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Determining Effects of Elaidic Acid on PPAR- Gamma Expression in RAW 264.7 Macrophage Cell Line
H Montakhab Yegane,H Babaahmadi Rezaiy,M Doosti
Tehran University Medical Journal , 2012,
Abstract: Background: Several dietary factors are involved in cardiovascular coronary heart diseases, including trans fatty acids, which are generally formed during hydrogenation of vegetable oils, a process that causes conversion of liquid oils into semisolid fats. Nowadays, it is well-known that trans fatty acids form a major risk factor in the occurrence and progression of atherosclerosis. On the other hand, it has been identified that some nuclear receptors, such as PPARs, are involved and play important roles in lipid homeostasis and pathogenesis of cardiovascular diseases. Therefore, we studied the effect of elaidic acid on gene expression of peroxisome proliferator activated receptor gamma (PPARγ).Methods: Murine macrophage RAW264.7 cells were treated by 0.5, 1, and 2 mM concentrations of elaidic acid for 6 h. The control group was treated by 50% ethanol (as solvent), equivalent to the amount of ethanol used in 2 mM concentration of elaidic acid. Later, the total RNA was extracted and its cDNA was synthesized. Finally, the quantity of PPARγ gene expression was measured by real-time PCR.Results: Overall, 0.5, 1, and 2 mM concentrations of elaidic acid decreased PPARγ gene expression in RAW264.7 macrophage cell line by -1.36, -1.68, and -3.24 folds compared with the control group, respectively.Conclusion: By decreasing the expression of nuclear receptor PPARγ, elaidic acid causes, intensifies or accelerates the occurrence of cardiovascular diseases, especially atherosclerosis. This finding shows the importance of reducing the consumption of elaidic acid containing foods.
Relativistic three-partite non-locality
A. Montakhab,H. Moradpour
Physics , 2015,
Abstract: Bell-like inequalities have been used in order to distinguish non-local quantum pure states by various authors. The behavior of such inequalities under Lorentz transformation has been a source of debate and controversies in the past. In this paper, we consider the two most commonly studied three-particle pure states, that of W and GHZ states which exhibit distinctly different type of entanglement. We discuss the various types of three-particle inequalities used in previous studies and point to their corresponding shortcomings and strengths. Our main result is that if one uses Svetlichny's inequality as the main measure of non-locality and uses the same angles in the rest frame ($S$) as well as the moving frame ($S^{\prime}$), then maximally violated inequality in $S$ will decrease in the moving frame, and will eventually lead to lack of non-locality ( i.e. satisfaction of inequality) in the $v \rightarrow c$ limit. This is shown for both GHZ and W states and in two different configurations which are commonly studied (\textbf{Case $I$} and \textbf{Case $II$}). Our results is in line with a more familiar case of two particle case. We also show that the satisfaction of Svetlichny's inequality in the $v\rightarrow c$ limit is independent of initial particles' velocity. We use Czachor's relativistic spin operators instead of Pauli spin operators in our calculations. Our results draws a clear picture of three-particle non-locality making its general properties consistent with previous studies on two-particle systems regardless of the W state or the GHZ state is involved.
Investigation of the field-induced ferromagnetic phase transition in spin polarized neutron matter: a lowest order constrained variational approach
G. H. Bordbar,Z. Rezaei,Afshin Montakhab
Physics , 2011, DOI: 10.1103/PhysRevC.83.044310
Abstract: In this paper, the lowest order constrained variational (LOCV) method has been used to investigate the magnetic properties of spin polarized neutron matter in the presence of strong magnetic field at zero temperature employing $AV_{18}$ potential. Our results indicate that a ferromagnetic phase transition is induced by a strong magnetic field with strength greater than $10^{18}\ G$, leading to a partial spin polarization of the neutron matter. It is also shown that the equation of state of neutron matter in the presence of magnetic field is stiffer than the case in absence of magnetic field.
A Novel Practical Service Delivery Platform for Next Generation Networks
A.H. Darvishan,F. Sarabchi,H. Yegane
Information Technology Journal , 2008,
Abstract: In this research, model for service layer creation for providing various multimedia services in next generation networks is introduced. In this model, open standards and commercial software frame works have been utilized so that model implantation is completely practical. Also, a new architecture based on TISPAN model explains participation of 3rd party operators in creation and implementation of services on an integrated telecom network.
Dabigatran Etexilate, A Novel Oral Direct Thrombin Inhibitor, for Preventing Thromboembolic Events After Knee Replacement Arthroplasty
Moghtadaee M,Shahhoseini Gh,Farahini H,Yegane A
Tehran University Medical Journal , 2012,
Abstract: Background: Dabigatran etexilate is one of the few direct thrombin inhibitors with anti-coagulant activities and the following distinctive features: taken orally, no need to closely monitor for complications, and no need for regular dose adjustments. Relying on the above mentioned valuable advantages, dabigatran etexilate can be considered as a premier choice for the prevention of venous thromboembolism after knee replacement arthroplasty. Methods: Forty five patients undergoing 50 knee replacement surgeries were included in this case-series study undertaken in Hazrat Rasool Akram and Khatam-alanbia Hospitals during 2010. Dabigatran etexilate was administered for the prevention of venous thromboembolism after knee arthroplasty in doses of 110 mg in the first 1-4 h after surgery followed by daily doses of 220 mg for 10 days. Patients were examined 3 times and a color Doppler sonography was performed on the 11th day to check for venous thrombosis. Finally, the patients were re-examined at the end of the 1st and the 3rd months postoperatively. Results: Only one out of 45 patients was diagnosed to have venous thrombosis on sonography done on the 11th day but the patient did not have any symptoms and repeat sonographies at the end of the 1st and the 3rd months postoperatively showed no venous thrombosis either. No complications were witnessed in the patients in the 3-month follow-up period. Conclusion: Dabigatran etexilate (220 mg/d for 10 days) can be an effective drug against venous thrombosis after total knee replacement surgeries.
EVALUATION OF THE MODIFIED ALVARADO SCORE
R Yegane,H Peyvandi,E Hajinasrollah,N Salehei
Acta Medica Iranica , 2008,
Abstract: "nVarious scoring systems have been devised to aid diagnosis of acute appendicitis. The main objective of this study was finding the accuracy of modified Alvarado score in prediction of acute appendicitis. The registries of cases with appendectomy, who had been admitted to a referral medical center in the capital of Iran from February 2000 to March 2004, were studied. Sensitivity and specificity of modified Alvarado scoring and clinical diagnostic system used in our center were calculated. ROC curve analysis demonstrated increasing chance of acute appendicitis by increasing of the modified Alvarado score (P = 0.001), but it was neither sensitive nor specific (sensitivity, 55%; specificity, 59%). Diagnosis based on surgeons' decision was more sensitive than Alvarado scoring (sensitivity 93-95% in different age groups). Diagnosis of acute appendicitis based on surgeons' decision is more helpful than modified Alvarado score. "n
Time parameterization and stationary distributions in a relativistic gas
Malihe Ghodrat,Afshin Montakhab
Physics , 2009, DOI: 10.1103/PhysRevE.82.011110
Abstract: In this paper we consider the effect of different time parameterizations on the stationary velocity distribution function for a relativistic gas. We clarify the distinction between two such distributions, namely the J\"{u}ttner and the modified J\"{u}ttner distributions. Using a recently proposed model of a relativistic gas, we show that the obtained results for the proper-time averaging does not lead to modified J\"{u}ttner distribution (as recently conjectured), but introduces only a Lorentz factor $\gamma$ to the well-known J\"{u}ttner function which results from observer-time averaging. We obtain results for rest frame as well as moving frame in order to support our claim.
Dynamics of Global Entanglement under Decoherence
Afshin Montakhab,Ali Asadian
Physics , 2008, DOI: 10.1103/PhysRevA.77.062322
Abstract: We investigate the dynamics of global entanglement, the Meyer-Wallach measure, under decoherence, analytically. We study two important class of multi-partite entangled states, the Greenberger-Horne-Zeilinger and the W state. We obtain exact results for various models of system-environment interactions (decoherence). Our results shows distinctly different scaling behavior for these initially entangled states indicating a relative robustness of the W state, consistent with previous studies.
Fine Structure of Avalanches in the Abelian Sandpile Model
Amir Abdolvand,Afshin Montakhab
Physics , 2008, DOI: 10.1140/epjb/e2010-00164-8
Abstract: We study the two-dimensional Abelian Sandpile Model on a square lattice of linear size L. We introduce the notion of avalanche's fine structure and compare the behavior of avalanches and waves of toppling. We show that according to the degree of complexity in the fine structure of avalanches, which is a direct consequence of the intricate superposition of the boundaries of successive waves, avalanches fall into two different categories. We propose scaling ans\"{a}tz for these avalanche types and verify them numerically. We find that while the first type of avalanches has a simple scaling behavior, the second (complex) type is characterized by an avalanche-size dependent scaling exponent. This provides a framework within which one can understand the failure of a consistent scaling behavior in this model.
Heat transport and diffusion in a canonical model of a relativistic gas
Malihe Ghodrat,Afshin Montakhab
Physics , 2013, DOI: 10.1103/PhysRevE.87.032120
Abstract: Relativistic transport phenomena are important from both theoretical and practical point of view. Accordingly, hydrodynamics of relativistic gas has been extensively studied theoretically. Here, we introduce a three-dimensional canonical model of hard-sphere relativistic gas which allows us to impose appropriate temperature gradient along a given direction maintaining the system in a non-equilibrium steady state. We use such a numerical laboratory to study the appropriateness of the so-called first order (Chapman-Enskog) relativistic hydrodynamics by calculating various transport coefficients. Our numerical results are consistent with predictions of such a theory for a wide range of temperatures. Our results are somewhat surprising since such linear theories are not consistent with the fundamental assumption of the special theory of relativity ($v\leq c$). We therefore seek to explain such results by studying the appropriateness of diffusive transport in the relativistic gas, comparing our results with that of a classical gas. We find that the relativistic correction (constraint) in the hydrodynamic limit amounts to small negligible corrections, thus indicating the validity of the linear approximation in near equilibrium transport phenomena.
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