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Search Results: 1 - 10 of 20573 matches for " Hack-Lyoung Kim "
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The association between arterial stiffness and left ventricular filling pressure in an apparently healthy Korean population
Hack-Lyoung Kim, Moon-Sun Im, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
Cardiovascular Ultrasound , 2013, DOI: 10.1186/1476-7120-11-2
Abstract: A total of 115 healthy subjects without known cardiovascular risk factors or overt heart disease who underwent both transthoracic echocardiography and brachial-ankle pulse wave velocity (baPWV) measurement at the same day during their routine check-ups were analyzed.The mean age of study subjects was 52.8 ± 8.4 years, and 78 (67.8%) were men. The mean baPWV value was 1,325 ± 185 cm/s. Study subjects were divided into 3 groups according to E/E’ value: subjects with E/E’ < 8, 8–12.9 and E/E’ ≥ 13. As E/E’ increased, baPWV value increased gradually: baPWV in subjects with E/E’ < 8, E/E’ 8–12.9 and E/E’ ≥ 13, were 1,261 ± 163, 1,345 ± 169, 1,569 ± 232 cm/s, respectively (p < 0.001). In multiple linear regression analyses, baPWV was significantly associated with E/E’ (β = 0.371, p < 0.001) after controlling confounders including age, sex and body mass index. In receiver-operating characteristic (ROC) curve analysis, the sensitivity and specificity for detection of E/E’ ≥ 10 were 78.6% and 59.8%, respectively with mean baPWV of 1,282 cm/s as the cut off value. The discriminatory capacity for predicting E/E’ ≥ 10 was improved from an area under the ROC curve of 0.646 with age alone to 0.734 when baPWV was added (p < 0.001).There is a significant association between baPWV and E/E’ in an apparently healthy Korean population. BaPWV is useful as a simple and non-invasive method for early detection of increased LV filling pressure among these people.Stiffened artery increases pulse pressure leading to left ventricular hypertrophy and coronary artery disease [1]. Arterial stiffness has been reported to be associated with cardiovascular morbidity and mortality [2,3].There are several methods to estimate arterial stiffness. Among them, pulse wave velocity (PWV) is generally accepted as the most simple, non-invasive and validated indicator of arterial stiffness [4,5]. Recently, the brachial-ankle PWV (baPWV) measurement, which is easy to perform, has become available in clinical pr
Identification of copy number variations and common deletion polymorphisms in cattle
Joon Bae, Hyun Cheong, Lyoung Kim, Suk NamGung, Tae Park, Ji-Yong Chun, Jason Kim, Charisse Pasaje, Jin Lee, Hyoung Shin
BMC Genomics , 2010, DOI: 10.1186/1471-2164-11-232
Abstract: In our study of cattle, we used Illumina BovineSNP50 BeadChip (54,001 markers) to obtain each marker's signal intensity (Log R ratio) and allelic intensity (B allele frequency), which led to our discovery of 855 bovine CNVs from 265 cows. For these animals, the average number of CNVs was 3.2, average size was 149.8 kb, and median size was 171.5 kb. Taking into consideration some overlapping regions among the identified bovine CNVs, 368 unique CNV regions were detected. Among them, there were 76 common CNVRs with > 1% CNV frequency. Together, these CNVRs contained 538 genes. Heritability errors of 156 bovine pedigrees and comparative pairwise analyses were analyzed to detect 448 common deletion polymorphisms. Identified variations in this study were successfully validated using visual examination of the genoplot image, Mendelian inconsistency, another CNV identification program, and quantitative PCR.In this study, we describe a map of bovine CNVs and provide important resources for future bovine genome research. This result will contribute to animal breeding and protection from diseases with the aid of genomic information.Cattle have been important to human culture for over 8,000 years as an agricultural means, for transportation, and as a supply of meat and milk [1]. In recent years, studies have been conducted that attempt to increase the productivity of meat and marbling grades by utilizing genetic factors [2-5], and the results of these studies have been deemed economically significant. The bovine genome is made up of 29 autosomes and sex chromosomes with a genome size estimated to be around 2.87 Gbp. Because of the economic importance of cows, the Bovine Genome Sequencing and Analysis Consortium has decoded bovine whole-genomic information (Bovine Genome Project) and has reported that a minimum of 22,000 genes are included in the cattle genome [6]. These findings show that bovine genome analysis is becoming increasingly popular.Copy number variation (CNV) is an
A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle
Hyun Cheong, Du-Hak Yoon, Byung Park, Lyoung Kim, Joon Bae, Sohg Namgoong, Hae Lee, Chang Han, Ji Kim, Il-Cheong Cheong, Hyoung Shin
BMC Genetics , 2008, DOI: 10.1186/1471-2156-9-33
Abstract: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 39 sequence variants within exons and their flanking regions in CAPN1. Among them, 12 common polymorphic sites were selected for genotyping in the beef cattle (n = 421). Statistical analysis revealed that a polymorphism in the 3'UTR (c.2151*479C>T) showed significant association with MS (Pcor. = 0.02).Our findings suggest that polymorphisms in CAPN1 might be one of the important genetic factors involved in carcass quality in beef cattle, although it could be false positive association.Genetic improvement has long been considered an important factor in the competitiveness of beef cattle production. Identification of the genes and/or polymorphisms underlying quantitative/qualitative traits, and an understanding of how these genes/polymorphisms interact with the environment or with other genes affecting economic traits might be the keys to successful application of marker-assisted selection in the commercial animal population. As one of these economic traits, marbling is intramuscular fat that gives meat flavor and tenderness. Thus, an increase in the degree of marbling raises the level of meat quality.Calpain is a ubiquitous cytoplasmic cysteine protease, the activity of which is absolutely dependent on calcium [1]. Two genes of calpain (CAPN1 [macro-calpain] and CAPN2 [mili-calpain]) have been identified [2]. CAPN1 degrades myofibrillar proteins under postmortem conditions and appears to be the primary enzyme in the postmortem tenderization process [3-6]. Regulation of CAPN1 activity has been correlated with variation in meat tenderness, and previous studies also identified a quantitative trait locus influencing meat tenderness on chromosome 29 where CAPN1 lies [7-9].In the CAPN1 gene, more than 100 single nucleotide polymorphisms (SNPs) have been identified in Bos indicus or Bos taurus [8,10,11] (S. N. White and T. Smith, unpublished data). Among them, four polymorphisms, two non-synonymous SNPs (
Parresía: Semantizaciones en el Nuevo Testamento
Hack,Viviana;
Circe de cl??sicos y modernos , 2007,
Abstract: the koine greek of the new testament shows resemantizations of ancient greek words. the voice , translated as "freedom of speech", extends its meaningfulness through the bible text. this work analyses contexts for semantization of and into the greek new testament and into five different spanish translations.
Payment schemes for hydrological ecosystem services as a political instrument for the sustainable management of natural resources and poverty reduction – a case study from Belén, Nicaragua
J. Hack
Advances in Geosciences (ADGEO) , 2010,
Abstract: The importance of intact ecosystems for human-wellbeing as well as the dependence on functions and services they provide is undoubted. But still neither the costs of ecosystem degradation nor the benefits from ecosystem functions and services appear on socio-economic balance sheets when development takes place. Consequently overuse of natural resources is socio-economically promoted by conventional resource management policies and external effects (externalities), equally positives and negatives, remain unregarded. In this context the potential of payments for hydrological ecosystem services as a political instrument to foster sustainable natural resource use, and rural development shall be investigated. This paper introduces the principle concept of such payments, presents a case study from Nicaragua and highlights preliminary effects of the application of this instrument on natural resource use and development.
The protection of the contributive capacity of taxes by the international human rights A prote o da capacidade contributiva tributária pelos direitos humanos internacionais
érico Hack
Scientia Iuris , 2007,
Abstract: This article analyses the principle of contributive capacity applied to the tax payment, and its protection by the regional systems of human rights. At first, the principle is analysed, as well as the limits imposed by it, pointing the tax payer′s rights that derivate from it. Then, it show how the human rights conventions protect this principle and the limits to the taxation. Este artigo analisa o princípio da capacidade contributiva que deve reger a tributa o e sua prote o pelos sistemas regionais dos direitos humanos. Inicialmente analisa-se o princípio e seus limites, apontando os direitos dos contribuintes que surgem dele. Após, analisa-se de que forma tal princípio e os limites respectivos s o protegidos pelos sistemas regionais de prote o aos direitos humanos.
Parresía: Semantizaciones en el Nuevo Testamento Semantizations in the New Testament
Viviana Hack
Circe de Clásicos y Modernos , 2007,
Abstract: La koiné del Nuevo Testamento presenta numerosas resemantizaciones de lexemas griegos de los siglos anteriores. El término o 'libertad para hablar' en el griego antiguo amplía su campo de significación en el texto bíblico. El presente trabajo analiza la semantización de en el Nuevo Testamento Griego y en cinco traducciones diferentes en castellano. The koine Greek of the New Testament shows resemantizations of Ancient Greek words. The voice , translated as "freedom of speech", extends its meaningfulness through the Bible text. This work analyses contexts for semantization of and into the Greek New Testament and into five different Spanish translations.
Genome-Wide Profiling of Structural Genomic Variations in Korean HapMap Individuals
Joon Seol Bae,Hyun Sub Cheong,Byung Lae Park,Lyoung Hyo Kim,Chang Soo Han,Tae Joon Park,Jason Yongha Kim,Charisse Flerida A. Pasaje,Jin Sol Lee,Hyoung Doo Shin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011417
Abstract: Structural genomic variation study, along with microarray technology development has provided many genomic resources related with architecture of human genome, and led to the fact that human genome structure is a lot more complicated than previously thought.
Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meat in Korean cattle
Hyun Cheong, Du-Hak Yoon, Lyoung Kim, Byung Park, Yoo Choi, Eui Chung, Yong Cho, Eng Park, Il-Cheong Cheong, Sung-Jong Oh, Sung-Gon Yi, Taesung Park, Hyoung Shin
BMC Genetics , 2006, DOI: 10.1186/1471-2156-7-35
Abstract: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 12 single nucleotide polymorphisms within the 9 kb full gene region, including the 1.5 kb promoter region. Among them, six polymorphic sites were selected for genotyping in our beef cattle (n = 428) and five marker haplotypes (frequency > 0.1) were identified. Statistical analysis revealed that -4241A>T showed significant associations with CW and EMA.Our findings suggest that polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle. Sequence variation/haplotype information identified in this study would provide valuable information for the production of a commercial line of beef cattle.The successful application of marker-assisted selection in the commercial animal population will depend on the identification of genes, including identification of genes underlying quantitative traits, exploration of genetic polymorphisms that are involved in different phenotypes of quantitative traits, and understanding how these genes/polymorphisms interact with the environment or with other genes affecting economic traits.The growth hormone (GH) is essential for post-natal growth and general metabolism, and also plays an important role in lactation. Current knowledge indicates that GH exerts a key influence in nutrient use [1], mammary development [2], and growth [3]. There have been several reports of association between quantitative traits in cattle, such as growth performance and carcass merit, and polymorphisms in the GH gene [4-6].The regulation of GH synthesis and secretion is multifactorial, but the predominant regulators of GH are the hypothalamic hormones, GH-releasing hormone (GHRH), GH secretagogue (GHS), and somatostatin (SS) [7]. In spite of the functional importance of GHRH in the regulation of GH, only one PCR-restriction fragment-length polymorphism (RFLP) [8] has been reported in cattle.In this study, we examined GHRH as one of candidate gene
Long-term outcome and toxicity of hypofractionated stereotactic body radiotherapy as a boost treatment for head and neck cancer: the importance of boost volume assessment
Dong Soo Lee, Yeon Sil Kim, Jae Seok Cheon, Jin Ho Song, Seok Hyun Son, Ji Sun Jang, Young Nam Kang, Jing Hyoung Kang, So Lyoung Jung, Ie Ryung Yoo, Hong Seok Jang
Radiation Oncology , 2012, DOI: 10.1186/1748-717x-7-85
Abstract: Between March 2004 and July 2007, 26 patients with locally advanced, medically inoperable head and neck cancer or gross residual tumors in close proximity to critical structures following head and neck surgery were treated with SBRT as a boost treatment. All patients were initially treated with standard external beam radiotherapy (EBRT). SBRT boost was prescribed to the median 80% isodose line with a median dose of 21 (range 10–25) Gy in 2–5 (median, 5) fractions.The median follow-up after SBRT was 56 (range 27.6???80.2) months. The distribution of treatment sites in 26 patients was as follows: the nasopharynx, including the base of the skull in 10 (38.5%); nasal cavity or paranasal sinus in 8 (30.8%); periorbit in 4 (15.4%); tongue in 3 (11.5%); and oropharyngeal wall in 1 (3.8%). The median EBRT dose before SBRT was 50.4?Gy (range 39.6???70.2). The major response rate was 100% with 21 (80.8%) complete responses (CR). Severe (grade?≥?3) late toxicities developed in 9 (34.6%) patients, and SBRT boost volume was a significant parameter predicting severe late complication.The present study demonstrates that a modern SBRT boost is a highly efficient tool for local tumor control. However, we observed a high frequency of serious late complications. More optimized dose fractionation schedule and patient selection are required to achieve excellent local control without significant late morbidities in head and neck boost treatment.
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