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Search Results: 1 - 10 of 24632 matches for " HS Yong "
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Cytoprotective and enhanced anti-inflammatory activities of liposomal piroxicam formulation in lipopolysaccharide-stimulated RAW 264.7 macrophages
Chiong HS,Yong YK,Ahmad Z,Sulaiman MR
International Journal of Nanomedicine , 2013,
Abstract: Hoe Siong Chiong,1 Yoke Keong Yong,1 Zuraini Ahmad,1 Mohd Roslan Sulaiman,1 Zainul Amiruddin Zakaria,1 Kah Hay Yuen,2 Muhammad Nazrul Hakim1,31Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia; 2School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Malaysia; 3Sports Academy, Universiti Putra Malaysia, Serdang, MalaysiaBackground: Liposomal drug delivery systems, a promising lipid-based nanoparticle technology, have been known to play significant roles in improving the safety and efficacy of an encapsulated drug.Methods: Liposomes, prepared using an optimized proliposome method, were used in the present work to encapsulate piroxicam, a widely prescribed nonsteroidal anti-inflammatory drug. The cytotoxic effects as well as the in vitro efficacy in regulation of inflammatory responses by free-form piroxicam and liposome-encapsulated piroxicam were evaluated using a lipopolysaccharide-sensitive macrophage cell line, RAW 264.7.Results: Cells treated with liposome-encapsulated piroxicam demonstrated higher cell viabilities than those treated with free-form piroxicam. In addition, the liposomal piroxicam formulation resulted in statistically stronger inhibition of pro-inflammatory mediators (ie, nitric oxide, tumor necrosis factor-α, interleukin-1β, and prostaglandin E2) than piroxicam at an equivalent dose. The liposome-encapsulated piroxicam also caused statistically significant production of interleukin-10, an anti-inflammatory cytokine.Conclusion: This study affirms the potential of a liposomal piroxicam formulation in reducing cytotoxicity and enhancing anti-inflammatory responses in vitro.Keywords: liposomes, nitric oxide, cytokines, prostaglandin E2, interleukin-1β, piroxicam
Application of a high density adsorbent in expanded bed adsorption of lipase from Burkholderia pseudomallei
HS Yong, BT Tey, SL Hii, SMM Kamal, A Ariff, TC Ling
African Journal of Biotechnology , 2010,
Abstract: The application of STREAMLINE Direct HST adsorbent in expanded bed adsorption of lipase from Burkholderia pseudomallei was explored in this study. Scouting of optimum binding and elution condition was performed in batch binding mode. The addition of 0.2 M salt in acetate buffer (pH 5) during adsorption has increased the specificity and quantity of lipase binding onto the adsorbent. The addition of 0.4 M salt in phosphate buffer (pH 7) achieved the highest purification fold (2.5) in elution. The high density of the adsorbent allowed the EBA to be operated at linear velocity as high as 657 cm/h with feedstock containing 4.5% (w/v) wet biomass. The Richardson-Zaki correlation obtained for this EBA system at the presence of 4.5% (w/v) wet biomass is 5.14, a value closed to the laminar flow regime of 4.8, demonstrated that a stable bed is achieved under this operating condition. Meanwhile, a flow velocity of 343 cm/h with bed expansion of 3.2 gave highest dynamic binding capacity (4979.28 U/ml) and productivity (61.52 U/ml.min) for this EBA operation. It also demonstrated that biomass concentration up to 4.5% (w/v) wet weight showed slightly drop of sorption efficiency (0.82) compared to lower biomass concentration (0.94). Further increase of biomass concentration above 4.5% (w/v) wet weight has greatly decreased the equilibrium and dynamic capacity. Application of high density adsorbent tolerated to high density and biomass has reduced the processing time and increased the productivity.
Cytoprotective and enhanced anti-inflammatory activities of liposomal piroxicam formulation in lipopolysaccharide-stimulated RAW 264.7 macrophages
Chiong HS, Yong YK, Ahmad Z, Sulaiman MR, Zakaria ZA, Yuen KH, Hakim MN
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S42801
Abstract: oprotective and enhanced anti-inflammatory activities of liposomal piroxicam formulation in lipopolysaccharide-stimulated RAW 264.7 macrophages Original Research (256) Total Article Views Authors: Chiong HS, Yong YK, Ahmad Z, Sulaiman MR, Zakaria ZA, Yuen KH, Hakim MN Published Date March 2013 Volume 2013:8 Pages 1245 - 1255 DOI: http://dx.doi.org/10.2147/IJN.S42801 Received: 15 January 2013 Accepted: 07 February 2013 Published: 25 March 2013 Hoe Siong Chiong,1 Yoke Keong Yong,1 Zuraini Ahmad,1 Mohd Roslan Sulaiman,1 Zainul Amiruddin Zakaria,1 Kah Hay Yuen,2 Muhammad Nazrul Hakim1,3 1Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia; 2School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Malaysia; 3Sports Academy, Universiti Putra Malaysia, Serdang, Malaysia Background: Liposomal drug delivery systems, a promising lipid-based nanoparticle technology, have been known to play significant roles in improving the safety and efficacy of an encapsulated drug. Methods: Liposomes, prepared using an optimized proliposome method, were used in the present work to encapsulate piroxicam, a widely prescribed nonsteroidal anti-inflammatory drug. The cytotoxic effects as well as the in vitro efficacy in regulation of inflammatory responses by free-form piroxicam and liposome-encapsulated piroxicam were evaluated using a lipopolysaccharide-sensitive macrophage cell line, RAW 264.7. Results: Cells treated with liposome-encapsulated piroxicam demonstrated higher cell viabilities than those treated with free-form piroxicam. In addition, the liposomal piroxicam formulation resulted in statistically stronger inhibition of pro-inflammatory mediators (ie, nitric oxide, tumor necrosis factor-α, interleukin-1β, and prostaglandin E2) than piroxicam at an equivalent dose. The liposome-encapsulated piroxicam also caused statistically significant production of interleukin-10, an anti-inflammatory cytokine. Conclusion: This study affirms the potential of a liposomal piroxicam formulation in reducing cytotoxicity and enhancing anti-inflammatory responses in vitro.
Kynurenine and serotonin pathways: A review
HS Adegbusi
Bayero Journal of Pure and Applied Sciences , 2012,
Abstract: This paper seeks to elucidate the two-key pathways involving tryptophan matabolism, namely, kynurenine and serotonin pathways. In the kynurenine pathway (KP), the discussion considers the steps of the oxidative degradation of tryptophan to yield nicotinate mononucleotide, a precursors for the biosynthesis of nicotinate nucleotides ( NAD+ and NADP+), while serotonin pathway (SP) considers the biosynthesis of serotonin from tryptophan. Two different isoforms of tryptophan hydroxylase (TPH) are involved in SP: Tryptophan hydroxylase -1 (TPH1) catalysis SP in enterochromaffin cells of the gut, while Tryptophan hydroxylase-2 (TPH2) catalysis SP in the nerve cells of the central nervous system, the brain. Emphasis is given to the relevance of pyridoxal phosphate (PLP) in KP and also identified in the pathway of KP is the liberation of alanine as a biproduct, a basis for the gluconeogenecity of tryptophan. Serotonin, a major bioactive end-product of SP is a potent neurotransmitter, vasoconstrictor, regulation of intestinal motility and a player in cognitive function. Foods that give an increased ratio of tryptophan to phenylalanine and leucine such as nuts of walnut, plantains, bananas, dates, pineapples and tomatoes are good sources of serotonin. Research suggests a diet rich in carbohydrates and low protein is also a good source. Owning to the significance of some the major bioactive end-products, intermediates and byproducts of these pathways for the well-being and happiness of human beings, more research should be carried out therein not only to unravel some of the disorders they may be associated with but to also help in the development and production of; therapeutic drugs for psychiatric and sexual disorders, and intestinal antidote.
Considerations in selecting rapid-onset opioids for the management of breakthrough pain
Smith HS
Journal of Pain Research , 2013, DOI: http://dx.doi.org/10.2147/JPR.S40745
Abstract: nsiderations in selecting rapid-onset opioids for the management of breakthrough pain Review (492) Total Article Views Authors: Smith HS Published Date March 2013 Volume 2013:6 Pages 189 - 200 DOI: http://dx.doi.org/10.2147/JPR.S40745 Received: 26 November 2012 Accepted: 17 January 2013 Published: 06 March 2013 Howard S Smith Departments of Anesthesiology, Medicine, and Physical Medicine and Rehabilitation Albany Medical College, Albany, NY, USA Abstract: Breakthrough pain (BTP) is a transitory pain that occurs despite the use of long-term, around-the-clock analgesia. It is highly prevalent in certain populations and places a significant burden on patients, their families, caregivers, and health-care systems. Despite its prevalence and impact, BTP is sometimes unrecognized and often undertreated. Various formulations of fentanyl – a rapid-onset opioid with short duration of action – are available for the management of BTP. The efficacy of formulations using transmucosal, transbuccal, sublingual, and intranasal administration routes has been demonstrated for BTP treatment in clinical trials. However, a lack of head-to-head trials evaluating their relative efficacy makes it challenging for physicians to reach informed decisions on the most efficacious intervention for individual patients. In the absence of clear data on the relative efficacy of fentanyl formulations, prescribing decisions need to be based on physician understanding and experience and product cost and availability, taking into account the individual patient's needs, the ability of the patient or caregivers to administer medication, and the patient's wishes. This review evaluates current pharmacologic methods of alleviating BTP and discusses factors that should be considered when selecting the most appropriate formulation for individual patients. With the range of fentanyl formulations available, it is now possible to successfully address BTP in the majority of patients.
Pregnancy complicated by morbidly adherent placenta in a patient with bilateral ovarian agenesis: a case report
Wong HS
International Journal of Women's Health , 2013, DOI: http://dx.doi.org/10.2147/IJWH.S37380
Abstract: egnancy complicated by morbidly adherent placenta in a patient with bilateral ovarian agenesis: a case report Case report (500) Total Article Views Authors: Wong HS Published Date February 2013 Volume 2013:5 Pages 53 - 55 DOI: http://dx.doi.org/10.2147/IJWH.S37380 Received: 27 August 2012 Accepted: 25 September 2012 Published: 05 February 2013 Hong Soo Wong Australian Women's Ultrasound Centre, Brisbane, Australia Abstract: The author presents a case of in vitro fertilization pregnancy complicated by morbidly adherent placenta in a patient with congenital bilateral ovarian agenesis. A 31-year-old woman with congenital bilateral ovarian agenesis who had undergone two previous dilatation and curettage procedures conceived following in vitro fertilization with a donor egg. Spontaneous labor occurred at 38 weeks and 5 days' gestation. The labor was augmented in the active phase and resulted in instrumental vaginal delivery. The third stage was complicated by hemorrhage and retained placenta. Morbidly adherent placenta was diagnosed on attempt at manual removal of the placenta, and the adherent part of the placenta was left in situ. This was removed uneventfully at 5 weeks following childbirth when there was no blood flow observed between the placenta and the myometrium on Doppler ultrasound examination. In conclusion, successful parturition is possible in patients with congenital bilateral ovarian agenesis. When morbidly adherent placenta is managed conservatively, the placenta may be safely removed if there is no vascularity between the placenta and the myometrium.
Surgical approach to the cerebellopontine angle and dissection of the temporal bone: a continuing medical education course at Hacettepe University
Surucu HS
Neuroanatomy , 2004,
Abstract: When two complex structures like cerebellum and pons build up anangle, the one formed is not simple like the ones formed by twointersecting lines in geometry, but one, difficult to understand even by thepeople who see and cut it every day. To get close to a tumor here, onewill have to cut the complex temporal bone but from which direction andhow? Answering to a question like this and many difficult others in oneday was the aim of this meeting. Diverging the attention to the surgicaltechniques and anatomy, rather than the indications of surgery made thisgoal accomplished successfully.There were 30 participants, of almost equal numbers of anatomists,otolaryngologists and neurosurgeons, by coincidence. Even this was givinga good clue about how the chosen field was in the center of clinical andbasic science cooperation. The plenary session started and chaired byRuhgun Basar. The first presentation by Nuran Yener was giving everydetail of clinical anatomy of the temporal bone. Following, Sarp Saracpresented mastoidectomy and facial nerve decompression techniques withbeautiful schematic slides and real operation movies. The movies werecleverly montaged focusing on the important moments and landmarks andcropping out the intervals in between. Otherwise the movies of these longoperations can be more difficult to watch than doing the operation.After a fifteen minute coffee break, the second session started with thebeautiful presentation of Levent Sennaroglu about labyrnthectomy andtranslabyrenthal approach to the cerebellopontine angle. He describedmedial, lateral and inferior approaches which are used for different purposes.The next presentation was about anatomy of the neurovascular structures ofthe cerebellopontine angle by Beliz Tascioglu. Her presentation was mostlyby real photographs and their explanory drawings at each slide. This typeof presentation supplied extreme good orientation to the surgeons besidesteaching the complex anatomy of the region.Ibrahim Ziyal presented the middle cranial and retrosigmoid approach ofthe neurosurgeons. He also demonstrated some operational movies andgave important clues to the surgeons. The discussion became interesting byparticipation of Dr Gokhan Akdemir and his experiences from his studieswith the famous surgeon Dr Mecit Sami.At the lunch everybody was fascinated with the presentations of the morningand waiting impatiently for the practical part which would be held in theanatomy dissection laboratory. The practicals were not less successful. Theanatomy laboratory has almost turned to an operation hall or even betterwith
Pregnancy complicated by morbidly adherent placenta in a patient with bilateral ovarian agenesis: a case report
Wong HS
International Journal of Women's Health , 2013,
Abstract: Hong Soo WongAustralian Women's Ultrasound Centre, Brisbane, AustraliaAbstract: The author presents a case of in vitro fertilization pregnancy complicated by morbidly adherent placenta in a patient with congenital bilateral ovarian agenesis. A 31-year-old woman with congenital bilateral ovarian agenesis who had undergone two previous dilatation and curettage procedures conceived following in vitro fertilization with a donor egg. Spontaneous labor occurred at 38 weeks and 5 days' gestation. The labor was augmented in the active phase and resulted in instrumental vaginal delivery. The third stage was complicated by hemorrhage and retained placenta. Morbidly adherent placenta was diagnosed on attempt at manual removal of the placenta, and the adherent part of the placenta was left in situ. This was removed uneventfully at 5 weeks following childbirth when there was no blood flow observed between the placenta and the myometrium on Doppler ultrasound examination. In conclusion, successful parturition is possible in patients with congenital bilateral ovarian agenesis. When morbidly adherent placenta is managed conservatively, the placenta may be safely removed if there is no vascularity between the placenta and the myometrium.Keywords: IVF, placenta accreta, parturition, myometrium
Considerations in selecting rapid-onset opioids for the management of breakthrough pain
Smith HS
Journal of Pain Research , 2013,
Abstract: Howard S SmithDepartments of Anesthesiology, Medicine, and Physical Medicine and Rehabilitation Albany Medical College, Albany, NY, USAAbstract: Breakthrough pain (BTP) is a transitory pain that occurs despite the use of long-term, around-the-clock analgesia. It is highly prevalent in certain populations and places a significant burden on patients, their families, caregivers, and health-care systems. Despite its prevalence and impact, BTP is sometimes unrecognized and often undertreated. Various formulations of fentanyl – a rapid-onset opioid with short duration of action – are available for the management of BTP. The efficacy of formulations using transmucosal, transbuccal, sublingual, and intranasal administration routes has been demonstrated for BTP treatment in clinical trials. However, a lack of head-to-head trials evaluating their relative efficacy makes it challenging for physicians to reach informed decisions on the most efficacious intervention for individual patients. In the absence of clear data on the relative efficacy of fentanyl formulations, prescribing decisions need to be based on physician understanding and experience and product cost and availability, taking into account the individual patient's needs, the ability of the patient or caregivers to administer medication, and the patient's wishes. This review evaluates current pharmacologic methods of alleviating BTP and discusses factors that should be considered when selecting the most appropriate formulation for individual patients. With the range of fentanyl formulations available, it is now possible to successfully address BTP in the majority of patients.Keywords: rapid-onset opioid, breakthrough pain, pain, fentanyl
Updated status of Nepal’s wetland birds
HS Baral
Banko Janakari , 2009, DOI: 10.3126/banko.v19i3.2209
Abstract: Wetland birds in Nepal comprise significant portion of avian fauna of Nepal. However, they are also highly threatened because of several factors. A thorough study on wetland bird communities is lacking which is hampering conservation of wetlands and bird communities dependent on them. Proper management of the wetland beyond the protected areas is essential to conserve wetland birds in Nepal. Key words: Wetlands, birds, threatened, management ? doi: 10.3126/banko.v19i3.2209 Banko Janakari , Special Issue February 2009, 30-35
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