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Search Results: 1 - 10 of 149753 matches for " H Atapour Mashhad "
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Effects of Probiotic Lactobacillus Acidophilus and Lactobacillus Casei on the Behavior of Colorectal Tumor Cells
MM Soltan Dallal,M Mojarrad,Z Salehipour,H Atapour Mashhad
Tehran University Medical Journal , 2012,
Abstract: Background: Probiotic microorganisms are living normal flora of human body that have nutritional value and health benefits when administered in adequate amounts. The health benefits include prevention of bacterial diarrhea, skin eczema and recently understood, prevention and control of various cancers, as well. Different mechanisms such as stimulating the immune system, modifying the composition of gastrointestinal and genitourinary tract normal flora and prevention of the carcinogenic activity of fecal enzymes have been identified for their probiotic activity. Due to the high density of the normal flora in the gut and also preferentially sporadic nature of colorectal cancers, these cancers are among the main candidates of treatment trials with probiotics. In this study, direct effects of probiotic lactobacilli on colon cancer tumor cells were studied. Methods: Supernatant fluid and bacterial extracts were prepared and CaCo-2 cells were treated by these materials. Subsequently, the effects of the aforesaid elements were evaluated on cell proliferation, cell necrosis and cell apoptosis by MTT assay, LDH assay and caspase-3 activity. Results: The supernatants of lactobacilli decreased cell proliferation and increased cell apoptosis but they did not have any effect on cell necrosis. In contrast, when cancerous cells were treated by lactobacilli extract, it lead to cell necrosis in addition to reduction in cell proliferation and increase in cell apoptosis. Conclusion: The use of lactobacillus probiotics may reduce proliferation of tumor cells in the early stages of colorectal cancers.
On total dominating sets in graphs
Maryam Atapour,Nasrin Soltankhah
Mathematics , 2008,
Abstract: A set $S$ of vertices in a graph $G(V,E)$ is called a dominating set if every vertex $v\in V$ is either an element of $S$ or is adjacent to an element of $S$. A set $S$ of vertices in a graph $G(V,E)$ is called a total dominating set if every vertex $v\in V$ is adjacent to an element of $S$. The domination number of a graph $G$ denoted by $\gamma(G)$ is the minimum cardinality of a dominating set in $G$. Respectively the total domination number of a graph $G$ denoted by $\gamma_t(G)$ is the minimum cardinality of a total dominating set in $G$. An upper bound for $\gamma_t(G)$ which has been achieved by Cockayne and et al. in $\cite{coc}$ is: for any graph $G$ with no isolated vertex and maximum degree $\Delta(G)$ and $n$ vertices, $\gamma_t(G)\leq n-\Delta(G)+1$. Here we characterize bipartite graphs and trees which achieve this upper bound. Further we present some another upper and lower bounds for $\gamma_t(G)$. Also, for circular complete graphs, we determine the value of $\gamma_t(G)$.
Does Tunneling the Temporary Vascular Access Extend Its Lifetime?
A Atapour,S Shahidi,Sh Sairafian
Journal of Research in Medical Sciences , 2006,
Abstract: Introduction: A significant proportion of infertile men with azoospermia and severe oligoazoospermia have a genetic etiology for their reproductive failure. Genetic analysis has major effects on finding the causes of infertility in last decade, but still in some cases, we still do not have clear answer for our patients. During last years it has become evident that endogenous estrogens and estrogen receptors (ER) play role in the regulation of testicular function. Present study was performed to evaluate the significance of RsaI and AluI single nucleotide polymorphism in the ER gene in infertile patients in comparison with normal fertile male control. Methods: From 120 infertile men referred to our center after ruling out all the known causes of the infertility such as chromosomal abnormalities, Y-chromosome microdeletion, and other pathologic disorders, 5 ml peripheral blood were obtained for DNA extraction. PCR amplification of the polymorphic region was carried out and after running the PCR products on 1.5% agarose gel, the frequency of the polymorphism were calculated. Results: A 3 times higher frequency of the heterozygous RsaI genotype was found in men with low sperm concentration compared to control (P=0.003). In contrast, the proportion of homozygous AluI genotype was only 1/3 in severely oligoazoospermic men in comparison with control (P=0.03). Conclusion: Our results could suggest that ER and RsaI and AluI single nucleotide polymorphisms on this gene are important for spermatogenesis in humans, and could play an important role in the spermatogenesis process in males. Also it is possible to conclude that different conditions of infertility may not have genetic predisposition in common. Key words: estrogen receptor, polymorphism
Foxby equivalence, local duality and Gorenstein homological dimensions
Fatemeh Mohammadi Aghjeh Mashhad,Kamran Divaani-Aazar
Mathematics , 2010,
Abstract: Let $(R,\fm)$ be a local ring and $(-)^{\vee}$ denote the Matlis duality functor. We investigate the relationship between Foxby equivalence and local duality through generalized local cohomology modules. Assume that $R$ possesses a normalized dualizing complex $D$ and $X$ and $Y$ are two homologically bounded complexes of $R$-modules with finitely generated homology modules. We present several duality results for $\fm$-section complex ${\bf R}\Gamma_{\fm}({\bf R}\Hom_R(X,Y))$. In particular, if G-dimension of $X$ and injective dimension of $Y$ are finite, then we show that $${\bf R}\Gamma_{\fm}({\bf R}\Hom_R(X,Y))\simeq ({\bf R}\Hom_R(Y,D\otimes_ R^{{\bf L}}X))^{\vee}.$$ We deduce several applications of these duality results. In particular, we establish Grothendieck's non-vanishing Theorem in the context of generalized local cohomology modules.
On the existence of certain modules of finite Gorenstein homological dimensions
Kamran Divaani-Aazar,Fatemeh Mohammadi Aghjeh Mashhad,Massoud Tousi
Mathematics , 2012,
Abstract: Let (R,m) be a commutative Noetherian local ring. It is known that R is Cohen-Macaulay if there exists either a nonzero finitely generated R-module of finite injective dimension or a nonzero Cohen-Macaulay R-module of finite projective dimension. In this paper, we investigate the Gorenstein analogues of these facts.
On the existence of certain modules of finite Gorenstein homological dimensions, II
Kamran Divaani-Aazar,Fatemeh Mohammadi Aghjeh Mashhad,Massoud Tousi
Mathematics , 2014,
Abstract: One of the remaining questions in Gorenstein homology is whether a local ring R is Cohen-Macaulay if it possesses a nonzero module which is either finitely generated of finite Gorenstein injective dimension or Cohen-Macaulay of finite G-dimension. In this paper, we continue our investigation on this question. Also, we treat two other closely related questions.
Local homology and Gorenstein flat modules
Fatemeh Mohammadi Aghjeh Mashhad,Kamran Divaani-Aazar
Mathematics , 2012,
Abstract: Let $R$ be a commutative Noetherian ring, $\fa$ an ideal of $R$ and $\mathcal{D}(R)$ denote the derived category of $R$-modules. We investigate the theory of local homology in conjunction with Gorenstein flat modules. Let $X$ be a homologically bounded to the right complex and $Q$ a bounded to the right complex of Gorenstein flat $R$-modules such that $Q$ and $X$ are isomorphic in $\mathcal{D}(R)$. We establish a natural isomorphism ${\bf L}\Lambda^{\fa}(X)\simeq \Lambda^{\fa}(Q)$ in $\mathcal{D}(R)$ which immediately asserts that $\sup {\bf L}\Lambda^{\fa}(X)\leq \Gfd_RX$. This isomorphism yields several consequences. For instance, in the case $R$ possesses a dualizing complex, we show that $\Gfd_R {\bf L}\Lambda^{\fa}(X)\leq \Gfd_RX$. Also, we establish a criterion for regularity of Gorenstein local rings.
Frequency of Chlamydia trachomatis in genital specimens: kerman city, PCR method
Khalili M,Atapour M,Aali S,Azizollahi GA
Tehran University Medical Journal , 2008,
Abstract: Background: Chlamydia trachomatis (CT) is an obligate intracellular bacterium that causes genital disease and the most common sexually transmitted infection in the world. The most frequent risk factors associated with chlamydial infection are related to sexual behavior, multiple partners, and inconsistent condom use. Presenting primarily as urtheritis in men and cervicitis in women, CT a major cause of chronic pelvic inflammatory disease and subsequent infertility in women, eye and lung infection in newborns and other manifestations. Identification of CT-infected patients may prevent its spread and thereby reduce the high morbidity associated with CT infections. Polymerase chain reaction (PCR) is a sensitive and specific method for the detection of small quantity of bacterial DNA in clinical samples. The aim of this study was to determine the frequency of C. trachomatis by PCR in genital samples from patients in the city of Kerman.Methods: A total of 130 genital samples including 64 endocervical and 66 urethral swab samples were collected by physicians. Nucleic acid was extracted from each sample using a commercial DNA extraction kit. PCR primers specific for a conserved region of the C. trachomatis omp2 gene, encoding an outer membrane protein, were used for amplification. Results: A total of 9.2% (6.25% of cervicitis and 12.1% of urethritis) of the samples were found positive for CT using this PCR method. Conclusions: The present study shows a high prevalence of CT infection, especially in men with urethritis. Such patients should be referred to genitourinary clinics for treatment and partner notification. Given its worldwide prevalence, further CT studies on more populations are needed to assess potential public health implications of these infections.
Advances of Soft Computing Methods in Edge Detection
Amir Atapour Abarghouei,Afshin Ghanizadeh,Siti Mariyam Shamsuddin
International Journal of Advances in Soft Computing and Its Applications , 2009,
Abstract: Artificial Intelligence (AI) techniques are now commonly used tosolve complex and ill-defined problems. AI a broad field and willbring different meanings for different people. John McCarthy wouldprobably use AI as “computational intelligence”, while Zadehclaimed that computational intelligence is actually Soft Computing(SC) techniques. Regardless of its definition, AI concerns with tasksthat require human intelligence which require complex andadvanced reasoning processes and knowledge. Due to its ability tolearn, handle incomplete or incomprehensible data, deal with nonlinearproblems, and perform reasonable tasks very fast, AI has beenused in diverse applications in control, robotics, pattern recognition,forecasting, medicine, power systems, manufacturing, optimization,signal processing, and social sciences. However, in this paper, wewill focus on Soft Computing (SC), one of the AI influences thatsprang from the concept of cybernetics. The main objective of thispaper is to illustrate how some of these SC techniques generallywork on detecting the edges. The paper also outlines practicaldifferences among these techniques when they are applied to solvingthe problem of edge detection.
Influence of intralumenal and antibiotic-lock of vancomycin on the rate of catheter removal in the patients with permanent hemodialysis catheters
Beigi Ali,Khansoltani Sahar,Masoudpour Hassan,Atapour Abdol
Saudi Journal of Kidney Diseases and Transplantation , 2010,
Abstract: Infection of permanent catheters (Permcath) in hemodialysis (HD) patients can lead to catheter removal. The successful use of an antibiotic-lock to treat infection has reported good results in the treatment of catheters′ infections. This study was designed to evaluate the impact of the intraluminal vancomycin in comparison with intravenous antibiotic administration. We included 67 (37 males and 30 females) chronic HD patients requiring Permcath insertion at our tertiary care hospital from July 2004 to June 2007. We studied two subgroups: an intervention group, which received 500 mg vancomycin infusion via both lumens of the Permcath and antibiotic lock of 1.5 mL each 48 hours with 1 g i.v. ceftriaxone every 12 hours for 7 days, followed by oral antibiotics according to the culture for three weeks; and a control group, which received 500 mg intravenous vancomycin with daily 100-150 mg amikacin intravenously. Our endpoint was the rate of catheter removal. The patients characteristics including age, sex, time of insertion of the catheter and number of dialysis sessions per week did not differ between both subgroups. Of 28 patients in the intervention group, there was one catheter removal, and of 39 patients in the control group, there were 22 catheter removals, (P< 0.001). We conclude that administration of vancomycin as an antibiotic-lock in permcaths is more effective than its mere intravenous injection, and can increase the life span of catheters.
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