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Search Results: 1 - 10 of 404191 matches for " H. J. Woo "
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Serpin genes AtSRP2 and AtSRP3 are required for normal growth sensitivity to a DNA alkylating agent in Arabidopsis
Joon-Woo Ahn, Brian J Atwell, Thomas H Roberts
BMC Plant Biology , 2009, DOI: 10.1186/1471-2229-9-52
Abstract: Six Arabidopsis genes encoding full-length serpins were differentially expressed in developing seedlings and mature tissues. Basal levels of AtSRP2 (At2g14540) and AtSRP3 (At1g64030) transcripts were highest in reproductive tissues. AtSRP2 was induced 5-fold and AtSRP3 100-fold after exposure of seedlings to low concentrations of methyl methanesulfonate (MMS), a model alkylating reagent that causes DNA damage. Homozygous T-DNA insertion mutants atsrp2 and atsrp3 exhibited no differential growth when mutant and wild-type plants were left untreated or exposed to γ-radiation or ultraviolet light. In contrast, atsrp2 and atsrp3 plants exhibited greater root length, leaf number and overall size than wild-type plants when exposed to MMS. Neither of the two serpins was required for meiosis. GFP-AtSRP2 was localized to the nucleus, whereas GFP-AtSRP3 was cytosolic, suggesting that they target different proteinases. Induction of cell cycle- and DNA damage-related genes AtBRCA1, AtBARD1, AtRAD51, AtCYCB1;1 and AtCYCD1;1, but not AtATM, was reduced relative to wild-type in atsrp2 and atsrp3 mutants exposed to MMS.Expression of specific serpin genes (AtSRP2 and AtSRP3 in Arabidopsis) is required for normal responses of plants following exposure to alkylating genotoxins such as MMS.DNA damage results from exposure to specific chemicals in the environment, UV light, ionizing radiation and errors in DNA replication and proofreading. Plants utilize several pathways for DNA repair, including photoreactivation, nucleotide excision repair, base excision repair, mismatch repair and double-stranded break repair [1]. Methyl methanesulfonate (MMS) is a simple, direct alkylating agent recognized as a standard for genotoxicity assays of environmental pollutants [2]. MMS has been widely utilized as a γ-radiation mimic in the belief it causes double-stranded breaks (DSBs). A recent report found, however, that no MMS-mediated DSBs could be detected in vivo in yeast or mammalian cells, and thos
A Geographical Study of Health Services Utilization Among the Elderly in Hong Kong: From Spatial Variations to Health Care Implications
M. Wong, P.H. Chau, W. Goggins and J. Woo
Health Services Insights , 2012,
Abstract: Introduction: Levels of utilization of health services vary socially and geographically. Differences in the rates of usage are also associated with geographical aspects of health care systems. The purpose of this study was to capture spatial variations in hospital health services utilization in the elderly population in Hong Kong, a Special Administrative Region of China. Materials and Methods: We carried out a secondary analysis of a database from the Hospital Authority (HA) which covers 98% (N = 243,245) of the total registered deaths in Hong Kong during 1999 to 2005. Deaths at age 65y and above (N = 184,671) were included in the analysis. Age-sex weighted mean utilization ratio of hospital services was calculated by dividing the age-sex weighted mean usage of a particular service for each district by that for the whole territory. The variation in utilization by the seniors was analyzed in terms of four types of services: length of stay (LOS) in HA hospitals, number of inpatient admissions, number of visits to specialist outpatient department (SOPD), and attendances at accident and emergency department (AED). Results: Deaths at age 65y and above contributed to 76% of the total registered deaths. Each district contributed 1.0% to 9.1% of the total number of deaths in Hong Kong. Spatial analysis of the age-sex weighted mean utilization ratio showed significant geographic variation in the use of hospital services: the range of difference in the LOS between the lowest and highest district was 44%, while some differences as high as 33%, 35% and 39% in utilization ratios were observed in relation to number of inpatient admissions, visits to SOPD, and attendances at AED respectively. However, the patterns of these variations were not consistent for the four types of service being analyzed. Conclusions: Geographic variation in the utilization of hospital health services across the 18 districts in Hong Kong among the elderly population during the last three years before death was demonstrated. However, the patterns of variation were different for the types of services being examined. Further studies using primary data at an individual level are needed to explain the variations. Detailed analysis examining the relationship between service provision, accessibility and health outcomes are also indicated in order to inform the planning of health service delivery.
Monte-Carlo Simulation of Pulsed Laser Deposition
Pui-Man Lam,S. J. Liu,C. H. Woo
Physics , 2002, DOI: 10.1103/PhysRevB.66.045408
Abstract: Using the Monte Carlo method, we have studied the pulsed laser deposition process at the sub-monolayer regime. In our simulations, dissociation of an atom from a cluster is incorporated. Our results indicate that the pulsed laser deposition resembles molecular beam epitaxy at very low intensity, and that it is characteristically different from molecular beam epitaxy at higher intensity. We have also obtained the island size distributions. The scaling function for the island size distribution for pulsed laser deposition is different from that of molecular beam epitaxy.
Spectrophotometric Dating of Elliptical Galaxies in the Ultraviolet
Y. -W. Lee,J. -H. Woo,S. Yi,J. -H. Park
Physics , 1999,
Abstract: The UV upturn phenomenon observed in elliptical galaxies is attractive for its potential value as an age indicator of old stellar systems. We present our most recent population models for the UV evolution of elliptical galaxies. We confirm that the dominant UV sources are either metal-poor or metal-rich hot horizontal-branch (HB) stars in local giant ellipticals, but we also note that the contribution from post-asymptotic-giant-branch (PAGB) stars overwhelms the UV spectrum at higher redshifts (look-back times). The model UV spectral energy distribution (SED) is therefore strongly affected by the current uncertainty of the mean mass of PAGB stars at higher redshifts. Fortunately, our models suggest that the far-UV observations at z > 0.35 could produce strong constraint on the PAGB mass, while observations at could produce strong constraint on the PAGB mass, while observations at lower redshifts (0.15 < z < 0.30) would still provide constraints on the models on the origin of the UV upturn. Future observations of ellipticals from the STIS/HST and planned GALEX space UV facility will provide crucial database required for more concrete calibration of our UV dating techniques for old stellar systems.
Wave Propagation in Lossy and Superconducting Circular Waveguides
K. H. Yeap,C. Y. Tham,K. C. Yeong,H. J. Woo
Radioengineering , 2010,
Abstract: We present an accurate approach to compute the attenuation of waves, propagating in circular waveguides with lossy and superconducting walls. A set of transcendental equation is developed by matching the fields at the surface of the wall with the electrical properties of the wall material. The propagation constant kz is found by numerically solving for the root of the equation. The complex conductivity of the superconductor is obtained from the Mattis-Bardeen equations. We have compared the loss of TE11 mode computed using our technique with that using the perturbation and Stratton’s methods. The results from the three methods agree very well at a reasonable range of frequencies above the cutoff. The curves, however, deviate below cutoff and at millimeter wave frequencies. We attribute the discrepancies to the dispersive effect and the presence of the longitudinal fields in a lossy waveguide. At frequencies below the gap, the superconducting waveguide exhibits lossless transmission behavior. Above the gap frequency, Cooper-pair breaking becomes dominant and the loss increases significantly.
Effects of Indole-3-Acetic Acid on the Transcriptional Activities and Stress Tolerance of Bradyrhizobium japonicum
Andrew J. Donati, Hae-In Lee, Johan H. J. Leveau, Woo-Suk Chang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076559
Abstract: A genome-wide transcriptional profile of Bradyrhizobium japonicum, the nitrogen-fixing endosymbiont of the soybean plant, revealed differential expression of approximately 15% of the genome after a 1 mM treatment with the phytohormone indole-3-acetic acid (IAA). A total of 1,323 genes were differentially expressed (619 up-regulated and 704 down-regulated) at a two-fold cut off with q value ≤ 0.05. General stress response genes were induced, such as those involved in response to heat, cold, oxidative, osmotic, and desiccation stresses and in exopolysaccharide (EPS) biosynthesis. This suggests that IAA is effective in activating a generalized stress response in B. japonicum. The transcriptional data were corroborated by the finding that stress tolerance of B. japonicum in cell viability assays was enhanced when pre-treated with 1 mM IAA compared to controls. The IAA treatment also stimulated biofilm formation and EPS production by B. japonicum, especially acidic sugar components in the total EPS. The IAA pre-treatment did not influence the nodulation ability of B. japonicum. The data provide a comprehensive overview of the potential transcriptional responses of the symbiotic bacterium when exposed to the ubiquitous hormone of its plant host.
Large-scale outflows in luminous QSOs revisited: The impact of beam smearing on AGN feedback efficiencies
B. Husemann,J. Scharw?chter,V. N. Bennert,V. Manieri,J. -H. Woo,D. Kakkad
Physics , 2015,
Abstract: Enormous observational effort has been made to constrain the energetics of AGN feedback by mapping the kinematics of the ionized gas on kpc scale with integral-field spectroscopy. Here, we investigate how the observed kinematics and inferred energetics are affected by beam smearing of a bright unresolved NLR due to seeing effects. We analysed optical IFU spectroscopy of a sample of twelve luminous unobscured QSOs (0.4
The MUSE view of QSO PG1307+085: An elliptical galaxy on the $M_{BH}-σ_*$ relation interacting with its group environment
B. Husemann,V. N. Bennert,J. Scharw?chter,J. -H. Woo,O. S. Choudhury
Physics , 2015,
Abstract: We report deep optical integral-field spectroscopy with the MUSE of the luminous radio-quiet QSO PG1307+085 (z=0.154) obtained during the commissioning of the instrument. Given the high sensitivity and spatial resolution delivered by MUSE, we are able to resolve the compact ($r_e$~1.3") elliptical host galaxy. After careful spectroscopic deblending of the QSO and host galaxy emission, we infer a stellar velocity dispersion of $155\pm19$km/s. This places PG1307+085 local $M_{BH}-\sigma_*$ relation within the intrinsic scatter but offset towards a higher black hole mass with respect to the mean relation. The observations with MUSE also reveal a large extended ENLR around PG1307+085 reaching out to 30kpc. In addition, we detect a faint bridge of ionized gas towards the most massive galaxy of the galaxy group being just 20" (50kpc) away. Previous long-slit spectroscopic observations missed most of these extended features due to a miss-aligned slit. The ionized gas kinematics does not show any evidence for gas outflows on kpc scales despite the high QSO luminosity of $L_\mathrm{bol}>10^{46}$ erg/s. Based on the ionized gas distribution, kinematics and metallicity we discuss the origin of the ENLR with respect to its group environments including minor mergers, ram-pressure stripping or filamentary gas accretion as the most likely scenarios. We conclude that PG1307+085 is a normal elliptical host in terms of the scaling relations, but that the gas is most likely affected by the environment through gravity or ambient pressure. It is possible that the ongoing interaction with the environment, mainly seen in the ionized gas, is also be responsible for driving sufficient gas to feed the black hole at the centre of the galaxy.
Current Status of Biomarkers for Prostate Cancer
Vicki M. Velonas,Henry H. Woo,Cristobal G. dos Remedios,Stephen J. Assinder
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140611034
Abstract: Prostate cancer (PCa) is a leading cause of cancer-related death of men globally. Since its introduction, there has been intense debate as to the effectiveness of the prostate specific antigen (PSA) test as a screening tool for PCa. It is now evident that the PSA test produces unacceptably high rates of false positive results and is not prognostic. Here we review the current status of molecular biomarkers that promise to be prognostic and that might inform individual patient management. It highlights current efforts to identify biomarkers obtained by minimally invasive methods and discusses current knowledge with regard to gene fusions, mRNA and microRNAs, immunology, and cancer-associated microparticles.
Single-photon detection timing jitter in a visible light photon counter
Burm Baek,Kyle S. McKay,Martin J. Stevens,Jungsang Kim,Henry H. Hogue,Sae Woo Nam
Physics , 2009, DOI: 10.1109/JQE.2010.2042141
Abstract: Visible light photon counters (VLPCs) offer many attractive features as photon detectors, such as high quantum efficiency and photon number resolution. We report measurements of the single-photon timing jitter in a VLPC, a critical performance factor in a time-correlated single-photon counting measurement, in a fiber-coupled closed-cycle cryocooler. The measured timing jitter is 240 ps full-width-at-half-maximum at a wavelength of 550 nm, with a dark count rate of 25 000 counts per second. The timing jitter increases modestly at longer wavelengths to 300 ps at 1000 nm, and increases substantially at lower bias voltages as the quantum efficiency is reduced.
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