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We studied the changes
of macrophage populations in splenic mononuclear cells of experimental
autoimmune ence-phalomyelitis (EAE) mice treated with or without Fasudil. Phenotypic
analysis using flow cytometry showed that the levels of TLR4, CD11c and CD40
which represent the type 1 macrophage, were depressed in Fasudil-treated mice.
was observed the expressions of CD200 and CD14 which typify the type 2
macrophage were elevated in Fasudil-treated mice as compared to EAE mice. And
we also found that Fasudil at dose of 40 mg/kg alleviated the se-verity of symptom in EAE mice.
Based on the evidence that M1 macrophages are neurotoxic and M2 macrophages
promote a regenerative growth, indicating that polarization and shifting of
macrophages into M2 cells may also play key roles in treatment of EAE.