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Search Results: 1 - 10 of 7313 matches for " Gupta Soham "
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Active Flow Control of a Low Reynolds Number S809 Wind Turbine Blade Model under Dynamic Pitching Maneuvers  [PDF]
Victor Maldonado, Soham Gupta
Open Journal of Fluid Dynamics (OJFD) , 2017, DOI: 10.4236/ojfd.2017.72012
Abstract: A low Reynolds number wind turbine blade model based on the S809 airfoil was tested in a subsonic wind tunnel to study the structural vibration of the blade under dynamic pitching maneuvers. Piezoelectric-based synthetic jet actuators were embedded inside the blade and activated with a synthetic jet momentum coefficient, Cμ of 2.30 × 10-3. Structural vibration was quantified for a range of unsteady angles undergoing “pitch up and down” and “sinusoidal pitch” maneuvers at a Reynolds number of 5.28 × 104. The blade tip deflection amplitude and frequency were acquired utilizing a pair of strain gauges mounted at the root of the model. Using active flow control vibration reduction was more effective during the pitch up portion of the blade motion cycle compared to the pitch down portion. This effect is due to dynamic stall, where a leading edge vortex is shed during the pitch up motion and contributes to higher lift compared to static angles of attack and lower lift when the blade is pitched down. Dynamic stall was measured with phase-locked stereoscopic particle image velocimetry (SPIV), where global mean flow measurements reveal a shift in location and reduction in the size of a recirculating flow structure near the suction surface of the blade during the pitch up motion compared to the pitch down.
A Comparative Analysis of Bacterial Growth with Earphone Use
Chiranjay Mukhopadhyay,Soham Basak,Soham Gupta,Kiran Chawla
Online Journal of Health & Allied Sciences , 2008,
Abstract: Background: Recently the worldwide usage of earphones has increased especially among the school and college students who have a high rate of sharing among them. Alike airline headsets, headphones and stethoscope ear-pieces, ear phones can easily be a vector of potential pathogens, which can give rise to otitis externa. Purpose: To compare the bacterial growth of the external ear in association with earphone and assess the role of earphones as vector or microorganisms. Material and Methods: 50 voluntary male subjects (age 18-25 years) were chosen and divided into two groups, A and B, according to the use of earphones. Swabs were taken from their left ear and the left earpiece of the earphone. Samples were processed as recommended. Results: In group A, bacteria were found in 20 (80%) ear and 14 (56%) earphone swabs. In group B, bacteria were found in 23 (92%) ear and 17 (68%) earphone swabs. Group B showed heavy growth and a significant increase in the number of bacterial growths after frequent and constant use. Conclusion: Frequent and constant use of earphones increases the bacterial growth in the ear and sharing of earphones might be a potential vector of commensals. It is therefore, always better not to share or else to clean the earphones before sharing.
Oncoproteomics: New trends in analytical techniques
Girish Gupta,Nikhil Gupta,Mayank Gupta,Soham Trivedi
International Journal of Drug Discovery , 2009,
Abstract: Oncoproteomics is the study of proteins and their interactions in a cancer cell by proteomictechnologies and has the potential to revolutionize clinical practice, including cancer diagnosis.Oncoproteomics screening based on proteomic platforms as a complement to histopathology, individualizedselection of therapeutic combinations that target the entire cancer-specific protein network, real-timeassessment of therapeutic efficacy and toxicity and rational modulation of therapy based on changes in thecancer protein network associated with prognosis and drug resistance. Oncoproteomics refers to theapplication of proteomic technologies in oncology and parallels the related field of oncogenomics. Thechallenges ahead and perspectives of oncoproteomics for biomarkers development are also addressed.With a wealth of information that can be applied to a broad spectrum of biomarker research projects servesas a reference for biomarker researchers, scientists working in proteomics and bioinformatics, oncologists,pharmaceutical scientists, biochemists, biologists, and chemists.
Immunogenomics: recent discoveries
Mayank Gupta,Nikhil Gupta,Soham Trivedi,Prasad Patil
International Journal of Genetics , 2009,
Abstract: Immunogenomics is a new research field, which addresses the interface between host and(pathogen) proteome, bridging informatics technology, genomics, proteomics, immunology and clinicalmedicine. The switch from the paradigm of solely hypothesis-driven immunological research to a moreinteractive and flexible relationship between classical research and a new discovery-driven approach istermed immunogenomics. This review will focus on the immunogenomics and recent discoveries inImmunogenomics, which are leading to insights into novel immunomodulatory therapies. The researchregarding the different aspects of immunogenomics; rather than providing a comprehensive review, we willhighlight various factors that influence immunogenomics and how modulation of the immune response maybe incorporated into future trends.
Compara??o entre três métodos de colora??o a frio no diagnóstico primário de tuberculose: um estudo piloto
Gupta, Soham;Shenoy, Vishnu Prasad;Bairy, Indira;Muralidharan, Sethumadhavan;
Jornal Brasileiro de Pneumologia , 2010, DOI: 10.1590/S1806-37132010000500013
Abstract: objective: in developing countries, sputum smear microscopy is the main tool for pulmonary tuberculosis case finding. the objective of the present study was to evaluate the diagnostic efficacy of gabbett's staining (gs) and modified cold staining (mcs), both of which are two-step methods, in comparison with that of fluorescent staining (fs), which is a three-step method, for the detection of afb in sputum smears. methods: our sample comprised 260 sputum samples collected from individuals suspected of having pulmonary tuberculosis at kasturba hospital, in manipal, india. smears were prepared in triplicate: one each for fs, mcs, and gs. the smears were randomly numbered so that the examiner was blinded to the sample identities. results: of the 260 samples, 16 (6.15%), 15 (5.77%), and 13 (5.00%) showed positive afb results with fs, mcs, and gs, respectively. the sensitivity of gs and mcs, in comparison with that of fs, was 81.25% and 93.75%, respectively. the concordance of gs and mcs with fs was good (0.988 and 0.996, respectively), and no statistically significant differences were found. conclusions: although mcs and gs were found to be less sensitive than was fs, which is evaluated under fluorescence microscopy, the first two are promising methods for the diagnosis of tuberculosis.
Ceftriaxone resistant Shigella Flexneri, an emerging problem
Gupta Soham,Mishra Baijayanti,Muralidharan Sethumadhavan,Srinivasa Hiresave
Indian Journal of Medical Sciences , 2010,
Abstract: Shigellosis is a disease of public health importance in developing countries. It may cause self-limited diarrhea to severe dysentery. Emergence of multi drug resistant (MDR) strains is a growing concern globally. Ceftriaxone and ciprofloxacin are the drugs of choice for MDR cases. Here, we report a case of MDR Shigella flexneri from an immunocompromised patient. The strain was resistant to ceftriaxone [minimum inhibitory concentration (MIC) ≥ 64 μg/ml], limiting the treatment option. Simultaneously, the strain was also found to be resistant to ciprofloxacin (MIC ≥ 4 μg/ml). However, it was susceptible to ceftazidime (MIC 4 μg/ml). This is the first case of ceftriaxone resistant Shigella spp. reported from our hospital.
Emerging Frontiers in Therapeutics of Diffuse Large B Cell Lymphoma: Epigenetics and B Cell Receptor Signaling  [PDF]
Soham Puvvada, Lisa Rimsza
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.43A059

This review discusses the impact of gene expression profiling and sequencing discoveries on new therapeutic strategies in Non-Hodgkin Lymphomas, particularly Diffuse Large B cell Lymphoma. Alterations in oncogenes, over-active signaling pathways down-stream of the B cell receptor, and epigenetic gene mutations will be described. We will also review new targeting strategies aimed at each of these aspects of cell biology encompassing BCL2, BTK, PKCβ, PI3K/mTOR and HDAC inhibition. Specific new drugs in clinical trials and early trial results are included as well.

Community prevalence of methicillin and vancomycin resistant Staphylococcus aureus in and around Bangalore, southern India
Goud, Rajendra;Gupta, Soham;Neogi, Ujjwal;Agarwal, Deepali;Naidu, Kesava;Chalannavar, Raju;Subhaschandra, Gaddad;
Revista da Sociedade Brasileira de Medicina Tropical , 2011, DOI: 10.1590/S0037-86822011005000035
Abstract: introduction: staphylococcus aureus is a known colonizer in humans and has been implicated in community acquired soft tissue infections. however emergence of methicillin resistant s. aureus (mrsa) has aroused great concern worldwide. this study aimed to determine the prevalence of mrsa in the community of bangalore, southern india. methods: swabs were collected from anterior nares, forearm, dorsum and palm of the hands of 1,000 healthy individuals residing in and around bangalore, belonging to different socioeconomic strata and age groups. results: analysis verified that 22.5% and 16.6% of the individuals presented staphylococcus aureus and mrsa, respectively, at any of the three sites. vancomycin resistance was observed in 1.4% of the s. aureus isolates, which was confirmed by detection of the vana gene. it was interesting to note that 58.8% of the children in the age group 1-5 years-old presented mrsa, the highest percentage compared to other age groups of < 1 (44.4%) year-old, 5-20 (21.7%) years-old, > 40 (11%) years-old and 20-40 (9.9%) years-old. among the population of various socioeconomic strata, maximum mrsa colonization was observed among doctors (22.2%), followed by upper economic class (18.8%), lower economic class (17.7%), apparently healthy hospital in-patients (16.5%), nurses (16%) and middle economic class (12.5%). most of the mrsa isolates were capsular polysaccharide antigen type 8 (57.1%). conclusions: there is a need for continuous surveillance and monitoring of the presence of mrsa in the community and a clearer understanding of the dynamics of the spread of mrsa will assist in controlling its dissemination.
Soham Shukla
International Journal of Pharmaceutical Sciences and Research , 2011,
Abstract: Among the various methods of drying, this article has mentioned only one most important method, “Freeze drying”. This method is mainly used for the drying of thermo labile materials. This method works on the principle of sublimation. This method is divided into 3 steps for its better understanding; these are Freezing, Primary drying, and secondary drying. There are many advantages and disadvantages of this method, but still this is the most useful drying method nowadays.
Molecular Epidemiology of HIV-1 Subtypes in India: Origin and Evolutionary History of the Predominant Subtype C
Ujjwal Neogi, Irene Bontell, Anita Shet, Ayesha De Costa, Soham Gupta, Vishal Diwan, Ranbir S. Laishram, Ajay Wanchu, Udaykumar Ranga, Akhil C. Banerjea, Anders S?nnerborg
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039819
Abstract: Background India has the third largest HIV-1 epidemic with 2.4 million infected individuals. Molecular epidemiological analysis has identified the predominance of HIV-1 subtype C (HIV-1C). However, the previous reports have been limited by sample size, and uneven geographical distribution. The introduction of HIV-1C in India remains uncertain due to this lack of structured studies. To fill the gap, we characterised the distribution pattern of HIV-1 subtypes in India based on data collection from nationwide clinical cohorts between 2007 and 2011. We also reconstructed the time to the most recent common ancestor (tMRCA) of the predominant HIV-1C strains. Methodology/Principal Findings Blood samples were collected from 168 HIV-1 seropositive subjects from 7 different states. HIV-1 subtypes were determined using two or three genes, gag, pol, and env using several methods. Bayesian coalescent-based approach was used to reconstruct the time of introduction and population growth patterns of the Indian HIV-1C. For the first time, a high prevalence (10%) of unique recombinant forms (BC and A1C) was observed when two or three genes were used instead of one gene (p<0.01; p = 0.02, respectively). The tMRCA of Indian HIV-1C was estimated using the three viral genes, ranged from 1967 (gag) to 1974 (env). Pol-gene analysis was considered to provide the most reliable estimate [1971, (95% CI: 1965–1976)]. The population growth pattern revealed an initial slow growth phase in the mid-1970s, an exponential phase through the 1980s, and a stationary phase since the early 1990s. Conclusions/Significance The Indian HIV-1C epidemic originated around 40 years ago from a single or few genetically related African lineages, and since then largely evolved independently. The effective population size in the country has been broadly stable since the 1990s. The evolving viral epidemic, as indicated by the increase of recombinant strains, warrants a need for continued molecular surveillance to guide efficient disease intervention strategies.
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