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Search Results: 1 - 10 of 312873 matches for " H G Rangaraju "
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Low Power Reversible Parallel Binary Adder/Subtractor
Rangaraju H G,Venugopal U,Muralidhara K N,Raja K B
International Journal of VLSI Design & Communication Systems , 2010,
Abstract: In recent years, Reversible Logic is becoming more and more prominent technology having its applications inLow Power CMOS, Quantum Computing, Nanotechnology, and Optical Computing. Reversibility plays animportant role when energy efficient computations are considered. In this paper, Reversible eight-bit ParallelBinary Adder/Subtractor with Design I, Design II and Design III are proposed. In all the three designapproaches, the full Adder and Subtractors are realized in a single unit as compared to only full Subtractorin the existing design. The performance analysis is verified using number reversible gates, Garbageinput/outputs and Quantum Cost. It is observed that Reversible eight-bit Parallel Binary Adder/Subtractorwith Design III is efficient compared to Design I, Design II and existing design
Low Power Reversible Parallel Binary Adder/Subtractor
H G Rangaraju,U. Venugopal,K N Muralidhara,K B Raja
Computer Science , 2010, DOI: 10.5121/vlsic.2010.1303
Abstract: In recent years, Reversible Logic is becoming more and more prominent technology having its applications in Low Power CMOS, Quantum Computing, Nanotechnology, and Optical Computing. Reversibility plays an important role when energy efficient computations are considered. In this paper, Reversible eight-bit Parallel Binary Adder/Subtractor with Design I, Design II and Design III are proposed. In all the three design approaches, the full Adder and Subtractors are realized in a single unit as compared to only full Subtractor in the existing design. The performance analysis is verified using number reversible gates, Garbage input/outputs and Quantum Cost. It is observed that Reversible eight-bit Parallel Binary Adder/Subtractor with Design III is efficient compared to Design I, Design II and existing design.
TMV ( Sv) 7 – A high yielding cosmopolitan sesame variety
V. Manoharan, M. Vaithiyalingan, M. Sudha, G. Rangaraju, R. Vishnupriya, P. Renugadevi and S. Jebaraj
Electronic Journal of Plant Breeding , 2010,
Abstract: The sesame culture TVS 0039 is a hybrid derivative of Si 250 x ES 22. It is an high yielding sesame variety with brown colour seed. It matures in85- 90 days. TVS 0039 has recorded a mean yield of 737 kg/ha which is 12.8, 26.9 and 14.0 % superior to TMV 3, VRI (Sv) 1 and VRI(Sv 2),respectively under rainfed condition. During summer season, the culture registered an average yield of 781 kg/ha which is 25.6, 20.5, 34.3 and27.8 % increase over VRI (Sv) 1, VRI (Sv 2), TMV 4 and TMV 6 respectively. The seeds are brown coloured with an oil content of 51.0 percent. The culture is also tolerant to root rot disease.
CHARACTERIZATION OF TERNARY SYSTEM OF POORLY SOLUBLE DRUG IN VARIOUS HYDROPHILIC CARRIERS
Vijay Kumar,Shankaraiah MM,Venkatesh JS,Rangaraju D
International Research Journal of Pharmacy , 2011,
Abstract: The present study aims to experiment the solid dispersion of poorly water soluble drug fenbendazole as model drug. Fenbendazole is an Antihelmintic drug (BCS class 2).The purpose of this study was to enhance the dissolution of Fenbendazole by solid dispersions consisting of the drug, a polymeric carrier, Binary and ternary system were prepared by kneading method using hydrophilic polymers like polyvinylpyrrolidone K-25 (PVP K25), beta-cyclodextrin (BCD),mannitol and urea. The prepared formulations were characterized by polymer compatibility by using FT-IR.The drug content uniformity was found to be good in all formulations. The influence of various factors (type of polymer, ratio of the polymer) on the solubility and dissolution rate of the drug were also evaluated. The solubility of fenbendazole was greater with fenbendazole-betacyclodextrin-PVP K-25 system. Dissolution rates of fenbendazole were significantly increased by binary and ternary system. Among all the formulations, fenbendazole-betacyclodextrin-polyvinylpyrrolidone K-25 (VK3) Formulation was found to be better amorphous nature in relation with in-vitro release. The result confirmed that ternary system showed better solubility and dissolution characteristics when compared to binary system.
Genetic variations of β-MYH7 in hypertrophic cardiomyopathy and dilated cardiomyopathy
Tanjore Reena,RangaRaju Advithi,Vadapalli Shivani,Remersu Sushant
Indian Journal of Human Genetics , 2010,
Abstract: Context: Hypertrophic cardiomyopathy (HCM) is known to be manifested by mutations in 12 sarcomeric genes and dilated cardiomyopathy (DCM) is known to manifest due to cytoskeletal mutations. Studies have revealed that sarcomeric mutations can also lead to DCM. Therefore, in the present study, we have made an attempt to compare and analyze the genetic variations of beta-myosin heavy chain gene (β-MYH7), which are interestingly found to be common in both HCM and DCM. The underlying pathophysiological mechanism leading to two different phenotypes has been discussed in this study. Till date, about 186 and 73 different mutations have been reported in HCM and DCM, respectively, with respect to this gene. Aim: The screening of β-MYH7 gene in both HCM and DCM has revealed some common genetic variations. The aim of the present study is to understand the pathophysiological mechanism underlying the manifestation of two different phenotypes. Materials and Methods: 100 controls, 95 HCM and 97 DCM samples were collected. Genomic DNA was extracted following rapid nonenzymatic method as described by Lahiri and Nurnberger (1991), and the extracted DNA was later subjected to polymerase chain reaction (PCR) based single stranded conformation polymorphism (SSCP) analysis to identify single nucleotide polymorphism (SNP)s/mutations associated with the diseased phenotypes. Results and Conclusion: Similar variations were observed in β-MYH7 exons 7, 12, 19 and 20 in both HCM and DCM. This could be attributed to impaired energy compromise, or to dose effect of the mutant protein, or to even environmental factors/modifier gene effects wherein an HCM could progress to a DCM phenotype affecting both right and left ventricles, leading to heart failure.
Haplotypes of NOS3 Gene Polymorphisms in Dilated Cardiomyopathy
Lova Satyanarayana Matsa, Advithi Rangaraju, Viswamitra Vengaldas, Mona Latifi, Hossein Mehraban Jahromi, Venkateshwari Ananthapur, Pratibha Nallari
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070523
Abstract: Dilated Cardiomyopathy (DCM) is characterized by systolic dysfunction, followed by heart failure necessitating cardiac transplantation. The genetic basis is well established by the identification of mutations in sarcomere and cytoskeleton gene/s. Modifier genes and environmental factors are also considered to play a significant role in the variable expression of the disease, hence various mechanisms are implicated and one such mechanism is oxidative stress. Nitric Oxide (NO), a primary physiological transmitter derived from endothelium seems to play a composite role with diverse anti-atherogenic effects as vasodilator. Three functional polymorphisms of endothelial nitric oxide synthase (NOS3) gene viz., T-786C of the 5′ flanking region, 27bp VNTR in intron4 and G894T of exon 7 were genotyped to identify their role in DCM. A total of 115 DCM samples and 454 controls were included. Genotyping was carried out by PCR -RFLP method. Allelic and genotypic frequencies were computed in both control & patient groups and appropriate statistical tests were employed. A significant association of TC genotype (T-786C) with an odds ratio of 1.74, (95% CI 1.14 - 2.67, p = 0.01) was observed in DCM. Likewise the GT genotypic frequency of G894T polymorphism was found to be statistically significant (OR 2.10, 95% CI 1.34–3.27, p = 0.0011), with the recessive allele T being significantly associated with DCM (OR 1.64, 95% CI 1.18 - 2.30, p = 0.003). The haplotype carrying the recessive alleles of G894T and T-786C, C4bT was found to exhibit 7 folds increased risk for DCM compared to the controls. Hence C4bT haplotype could be the risk haplotype for DCM. Our findings suggest the possible implication of NOS3 gene in the disease phenotype, wherein NOS3 may be synergistically functioning in DCM associated heart failure via the excessive production of NO in cardiomyocytes resulting in decreased myocardial contractility and systolic dysfunction, a common feature of DCM phenotype.
HESS Opinions "The art of hydrology"*
H. H. G. Savenije
Hydrology and Earth System Sciences (HESS) & Discussions (HESSD) , 2009,
Abstract: Hydrological modelling is the same as developing and encoding a hydrological theory. A hydrological model is not a tool but a hypothesis. The whole discussion about the inadequacy of hydrological models we have witnessed of late, is related to the wrong concept of what a model is. Good models don't exist. Instead of looking for the "best" model, we should aim at developing better models. The process of modelling should be top-down, learning from the data while at the same time connection should be established with underlying physical theory (bottom-up). As a result of heterogeneity occurring at all scales in hydrology, there always remains a need for calibration of models. This implies that we need tailor-made and site-specific models. Only flexible models are fit for this modelling process, as opposed to most of the established software or "one-size-fits-all" models. The process of modelling requires imagination, inspiration, creativity, ingenuity, experience and skill. These are qualities that belong to the field of art. Hydrology is an art as much as it is science and engineering.
HESS Opinions "Topography driven conceptual modelling (FLEX-Topo)"
H. H. G. Savenije
Hydrology and Earth System Sciences (HESS) & Discussions (HESSD) , 2010,
Abstract: Heterogeneity and complexity of hydrological processes offer substantial challenges to the hydrological modeller. Some hydrologists try to tackle this problem by introducing more and more detail in their models, or by setting-up more and more complicated models starting from basic principles at the smallest possible level. As we know, this reductionist approach leads to ever higher levels of equifinality and predictive uncertainty. On the other hand, simple, lumped and parsimonious models may be too simple to be realistic or representative of the dominant hydrological processes. In this commentary, a new approach is proposed that tries to find the middle way between complex distributed and simple lumped modelling approaches. Here we try to find the right level of simplification while avoiding over-simplification. Paraphrasing Einstein, the maxim is: make a model as simple as possible, but not simpler than that. The approach presented is process based, but not physically based in the traditional sense. Instead, it is based on a conceptual representation of the dominant physical processes in certain key elements of the landscape. The essence of the approach is that the model structure is made dependent on a limited number of landscape classes in which the topography is the main driver, but which can include geological, geomorphological or land-use classification. These classes are then represented by lumped conceptual models that act in parallel. The advantage of this approach over a fully distributed conceptualisation is that it retains maximum simplicity while taking into account observable landscape characteristics.
Determination of evaporation from a catchment water balance at a monthly time scale
H. H. G. Savenije
Hydrology and Earth System Sciences (HESS) & Discussions (HESSD) , 1997,
Abstract: A method is presented to determine total evaporation from the earth's surface at a spatial scale that is adequate for linkage with climate models. The method is based on the water balance of catchments, combined with a calibrated autoregressive rainfall-runoff model. The time scale used is in the order of decades (10 days) to months. The rainfall-runoff model makes a distinction between immediate processes (interception and short term storage) and the remaining longer-term processes. Besides the calibrated rainfall-runoff model and the time series of observed rainfall and runoff, the method requires a relation between transpiration and soil moisture storage. The method is applied to data of the Bani catchment in Mali, a sub-catchment of the Niger river basin.
HESS Opinions "Topography driven conceptual modelling (FLEX-Topo)"
H. H. G. Savenije
Hydrology and Earth System Sciences Discussions , 2010, DOI: 10.5194/hessd-7-4635-2010
Abstract: Heterogeneity and complexity of hydrological processes offer substantial challenges to the hydrological modeller. Some hydrologists try to tackle this problem by introducing more and more detail in their models, or by setting-up more and more complicated models starting from basic principles at the smallest possible level. As we know, this reductionist approach leads to ever higher levels of equifinality and predictive uncertainty. On the other hand, simple, lumped and parsimonious models may be too simple to be realistic or representative of the dominant hydrological processes. In this commentary, a new model approach is proposed that tries to find the middle way between complex distributed and simple lumped modelling approaches. Here we try to find the right level of simplification while avoiding over-simplification. Paraphrasing Einstein, the maxim is: make a model as simple as possible, but not simpler than that. The approach presented is process based, but not physically based in the traditional sense. Instead, it is based on a conceptual representation of the dominant physical processes in certain key elements of the landscape. The essence of the approach is that the model structure is made dependent on a limited number of landscape classes in which the topography is the main driver, but which can include geological, geomorphological or land-use classification. These classes are then represented by lumped conceptual models that act in parallel. The advantage of this approach over a fully distributed conceptualisation is that it retains maximum simplicity while taking into account observable landscape characteristics.
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