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Search Results: 1 - 10 of 1476 matches for " Hajdukovi? Zoran "
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Liver hydatid disease: Morphological changes of protoscoleces after albendazole therapy
Stankovi? Neboj?a,Ignjatovi? Mile,No?i? Darko,HajdukoviZoran
Vojnosanitetski Pregled , 2005, DOI: 10.2298/vsp0503175s
Abstract: Background. Postoperative recurrence of the liver hydatid disease befalls approximately 10 30% of patients. Preoperative or postoperative therapy with albendazole in single therapeutic protocol (800 mg/d, within 28 days) indicated the need to evaluate the hydatid cyst liquid protoscoleces viability. Morphological changes of protoscoleces following the treatment with drugs are not well known. Aim. To estimate the viability of protoscoleces after preoperative or postoperative albendazole therapy, and their ability for cystic metamorphosis. Methods. A prospective, randomized clinical trial included 30 patients with liver hydatid disease, treated with albendazole and surgically (I group), and 30 patients in the control group treated only surgically (II group). The concentration of albendazole and its active metabolite albendazole sulphoxide in the cysts contents were determined using HPLC. Estimation of protoscoleces viability was based on the established micromorphologic criteria, and compared between the patients treated with albendazole, and the patients treated only surgically. Biological assessment of the viability was performed on protoscoleces with uncertain signs of the disturbed viability (unchanged structure, evaginated, without movements) using intraperitoneal injection of 1 ml of protoscoleces prepared suspension to AO type of rats. Results. The concentration of albendazole in cysts' contents ranged from 0 to 64.9 μg/ml, and of its active metabolite from 0.5 to 40.8 μg/ml. The presence of fully viabile protoscoleces in the albendazol treated patients was significantly lower than in the control group. A significant difference was noticed in the presence of disintegrated protoscoleces without movements in the albendazol treated group, compared to the control group. Biological assessment of the viability showed incapability of these protoscoleces for cystic metamorphoses. Conclusion. Low viability of parasites due to medicamentous therapy is very useful and important to surgeons, because the fertility of cysts is lower, and the risk of the disease recurrence is reduced.
Influence of orlistat therapy on serum insulin level and morphological and functional parameters of peripheral arterial circulation in obese patients
HajdukoviZoran,Joveli? Aleksandra,?ivoti?-Vanovi? Mirjana,Ra?en Slavica
Vojnosanitetski Pregled , 2005, DOI: 10.2298/vsp0511803h
Abstract: Background/Aim. Insulin resistance is related to accelerated atherosclerosis, whereas weight loss is associated with the increasing insulin sensitivity, the improvement of functional and the morphological parameters of arterial circulation, and the reduction of cardiovascular morbidity and mortality. The aim of our study was to evaluate the influence of orlistat treatment on serum insulin level and functional and morphologic parameters of peripheral arterial circulation. Methods. We conducted a prospective, randomized, double blind, placebo controlled study. Thirty patients with body mass index over 30 kg/m2 normotensive, nonsmokers, without clinically manifested cardiovascular disease or diabetes were randomly assigned either orlistat (120 mg, 3 times daily; n = 20) or placebo (n = 10) in a double blind manner. All of the patients were on individually calculated hypocaloric diet. The follow-up period was 24 weeks. Arterial pressure, fasting serum glucose and insulin level, triglycerides, total cholesterol and low density lipoprotein-cholesterol were determined at the beginning, following 3 and 6 months. Also, the intima media thickness of right superficial femoral artery and the mean blood flow velocity were determined with ultrasonography. Results. Inside the period of 3 and 6 months, there were the greater reductions of body mass index, arterial pressure, fasting glucose and insulin level, total cholesterol, low density lipoproteins, as well as the greater reductions of mean velocity blood flow and peripheral pulse pressure in the orlistat group vs the placebo group (p < 0.01). Greater reductions in the waist circumference and intima media thickness were registered following 6 months in the orlistat vs the placebo group (p < 0.01). Conclusion. In the group of obese patients orlistat therapy reduced risk factors, serum insulin level and improved early arterial functional changes as assessed with the reductions of the mean velocity blood flow and peripheral pulse pressure following 3 months. The regression of morphological changes, as assessed with the reduction in intima media thickness, was feasible over the six month period.
Cigarette smoking in military pilots and intima-media thickness of the carotid arteries
Joveli? Stojan,HajdukoviZoran,Joveli? Aleksandra,Ra?en Slavica
Vojnosanitetski Pregled , 2005, DOI: 10.2298/vsp0505365j
Abstract: Background. It is well known that smoking is associated with an increase in arterial wall thickness. However, most studies of this problem have been undertaken in age and sex heterogeneous groups, as well as in patients with already present other conventional risk factors. The aim of this study was to assess the effect of cigarette smoking on arterial wall thickness of the common carotid artery in asymptomatic pilots. Methods. The imaging of intima media thickness of the posterior wall of the distal 1 cm of both common carotid arteries was performed using a B mode ultrasound device, in 39 pilots (37.05 ± 6.66 years), for whom smoking was the single cardiovascular risk factor. Comparisons were made with 49 non-smokers (35.12 ± 7.39 years). Results. The posterior walls of both common carotid arteries were thicker in smokers (left, p < 0.05; right, p > 0,05). Intima-media thickness was significantly lower on the right side than on the left side in both smokers and nonsmokers (p < 0.01). Conclusion. Cigarette smoking as the single cardiovascular risk factor was associated with the wall thickness of the carotid arteries in our study. This finding indicated that early atherosclerosis was already present in pilots - smokers entering middle age.
The relationship between C-reactive protein and subclinical carotid arteriosclerosis in military pilots
Joveli? Aleksandra,Ra?en Slavica,HajdukoviZoran,?anji Tibor
Vojnosanitetski Pregled , 2009, DOI: 10.2298/vsp0906465j
Abstract: Background/Aim. Inflammation plays a key role in the physiopathology of arteriosclerosis. C-reactive protein (CRP) and common carotid artery intima-media thickness are independent predictors of cardiovascular events and diabetes mellitus in apparently healthy men, but relationship between them is not fully elucidated. The aim of the study was to assess the cross-sectional relationship between CRP and cardiovascular risk factors with common carotid artery intima-media thickness in military pilots as representatives of healthy men. Methods. We studied 161 military pilots (age 38 ± 6 years) free of cardiovascular disease and diabetes mellitus. Traditional and metabolic risk factors were determined. Plasma CRP was measured by immunonephelometry. The common carotid artery intima-media thickness was measured by ultrasonography in the posterior wall of both common carotid arteries. Results. A total of 66.5% subjects had common carotid artery intima-media thickness > 0.9 mm (p < 0.01). The mean CRP plasma concentration was significantly higher in the subjects with common carotid artery intima- media thickness > 0.9 mm than in those with common carotid artery intima-media thickness ≤ 0.9 mm. In a simple regression analysis age adjusted CRP was associated with common carotid artery intima-media thickness (β = 0.285, p < 0.01), and only high density lipoprotein cholesterol was not associated with common carotid artery intima-media thickness. The association between CRP and common carotid artery intima-media thickness remained highly significant after controlling for body mass index, blood pressure, total cholesterol, low density lipoprotein cholesterol, triglycerides, glycosylated hemoglobin and smoking (p < 0.01). Controlling for glucose, triglycerides to high density lipoprotein cholesterol ratio, and total cholesterol to high density lipoprotein cholesterol ratio resulted in some reduction in the strength of the association, but including waist circumference in the regression made the relationship no longer significant (p = 0.119). Body mass index (β = 0.352; p < 0.01), total cholesterol to high density lipoprotein cholesterol ratio (β = 0.334; p < 0.01) and age (β = 0.190; p = 0.036) were the independent predictors of common carotid artery intima-media thickness. Conclusions. In the studied group of healthy men CRP per se is not an independent predictor of early arteriosclerosis, and may mediate the effect of certain traditional risk factors, especially visceral obesity, on promoting aterogenesis.
Colour as an Element of the Creativity in Education of Design  [PDF]
Zoran Markovic
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.25015
Abstract: Education of Design is creativity based process. From Kansei Engineering to Emotional Design, there are several different approaches in involving feelings and emotions in designing process. Analysing all tools and techniques used by designers, colour has one of the biggest psychological impacts on the final users. Colour has the power not only to change the existing architectural language, but also to be a language on its own. Within architectural semiology, colour has a very important role. The paper presents the preliminary results of the research on cultural background and its influence on the psychological impact of the colour in design (architectural, interior, etc.). The research started in the beginning of 2012 and it has been conducted in Serbia, Botswana, Kenya (fully finalized), India, Slovenia, Brazil (ongoing), Singapore, South Africa and Malaysia (in the preparation stage), Japan, China, Russia, South Korea and Mexico (organization started). The Research objective is to describe, analyse and present importance of the emotional creativity in education, the current status of the role cultural background plays in colour choices in design, as well as to analyse psychological (personal) and social (group) impact and influence of colour. Moreover, the experiments planned are intended not only to outline contemporary cultural influence on colour preferences but also to revisit, revive and expand on the existing research in this field (e.g. [1] Kaya/Epps research at University of Georgia, USA, etc.) by adding the notion of multi-cultural background.
Maxwell-Proca Fields in Relativistic Astrophysical Compact Objects  [PDF]
Zoran Pazameta
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.48A023

A general-relativistic model is formulated for hypothetical ultra-compact astrophysical objects composed of fluid infused with charges carrying a generalized massless Maxwell-Proca field. The chosen interior metric has the algebraic property that \"\"; the fluid consequently possesses a negative pressure which halts gravitational collapse and establishes hydrostatic equilibrium. For an object containing a global distribution of non-interacting Maxwell-Proca charges, it is shown that physical considerations define the relationship between the charge density and the metric function uniquely, corroborating an earlier finding (for an electrostatic distribution of charge) that the interior field must increase with radial distance and the exterior field necessarily follows an inverse-square law. For the case of a charged fluid envelope surrounding a core of uncharged fluid, numerous solutions are possible. Assuming the interior field to vary as rn and requiring its strength to increase with radial distance while the charge density decreases, the range of values for n is found to be 0 < n ≤ 1 (where n is not necessarily an integer) with n = 1 denoting the special case of a continuous distribution of charge. For both continuous and stratified charge distributions, the exterior field is found to decrease as 1/r2 regardless of the interior field’s dependence on

Prostaglandin E2 in apical tissue fluid and postoperative pain in intact and teeth with large restorations in two endodontic treatment visits
Grga ?urica,D?eletovi? Bojan,Damjanov Marija,Hajdukovi?-Dragojlovi? Ljiljana
Srpski Arhiv za Celokupno Lekarstvo , 2013, DOI: 10.2298/sarh1302017g
Abstract: Introduction. Acute periapical inflammation is the most common cause of postoperative pain developing as a result of mechanical, chemical and/or microbial injury of periapical tissue. The major inflammatory event responsible for periapical pain is increased vasodilatation and vascular permeability, partly caused by prostaglandin E2, with consequent edema, which leads to the compression of nerve fibers. Objective. The aim of this study was to determine the concentrations of prostaglandin E2 in apical tissue fluid after endodontic treatment of intact and teeth with large restorations and to compare it with the occurrence and intensity of postoperative pain. Methods. Single-rooted teeth of 24 patients, selected for this study, were distributed into two groups: intact (group 1, n=27) and asymptomatic teeth with large restorations (group 2, n=20). Clinical examination of the involved teeth included the electric pulp test, recording pain on percussion, spontaneous pain, and a radiographic examination. Samples of apical tissues fluid were obtained from root canals at two treatment visits, and prostaglandin E2 concentrations were measured using radioimmunoassay. Pain intensity was assessed by visual analogue scale. Results. Prostaglandin E2 concentrations at the second visit, in teeth with large restorations, was significantly higher (36%) than at the first treatment visit (Wilcoxon signed rank test, p<0.05). Occurrence and intensity of spontaneous pain after the first visit were significantly higher in group 2 (p<0.05) than in group 1. Conclusion. These results suggest that the increased prostaglandin E2 concentration, caused by endodontic treatment of teeth with large restorations, is well correlated with the intensity of postoperative pain.
Natural regeneration of beech in mixed stands of beech and fir with spruce (Piceo-Abieti-Fagetum) in the virgin forest "Peru ica"
Govedar Zoran,Stanivukovi? Zoran
Glasnik ?umarskog Fakulteta , 2008, DOI: 10.2298/gsf0897107g
Abstract: Natural regeneration of beech in mixed stands of beech and fir was researched in the virgin forest Peru ica, e.g. the basic elements of stand structure with special reference to beech regeneration characteristics, and the regeneration process in the conditions of broken stand canopy. The analysis included the stand development stages in he virgin forest based on the elements of structure, as well as the silvigenetic phases on a transect 10×100 m. The characteristics of beech regeneration (abundance, height, crown size, length of apical and lateral shoots) were measured on the selected regeneration areas (initial regeneration gaps). The silvigenetic phases on the transect and the interdependence of beech regeneration characteristics were assessed based on regeneration characteristics, ways of occurrence and spatial distribution of the young growth.
Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences
Zoran Redzic
Fluids and Barriers of the CNS , 2011, DOI: 10.1186/2045-8118-8-3
Abstract: A constant and well-controlled composition of the extracellular fluid in the central nervous system (CNS) is essential for efficient neuronal processing. Invertebrate nervous systems, which are far less complex than the mammalian brain, are protected from fluctuations in composition of body fluids by a barrier that is formed by glial cells and this arrangement also applies to some ancestral vertebrates. With the CNS becoming more complex during evolution, an endothelial barrier appeared, giving a strong selective advantage. Consequently, all existing vertebrates, except for a few fish species, have endothelial blood-brain barriers (BBB).The BBB and the blood-cerebrospinal fluid barrier (BCSFB) are formed by brain endothelial cells (BECs) and choroid plexus (CP) epithelial cells, respectively. The BBB and the BCSFB are not only anatomical barriers, but also dynamic tissues that express multiple transporters, receptors and enzymes. Brain capillaries are closely associated with perivascular astrocytic end-feet, pericytes and microglia that influence BBB permeability and, together with brain endothelial cells, constitute a "neurovascular unit".The two main functions of these barriers are to impede free diffusion between brain fluids and blood and to provide transport processes for essential nutrients, ions and metabolic waste products. Hence, the aim of this review is to address similarities and differences in the molecular biology of cellular junctions, solute carrier transporters, ATP-binding cassette transporters and ion transporters at the BBB and the BCSFB.Although there are several similar features between the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB), it should be kept in mind that the cellular basis of these two structures as well as their primary functions differ: BBB is located in brain capillaries and, thus, it is an endothelial structure with its main role to protect the brain from physiological fluctuations in plasma concen
Mathematical explanation of the predictive power of the X-level approach reaction noise estimator method
Zoran Konkoli
Theoretical Biology and Medical Modelling , 2012, DOI: 10.1186/1742-4682-9-12
Abstract: Noise is an integral part of the workings of the living cell biochemistry [1]. There are many types of noise and this work focuses on the intrinsic noise. If reactant copy numbers are low they can fluctuate widely [2]. These fluctuations can severely influence the dynamics of the cell and need to be carefully controlled [3].Describing intrinsic noise has attracted a lot of effort. A range of theoretical methods have been developed to study intrinsic noise. However, an accurate characterization of the reaction noise is not easy. A direct solution of the chemical master equation for the system is often not possible since the number of configurations can be exponentially large. Numerical simulation methods can be used to avoid this problem, and are often implemented by using the Gillespie algorithm [4]. However, to obtain accurate prediction for moments of the particle number distribution function, e.g. the variance, sampling with a relatively large number of runs (simulations) is needed. This becomes impractical if the number of particle types is very large. A range of methods have been suggested to complement or replace these techniques. The focus of this work is on moment closure techniques [5-15].The main idea behind moment closure approaches is to construct the equation system that can describe various moments of the particle number distribution function. In such a way there is no need to directly solve the master equation or perform a largenumber of computer simulations. The problem is that the equation system that describes these moments is, in principle, infinite. The main issue is to cut (or close) the hierarchy. This is done in two ways. First, one can try to make some specific assumptions about the reacting system which can be used to express higher order moments in terms of lower order ones. This procedure defines the moment closure function for the problem. Second possibility is to take the distribution function centered approach and assume that the partic
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