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Effect of Repetitive Lysine-Tryptophan Motifs on the Eukaryotic Membrane
Ramamourthy Gopal,Jong Kook Lee,Jun Ho Lee,Young Gwon Kim,Gwang Chae Oh,Chang Ho Seo,Yoonkyung Park
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14012190
Abstract: In a previous study, we synthesized a series of peptides containing simple sequence repeats, (KW) n–NH 2 ( n = 2,3,4 and 5) and determined their antimicrobial and hemolytic activities, as well as their mechanism of antimicrobial action. However, (KW) 5 showed undesirable cytotoxicity against RBC cells. In order to identify the mechanisms behind the hemolytic and cytotoxic activities of (KW) 5, we measured the ability of these peptides to induce aggregation of liposomes. In addition, their binding and permeation activities were assessed by Trp fluorescence, calcein leakage and circular dichrorism using artificial phospholipids that mimic eukaryotic liposomes, including phosphatidylcholine (PC), PC/sphingomyelin (SM) (2:1, w/ w) and PC/cholesterol (CH) (2:1, w/ w). Experiments confirmed that only (KW) 5 induced aggregation of all liposomes; it formed much larger aggregates with PC:CH (2:1, w/ w) than with PC or PC:SM (2:1, w/ w). Longer peptide (KW) 5, but not (KW) 3 or (KW) 4, strongly bound and partially inserted into PC:CH compared to PC or PC:SM (2:1, w/ w). Calcein release experiments showed that (KW) 5 induced calcein leakage from the eukaryotic membrane. Greater calcein leakage was induced by (KW) 5 from PC:CH than from PC:SM (2:1, w/ w) or PC, whereas (KW) 4 did not induce calcein leakage from any of the liposomes. Circular dichroism measurements indicated that (KW) 5 showed higher conformational transition compared to (KW) 4 due to peptide-liposome interactions. Taken together, our results suggest that (KW) 5 reasonably mediates the aggregation and permeabilization of eukaryotic membranes, which could in turn explain why (KW) 5 displays efficient hemolytic activity.
Smart Small Cell for 5G: Theoretical Feasibility and Prototype Results
Jinyoung Jang,MinKeun Chung,Hae Gwang Hwang,Yeon-Geun Lim,Hong-jib Yoon,TaeckKeun Oh,Byung-Wook Min,Yongshik Lee,Kwang Soon Kim,Chan-Byoung Chae,Dong Ku Kim
Computer Science , 2015,
Abstract: In this article, we present a real-time three dimensional (3D) hybrid beamforming for fifth generation (5G) wireless networks. One of the key concepts in 5G cellular systems is a small cell network, which settles the high mobile traffic demand and provides uniform user-experienced data rates. The overall capacity of the small cell network can be enhanced with the enabling technology of 3D hybrid beamforming. This study validates the feasibility of the 3D hybrid beamforming, mostly for link-level performances, through the implementation of a real-time testbed using a software-defined radio (SDR) platform and fabricated antenna array. Based on the measured data, we also investigate system-level performances to verify the gain of the proposed smart small cell system over long term evolution (LTE) systems by performing system-level simulations based on a 3D ray-tracing tool.
Viral Infection Is Not Uncommon in Adult Patients with Severe Hospital-Acquired Pneumonia
Hyo-Lim Hong, Sang-Bum Hong, Gwang-Beom Ko, Jin Won Huh, Heungsup Sung, Kyung-Hyun Do, Sung-Han Kim, Sang-Oh Lee, Mi-Na Kim, Jin-Yong Jeong, Chae-Man Lim, Yang Soo Kim, Jun Hee Woo, Younsuck Koh, Sang-Ho Choi
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095865
Abstract: Background Viral pathogens have not generally been regarded as important causes of severe hospital-acquired pneumonia (HAP), except in patients with hematologic malignancy or transplant recipients. We investigated the role and distribution of viruses in adult with severe HAP who required intensive care. Methods From March 2010 to February 2012, adult patients with severe HAP required admission to the intensive care unit (ICU), 28-bed medical ICU in a tertiary care hospital, were prospectively enrolled. Respiratory viruses were detected using multiplex reverse-transcription polymerase chain reaction and/or shell vial culture. Results A total of 262 patients were enrolled and 107 patients (40.8%) underwent bronchoscopic BAL for etiologic diagnosis. One hundred and fifty-six patients (59.5%) had bacterial infections and 59 patients (22.5%) had viral infections. Viruses were detected in BAL fluid specimens of 37 patients (62.7%, 37/59). The most commonly identified viruses were respiratory syncytial virus and parainfluenza virus (both 27.1%, 16/59), followed by rhinovirus (25.4%, 15/59), and influenza virus (16.9%, 10/59). Twenty-one patients (8.0%, 21/262) had bacterial-viral coinfections and Staphylococcus aureus was the most commonly coexisting bacteria (n = 10). Viral infection in non-immunocompromised patients was not uncommon (11.1%, 16/143), although it was not as frequent as that in immunocompromised patients (36.4%, 43/119). Non-immunocompromised patients were significantly older than immunocompromised patients and had significantly higher rates of underlying chronic obstructive pulmonary disease, tuberculous destroyed lung and chronic kidney disease. The 28 day mortalities of patients with bacterial infections, viral infections and bacterial-viral coinfections were not significantly different (29.5%, 35.6% and 19.0%, respectively; p = 0.321). Conclusions Viral pathogens are not uncommon in adult patients with severe HAP who required ICU admission. Since viral pathogens may cause severe HAP and could be a potential source of viral transmission, further investigation is required to delineate the role of viral pathogens in severe HAP.
Attack Classification Based on Data Mining Technique and Its Application for Reliable Medical Sensor Communication.
Hayoung Oh,,Inshil Doh,,Kijoon Chae
International Journal of Computer Science & Applications , 2009,
A Fault Management and Monitoring Mechanism for Secure Medical Sensor Network.
Hayoung Oh,,Inshil Doh,,Kijoon Chae
International Journal of Computer Science & Applications , 2009,
Classical Geometry of De Sitter Spacetime : An Introductory Review
Yoonbai Kim,Chae Young Oh,Namil Park
Physics , 2002,
Abstract: Classical geometry of de Sitter spacetime is reviewed in arbitrary dimensions. Topics include coordinate systems, geodesic motions, and Penrose diagrams with detailed calculations.
Small data global existence and decay for relativistic Chern-Simons equations
Myeongju Chae,Sung-Jin Oh
Mathematics , 2015,
Abstract: We establish a general small data global existence and decay theorem for Chern-Simons theories with a general gauge group, coupled with a massive relativistic field of spin 0 or 1/2. Our result applies to a wide range of relativistic Chern-Simons theories considered in the literature, including the abelian/non-abelian self-dual Chern-Simons-Higgs equation and the Chern-Simons-Dirac equation. A key idea is to develop and employ a gauge invariant vector field method for relativistic Chern-Simons theories, which allows us to avoid the long range effect of charge.
Effect of Silane Coupling Agent on the Flexural Property of Glass Fiber Reinforced Composite Film  [PDF]
Hye-Hyun Kim, Si-Young Kim, Dae-Hee Kim, Chae-Young Oh, Nam-Ju Jo
Journal of Materials Science and Chemical Engineering (MSCE) , 2014, DOI: 10.4236/msce.2014.210006

Transparent glass fiber reinforced composites films ware fabricated by UV light induced chemical crosslinking of composite materials consisting of glass fiber and UV curable resin in film state. In order to apply film to flexible device, excellent flexural property is required, then the delamination should not occurred between glass fiber and UV curable resin when film is bent. To minimize delamination and improve the interfacial adhesion at interface between glass fiber and UV curable resin, the γ-aminopropyl triethoxy silane and γ-glycid oxypropyl trimethoxy silane were applied for the surface treatment of glass fibers. Silanization of glass fiber surface was checked by scanning electron microscopy and the degree of delamination of composite film was confirmed through the bending test, ASTEM290-96a, used by haze meter.

Reduction of porcine circovirus type 2 (PCV2) viremia by a reformulated inactivated chimeric PCV1-2 vaccine-induced humoral and cellular immunity after experimental PCV2 challenge
Hwi Seo, Yeonsu Oh, Kiwon Han, Changhoon Park, Chanhee Chae
BMC Veterinary Research , 2012, DOI: 10.1186/1746-6148-8-194
Abstract: A reduction of PCV2 viremia coincided with the appearance of both PCV2-specific neutralizing antibodies (NA) and interferon-γ-secreting cells (IFN-γ-SCs) in the vaccinated animals. However, the presence of anti-PCV2 IgG antibodies did not correlate with the reduction of PCV2 viremia. Lymphocyte subset analysis indicated that the numbers of CD3+ and CD4+ cells increased in vaccinated animals but the numbers of CD4+ cells decreased transiently in non-vaccinated animals. The observation of a delayed type hypersensitivity response in only the vaccinated animals also supports a CD4+ cell-associated protective cellular immune response induced by the reformulated inactivated chimeric PCV1-2 vaccine.The induction of PCV2-specific NA and IFN-γ-SCs, and CD4+ cells by the reformulated inactivated chimeric PCV1-2 vaccine is the important protective immune response leading to reduction of the PCV2 viremia and control of the PCV2 infection. To our knowledge this is the first demonstration of protective humoral and cellular immunity induced by the reformulated inactivated chimeric PCV1-2 vaccine and its effect on reduction of PCV2 viremia by vaccination.Porcine circovirus type 2 (PCV2) is one of the most economically important swine pathogens worldwide. The first commercial PCV2 vaccine was used under special license in France and Germany in 2004, 13 years after postweaning multisystemic wasting syndrome (PMWS) was first identified and reported in western Canada [1]. In addition to PMWS, PCV2 is also associated with a number of diseases and syndromes, collectively referred to as porcine circovirus-associated disease (PCVAD) [2,3].Currently, 5 commercial PCV2 vaccines are available worldwide and differ in their antigen [1]. One vaccine (Circovac, Merial) is based on the classical approach of an inactivated oil-adjuvanted vaccine. Three subunit vaccines (Circoflex, Boehringer Ingelheim; Circumvent PCV, Intervet/Merck; Porcillis PCV, Schering-Plough/Merck) are based on an open readin
Radical Scavenging Activity-Based and AP-1-Targeted Anti-Inflammatory Effects of Lutein in Macrophage-Like and Skin Keratinocytic Cells
Jueun Oh,Ji Hye Kim,Jae Gwang Park,Young-Su Yi
Mediators of Inflammation , 2013, DOI: 10.1155/2013/787042
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