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Search Results: 1 - 10 of 496495 matches for " Høyer M "
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P liteligheten av selvrapportert alkoholkonsum. Svalbardstudien 1988-89
Georg Hyer m. fl
Norsk Epidemiologi , 2009,
Abstract: SAMMENDRAG Svalbard er spesielt godt egnet til vurdere p liteligheten av selvrapportert alkoholkonsum. P grunn av det lave prisniv et for alkohol er ulovlig import eller hjemmeproduksjon av alkohol ukjent p Svalbard. Dessuten er samfunnet lite og oversiktlig, slik at det er praktisk mulig unders ke hele befolkningen. I den aktuelle studien registrerte vi alt salg av alkohol til fastboende nordmenn p Svalbard i oktober og november 1988. I samme tidsperiode ble alle nordmenn 18 r eller eldre invitert til ta del i en helseunders kelse der det inngikk sp rsm l om alkoholbruk. Vi fant at selvrapportert alkoholkonsum utgjorde rundt 40% av salgsvolumet. P grunn av de spesielle forhold n r det gjelder alkoholomsetning p Svalbard er det grunn til anta at estimatet i denne studien er mer p litelig sammenlignet med tilsvarende studier fra andre omr der. H yer G, Nilssen O, Brenn T, Schirmer H. The reliability of self-reported alcohol consumption. The Svalbard study 1988-89. Nor J Epidemiol 1996; 6 (1): 109-113. ENGLISH SUMMARY The Norwegian island of Spitzbergen, Svalbard offers a unique setting for validation studies on self-reported
Survival in patients with synchronous liver metastases in central and northern Denmark, 1998 to 2009
Høyer M,Erichsen R,Gandrup P,Nørgaard M
Clinical Epidemiology , 2011,
Abstract: Morten H yer1,2, Rune Erichsen1, Per Gandrup3, Mette N rgaard1, Jacob Bonde Jacobsen11Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of Oncology, Aarhus University Hospital, Aarhus, Denmark; 3Department of Gastrointestinal Surgery, Aarhus University Hospital, Aalborg, DenmarkObjective: In Denmark, the strategy for treatment of cancer with metastases to the liver has changed dramatically during the period 1998 to 2009, when multidisciplinary care and a number of new treatments were introduced. We therefore examined the changes in survival in Danish patients with colorectal carcinoma (CRC) or other solid tumors (non-CRC) who had liver metastases at time of diagnosis.Study design and methods: We included patients diagnosed with liver metastases synchronous with a primary cancer (ie, a solid cancer diagnosed at the same date or within 60 days after liver metastasis diagnosis) during the period 1998 to 2009 identified through the Danish National Registry of Patients. We followed those who survived for more than 60 days in a survival analysis (n = 1021). Survival and mortality rate ratio (MRR) at 1, 3, and 5 years stratified by year of diagnosis were estimated using Cox proportional hazards regression analysis.Results: In the total study population of 1021 patients, 541 patients had a primary CRC and 480 patients non-CRC. Overall, the 5-year survival improved from 3% (95% confidence interval [CI]: 1%–6%) in 1998–2000 to 10% (95% CI: 6%–14%) in 2007 to 2009 (predicted value). The 5-year survival for CRC-patients improved from 1% (95% CI: 0%–5%) to 11% (95% CI: 6%–18%) whereas survival for non-CRC patients only increased from 5% (95% CI: 1%–10%) to 8% (95% CI: 4%–14%).Conclusion: We observed improved survival in patients with liver metastases in a time period characterized by introduction of a structured multidisciplinary care and improved treatment options. The survival gain was most prominent for CRC-patients.Keywords: liver metastases, colorectal cancer, noncolorectal cancer, survival improvement
Survival of patients with primary liver cancer in central and northern Denmark, 1998–2009
Montomoli J,Erichsen R,Nørgaard M,Høyer M
Clinical Epidemiology , 2011,
Abstract: Jonathan Montomoli1, Rune Erichsen1, Mette N rgaard1, Morten H yer2, Jesper Bach Hansen3, Jacob Bonde Jacobsen11Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of Oncology, Aarhus University Hospital, Aarhus, Denmark; 3Medical Department of Gastroenterology, Aalborg Hospital, Aalborg, DenmarkObjective: Primary liver cancer (PLC) is a serious disease with high mortality. During the last decade, improvements in the diagnostic procedures and treatment of PLC may have improved survival. However, few updated longitudinal studies examined this issue. In a population-based setting, we studied changes in the prognoses over time.Methods: Between 1998 and 2009, we identified all patients with PLC in the central and northern Denmark regions, with a combined population of 1.8 million. We determined age- and period-stratified survival, and computed mortality rate ratios (MRRs) with 95% confidence intervals (CIs), using Cox proportional hazard regression to assess changes over time, while controlling for age and gender. We conducted the analyses for PLC overall and separately for hepatocellular carcinoma (HCC) and cholangiocarcinoma, respectively.Results: We included 1064 patients with PLC. Their median age was 69 years (range 17–94 years). The number of patients diagnosed with PLC in the period 2007–2009 was approximately 40% higher than the number in 1998–2000. One-year survival increased from 16% in 1998–2000 to 28% in 2007–2009, corresponding to an adjusted 1-year MRR of 0.65 (95% CI: 0.54–0.79). In patients aged ,60 years, we found the most pronounced increase in 1-year survival, from 14% to 49% in women and from 19% to 41% in men. The 3- and 5-year survival in the entire cohort increased from 5% to a predicted 11% and from 2% to a predicted 7% during our study period, respectively. Accordingly, the expected 3- and 5-year adjusted MRRs were 0.68 (95% CI: 0.57–0.82) and 0.68 (95% CI: 0.57–0.81), respectively. One-, 3-, and 5-year survival improved during the study period for both HCC and cholangiocarcinoma.Conclusion: PLC survival remains poor in the Danish population, although we observed an increase over the period 1998–2009, particularly in young people.Keywords: liver neoplasm, prognosis, mortality, epidemiology
Feedback og debriefing
Christian S. Hyer
Dansk Universitetspaedagogisk Tidsskrift , 2008,
Abstract: I denne artikel omtales feedback anvendt i den l gevidenskabelige uddannelse. Konteksten er simulations velser, hvor akutte, sj ldne eller komplekse h ndelser tr nes ved simulation. Det l ringsm ssige potentiale i simulations velser er meget stort og maksimeres ved at anvende en form for feedback, der betegnes debriefing. Debriefing indeholder dels en faglig del, dels en betydende emotionel del. Inddragelse af den emotionelle komponent er n dvendig hvis den n dvendige refleksion skal f re til l ring. Principperne anvendt ved debriefing, som den beskrives her, kan bringes til anvendelse i andre fag og sammenh nge, for eksempel ved tekstfeedback.
Fire fighters as basic life support responders: A study of successful implementation
Christian Hyer, Erika Christensen
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2009, DOI: 10.1186/1757-7241-17-16
Abstract: The aim of this study was to implement a system using Basic Life Support (BLS) responders equipped with an automatic external defibrillator in an area with relatively short emergency medical services' response times. Success criteria for implementation was defined as arrival of the BLS responders before the EMS, attachment (and use) of the AED, and successful defibrillation.This was a prospective observational study from September 1, 2005 to December 31, 2007 (28 months) in the city of Aarhus, Denmark. The BLS responder system was implemented in an area up to three kilometres (driving distance) from the central fire station, encompassing approximately 81,500 inhabitants. The team trained on each shift and response times were reduced by choice of area and by sending the alarm directly to the fire brigade dispatcher.The BLS responders had 1076 patient contacts. The median response time was 3.5 minutes (25th percentile 2.75, 75th percentile 4.25). The BLS responders arrived before EMS in 789 of the 1076 patient contacts (73%). Cardiac arrest was diagnosed in 53 cases, the AED was attached in 29 cases, and a shockable rhythm was detected in nine cases. Eight were defibrillated using an AED. Seven of the eight obtained return of spontaneous circulation (ROSC). Six of the seven obtaining ROSC survived more than 30 days.In this study, the implementation of BLS responders may have resulted in successful resuscitations. On basis of the close corporation between all participants in the chain of survival this project contributed to the first link: short response time and trained personnel to ensure early defibrillation.In cardiac arrest the time to defibrillation is of major importance for survival. One way of achieving early defibrillation is by using Basic Life Support (BLS) responders: lay persons trained to perform BLS (chest compressions and mouth-to-mouth ventilation) and use an automatic external defibrillator (AED) (which is able to distinguish between shockable and no
Kroppen politiske konomi. Om gr nsedragningen mellem person, krop og vare i medicinske udvekslingssystemet
Klaus Hyer,Maria Olejaz
Kulturstudier , 2011,
Abstract: Today, the medico industry is considered the largest export sector of Denmark, and the medical knowledge, on which it is based, requires access to bodies and human biological material. This material and these bodies are thus in a certain sense economic resources. At the same time, they are typically regarded as parts of individuals – of subjects. In certain situations, this duality becomes problematic. You cannot buy and sell “body parts”; individuals may own, but cannot be owned. It is, however, no easy task to keep the-body-as-subject separate from the-body-as-object, and the medical routine work is full of hybrids. In the present article, we discuss historically specific ways in which to create distinctions in the tension between being a patient who is the target for intervention, and supplying material for the treatment of others. We focus on the hip as a bone and as a metal prosthesis, where it becomes the subject of exchange. With the article, we specifically wish to underline the necessity of recognizing the basic ambiguity sourrounding the body, and the meaning of this ambiguity for how we organize the exchange of everything which is neither subject nor an unambiguous object.
Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells
Carla M. P. Cardoso, Line Groth-Pedersen, Maria Hyer-Hansen, Thomas Kirkegaard, Elizabeth Corcelle, Jens S. Andersen, Marja J??ttel?, Jesper Nylandsted
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004424
Abstract: Background Enhanced lysosomal trafficking is associated with metastatic cancer. In an attempt to discover cancer relevant lysosomal motor proteins, we compared the lysosomal proteomes from parental MCF-7 breast cancer cells with those from highly invasive MCF-7 cells that express an active form of the ErbB2 (ΔN-ErbB2). Methodology/Principal Findings Mass spectrometry analysis identified kinesin heavy chain protein KIF5B as the only microtubule motor associated with the lysosomes in MCF-7 cells, and ectopic ΔN-ErbB2 enhanced its lysosomal association. KIF5B associated with lysosomes also in HeLa cervix carcinoma cells as analyzed by subcellular fractionation. The depletion of KIF5B triggered peripheral aggregations of lysosomes followed by lysosomal destabilization, and cell death in HeLa cells. Lysosomal exocytosis in response to plasma membrane damage as well as fluid phase endocytosis functioned, however, normally in these cells. Both HeLa and MCF-7 cells appeared to express similar levels of the KIF5B isoform but the death phenotype was weaker in KIF5B-depleted MCF-7 cells. Surprisingly, KIF5B depletion inhibited the rapamycin-induced accumulation of autophagosomes in MCF-7 cells. In KIF5B-depleted cells the autophagosomes formed and accumulated in the close proximity to the Golgi apparatus, whereas in the control cells they appeared uniformly distributed in the cytoplasm. Conclusions/Significance Our data identify KIF5B as a cancer relevant lysosomal motor protein with additional functions in autophagosome formation.
Importance of kinestetic intelligence and multiple intelligence teory
Kür?at Osman Ergül,Hulusi Alp,Hatice ?aml?yer,Hüseyin ?aml?yer
International Journal of Human Sciences , 2007,
Abstract: Education is a concept that day by day develops and open to innovations. With this meaning some new teaching theories come forward as a educaiton’s theoretical base and also its validity proves. One of these theories that comes the first rank is Professor Doctor Howard Gardner’s theory about multiple intelligence.The study prepared with the help of the information in literature. For the improving the kinestetic intelligence, samples of studies devoted to the physical education lessons presented in this research. With these apllications students that have the kinestetic intelligence and determined and physiological fundamentals of kinestetic awareness had exposed.
Bicultural Literacy Curriculum  [PDF]
Yer J. Thao
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.32039
Abstract: This article examines the literacy issues in public school in the United States, and points out that current programs do not have a meaningful cultural connection to bicultural and bilingual students. The findings indicate that literacy must become part of bicultural and bilingual students’ reality in order to empower them. The pedagogical content of literacy must acknowledge bicultural and bilingual students’ culture so they can make connections to learning literacy. In order to help bicultural and bilingual students acquire the necessary academic skills to succeed on high-stakes tests that are demanded by No Child Left Behind Law, public schools need to infuse home culture literacy as part of literacy programs and practices.
Standards of resuscitation during inter-hospital transportation: the effects of structured team briefing or guideline review - A randomised, controlled simulation study of two micro-interventions
Christian B Hyer, Erika F Christensen, Berit Eika
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2011, DOI: 10.1186/1757-7241-19-15
Abstract: To examine whether inter-hospital resuscitation improved with a structured team briefing between physician and ambulance crew in preparation for transfer vs. review of resuscitation guidelines. The effect parameters were physician team leadership (requesting help, delegating tasks), time to resuscitation key elements (chest compressions, defibrillation, ventilations, medication, or a combination of these termed "the first meaningful action"), and hands-off ratio.Participants: 46 physicians graduated within 5 years. Design: A simulation intervention study with a control group and two interventions (structured team briefing or review of guidelines). Scenario: Cardiac arrest during simulated inter-hospital transfer.Forty-six candidates participated: 16 (control), 13 (review), and 17 (team briefing). Reviewing guidelines delayed requesting help to 162 seconds, compared to 21 seconds in control and team briefing groups (p = 0.021). Help was not requested in 15% of cases; never requesting help was associated with an increased hands-off ratio, from 39% if the driver's assistance was requested to 54% if not (p < 0.01). No statistically significant differences were found between groups regarding time to first chest compression, defibrillation, ventilation, drug administration, or the combined "time to first meaningful action".Neither review nor team briefing improved the time to resuscitation key elements. Review led to an eight-fold increase in the delay to requesting help. The association between never requesting help and an increased hands-off ratio underpins the importance of prioritising available resources. Other medical and non-medical domains have benefited from the use of guidelines reviews and structured team briefings. Reviewing guidelines may compromise the ability to focus on aspects such as team leading and delegating tasks and warrants the need for further studies focusing on how to avoid this cognitive impairment.Urgent inter-hospital transfer poses a risk of
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