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Search Results: 1 - 10 of 68727 matches for " HAN Jian-Dong "
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Glucocorticoids synergize with IL-1β to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells
Akihiro Sakai, Jiahuai Han, Andrew CB Cato, Shizuo Akira, Jian-Dong Li
BMC Molecular Biology , 2004, DOI: 10.1186/1471-2199-5-2
Abstract: We show that IL-1β, a key proinflammatory cytokine, greatly up-regulates TLR2 expression in human epithelial cells via a positive IKKβ-IκBα-dependent NF-κB pathway and negative MEKK1-MKK4/7-JNK1/2 and MKK3/6-p38 α/β pathways. Glucocorticoids synergistically enhance IL-1β-induced TLR2 expression via specific up-regulation of the MAP kinase phosphatase-1 that, in turn, leads to dephosphorylation and inactivation of both MAPK JNK and p38, the negative regulators for TLR2 induction.These results indicate that glucocorticoids not only suppress immune and inflammatory response, but also enhance the expression of the host defense receptor, TLR2. Thus, our studies may bring new insights into the novel role of glucocorticoids in orchestrating and optimizing host immune and defense responses during bacterial infections and enhance our understanding of the signaling mechanisms underlying the glucocorticoid-mediated attenuation of MAPK.Epithelial cells are often situated at host-environment boundaries, and thus act as the first line of defense against bacterial pathogens [1]. The epithelial cells are not merely a passive barrier but can detect foreign pathogens and generate a range of mediators that play important roles in the activation of innate and adaptive immunity. For effective host defense, the epithelial cells recognize highly conserved structural motifs only expressed by microbial pathogens, called pathogen-associated molecular patterns (PAMPs). Toll-like receptors (TLRs) play a critical role in early innate immunity to invading microorganisms by sensing PAMPs [2]. Stimulation of TLRs by PAMPs initiates a signaling cascade that induces the production and secretion of proinflammatory cytokines [3]. Moreover, stimulation of TLRs also induces the production of effector cytokines that leads to activation of adaptive immunity.Mammalian TLRs were originally found as homologues of the Drosophila Toll [4]. TLRs are type I transmembrane receptors, that possess extracellular leu
Analysis Method for the Projection Error of Circle Center in 3D Vision Measurement
三维视觉测量中圆中心投影误差分析方法

HAN Jian-dong,YANG Hong-ju,
韩建栋
,杨红菊

计算机科学 , 2010,
Abstract: Aiming to the misalignment of the perspective projection of the circle center and the imaged ellipse center when the circle surface and the image plane are not parallel,an analysis method for the projection error of ellipse center was proposed.The mathematical formulation of the projection error was deduced by building the mapping relation between image plane and circle surface,and the factors influencing the error were analyzed by the computer simulation.The method provides a valuable reference in theory for the measurement error evaluation of the circular center and the camera planning,and is valuable in engineering applications of vision measurement.
Bis(μ-pyridine-2,4-dicarboxylato)-κ3N,O2:O2;κ3O2:N,O2-bis[triaquamagnesium(II)]
Qing-Fu Zhang,Dan-Dan Han,Jian-Dong Pang,Ning-Ning Meng
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810030722
Abstract: In the title centrosymmetric MgII complex, [Mg2(C7H3NO4)2(H2O)6], each Mg cation is N,O-chelated by a pyridine-2,4-dicarboxylate dianion and is coordinated by three water molecules. A carboxylate O atom from the neighboring pyridine-2,4-dicarboxylate dianion bridges the Mg cation to complete the MgNO5 distorted octahedral coordination geometry. The dinuclear complex molecules are linked by intermolecular O—H...O hydrogen bonding, forming a three-dimensional supramolecular structure.
4,4′-Bipyridinium bis(perchlorate)–4-aminobenzoic acid–4,4′-bipyridine–water (1/4/2/2)
Qun-Hui Meng,Lu Han,Jian-Dong Hou,Yi-Fan Luo
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536808042207
Abstract: In the structure of the title compound, C10H10N22+·2ClO4 ·4C7H7NO2·2C10H8N2·2H2O, the 4,4′-bipyridinium cation has a crystallographically imposed centre of symmetry. The cation is linked by N—H...N hydrogen bonds to adjacent 4,4′-bipyridine molecules, which in turn interact via O—H...N hydrogen bonds with 4-aminobenzoic acid molecules, forming chains running parallel to [30overline{2}]. The chains are further connected into a three-dimensional network by N—H...O and O—H...O hydrogen-bonding interactions involving the perchlorate anion, the water molecules and the 4-aminobenzoic acid molecules. In addition, π–π stacking interactions with centroid–centroid distances ranging from 3.663 (6) to 3.695 (6) are present. The O atoms of the perchlorate anion are disordered over two sets of positions, with refined site occupancies of 0.724 (9) and 0.276 (9).
Poly[diaqua-μ-oxalato-μ-pyrazine-2-carboxylato-lanthanum(III)]
Lu Han,Qun-Hui Meng,Jian-Dong Hao,Yi-Fan Luo
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536808041664
Abstract: In the title complex, [La(C5H3N2O2)(C2O4)(H2O)2]n, the LaIII ion is coordinated by one N and three O atoms from two pyrazine-2-carboxylate ligands, by four O atoms from two oxalate ligands and by two O atoms of two water molecules, displaying a distorted bicapped square-antiprismatic geometry. The carboxylate groups of pyrazine-2-carboxylate and oxalate ligands link the lanthanum metal centres, forming layers parallel to (10overline{1}). The layers are further connected by intermolecular O—H...O and N—H...O hydrogen-bonding interactions, forming a three-dimensional supramolecular network.
Stripe formation in bacterial systems with density-suppressed motility
Xiongfei Fu,Lei-Han Tang,Chenli Liu,Jian-Dong Huang,Terence Hwa,Peter Lenz
Quantitative Biology , 2012, DOI: 10.1103/PhysRevLett.108.198102
Abstract: Engineered bacteria in which motility is reduced by local cell density generate periodic stripes of high and low density when spotted on agar plates. We study theoretically the origin and mechanism of this process in a kinetic model that includes growth and density-suppressed motility of the cells. The spreading of a region of immotile cells into an initially cell-free region is analyzed. From the calculated front profile we provide an analytic ansatz to determine the phase boundary between the stripe and the no-stripe phases. The influence of various parameters on the phase boundary is discussed.
PLANT DIVERSITY CHANGE IN GRASSLAND COMMUNITIES ALONG A GRAZING DISTURBANCE GRADIENT IN THE NORTHEAST CHINA TRANSECT
中国东北样带草地群落放牧干扰植物多样性的变化

YANG Li-Min,HAN Mei,LI Jian-Dong,
杨利民
,韩梅,李建东

植物生态学报 , 2001,
Abstract: Grazing disturbance is one of nain factors affecting change in plant diversity of grassland communities. The results of this study of nine major grassland communities along the grazing disturbance gradient in the Northeast China Transect showed that the Shannon index was the highest in moderate grazing or heavy grazing stages, changing as follows: Moderate grazing-Heavy grazing>Heavy grazing-Moderate grazing)>Light grazing>Over grazing. While species richness had a higher contribution to species diversity, compared with evenness, changes in evenness contributed most towards the rate of change in diversity than did changes in species richness. Life form diversity also manifested some obvious changes along the grazing disturbance gradient. The pattern of plant diversity of the steppe region in the Northeast China Transect was Meadow steppe > Typical steppe > Desert steppe > Alkaline meadow.
Structural characteristics of Hemiptelea davidii community on Kerqin sandy land.
科尔沁沙地刺榆群落的结构特征

BAI Yun-peng,HAN Da-yong,DONG Yan-hong,ZHAO Yu-jing,LI Jian-dong,
白云鹏

应用生态学报 , 2008,
Abstract: An investigation was made on the species composition and eco-type of Hemiptelea davidii community on Kerqin sandy land.The results showed that in study area,no shrub layer existed in H.davidii forest,while arbor layer could be divided into two sub-layers,with a height of 4.05-7.86 m for the upper layer,and of 2.05-3.20 m for the lower layer.In the community,there were 32 herbal species belonging to 27 genera of 13 families and dominant by Poaceae,Fabaceae and Compositae,and 11 areal types,among which,the species number in Mongolian-Northeastern China-Dahuricia-North China areal type was the highest(34.38%),followed by that in Northeastern China-North China areal type(12.5%).Among three water ecological types,mesophytes occupied 59.37% of the total,and mesoxerophytes and xerophytes occupied 25% and 15.63%,respectively.Hemicryptophytes had a larger amount in six life forms,accounting for 31.25% of the total.H.davidii community had the typical life form characteristics of temperate steppe.
A new record of Chrysosporium in China
中国金孢属一新记录种

LIANG Jian-Dong,HAN Yan-Feng,LIANG Zong-Qi,
梁建东
,韩燕峰,梁宗琦

微生物学报 , 2008,
Abstract: Fermentation broth of endophytic fungus Trichoderma taxi ZJUF0986 has high antifungal activity to the common 15 species of phytopathogenic fungi. Three bioactive metabolites I, II and III were obtained by extracted with petroleum ether, ethyl acetate and n-butanol and subsequent silica gel column chromatography and preparative HPLC. Among them, compound I, the main metabolite, has strong broad-spectrum antifungal activity, especially to Botrytis cinerea, Rhizoctonia solani and Sclerotinia sclerotiorum with IC50 1.06, 1.08 and 1.13 mg/L, respectively.
Research Progress About Some Problems on Cordyceps militaris
蛹虫草几个问题的最新研究进展

HAN Yan-Feng,LIANG Jian-Dong,DU Wen,LIANG Zong-Qi,
韩燕峰
,梁建东,杜 文,梁宗琦

微生物学通报 , 2009,
Abstract: Cordyceps militaris is of significant economic value in medical care and food exploitation because of its many physiological activities. This paper reviews (1) the taxonomic position of its anamorph, (2) interesting culture ways, (3) strain degeneration and genetic variability, and (4) research progress in bioactive compounds and pharmacological functions.
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