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Search Results: 1 - 10 of 9030 matches for " Guy St-Germain "
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Identifying filamentous fungi: a clinical laboratory handbook
St-GERMAIN Guy,SUMMERBELL Richard
Revista do Instituto de Medicina Tropical de S?o Paulo , 2003,
Abstract:
Gastrointestinal Mucormycosis following a Streptococcus pyogenes Toxic Shock Syndrome in a Previously Healthy Patient: A Case Report
Jean-Fran ois Roussy,Catherine Allard,Guy St-Germain,Jacques Pépin
Case Reports in Infectious Diseases , 2012, DOI: 10.1155/2012/476719
Abstract: Mucormycosis is an uncommon opportunistic infection and the gastrointestinal form is the rarest. Rhizopus sp. is the most frequent pathogen and infection occurs almost exclusively in immunocompromised patients. We describe the first case of intestinal mucormycosis occurring after a Streptococcus pyogenes toxic shock syndrome in a previously healthy patient caused by Rhizopus microsporus var. azygosporus.
Gastrointestinal Mucormycosis following a Streptococcus pyogenes Toxic Shock Syndrome in a Previously Healthy Patient: A Case Report
Jean-Fran?ois Roussy,Catherine Allard,Guy St-Germain,Jacques Pépin
Case Reports in Infectious Diseases , 2012, DOI: 10.1155/2012/476719
Abstract: Mucormycosis is an uncommon opportunistic infection and the gastrointestinal form is the rarest. Rhizopus sp. is the most frequent pathogen and infection occurs almost exclusively in immunocompromised patients. We describe the first case of intestinal mucormycosis occurring after a Streptococcus pyogenes toxic shock syndrome in a previously healthy patient caused by Rhizopus microsporus var. azygosporus. 1. Introduction Mucormycosis is an infection caused by members of the order Mucorales. Relatively uncommon, it is one of the most rapidly fatal infections known to man [1]. The gastrointestinal form is the rarest [1, 2]. Usually, individuals who develop mucormycosis have predisposing risk factors such as diabetes mellitus, deferoxamine chelating therapy, hematological or solid organ malignancies, organ transplantation, neutropenia, and immunosuppressive or corticosteroid therapy [1]. Here, we describe the case of a previously healthy patient who developed a severe form of gastrointestinal mucormycosis a few days after having recovered from a Streptococcus pyogenes toxic shock syndrome (TSS). This is to our knowledge the first case of mucormycosis occurring after a S. pyogenes TSS. 2. Case Report A previously healthy 53-year-old woman, who had been complaining of respiratory tract symptoms and fever for 3 days, was diagnosed with a S. pyogenes necrotizing pneumonia with TSS and transferred to our institution. Upon admission, she was found to have multiorgan failure with acute respiratory distress syndrome and immediately required intubation and vasopressors. She also received IV penicillin, clindamycin, immunoglobulins, activated C-protein, and three days of corticosteroids at physiological dose. Over the following week, the shock resolved and her respiratory parameters improved. However, on day 10 her condition critically deteriorated, vasopressors were resumed and piperacillin-tazobactam was administered. On physical examination, proctorrhagia and abdominal distension were noted, and she developed leukopenia (Table 1). Abdominal CT scan revealed a pneumoperitoneum near the hypogastric region (Figure 1(a)) with parietal pneumatosis of the caecum and sigmoid, compatible with acute ischemia (Figure 1(b)). An emergency laparotomy revealed intestinal and colonic necrosis which necessitated a 100?cm resection of the terminal ileum and subtotal colectomy with terminal ileostomy (Figure 2(a)). An abundant quantity of nonpurulent but foul-smelling fluid was recovered during the surgery but without any frank fecal peritonitis (Figure 2(b)). Peritoneal fluid
Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-κB/IκB pathway
Marie-Eve St-Germain, Veronique Gagnon, Sophie Parent, Eric Asselin
Molecular Cancer , 2004, DOI: 10.1186/1476-4598-3-7
Abstract: Three different human endometrial cancer cell lines known to have wild type PTEN (HEC 1-A) or a mutated inactive PTEN protein (RL 95-2 and Ishikawa) were used for these studies. Expression IκB and Phospho-IκB were evaluated by Western analysis. The presence of IκB phosphorylation was found in all cell lines studied. There was no difference between cell lines in term of NF-κB abundance. Inhibition of PI 3-K with Wortmannin and LY294002 blocked IκB phosphorylation, reduced NF-κB nuclear activity, reduced COX-2 expression and induced apoptosis. Transfection studies with a dominant negative Akt vector blocked IκB phosphorylation and reduced COX-2 expression. On the opposite, constitutively active Akt transfections resulted in the induction of IκB phosphorylation and up-regulation of COX-2.These results demonstrate that Akt signals through NF-κB/IκB pathway to induce COX-2 expression in mutated PTEN endometrial cancer cells.The phosphoinositide 3-kinase (PI 3-kinase) pathway has been implicated in the activation of the proinflammatory transcription factor nuclear factor κB (NF-κB) [1-3]. It has been demonstrated that both the regulatory and the catalytic subunit of phosphatidylinositol 3-kinase (PI 3-K) play a role in NF-κB activation by the tyrosine phosphorylation-dependent pathway [3]. The NF-κB transcription factor is a pleiotropic activator that participates in the induction of a wide variety of cellular genes [4]. In addition to its role in inflammation and immune response, NF-κB has also been implicated in the suppression of apoptosis [5], cellular survival, transformation, and oncogenesis [6]. Predominantly a heterodimeric complex of two polypeptides (p65/RelA and p50), NF-κB lies dormant in the cytoplasm through the binding IκB inhibitory proteins. When phosphorylated on serine 32 and serine 36, IκBα is targeted and degraded by ubiquitin/26 S proteasome pathway liberating the NF-κB heterodimer so that it may translocate to the nucleus and bind DNA. NF-κB binds t
Odin (ANKS1A) Modulates EGF Receptor Recycling and Stability
Jiefei Tong, Yaroslav Sydorskyy, Jonathan R. St-Germain, Paul Taylor, Ming S. Tsao, Michael F. Moran
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064817
Abstract: The ANKS1A gene product, also known as Odin, was first identified as a tyrosine-phosphorylated component of the epidermal growth factor receptor network. Here we show that Odin functions as an effector of EGFR recycling. In EGF-stimulated HEK293 cells tyrosine phosphorylation of Odin was induced prior to EGFR internalization and independent of EGFR-to-ERK signaling. Over-expression of Odin increased EGF-induced EGFR trafficking to recycling endosomes and recycling back to the cell surface, and decreased trafficking to lysosomes and degradation. Conversely, Odin knockdown in both HEK293 and the non-small cell lung carcinoma line RVH6849, which expresses roughly 10-fold more EGF receptors than HEK293, caused decreased EGFR recycling and accelerated trafficking to the lysosome and degradation. By governing the endocytic fate of internalized receptors, Odin may provide a layer of regulation that enables cells to contend with receptor cell densities and ligand concentration gradients that are physiologically and pathologically highly variable.
Télémonitorage des grandes fonctions physiologiques chez les primates vigiles Remote monitoring of physiologic functions in monkeys
GuyGermain
Revue de Primatologie , 2011, DOI: 10.4000/primatologie.533
Abstract: Les caractéristiques communes à l'étude des primates non-humains sont proches des contraintes que l'on rencontre dans l'application des principes de la télémédecine humaine. Elles découlent de l’éloignement des animaux et de leur dispersion géographique pour les études en milieu naturel, elles découlent aussi du besoin de contr ler au laboratoire les traitements expérimentaux en perturbant le moins possible le comportement social des animaux. Les ondes radio sont un excellent signal de transmission pour le suivi des animaux parce qu'elles peuvent propager des informations rapidement et sur de longues distances dans l'air. Tous les dispositifs télémétriques consistent en un ou plusieurs capteurs couplés à un émetteur encodeur radio et d'un système d'antenne couplé à un récepteur décodeur, analogique ou numérique. Le progrès des télétransmissions résulte par ailleurs de la miniaturisation des dispositifs électroniques d'acquisition et d'émission qui sont de moins en moins gourmands en énergie et acquièrent des durées d'autonomie beaucoup plus grande. De nombreux dispositifs télémétriques très souvent totalement implantables dans le corps de l'animal sont aujourd'hui commercialement disponibles. Ils permettent une surveillance détaillée des paramètres physiologiques des systèmes cardiovasculaire, nerveux, locomoteur, métabolique, respiratoire et reproducteur chez les primates non-humains entièrement libres de leurs mouvements. Ils sont très largement exploités dans les études pharmacologiques et toxicologiques. D'autres dispositifs encore au stade expérimental intègrent également la combinaison de l'enregistrement télémétrique des pressions, biopotentiels musculaires ou nerveux, température, avec des enregistrements audio et vidéo pouvant être eux-mêmes acquis et transmis, partiellement ou en totalité, par télémétrie. Le développement des systèmes futurs sera probablement axé sur les besoins accrus de caractériser des individus très mobiles ou des groupes d’animaux dans des environnements complexes, toujours en utilisant des systèmes portables et les moins invasifs possible. Ces systèmes devraient permettre de caractériser les tendances évolutives de certains états physiologiques (études éthophysiologiques, études de terrain) ou expérimentaux (physiologie, pharmacologie) et d'alerter suffisamment rapidement les observateurs pour qu'ils puissent appliquer en retour des actions correctives si nécessaire. Des pans entiers des grandes fonctions physiologiques, régulations métaboliques et régulations hormonales, pour ne citer que celles-là, ne peuvent pas encore
Benefits of short inspiratory muscle training on exercise capacity, dyspnea, and inspiratory fraction in COPD patients
Barakat Shahin,Michele Germain,Alzahouri Kazem,Guy Annat
International Journal of COPD , 2008,
Abstract: Barakat Shahin1, Michele Germain2, Alzahouri Kazem3, Guy Annat41Department of Physiology, University of Claude Bernard Lyon I, Lyon, France; 2Chef of the Service of EFR, Hospital of the Croix-Rousse at Lyon, France; 3Department of Medical Informatics, Hospital of St. Julien, Nancy, France; 4Department of Physiology, UFR Médecine Lyon Grange-Blanche Université Claude Bernard Lyon I, INSERM ESPRI ERI 22, Lyon, FranceAbstract: Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease (COPD). Given that most of these patients have respiratory and peripheral muscle weakness, dyspnea and functional exercise capacity may improve as a result of inspiratory muscle training (IMT). The present study is designed to investigate the benefits of a short outpatient program of IMT on inspiratory muscle performance, exercise capacity, perception of dyspnea, and the inspiratory fraction (IF). Thirty patients (24 males, 6 females) with significant COPD (forced expiratory volume in one second [FEV1] = 46.21% ± 6.7% predicted, FEV1 = 33.6% ± 8.04% predicted) were recruited for this study and had 3 months of IMT (30 minutes/day for 6 days/week) in an outpatient clinic. Following IMT, there was a statistically significant increase in inspiratory muscle performance (an increase of the maximal inspiratory pressure from 59% ± 19.1% to 79% ± 21.85% predicted; p = 0.0342), a decrease in dyspnea (from 5.8 ± 0.78 to 1.9 ± 0.57; p = 0.0001), an increase in the distance walked during the 6 minute walk test, from 245 ± 52.37 m to 302 ± 41.30 m, and finally an increase in the IF (the new prognostic factor in COPD) from 27.6 ± 9.7% to 31.4% ± 9.8%. The present study concludes that in patients with significant COPD, IMT results in improvement in performance, exercise capacity, sensation of dyspnea, and moreover an improvement in the IF prognostic factor.Keywords: inspiratory muscle training, dyspnea, inspiratory fraction
Finite Element Modelling of Micro-cantilevers Used as Chemical Sensors
Guy Louarn,Stéphane Cuenot
Physics , 2009,
Abstract: Nowadays, silicon micro-cantilevers with different geometrical shapes are widely used as micro-electro-mechanical systems and, more recently, as force sensor probes in atomic force microscopy (AFM). During the last ten years, several applications, which include these AFM micrometer-sized cantilevers as mass probes in microbalances or as chemical sensors in chemical micro-system devices, were developed. In the case of complex shapes of cantilevers, where the cross-section is not constant along the cantilever length (case of ?V-shaped? micro-cantilevers), their resonant frequencies can not be analytically calculated. Firstly, in order to validate the accuracy of our FEM approach, we carried out a comparison between analytical, experimental and FEM-computed values of the resonant frequencies for homogenous rectangular shaped micro-cantilevers. Then, we performed a modeling of silicon beams coated with a thin sensitive layer (50 nm of Gold). To precisely calculate the resonant frequencies of these multilayer-cantilevers, the influence of the mesh parameters on the calculated frequencies was strongly investigated. Secondly, the sensitivity of different ?V-shaped? silicon cantilevers was estimated, as a function of their geometrical dimensions and of their mechanical parameters (Young modulus, density). The resonant frequencies of uncoated cantilevers were calculated and compared with the values experimentally determined. Then, a similar approach was employed to predict the sensitivities of such cantilevers recovered with a sensitive layer.
Kac-Moody groups, hovels and Littelmann's paths
Stéphane Gaussent,Guy Rousseau
Mathematics , 2007,
Abstract: We give the definition of a kind of building I for a symmetrizable Kac-Moody group over a field K endowed with a dicrete valuation and with a residue field containing C. Due to some bad properties, we call this I a hovel. Nevertheless I has some good properties, for example the existence of retractions with center a sector-germ. This enables us to generalize many results proved in the semi-simple case by S. Gaussent and P. Littelmann [Duke Math. J; 127 (2005), 35-88]. In particular, if K= C((t)), the geodesic segments in I, with a given special vertex as end point and a good image under some retraction, are parametrized by a Zariski open subset P of C^N. This dimension N is maximum when this image is a LS path and then P is closely related to some Mirkovic-Vilonen cycle.
Spherical Hecke algebras for Kac-Moody groups over local fields
Stéphane Gaussent,Guy Rousseau
Mathematics , 2012,
Abstract: We define the spherical Hecke algebra H for an almost split Kac-Moody group G over a local non-archimedean field. We use the hovel I associated to this situation, which is the analogue of the Bruhat-Tits building for a reductive group. The stabilizer K of a special point on the standard apartment plays the role of a maximal open compact subgroup. We can define H as the algebra of K-bi-invariant functions on G with almost finite support. As two points in the hovel are not always in a same apartment, this support has to be in some large subsemigroup G+ of G. We prove that the structure constants of H are polynomials in the cardinality of the residue field, with integer coefficients depending on the geometry of the standard apartment. We also prove the Satake isomorphism between H and the algebra of Weyl invariant elements in some completion of a Laurent polynomial algebra. In particular, H is always commutative. Actually, our results apply to abstract "locally finite" hovels, so that we can define the spherical algebra with unequal parameters.
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