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Resection and Reconstruction of Small Intestine with Ligasure and Linear Stapler: A Comparative Study
A Tavassoli,A Abdollahi,H Golmohammadzadeh
Tehran University Medical Journal , 2012,
Abstract: Background: Regarding the limited number of studies on the feasibility of resection and repair of the small intestine by ligasure, we performed this study to compare ligasure with linear stapler for the previously mentioned operation.Methods: This phase 1 clinical trial study was performed in Ghaem Hospital, an educational hospital affiliated to Mashhad University of Medical Sciences, from 2010 to 2011. After obtaining permission from the University's ethics committee and a written informed consent from each patient, we recruited 18 patients. The participants who had morbid obesity and were candidates for laparoscopic gastric bypass surgery were randomly allocated to two stapler and ligasure groups. The data were collected and analyzed by three statistical tests, including Mann-Whitney U test, by SPSS 16.Results: All patients were female with the age range of 20-65 years. Cost in the stapler group ranged between 29,500,000 to 40,000,000 Rial (mean 31,830,000± 3,500,000 Rials) and in ligasure group it was between 24,000,000 to 35,000,000 Rials (mean 26,720,000± 3,290,000 Rials). There was a significant difference between the two groups in cost (P=0.004(. Duration of the operations were 200±3.4 and 240±10 minutes in the stapler and ligasure groups, respectively. The difference in duration was significant between the two groups (P=0.043). No significant differences were observed in complications.Conclusion: Application of ligasure in resection and reconstruction of small intestine is more cost-effective than stapler, although duration of surgery is longer.
Preparation, characterization and evaluation of moisturizing and UV protecting effects of topical solid lipid nanoparticles
Shiva Golmohammadzadeh,Mohsen Mokhtari,Mahmoud Reza Jaafari
Brazilian Journal of Pharmaceutical Sciences , 2012,
Abstract: Solid lipid nanoparticles (SLN) were recently proposed as carriers for various pharmaceutical and cosmetic actives. These lipid nanoparticles can act as moisturizers and physical sunscreens on their own. Therefore, the full potential of these carriers has yet to be determined. The present study was aimed to determine and compare moisturizing and UV-protecting effects of different solid lipid nanoparticles (SLN) prepared by different solid lipids including Glyceryl monostearate (GMS), Precirol (P) and cetyl palmitate (CP) as carrier systems of moisturizers and sunscreens. The influence of the size and matrix crystallinity of the solid lipids on the occlusive factor, skin hydration and UV-protection were evaluated by in vitro and in vivo methods. The SLN were prepared by high-shear homogenization and ultrasound methods. Size, zeta potential and morphological characteristics of the samples were assessed by transmission electron microscopy (TEM) and thermotropic properties with differential scanning calorimetry (DSC) technique. Results of the assessments showed that SLN-CP significantly increases skin hydration and UV-protection, compared to SLN-GMS and SLN-P. It was demonstrated that the size of SLN, crystallinity index of solid lipid in SLN and probably other mechanisms besides the occlusive factor can influence skin hydration and UV-protection indices. Furthermore, findings of the assessments demonstrated significant difference between in vitro and in vivo assessments regarding occlusive factor and moisturizing effects. Findings of the present study indicate that the SLN-CP could be a promising carrier for sunscreens and moisturizers. Nanopartículas lipídicas sólidas (NLS) foram, recentemente, propostas como carreadores de vários ativos cosméticos e farmacêuticos. Essas nanopartículas lipídicas podem atuar como hidratantes e protetores solares físicos por si só. Assim sendo, determinou-se o potencial desses carreadores. Os objetivos do presente estudo foram determinar e comparar os efeitos hidratantes e protetores contra UV das diferentes partículas lipídicas sólidas (NLS) preparadas com diferentes lipídios sólidos, incluindo o monoestearato de gligerila (MSG), Precirol (P) e palmitato de cetila (PC) como sistemas carreadores de hidratantes e de protetores solares. A influência do tamanho e da cristalinidade da matriz dos lipídios sólidos no fator oclusivo, na hidrata o da pele e na prote o ao UV foi avaliada por métodos in vitro e in vivo. As NLS foram preparadas por homogeneiza o por alto corte e métodos de ultrassom. Tamanho, potencial zeta e car
Research:PREPARATION AND CHARACTERIZATION OF LIPOSOMES ENCAPSULATED WITH CLINDAMYCIN AND TRETINOIN
Bizhan Malaekeh-Nikouei,Shiva Golmohammadzadeh*,Mahshid Hosseini,Horiyeh Nassirli
Pharmacie Globale : International Journal of Comprehensive Pharmacy , 2011,
Abstract: A formulation containing agents affecting the non-inflammatory like tretinoin as well as the inflammatory lesions of acne like clindamycin at the same time is preferable due to their high efficacy and shortening of the duration of treatment. Liposomes can improve the therapeutic effect of drugs and decrease the adverse effects. Therefore, liposomes containing clindamycin (Lip-CL), liposomes containing tretinoin (Lip-TRT) and liposomes loaded with both tretinoin and clindamycin (Lip-CL-TRT) were prepared and characterized. Lip-TRT were prepared by solvent evaporation method whereas Lip-CL and Lip-CL-TRT were prepared by dehydration-rehydration method. The morphologic, mean size and drug encapsulation efficiency were evaluated. Also, the amount of drug which was passed through or retained inside the skin was determined by Franz cell diffusion method and compared with the TRT cream. The particles of the liposomes were obtained in submicron size. The encapsulation efficiency (EE) of TRT and CL were high in the liposomal formulations. The retention of TRT and CL inside the skin from the Lip-CL-TRT were obtained more than 80%. Generally the results of the present study showed that it is possible to select liposomes as drug carrier for both CL and TRT.
Euler-Lagrange Elasticity: Differential Equations for Elasticity without Stress or Strain  [PDF]
H. H. Hardy
Journal of Applied Mathematics and Physics (JAMP) , 2013, DOI: 10.4236/jamp.2013.17004
Abstract:

Differential equations to describe elasticity are derived without the use of stress or strain. The points within the body are the independent parameters instead of strain and surface forces replace stress tensors. These differential equations are a continuous analytical model that can then be solved using any of the standard techniques of differential equations. Although the equations do not require the definition stress or strain, these quantities can be calculated as dependent parameters. This approach to elasticity is simple, which avoids the need for multiple definitions of stress and strain, and provides a simple experimental procedure to find scalar representations of material properties in terms of the energy of deformation. The derived differential equations describe both infinitesimal and finite deformations.

Euler-Lagrange Elasticity with Dynamics  [PDF]
H. H. Hardy
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.213138
Abstract: The equations of Euler-Lagrange elasticity describe elastic deformations without reference to stress or strain. These equations as previously published are applicable only to quasi-static deformations. This paper extends these equations to include time dependent deformations. To accomplish this, an appropriate Lagrangian is defined and an extrema of the integral of this Lagrangian over the original material volume and time is found. The result is a set of Euler equations for the dynamics of elastic materials without stress or strain, which are appropriate for both finite and infinitesimal deformations of both isotropic and anisotropic materials. Finally, the resulting equations are shown to be no more than Newton's Laws applied to each infinitesimal volume of the material.
Linear Algebra Provides a Basis for Elasticity without Stress or Strain  [PDF]
H. H. Hardy
Soft (Soft) , 2015, DOI: 10.4236/soft.2015.43003
Abstract: Linear algebra provides insights into the description of elasticity without stress or strain. Classical descriptions of elasticity usually begin with defining stress and strain and the constitutive equations of the material that relate these to each other. Elasticity without stress or strain begins with the positions of the points and the energy of deformation. The energy of deformation as a function of the positions of the points within the material provides the material properties for the model. A discrete or continuous model of the deformation can be constructed by minimizing the total energy of deformation. As presented, this approach is limited to hyper-elastic materials, but is appropriate for infinitesimal and finite deformations, isotropic and anisotropic materials, as well as quasi-static and dynamic responses.
Spectral resolution in hyperbolic orbifolds, quantum chaos, and cosmology
H. Then
Physics , 2007,
Abstract: We present a few subjects from physics that have one in common: the spectral resolution of the Laplacian.
Arithmetic quantum chaos of Maass waveforms
H. Then
Mathematics , 2003,
Abstract: We compute numerically eigenvalues and eigenfunctions of the quantum Hamiltonian that describes the quantum mechanics of a point particle moving freely in a particular three-dimensional hyperbolic space of finite volume and investigate the distribution of the eigenvalues.
Maass cusp forms for large eigenvalues
H. Then
Mathematics , 2003,
Abstract: We investigate the numerical computation of Maass cusp forms for the modular group corresponding to large eigenvalues. We present Fourier coefficients of two cusp forms whose eigenvalues exceed r=40000. These eigenvalues are the largest that have so far been found in the case of the modular group. They are larger than the 130millionth eigenvalue.
Static Electric-Spring and Nonlinear Oscillations  [PDF]
H. Sarafian
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2010, DOI: 10.4236/jemaa.2010.22011
Abstract: The author designed a family of nonlinear static electric-springs. The nonlinear oscillations of a massively charged particle under the influence of one such spring are studied. The equation of motion of the spring-mass system is highly nonlinear. Utilizing Mathematica [1] the equation of motion is solved numerically. The kinematics of the particle namely, its position, velocity and acceleration as a function of time, are displayed in three separate phase diagrams. Energy of the oscillator is analyzed. The nonlinear motion of the charged particle is set into an actual three-dimensional setting and animated for a comprehensive understanding.
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