaluate the pattern of conventional CHD risk factors in healthy individuals in two different age groups. A large scale population based survey of 31999 individuals from ten medical centers was designed. Screening of risk factors was performed upon these protocols: taking medical history, physical examination and blood tests of complete blood cell counts, fasting blood sugar, lipid profile, urinalysis and creatinine. Prevalence of the risk factors in healthy people aged above 55 years were: 8.1% for systolic blood pressure (SBP)>140 mmHg, 3.8% for diastolic blood pressure (DBP)>90mmHg, 13.9% for fasting blood glucose (FBS)≥126 Mg/dl, 36.9% for total cholesterol>200 Mg/dl, 19.2% for triglyceride (TG)>200 Mg/dl, 67.8% for HDL-c<40 Mg/dl, 27.2% for LDL-c>130 Mg/dl, 4.72 for TC/HDL-c ratio, 2.88 for LDL-c/HDL/c ratio and 4.24 for TG/HDL-c ratio. Prevalence of risk factors in individuals younger than 55 years were: 1.7% for SBP>140 mmHg, 1.2% for DBP>90 mmHg, 5.2% for FBS≥126 Mg/dl, 31.3% for TC>200 Mg/dl, 21.5% for TG>200 Mg/dl, 69.4% for HDL-c<40 Mg/dl, 23.2% for LDL-c>130 Mg/dl, 4.7 for TC/HDL-c ratio, 2.83 for LDL-c/HDL-c ratio and 4.43 for TG/HDL-c ratio. In univariate model of analysis: prevalence of the risk factors were significantly higher in age above 55 years than in people younger than 55 years except for hypertriglyceridemia and HDL-c<40 Mg/dl. In a multivariate model of logistic regression, pattern of following CHD risk factors remained to demonstrate a statistically significance difference between two age groups: FBS≥126 Mg/dl P=0.006, TG>200 Mg/dl P= 0.002, HDL-c<40 Mg/dl P= 0.019, education status P=0.001, sex P=0.012, and SBP>140 mmHg P=0.001. Pattern of such a CHD risk factors of FBS≥126 Mg/dl, TG>200 Mg/dl, HDL-c<40 Mg/dl, education status, sex and SBP>140 mmHg demonstrated a statistically significant difference in the age above 55 years to the healthy people younger than 55 years. These results cab be implicated to set up prediction models for stratifying individuals at higher risk of CHD.
Relationship Between the Pattern of Coronary Artery Disease Risk Factors And Lipid Ratios With Five Groups of Body Mass Index in 28566 Healthy Adults
Zinat Nadia Hatmi,Mitra Mahdavi-Mazde,Seyed Saeid Hashemi-Nazari,Ebrahim Hajighasemi
Acta Medica Iranica , 2011,
Abstract: Pattern of the coronary artery disease (CAD) risk factors across body mass index (BMI) categories remains uncertain. There is a different threshold of obesity for increasing cardiovascular hazard across populations, accordingly recognition and management of obesity and overweight can guide better control of CAD epidemic in the national level. To determine the discrepancy in the prevalence of CAD risk factors across five BMI categories. A population based survey of 28566 participants recruited to medical screening of taxi drivres in Tehran (MSTDT) was designed. According to a standardized protocol data on CAD risk factors were obtained by taking medical history, examination and laboratory tests. After adjustment for age, sex, literacy, smoking, systolic blood pressure (SBP), fasting blood sugar (FBS), and LDL-C/HDL-C ratio, these CAD risk factors of diastolic blood pressure (DBP)>90 mmHg, hypertriglyceridemia, high triglyceride/ HDL-C ratio, hypercholesterolemia, and high cholesterol/HDL-C ratio were increased significantly across five incremental categories of BMI. Prevalence of DBP> 90 mmHg, hypertriglyceridemia, hyper cholesterolemia and ratios of cholesterol/ HDL-C and TG/HDL-C increased considerably across five groups of BMI. This pattern is different from previous research and our results endorsed more features of pattern of CAD risk factors across BMI categories.
Kroniek
- F.
Nieuwe West-Indische Gids , 1949,
Abstract:
Kroniek
- F.
Nieuwe West-Indische Gids , 1949,
Abstract:
Kroniek
F.
Nieuwe West-Indische Gids , 1947,
Abstract:
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