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Search Results: 1 - 10 of 32773 matches for " HUANG Yongping "
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Protective Effects of Tetramethylpyrazine on Glutamate-Induced Neurotoxicity in Mice  [PDF]
Yongping Zhang, Zimo Huang, Lijiang Yu, Libin Zhang
Journal of Behavioral and Brain Science (JBBS) , 2012, DOI: 10.4236/jbbs.2012.23037
Abstract: The aim of this study was to investigate the potential protective effect of tetramethylpyrazine (TMP), one of available blood-activating and stasis-eliminating components from traditional Chinese medicines, on glutamate-induced neurotoxicity in mice and its possible mechanism. Mice, except for controls, received simultaneously intragastric (ig) administration of monosodium glutamate [MSG, 4.0 g/(kg·d)] or/and intraperitoneal (ip) administration of TMP [10, 20, 40 mg/(kg·d)] for 10 d, and then behavioral tests, as well as histopathological and immunohistochemical examination of hippocampi were performed to analyze the glutamate-induced functional and morphological changes and the possible protective effect of TMP. The results showed that ip administration of TMP countered the effects of ig administration of MSG on behavior and histopathology, suggesting that TMP was a neuroprotective agent. This study provides evidence that TMP possesses obviously neuroprotection against glutamate-induced neurotoxicity, and the neuroprotection effect may result from its inhibiting expression of NMDARs, consequently blocking-up Ca2+ influx through the receptor’s associated ion channel, which can be neurotoxic.
Application of High-Resolution DNA Melting for Genotyping in Lepidopteran Non-Model Species: Ostrinia furnacalis (Crambidae)
FengBo Li, BaoLong Niu, YongPing Huang, ZhiQi Meng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029664
Abstract: Development of an ideal marker system facilitates a better understanding of the genetic diversity in lepidopteran non-model organisms, which have abundant species, but relatively limited genomic resources. Single nucleotide polymorphisms (SNPs) discovered within single-copy genes have proved to be desired markers, but SNP genotyping by current techniques remain laborious and expensive. High resolution melting (HRM) curve analysis represents a simple, rapid and inexpensive genotyping method that is primarily confined to clinical and diagnostic studies. In this study, we evaluated the potential of HRM analysis for SNP genotyping in the lepidopteran non-model species Ostrinia furnacalis (Crambidae). Small amplicon and unlabeled probe assays were developed for the SNPs, which were identified in 30 females of O. furnacalis from 3 different populations by our direct sequencing. Both assays were then applied to genotype 90 unknown female DNA by prior mixing with known wild-type DNA. The genotyping results were compared with those that were obtained using bi-directional sequencing analysis. Our results demonstrated the efficiency and reliability of the HRM assays. HRM has the potential to provide simple, cost-effective genotyping assays and facilitates genotyping studies in any non-model lepidopteran species of interest.
Analyses of the oligopeptide transporter gene family in poplar and grape
Jun Cao, Jinling Huang, Yongping Yang, Xiangyang Hu
BMC Genomics , 2011, DOI: 10.1186/1471-2164-12-465
Abstract: In the present study, a comprehensive analysis of the OPT gene family in Populus (P. trichocarpa) and Vitis (V. vinifera) was performed. A total of 20 and 18 full-length OPT genes have been identified in Populus and Vitis, respectively. Phylogenetic analyses indicate that these OPT genes consist of two classes that can be further subdivided into 11 groups. Gene structures are considerably conserved among the groups. The distribution of OPT genes was found to be non-random across chromosomes. A high proportion of the genes are preferentially clustered, indicating that tandem duplications may have contributed significantly to the expansion of the OPT gene family. Expression patterns based on our analyses of microarray data suggest that many OPT genes may be important in stress response and functional development of plants. Further analyses of functional divergence and adaptive evolution show that, while purifying selection may have been the main force driving the evolution of the OPTs, some of critical sites responsible for the functional divergence may have been under positive selection.Overall, the data obtained from our investigation contribute to a better understanding of the complexity of the Populus and Vitis OPT gene family and of the function and evolution of the OPT gene family in higher plants.Substrate transport is vital for all living organisms, and many transporters play important roles in this process. More than 600 transporter families are currently documented in the Transporter Classification Database (TCDB) [1,2]. These protein families are further classed into seven subclasses (channels/pores, electrochemical potential-driver transporters, primary active transporters, group translocators, transport electron carriers, accessory factors involved in transport, and incompletely characterized transport systems). In general, they have specific localizations within the cell and are specialized to carry different compounds, including nitrate, phosphate, sucr
Image interpretation of weak-coupling N-mer adsorbate’s STM system
Xintang Huang,Shouren Qi,Xinjiao Li,Yongping Li
Chinese Science Bulletin , 1997, DOI: 10.1007/BF02884223
Abstract:
A molecular dynamics investigation of the mechanical properties of graphene nanochain
Yongping Zheng,Lanqing Xu,Zheyong Fan,Ning Wei,Zhigao Huang
Physics , 2012, DOI: 10.1039/C2JM16626G
Abstract: In this paper, we investigate, by molecular dynamics simulations, the mechanical properties of a new carbon nanostructure, termed graphene nanochain, constructed by sewing up pristine or twisted graphene nanoribbons (GNRs) and interlocking the obtained nanorings. The obtained tensile strength of defect-free nanochain is a little lower than that of pristine GNRs and the fracture point is earlier than that of the GNRs. The effects of length, width and twist angle of the constituent GNRs on the mechanical performance are analyzed. Furthermore, defect effect is investigated and in some high defect coverage cases, an interesting mechanical strengthening-like behavior is observed. This structure supports the concept of long-cable manufacturing and advanced material design can be achieved by integration of nanochain with other nanocomposites. The technology used to construct the nanochain is experimentally feasible, inspired by the recent demonstrations of atomically precise fabrications of GNRs with complex structures [Phys. Rev. Lett,2009,\textbf{102},205501; Nano Lett., 2010, \textbf{10},4328; Nature,2010,\textbf{466},470]
ThecomingofRNA-basedpestcontrols
Xu Linghua,Zeng Baosheng,Noland Jeffery,Huang Yongping,Zhou Xuguo
植物保护学报 , 2015,
Abstract: RNAinterference(RNAi)isagenesilencingtoolthattargetsmessengerRNA(mRNA)transcriptsinasequencespecificmanneranddownregulatesgeneexpressionbyinteractingwithsmallinterferingRNAs(siRNAs).mRNAscanbesilencedeitherthroughendogenousdegradationvianucleaseactivity(e.g.,RNAipathway),orbyinhibitingtranslation(e.g.,miRNA).Overthepastdecade,RNAihasbeenusedbroadlyinentomologicalresearchtodecipherthegenefunctionsininsects.WiththesuccessofRNAiinfunctionalgenomicsresearch,muchattentionhasshiftedtothepotentialapplicationsofRNAiinagriculture,especiallyforthecontrolofinsectpests.InadditiontoRNAi-basedgenesilencing,genomeediting,anexcitingnewbiotechnology,offersyetanotheroptionforpestcontrols.Themodificationofplantgenomestoknock-ingenesthatareheritabletoincreasethetoleranceofplantstoinsectinfestation,orknock-outgenesinpestinsectsthroughgeneticallymodified(GM)-insectreleasesareontheforefrontofthegenetic-basedpestmanagements.Inthisreview,wesummarizethecurrentknowledgeregardingRNAi-basedgenesilencingandCRISPR/Cas9-basedgenomeediting.TechnicalchallengesandregulatoryconcernsforthisnewwaveofRNA-basedpestcontrolsarediscussedingreatdetail.WealsosharetheperspectiveofmodifyingcurrentenvironmentalriskassessmentframeworkstobetterfittheRNA-basedpestmanagementstrategies.Giventhecurrentdiscussions/attentionsoverthesafetyofGeneticallyModifiedOrganisms(GMO),we,respectively,comparedprosandconsofRNAi-basedgenesilencingandCRISPR/Gas9-basedgenomeediting,andlaterweidentifiedtheregulatoryissuesthatshouldbeaddressedbeforetheseemergingbiotechnologiescanmovefromthebenchtoptothetabletop.
The Best m-Term One-Sided Approximation of Besov Classes by the Trigonometric Polynomials  [PDF]
Rensuo Li, Yongping Liu
Advances in Pure Mathematics (APM) , 2012, DOI: 10.4236/apm.2012.23025
Abstract: In this paper, we continue studying the so called best m-term one-sided approximation and Greedy-liked one-sided ap- proximation by the trigonometric polynomials. The asymptotic estimations of the best m-terms one-sided approximation by the trigonometric polynomials on some classes of Besov spaces in the metricLp(Td(1≤p≤∞ are given.
Existence and Uniqueness of Positive Solution for Third-Order Three-Point Boundary Value Problems  [PDF]
Tongchun Hu, Yongping Sun
Advances in Pure Mathematics (APM) , 2014, DOI: 10.4236/apm.2014.46037
Abstract:

This paper is devoted to the study of the existence and uniqueness of the positive solution for a type of the nonlinear third-order three-point boundary value problem. Our results are based on an iterative method and the Leray-Schauder fixed point theorem.

Evolution of the Surface Area of Limestone during Calcination and Sintering  [PDF]
Yang Liu, Yongping Yang
Journal of Power and Energy Engineering (JPEE) , 2015, DOI: 10.4236/jpee.2015.34009
Abstract:

The calcination reaction of limestone is always companied by sintering of the calcined product. In addition, accelerated sintering rates and a reduced specific surface area are observed in the presence of steam and carbon dioxide. To simulate the change of surface area and the porosity of limestone samples in a simultaneous calcination and sintering process, a combined model based on both a sintering model and a calcination model is established. The calcination model, which predicts calcination conversion as a function of time, is based on the initial properties of the sorbent. The sintering model is according to the German and Munir model in which the main transport mechanism is supposed to be lattice diffusion. In a flow reactor, the surface area value and calcination rate of limestone in the presence of steam and CO2 are also described by the combined model with modified parameters.

Nanocrystalline Diamond Films Grown by Microwave Plasma Chemical Vapor Deposition and Its Biocompatible Property  [PDF]
Jihan Yang, Yongping Zhang
Advances in Materials Physics and Chemistry (AMPC) , 2018, DOI: 10.4236/ampc.2018.84011
Abstract: Due to its unique properties such as high hardness, light transmittance, thermal conductance, chemical stability and corrosion resistance, diamond has drawn tremendous attention in last two decades. These specific properties made diamond film a promising material for cutting tools, microwave windows, heat sinks for electronic devices and diamond electrodes. However, the diamond film with grain sizes at microscale usually exhibits high surface roughness and hinders its applications in the microelectro mechanical system (MEMS) and biological field because it is difficult to be polished by mechanical and chemical methods. With the development of the chemical vapor deposition, the nanocrystalline diamond (NCD) film has been fabricated and found new applications. The grain size of NCD film is in the range of 10 to 100 nm, which inherits the properties of the diamond and possesses the unique properties of the nanoscale materials, and the morphology of the NCD film is granular or needle-like structure. The microwave plasma chemical vapor deposition (MPCVD) has been regarded as the most promising method to deposit NCD film at low temperature. Compared to the hot filament CVD, MPCVD can grow high quality NCD film avoiding of the contamination from the filament materials. The MPCVD technique has high plasma density to activate carbonaceous compound and grow NCD film in high growth rate and low substrate temperature. The unique properties of NCD film, such as the superior electrical, mechanical and biological properties facilitate their application in various fields. The biological application, especially as a biocompatible coating, mainly includes the joint replacement implants and protective coatings and the ophthalmological prosthesis.
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